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Journal of the National Cancer Institute, ISSN 0027-8874, 04/2011, Volume 103, Issue 8, pp. 645 - 661
Background Ionizing radiation (IR) is effectively used in cancer therapy. However, in subsets of patients, a few radioresistant cancer cells survive and cause... 
STEM-CELLS | IN-VITRO | ONCOLOGY | TYROSINE KINASE | HGF | CELL INVASION | RECEPTOR | EPITHELIAL-MESENCHYMAL TRANSITIONS | NF-KAPPA-B | SCATTER-FACTOR | PROTOONCOGENE | Humans | Neoplasm Invasiveness - prevention & control | Radiation Tolerance | Receptors, Growth Factor - antagonists & inhibitors | NF-kappa B - metabolism | RNA, Messenger - metabolism | NF-kappa B - radiation effects | Receptors, Growth Factor - genetics | Proto-Oncogene Proteins c-met - radiation effects | Signal Transduction - radiation effects | Protein-Serine-Threonine Kinases - metabolism | Radiation, Ionizing | Tumor Suppressor Proteins - metabolism | DNA-Binding Proteins - radiation effects | Proto-Oncogene Proteins c-met - antagonists & inhibitors | Cell Cycle Proteins - metabolism | Cell Cycle Proteins - radiation effects | Receptors, Growth Factor - radiation effects | Proto-Oncogene Proteins c-met - drug effects | Ataxia Telangiectasia Mutated Proteins | Phosphorylation - radiation effects | Cell Line, Tumor | Mice | RNA, Small Interfering | Tumor Suppressor Proteins - radiation effects | Receptors, Growth Factor - metabolism | Neoplasms - metabolism | Proto-Oncogene Proteins c-met - metabolism | Apoptosis - radiation effects | Up-Regulation - radiation effects | Transcription, Genetic - radiation effects | Transplantation, Heterologous | Sulfones - pharmacology | DNA-Binding Proteins - metabolism | Chromatin Immunoprecipitation | Protein-Serine-Threonine Kinases - radiation effects | Tumor Suppressor Proteins - genetics | Polymerase Chain Reaction | Cell Cycle Proteins - genetics | Indoles - pharmacology | Neoplasms - radiotherapy | Gene Expression Regulation, Neoplastic - drug effects | In Situ Nick-End Labeling | Enzyme-Linked Immunosorbent Assay | Radiation-Sensitizing Agents - pharmacology | Gene Silencing | Protein-Serine-Threonine Kinases - genetics | DNA-Binding Proteins - genetics | Cell Survival - radiation effects | Cell Movement - radiation effects | Proto-Oncogene Proteins c-met - genetics | Blotting, Northern | Animals | NF-kappa B - genetics | Protein Kinase Inhibitors - pharmacology | Neoplasms - pathology | Receptors, Growth Factor - drug effects | DNA Damage - radiation effects | Mitogen-Activated Protein Kinases - metabolism | Ionizing radiation | Physiological aspects | Genetic aspects | Cancer invasiveness | Research | Gene expression | Radiotherapy | Health aspects | Oncology | Radiation therapy | Kinases | Index Medicus
Journal Article
International Journal of Biochemistry and Cell Biology, ISSN 1357-2725, 11/2013, Volume 45, Issue 11, pp. 2553 - 2562
In order to find a novel photosensitizer to be used in photodynamic therapy for cancer treatment, we have previously showed that the cationic zinc(II)... 
Phthalocyanine | Bcl-2 family proteins | Photodynamic therapy | Apoptosis | Lysosomal proteases | OXIDATIVE STRESS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CYSTEINE CATHEPSINS | CLEAVAGE | CELL BIOLOGY | PROGRAMMED CELL-DEATH | BAX | CYTOCHROME-C RELEASE | MEMBRANE PERMEABILIZATION | Cell Death - radiation effects | Reactive Oxygen Species - metabolism | Membrane Potential, Mitochondrial - radiation effects | Humans | Dermatitis, Phototoxic - pathology | Protein Transport - drug effects | Membrane Potential, Mitochondrial - drug effects | Photochemotherapy | Lysosomes - radiation effects | Caspases - metabolism | Lysosomes - metabolism | Mitochondria - radiation effects | Intracellular Membranes - radiation effects | Cell Death - drug effects | Signal Transduction - radiation effects | Cathepsins - antagonists & inhibitors | Radiation, Ionizing | Lysosomes - drug effects | Permeability - drug effects | Organometallic Compounds - toxicity | Cytochromes c - metabolism | bcl-2-Associated X Protein - metabolism | Indoles - toxicity | Mitochondria - metabolism | Mitochondria - drug effects | Enzyme Activation - drug effects | Enzyme Activation - radiation effects | Permeability - radiation effects | Signal Transduction - drug effects | Cathepsins - metabolism | Dermatitis, Phototoxic - metabolism | Models, Biological | Protein Transport - radiation effects | Cell Line, Tumor | Organometallic Compounds - chemistry | Intracellular Membranes - drug effects | Indoles - chemistry | Intracellular Membranes - metabolism | Zinc | Phthalocyanins | Index Medicus | Proteins | Membranes | Pathways | Protease | Cationic | Lysosomes | Cleavage | Activation
Journal Article
Journal Article
Biological Psychiatry, ISSN 0006-3223, 2008, Volume 64, Issue 4, pp. 293 - 301
Background Depression and anxiety disorders have been linked to dysfunction of the hypothalamo-pituitary-adrenal (HPA) axis and structural changes within the... 
Psychiatry | unpredictable chronic mild stress | x-irradiation | Corticotrophin-releasing factor | fluoxetine | depression | vasopressin | ADULT HIPPOCAMPUS | PSYCHIATRY | corticotrophin-releasing factor | CHRONIC MILD STRESS | CEREBRAL METABOLITES | CELL-PROLIFERATION | MAJOR DEPRESSION | NEUROSCIENCES | PREFRONTAL CORTEX | FLUOXETINE TREATMENT | FACTOR RECEPTOR ANTAGONIST | HYDROCHLORIDE SSR125543A | DENTATE GYRUS | Depression - pathology | Motor Activity - drug effects | Male | Hemibody Irradiation - methods | Pyrrolidines - pharmacology | Depression - drug therapy | Hemibody Irradiation - adverse effects | Time Factors | Exploratory Behavior - radiation effects | Reaction Time - drug effects | Exploratory Behavior - drug effects | Thiazines - pharmacology | Behavior, Animal - drug effects | Indoles - pharmacology | Antidepressive Agents - pharmacology | Bromodeoxyuridine - metabolism | Neurons - drug effects | Hydrocarbons, Halogenated - pharmacology | Disease Models, Animal | Antidepressive Agents - classification | Hippocampus - pathology | Corticotropin-Releasing Hormone - metabolism | Antidepressive Agents - therapeutic use | Animals | Cell Count - methods | Analysis of Variance | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Biogenic Monoamines - metabolism | Neurons - radiation effects | Cell Proliferation - radiation effects | Reaction Time - radiation effects | Anxiety | Pituitary hormones | Stress (Psychology) | Fluoxetine | Analysis | Index Medicus
Journal Article
Molecular Plant, ISSN 1674-2052, 05/2012, Volume 5, Issue 3, pp. 642 - 652
Light is emerging as a central regulator of plant immune responses against herbivores and pathogens. Solar UV-B radiation plays an important role as a positive... 
photomorphogenesis | plant–microbe interactions | defense | jasmonate | photoreceptor | phenylpropanoids | phenolics | plant-microbe interactions | SECONDARY METABOLITES | CHLOROPHYLL FLUORESCENCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BLISTER BLIGHT DISEASE | PSEUDOMONAS-SYRINGAE | NICOTIANA-LONGIFLORA | PLANT SCIENCES | SIGNAL-TRANSDUCTION | HERBIVOROUS INSECTS | LEAF EPIDERMAL TRANSMITTANCE | SALICYLIC-ACID | ULTRAVIOLET-RADIATION | Thiazoles - metabolism | Coumaric Acids - chemistry | Plant Diseases - immunology | Arabidopsis - immunology | Glucosinolates - metabolism | Plant Diseases - microbiology | Disease Resistance - immunology | Botrytis - physiology | Arabidopsis Proteins - metabolism | Arabidopsis - radiation effects | Indoles - metabolism | Ultraviolet Rays | Botrytis - radiation effects | Signal Transduction - radiation effects | Gene Expression Regulation, Plant - radiation effects | Chromosomal Proteins, Non-Histone - metabolism | Coumaric Acids - metabolism | Disease Resistance - drug effects | Signal Transduction - genetics | Cyclopentanes - pharmacology | Phenols - metabolism | Mutation - genetics | Disease Resistance - radiation effects | Arabidopsis - genetics | Arabidopsis - microbiology | Gene Expression Regulation, Plant - drug effects | Botrytis - drug effects | Signal Transduction - drug effects | Oxylipins - pharmacology | Ultraviolet radiation | Flowers & plants | Index Medicus
Journal Article
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2011, Volume 80, Issue 3, pp. 860 - 868
Purpose To evaluate the effectiveness of mitigation of acute ionizing radiation damage by mitochondrion-targeted small molecules. Methods and Materials We... 
Radiology | Hematology, Oncology and Palliative Medicine | Mitigation | Radiation injury | Mitochondrial targeting | Antioxidant | Nitric oxide synthase inhibitor | p53 inhibitor | OXIDATIVE STRESS | STROMAL CELL-LINES | NITRIC-OXIDE SYNTHASE | DRUG DISCOVERY | CYTOCHROME-C | GAMMA-IRRADIATION | ONCOLOGY | INHIBITORS | ANTAGONISTS | SUPEROXIDE-DISMUTASE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | LEAD COMPOUNDS | Cell Survival - drug effects | Whole-Body Irradiation | Enzyme Inhibitors | Tumor Suppressor Protein p53 - antagonists & inhibitors | Humans | Mice, Inbred C57BL | Nitric Oxide Synthase - antagonists & inhibitors | Imidazoles - pharmacology | Mitochondria - drug effects | Radiation Dosage | Cell Line - radiation effects | Cell Line - drug effects | Animals | Radiation Injuries, Experimental - drug therapy | Nitrogen Oxides - pharmacology | Mitochondria - radiation effects | Radiation-Protective Agents - pharmacology | Thiazines - pharmacology | Female | Indoles - pharmacology | Mice | DNA Damage | Radiation Injuries, Experimental - mortality | Antioxidants | Radiation | Universities and colleges | Index Medicus | OXYGEN COMPOUNDS | NITRIC OXIDE | MITOCHONDRIA | RADIATION EFFECTS | BONE MARROW | ANIMAL TISSUES | 60 APPLIED LIFE SCIENCES | IRRADIATION | BIOLOGICAL EFFECTS | NITROGEN OXIDES | DRUGS | VERTEBRATES | RADIOLOGY AND NUCLEAR MEDICINE | BIOLOGICAL RADIATION EFFECTS | MICE | HEMATOPOIETIC SYSTEM | NITROGEN COMPOUNDS | EXTERNAL IRRADIATION | MAMMALS | ANIMALS | WHOLE-BODY IRRADIATION | INJURIES | RODENTS | ORGANIC COMPOUNDS | RADIATION INJURIES | CHALCOGENIDES | ORGANS | PEPTIDES | DISEASES | OXIDES | PROTEINS | BODY | CELL CONSTITUENTS
Journal Article
Journal Article
Radiation Research, ISSN 0033-7587, 01/2018, Volume 189, Issue 1, pp. 68 - 83
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2013, Volume 8, Issue 7, pp. e69106 - e69106
Based on previous data on the histamine radioprotective effect on highly radiosensitive tissues, in the present work we aimed at investigating the... 
Whole-Body Irradiation | Mutagens - toxicity | Salivary Glands - pathology | Intestine, Small - pathology | Receptors, G-Protein-Coupled - metabolism | Hematopoietic System - drug effects | Humans | Male | Bone Marrow - radiation effects | Sulfhydryl Compounds - metabolism | Salivary Glands - radiation effects | Hematopoietic System - radiation effects | Radiation-Protective Agents - pharmacology | Female | Indoles - pharmacology | Intestine, Small - radiation effects | Receptors, Histamine H4 | Salivary Glands - drug effects | Bone Marrow - drug effects | Rats | Thiobarbituric Acid Reactive Substances - metabolism | Piperazines - pharmacology | Rats, Sprague-Dawley | Receptors, Histamine - metabolism | Animals | Breast Neoplasms - pathology | Bone Marrow - pathology | Intestine, Small - drug effects | Cell Line, Tumor | Ligands | Cell Proliferation - drug effects | Hematopoietic System - pathology | Immunohistochemistry | Cesium radioisotopes | Mucosa | Erythrocytes | Genotoxicity | Radioisotopes | Cytotoxicity | Biochemistry | Small intestine | Cancer therapies | Blood | Ionizing radiation | Methacholine | Animal tissues | Peripheral blood | Bone marrow | Physiology | Drug dosages | Deoxyribonucleic acid--DNA | Radiation effects | Melanoma | Submandibular gland | Mammals | Histamine | Councils | Crypts | Pharmacy | Irradiation | Radiation damage | Glands | DNA damage | Irradiated | Atrophy | Red blood cells | Rodents | Radiation injuries | Damage assessment | Repopulation | Salivary glands | Research & development--R&D | Cesium | Radiation therapy | Dentistry | Hemopoiesis | Aplasia | Hematopoietic system | Laboratory animals | Apoptosis | Index Medicus | Research & development | R&D | Deoxyribonucleic acid | DNA
Journal Article
Radiotherapy and Oncology, ISSN 0167-8140, 2016, Volume 119, Issue 2, pp. 259 - 264