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Science, ISSN 0036-8075, 10/2010, Volume 330, Issue 6000, pp. 70 - 74
Taxol (paclitaxel) is a potent anticancer drug first isolated from the Taxus brevifolia Pacific yew tree. Currently, cost-efficient production of Taxol and its... 
Enzymes | Cellular metabolism | Terpenoids | Chemical engineering | Bioreactors | Plasmids | REPORTS | Operons | Biosynthesis | Indoles | Streams | YEAST | CYTOCHROME-P450 | TAXADIENE | CELLS | MULTIDISCIPLINARY SCIENCES | CONSTRUCTION | BIOSYNTHETIC GENES | STEP | OXYGENASES | LYCOPENE PRODUCTION | TERPENOIDS | Metabolomics | NADPH-Ferrihemoprotein Reductase - genetics | Erythritol - analogs & derivatives | Cytochrome P-450 Enzyme System - metabolism | Taxoids - metabolism | Organophosphorus Compounds - metabolism | Recombinant Fusion Proteins - metabolism | Farnesyltranstransferase - metabolism | Escherichia coli K12 - metabolism | Hemiterpenes - metabolism | Indoles - metabolism | Terpenes - metabolism | Erythritol - metabolism | Isomerases - genetics | Diterpenes - metabolism | NADPH-Ferrihemoprotein Reductase - metabolism | Paclitaxel - biosynthesis | Oxidation-Reduction | Fermentation | Taxus - enzymology | Metabolic Networks and Pathways - genetics | Genetic Engineering | Sugar Phosphates - metabolism | Farnesyltranstransferase - genetics | Cytochrome P-450 Enzyme System - genetics | Isomerases - metabolism | Escherichia coli K12 - genetics | Alkenes - metabolism | Escherichia coli K12 - enzymology | Physiological aspects | Research | Health aspects | Escherichia coli | Biological transport | Biochemistry | Pharmacology | E coli | Drugs | Pathways | Searching | Taxol | Modules | Modular | Pacific yew | Optimization | Index Medicus
Journal Article
Nature Genetics, ISSN 1061-4036, 09/2009, Volume 41, Issue 9, pp. 1027 - 1031
The primary cilium is an antenna-like structure that protrudes from the cell surface of quiescent/differentiated cells and participates in extracellular signal... 
NETWORK | INOSITOL-POLYPHOSPHATE 5-PHOSPHATASE | POLYCYSTIC KIDNEY-DISEASE | BIOLOGY | GENETICS & HEREDITY | DISORDERS | PROTEINS | FIBROBLASTS | Humans | Fluorescent Dyes - metabolism | Culture Media, Serum-Free | Male | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Fibroblasts - ultrastructure | Obesity - genetics | Embryo, Mammalian - metabolism | Intellectual Disability - genetics | Indoles - metabolism | Tubulin - metabolism | Cell Nucleus - metabolism | Transfection | Mice, Mutant Strains | Cilia - ultrastructure | Bardet-Biedl Syndrome - genetics | Chromones - pharmacology | Microsatellite Repeats | Fibroblasts - metabolism | Genetic Linkage | Cell Line | Green Fluorescent Proteins - metabolism | Phosphoric Monoester Hydrolases - genetics | Cilia - pathology | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Fluorescent Antibody Technique, Direct | Retinal Degeneration - genetics | Cells, Cultured | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Mice, Transgenic | Genetic Markers | Cilia - metabolism | Cilia - genetics | Pigment Epithelium of Eye - metabolism | Animals | Embryo, Mammalian - cytology | Signal Transduction - physiology | Fibroblasts - cytology | Mice | Polymorphism, Single Nucleotide | Mutation | Pigment Epithelium of Eye - cytology | Penis - abnormalities | Gene mutations | Genetic aspects | Cellular signal transduction | Research | Health aspects | Risk factors | Brain diseases | Proteins | Tissue | Scanning electron microscopy | Transmission electron microscopy | Cysts | Rodents | Cell division | Index Medicus
Journal Article
The Plant Cell, ISSN 1040-4651, 3/2010, Volume 22, Issue 3, pp. 973 - 990
Despite the fact that roots are the organs most subject to microbial interactions, very little is known about the response of roots to microbe-associated... 
Pathogens | Microorganisms | Rhizodeposition | Plant roots | Bacteria | Chitin | Biosynthesis | Plants | Seedlings | Plant cells | ALTERNARIA-BRASSICICOLA | BIOCHEMISTRY & MOLECULAR BIOLOGY | PSEUDOMONAS-SYRINGAE | SYSTEMIC ACQUIRED-RESISTANCE | PLANT SCIENCES | CELL BIOLOGY | PHYTOTOXIN CORONATINE | NONHOST RESISTANCE | SALICYLIC-ACID | METHYL JASMONATE | PLANT DEFENSE | RHIZOSPHERE BACTERIA | PHYTOALEXIN CAMALEXIN | Peptidoglycan - metabolism | Thiazoles - metabolism | Salicylic Acid - metabolism | Arabidopsis - immunology | Cytochrome P-450 Enzyme System - metabolism | Plant Roots - genetics | Pseudomonas | Ethylenes - metabolism | Arabidopsis Proteins - metabolism | Indoles - metabolism | Chitin - metabolism | Glucans - metabolism | Plant Roots - metabolism | Plants, Genetically Modified - genetics | Signal Transduction | Plants, Genetically Modified - immunology | RNA, Plant - genetics | Arabidopsis - metabolism | N-Glycosyl Hydrolases - metabolism | Arabidopsis - genetics | Host-Pathogen Interactions | Oxylipins - metabolism | Flagella - metabolism | Plants, Genetically Modified - metabolism | Plant Roots - immunology | Cyclopentanes - metabolism | Arabidopsis thaliana | Immune response | Plant molecular genetics | Diseases and pests | Roots (Botany) | Genetic aspects | Research | Index Medicus | Life Sciences | Cellular Biology
Journal Article
Nature Immunology, ISSN 1529-2908, 08/2005, Volume 6, Issue 8, pp. 777 - 784
Journal Article
Science, ISSN 0036-8075, 1/2009, Volume 323, Issue 5910, pp. 101 - 106
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 08/2007, Volume 35, Issue 8, pp. 1308 - 1314
Hepatic uptake carriers of the organic anion-transporting peptide (OATP) family of solute carriers are more and more recognized as being involved in hepatic... 
RAT | SEVERE RHABDOMYOLYSIS | COMBINATION THERAPY | LIVER | PHARMACOLOGY & PHARMACY | CERIVASTATIN | HEPATIC-UPTAKE | TRANSPLANT RECIPIENTS | ROSUVASTATIN | POLYPEPTIDE | FAMILY | Organic Anion Transporters, Sodium-Independent - genetics | Fatty Acids, Monounsaturated - pharmacology | Cricetulus | Hypolipidemic Agents - metabolism | Hypoglycemic Agents - metabolism | Taurocholic Acid - metabolism | Humans | Hepatocytes - metabolism | Simvastatin - pharmacology | Organic Anion Transporters - metabolism | Chromans - metabolism | Hepatocytes - cytology | Indoles - metabolism | Organic Anion Transporters - genetics | Drug Interactions | Anticholesteremic Agents - metabolism | Chromans - pharmacology | Fatty Acids, Monounsaturated - metabolism | Organic Anion Transporters, Sodium-Independent - metabolism | Indoles - pharmacology | Biological Transport - drug effects | Thiazolidinediones - pharmacology | Hepatocytes - drug effects | Solute Carrier Organic Anion Transporter Family Member 1B3 | CHO Cells | Pravastatin - pharmacology | Recombinant Proteins - metabolism | Taurocholic Acid - pharmacology | Cell Line | Cricetinae | Pravastatin - metabolism | Simvastatin - metabolism | Gemfibrozil - pharmacokinetics | Gemfibrozil - pharmacology | Hypolipidemic Agents - pharmacology | Thiazolidinediones - metabolism | Hypoglycemic Agents - pharmacology | Animals | Estrone - analogs & derivatives | Estrone - metabolism | Protein Binding | Fatty Acids, Monounsaturated - pharmacokinetics | Indoles - pharmacokinetics | Kinetics | Solute Carrier Organic Anion Transporter Family Member 1b1 | Anticholesteremic Agents - pharmacology | Gemfibrozil - metabolism | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2017, Volume 12, Issue 10, pp. e0186615 - e0186615
Background Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and fatal disease. Histone deacetylase 6 (HDAC6) alters function and fate of various... 
EPITHELIAL-MESENCHYMAL TRANSITION | LUNG FIBROSIS | IN-VITRO | TGF-BETA | HISTONE DEACETYLASE INHIBITION | MULTIDISCIPLINARY SCIENCES | TUBULIN ACETYLATION | DISEASE | AUTOPHAGY | MYOFIBROBLAST DIFFERENTIATION | EXPRESSION | Idiopathic Pulmonary Fibrosis - genetics | Ribosomal Protein S6 Kinases - metabolism | TOR Serine-Threonine Kinases - metabolism | Humans | Middle Aged | Phosphoprotein Phosphatases - metabolism | Male | Phosphatidylinositol 3-Kinases - metabolism | Vascular Endothelial Growth Factor A - metabolism | RNA, Messenger - metabolism | Autophagy - drug effects | Idiopathic Pulmonary Fibrosis - metabolism | Mechanistic Target of Rapamycin Complex 1 | Autophagosomes - drug effects | Multiprotein Complexes - metabolism | Tubulin - metabolism | Bleomycin | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Aged, 80 and over | Female | Indoles - pharmacology | Lung - metabolism | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Hydroxamic Acids - pharmacology | Fibroblasts - metabolism | Lung - pathology | Collagen Type I - metabolism | Histone Deacetylases - genetics | Histone Deacetylase 6 | RNA, Messenger - genetics | Histone Deacetylases - metabolism | Nuclear Proteins - metabolism | Autophagosomes - metabolism | Mice, Knockout | Transforming Growth Factor beta - pharmacology | Animals | Signal Transduction - drug effects | Fibroblasts - drug effects | Idiopathic Pulmonary Fibrosis - pathology | Hydroxamic Acids - therapeutic use | Indoles - therapeutic use | Aged | Transforming Growth Factor beta - metabolism | Idiopathic Pulmonary Fibrosis - drug therapy | Histone deacetylase | Deregulation | Collagen (type I) | Phosphorylation | Disease | Mesenchyme | Pathogenesis | Lung | Critical care | AKT protein | Leucine | Kinases | Autophagy | Proteins | Fibroblasts | Vascular endothelial growth factor | Internal medicine | Lung diseases | Environmental health | 1-Phosphatidylinositol 3-kinase | Medicine | Pulmonary fibrosis | Inhibitors | Lungs | Lysine | Deacetylation | Collagen | Fibrosis | Mice | Protein phosphatase | Phagocytosis | Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 06/2016, Volume 22, Issue 6, pp. 586 - 597
Astrocytes have important roles in the central nervous system (CNS) during health and disease. Through genome-wide analyses we detected a transcriptional... 
MEDICINE, RESEARCH & EXPERIMENTAL | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MYELOID CELLS | BLOOD-BRAIN-BARRIER | BETA | CELL BIOLOGY | RESPONSES | MULTIPLE-SCLEROSIS | REGULATORY T-CELLS | DIFFERENTIATION | NF-KAPPA-B | EXPRESSION | Optical Imaging | Cell Proliferation | Central Nervous System - metabolism | Encephalomyelitis, Autoimmune, Experimental - metabolism | Humans | Encephalomyelitis, Autoimmune, Experimental - immunology | Immunoblotting | Gene Expression Profiling | Chromatography, High Pressure Liquid | Glial Fibrillary Acidic Protein - metabolism | Interferon Type I - immunology | Suppressor of Cytokine Signaling Proteins | Tryptophan - metabolism | Case-Control Studies | Central Nervous System - immunology | Tryptophanase - metabolism | Gene Knockdown Techniques | Indoles - metabolism | STAT1 Transcription Factor - metabolism | Lactobacillus reuteri | Astrocytes - immunology | Chromatin Immunoprecipitation | Polymerase Chain Reaction | Receptors, Aryl Hydrocarbon - metabolism | Chemokine CCL2 - metabolism | Receptor, Interferon alpha-beta - genetics | Multiple Sclerosis - metabolism | Indican - urine | Serotonin | Gastrointestinal Microbiome | Inflammation | Mice, Knockout | Animals | Interferon-beta - pharmacology | Fluorescent Antibody Technique | Multiple Sclerosis - immunology | T-Lymphocytes - immunology | Mice | Myxovirus Resistance Proteins - metabolism | Receptors, Aryl Hydrocarbon - immunology | Nitric Oxide Synthase Type II - metabolism | Microbiota (Symbiotic organisms) | Astrocytes | Physiological aspects | Tryptophan | Interferon | Genetic aspects | Research | Autoimmunity | Multiple sclerosis | Care and treatment | Encephalomyelitis | Central nervous system | Prevention | Metabolites | Analysis | Dosage and administration | Diagnosis | Health aspects | Nervous system | Microorganisms | Immune system | Index Medicus
Journal Article
Gut, ISSN 0017-5749, 08/2014, Volume 63, Issue 8, pp. 1300 - 1312
Objective Enteric glia activation has been reported to amplify intestinal inflammation via the enteroglial-specific S100B protein. This neurotrophin promotes... 
NITRIC-OXIDE PRODUCTION | INHIBITION | CROHNS-DISEASE | MACROPHAGES | ULCERATIVE-COLITIS | FATTY-ACID AMIDE | S100B PROTEIN | N-PALMITOYL-ETHANOLAMINE | GLIAL-CELLS | GASTROENTEROLOGY & HEPATOLOGY | BOWEL-DISEASE | Tumor Necrosis Factor-alpha - metabolism | Dextran Sulfate | Ethanolamines - pharmacology | Endocannabinoids - pharmacology | Rectum - pathology | Humans | Middle Aged | Palmitic Acids - therapeutic use | Male | NF-kappa B - metabolism | Glial Fibrillary Acidic Protein - metabolism | Nitric Oxide - analysis | Colon, Sigmoid - chemistry | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Neuroglia - drug effects | Colitis - chemically induced | Female | Indoles - pharmacology | Colitis - drug therapy | S100 Calcium Binding Protein beta Subunit - metabolism | Colitis, Ulcerative - drug therapy | Palmitic Acids - pharmacology | Colon, Sigmoid - pathology | Endocannabinoids - therapeutic use | Neutrophil Infiltration - drug effects | Severity of Illness Index | PPAR alpha - antagonists & inhibitors | Signal Transduction | Colitis, Ulcerative - metabolism | Cells, Cultured | Colitis, Ulcerative - pathology | Toll-Like Receptor 4 - metabolism | Dinoprostone - metabolism | Nerve Tissue Proteins - metabolism | Animals | PPAR gamma - antagonists & inhibitors | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Anilides - pharmacology | Colitis - metabolism | Cyclooxygenase 2 - metabolism | Rectum - chemistry | Ethanolamines - therapeutic use | Neuroglia - metabolism | Mice | PPAR alpha - metabolism | Nitric Oxide - metabolism | Nitric Oxide Synthase Type II - metabolism | Influence | Amides | Inflammation | Neuroglia | Analysis | Risk factors | Index Medicus | Abridged Index Medicus
Journal Article