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Journal of Neuroscience, ISSN 0270-6474, 10/2012, Volume 32, Issue 43, pp. 15148 - 15157
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 11/2011, Volume 103, Issue 22, pp. 1665 - 1675
Recent advances in tumor biology have made remarkable achievements in the development of therapy for metastatic castrate-resistant prostate cancer. These... 
GROWTH-FACTOR RECEPTOR | CONTROLLED-TRIAL | ANTIANGIOGENIC THERAPY | ONCOLOGY | RANDOMIZED PHASE-II | BONE METASTASES | C-MET | SIPULEUCEL-T APC8015 | ABIRATERONE ACETATE | TUMOR MICROENVIRONMENT | ANGIOGENESIS INHIBITION | Cancer Vaccines - pharmacology | Humans | Male | Antineoplastic Agents - therapeutic use | Bevacizumab | Prostatic Neoplasms - immunology | RANK Ligand - pharmacology | Receptors, Androgen - drug effects | Treatment Failure | Prostatic Neoplasms - drug therapy | Phenylthiohydantoin - pharmacology | Tumor Microenvironment - drug effects | Dasatinib | Antibodies, Monoclonal - pharmacology | Angiogenesis Inhibitors - pharmacology | Clusterin - pharmacology | Pyrimidines - pharmacology | Denosumab | Prostate-Specific Antigen - blood | Orchiectomy | Signal Transduction - drug effects | Anilides - pharmacology | Mice | Receptor Cross-Talk - drug effects | Endothelin-1 - antagonists & inhibitors | Immunotherapy - methods | Taxoids - pharmacology | Ipilimumab | Tissue Extracts - pharmacology | Bone Remodeling - drug effects | Pyrrolidines - pharmacology | Antibodies, Monoclonal, Humanized - pharmacology | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Molecular Targeted Therapy - methods | Prostatic Neoplasms - pathology | Antineoplastic Agents, Hormonal - pharmacology | Androstenols - pharmacology | Androstenes | Clinical Trials as Topic | Mice, SCID | Phenylthiohydantoin - analogs & derivatives | Biomarkers, Tumor - blood | Xenograft Model Antitumor Assays | Cancer Vaccines - immunology | Pyrroles - pharmacology | Animals | RANK Ligand - antagonists & inhibitors | Pyridines - pharmacology | Thiazoles - pharmacology | Immune response | Development and progression | Cellular signal transduction | Research | Drug therapy | Health aspects | Prostate cancer | Risk factors | Review
Journal Article
Biochemical journal, ISSN 0264-6021, 2000, Volume 351, Issue 1, pp. 95 - 105
Journal Article
Nature communications, ISSN 2041-1723, 2014, Volume 5, Issue 1, p. 5712
Increased expression of the Microphthalmia-associated transcription factor (MITF) contributes to melanoma progression and resistance to BRAF pathway... 
BRAF INHIBITION | TYROSINE KINASE AXL | RAF INHIBITION | CELLS | BREAST-CANCER METASTASIS | MULTIDISCIPLINARY SCIENCES | ACQUIRED-RESISTANCE | IMPROVED SURVIVAL | MEK INHIBITORS | UP-REGULATION | CONFERS RESISTANCE | Prognosis | Skin Neoplasms - drug therapy | Humans | Gene Expression Regulation, Neoplastic | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Melanoma - genetics | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Indoles - pharmacology | Pyrimidinones - pharmacology | Antineoplastic Agents - pharmacology | Benzamides - pharmacology | Proto-Oncogene Proteins B-raf - metabolism | Melanoma - metabolism | Proto-Oncogene Proteins - metabolism | Skin Neoplasms - pathology | Proto-Oncogene Proteins - antagonists & inhibitors | Microphthalmia-Associated Transcription Factor - metabolism | Signal Transduction | Proto-Oncogene Proteins - genetics | Imidazoles - pharmacology | Melanoma - pathology | Pyrimidines - pharmacology | Receptor Protein-Tyrosine Kinases - metabolism | Sulfonamides - pharmacology | Imatinib Mesylate | Piperazines - pharmacology | Skin Neoplasms - metabolism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Animals | Receptor Protein-Tyrosine Kinases - genetics | Proto-Oncogene Proteins B-raf - genetics | Aminopyridines - pharmacology | Melanoma - drug therapy | Skin Neoplasms - genetics | Cell Line, Tumor | Oximes - pharmacology | Mice | Protein Kinase Inhibitors - pharmacology | Microphthalmia-Associated Transcription Factor - genetics | Pyridones - pharmacology
Journal Article
Behavioural Pharmacology, ISSN 0955-8810, 10/2015, Volume 26, Issue 7 - Special Issue Pharmacological Approaches To The Study Of Social Behaviour - Part 2: Social Modulation Of Drug Effects, pp. 681 - 690
Journal Article
Gastroenterology, ISSN 0016-5085, 2008, Volume 134, Issue 7, pp. 2004 - 2013
Background & Aims: Chemotherapy with an anticancer agent generally causes gastrointestinal tract disorders such as vomiting and anorexia, but the mechanism... 
Gastroenterology and Hepatology | SEROTONIN RECEPTOR | GHRELIN LEVELS | SYMPTOMS | MICE | EMESIS | GASTROENTEROLOGY & HEPATOLOGY | STOMACH | Receptor, Serotonin, 5-HT2B - metabolism | Receptor, Serotonin, 5-HT2C - metabolism | Body Weight - drug effects | Drugs, Chinese Herbal - pharmacology | Male | Stomach - metabolism | Drugs, Chinese Herbal - metabolism | Anorexia - physiopathology | Quinolines - pharmacology | Serotonin Receptor Agonists - pharmacology | Dose-Response Relationship, Drug | Serotonin 5-HT2 Receptor Antagonists | Chalcones - pharmacology | Dopamine Antagonists - metabolism | Receptors, Ghrelin - metabolism | Indoles - pharmacology | Stomach - innervation | Stomach - drug effects | Drugs, Chinese Herbal - therapeutic use | Flavones - pharmacology | Acylation | Disease Models, Animal | Antineoplastic Agents | Rats | Thiophenes - pharmacology | Anorexia - metabolism | Dopamine Antagonists - therapeutic use | Receptors, Ghrelin - drug effects | Piperazines - pharmacology | Rats, Sprague-Dawley | Vagotomy | Cisplatin | Ghrelin - metabolism | Eating - drug effects | Gastrointestinal Agents - pharmacology | Ghrelin - blood | Animals | Dopamine Antagonists - pharmacology | Aminopyridines - pharmacology | Serotonin - metabolism | Gastrointestinal Agents - therapeutic use | Anorexia - prevention & control | Hesperidin - pharmacology | Protein Binding | Anorexia - chemically induced | Oligopeptides - pharmacology | Gastrointestinal Agents - metabolism | Medicine, Botanic | Medicine, Herbal
Journal Article
The Journal of physiology, ISSN 0022-3751, 2010, Volume 588, Issue 14, pp. 2605 - 2619
In vertebrate retina, melatonin regulates various physiological functions. In this work we investigated the mechanisms underlying melatonin‐induced... 
CIRCADIAN CLOCK | PROTEIN-KINASE-C | ACTIVATION | PHYSIOLOGY | PHOSPHOLIPASE-C | VISUAL PATHWAY | FUNCTIONAL-ROLE | RECEPTOR | MT2 MELATONIN | EXPRESSION | NEUROSCIENCES | MODULATION | Cyclic GMP - pharmacology | Receptor, Melatonin, MT2 - antagonists & inhibitors | Tetradecanoylphorbol Acetate - pharmacology | Maleimides - pharmacology | Male | Calcium - analysis | Melatonin - physiology | Type C Phospholipases - antagonists & inhibitors | Cyclic GMP-Dependent Protein Kinases - antagonists & inhibitors | Cyclic GMP-Dependent Protein Kinases - physiology | Isoquinolines - pharmacology | Cyclic GMP - analogs & derivatives | Estrenes - pharmacology | Pyrrolidinones - pharmacology | Bridged-Ring Compounds - pharmacology | Egtazic Acid - analogs & derivatives | Indoles - pharmacology | Guanosine Diphosphate - pharmacology | Pertussis Toxin - pharmacology | Retinal Ganglion Cells - physiology | Protein Kinase C - physiology | Retinal Ganglion Cells - enzymology | 8-Bromo Cyclic Adenosine Monophosphate - pharmacology | Rats | Protein Kinase C - antagonists & inhibitors | Receptor, Melatonin, MT2 - physiology | Sulfonamides - pharmacology | Rats, Sprague-Dawley | Animals | Egtazic Acid - pharmacology | Glycine - physiology | Guanosine Diphosphate - analogs & derivatives | Signal Transduction - drug effects | Tetrahydronaphthalenes - pharmacology | Thiones - pharmacology | Carbazoles - pharmacology | Type C Phospholipases - physiology | Melatonin | Phospholipids | Glycine | Ganglion | Gross domestic product | Protein kinases | Kinases | Retina | Physiology | Neuroscience
Journal Article
Nature medicine, ISSN 1546-170X, 2016, Volume 22, Issue 2, pp. 194 - 201
Journal Article
Biochemical journal, ISSN 1470-8728, 2003, Volume 371, Issue 1, pp. 199 - 204
We have previously examined the specificities of 28 commercially available compounds, reported to be relatively selective inhibitors of particular... 
SELECTIVE-INHIBITION | ACTIVATION | VIVO | Src | protein kinase inhibitors | TYROSINE KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | protein phosphorylation | CYCLIN-DEPENDENT KINASES | GLYCOGEN-SYNTHASE KINASE-3-BETA | IN-VITRO | POTENT | SP 600125 | Roscovitine | Kenpaullone | LITHIUM | SMOOTH-MUSCLE CELLS
Journal Article
British journal of pharmacology, ISSN 1476-5381, 2002, Volume 137, Issue 7, pp. 1021 - 1030
The mechanism(s) by which vascular endothelial growth factor (VEGF) induces endothelial nitric oxide synthase (eNOS) activation remain(s) unclear up to a... 
eNOS | PAF | PI3K | VEGF | PLC | PLA2 | PKC | PLA | PROTEIN-KINASE-C | PHOSPHORYLATION | NITRIC-OXIDE SYNTHASE | VASCULAR-PERMEABILITY | CALMODULIN | CALCIUM | PAF SYNTHESIS | PHARMACOLOGY & PHARMACY | PLATELET-ACTIVATING-FACTOR | GROWTH-FACTOR | NEOVASCULARIZATION | Endothelium, Vascular - cytology | Vascular Endothelial Growth Factors | Platelet Activating Factor - pharmacology | Protein-Serine-Threonine Kinases | Type C Phospholipases - metabolism | Endothelium, Vascular - drug effects | Endothelial Growth Factors - pharmacology | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Receptors, Cell Surface - antagonists & inhibitors | Lactones - pharmacology | Platelet Membrane Glycoproteins - antagonists & inhibitors | Calcium - antagonists & inhibitors | Time Factors | Cattle | Protein Kinase C - metabolism | Phosphorylation - drug effects | Chromones - pharmacology | Enzyme Inhibitors - pharmacology | Nitric Oxide Synthase Type III | Receptors, G-Protein-Coupled | Chelating Agents - pharmacology | Serine - metabolism | 1-Methyl-3-isobutylxanthine - pharmacology | Ginkgolides | Platelet Activating Factor - metabolism | Cyclic GMP - metabolism | Endothelium, Vascular - metabolism | Intercellular Signaling Peptides and Proteins - pharmacology | Nitric Oxide Synthase - metabolism | Vascular Endothelial Growth Factor A | Maleimides - pharmacology | Nitric Oxide Synthase - antagonists & inhibitors | Phosphatidylinositol 3-Kinases - metabolism | Nitroprusside - pharmacology | Type C Phospholipases - antagonists & inhibitors | Dose-Response Relationship, Drug | Egtazic Acid - analogs & derivatives | Indoles - pharmacology | Lymphokines - pharmacology | Nitric Oxide Donors - pharmacology | Ionophores - pharmacology | NG-Nitroarginine Methyl Ester - pharmacology | Proto-Oncogene Proteins - metabolism | Cells, Cultured | Morpholines - pharmacology | Protein Kinase C - antagonists & inhibitors | Calcimycin - pharmacology | Proto-Oncogene Proteins c-akt | Animals | Egtazic Acid - pharmacology | Androstadienes - pharmacology | Diterpenes | Signal Transduction - physiology | Nitric Oxide - metabolism | Papers
Journal Article