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Pharmacological Research, ISSN 1043-6618, 09/2012, Volume 66, Issue 3, pp. 251 - 259
Endocannabinoids exhibit vasodilatory properties and reduce blood pressure . However, the influence and mechanism of action of the prominent endocannabinoid,... 
Endocannabinoid | Abnormal cannabidiol | Pulmonary artery | Anandamide | Endothelium | VIRODHAMINE | VASORELAXATION | SMALL MESENTERIC-ARTERY | CANNABINOID RECEPTOR | VESSELS | VASCULATURE | RESISTANCE | PHARMACOLOGY & PHARMACY | CHANNELS | HYPERTENSION | ABNORMAL-CANNABIDIOL | Tetraethylammonium - pharmacology | Endocannabinoids - pharmacology | Rats, Wistar | Capsaicin - pharmacology | Anisoles - pharmacology | Cyclohexanes - pharmacology | Nitric Oxide Synthase - antagonists & inhibitors | Endothelium, Vascular - drug effects | Male | Apamin - pharmacology | Receptors, Cannabinoid - metabolism | TRPV Cation Channels - metabolism | Piperidines - pharmacology | Charybdotoxin - pharmacology | TRPV Cation Channels - antagonists & inhibitors | Potassium Chloride - metabolism | Cannabinoid Receptor Antagonists - pharmacology | Indoles - pharmacology | Benzamides - pharmacology | Potassium Channel Blockers - pharmacology | Carbamates - pharmacology | Pyrazoles - pharmacology | Amidohydrolases - metabolism | NG-Nitroarginine Methyl Ester - pharmacology | Receptors, Epoprostenol - metabolism | Rats | Amidohydrolases - antagonists & inhibitors | Capsaicin - analogs & derivatives | Imidazoles - pharmacology | Pulmonary Artery - drug effects | Arachidonic Acids - pharmacology | Indomethacin - pharmacology | Receptors, Epoprostenol - antagonists & inhibitors | Animals | Benzyl Compounds - pharmacology | Endothelium, Vascular - metabolism | Prostaglandin-Endoperoxide Synthases - metabolism | 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology | Polyunsaturated Alkamides - pharmacology | Nitric Oxide Synthase - metabolism | Vasodilation - drug effects | Hypertension | Enzymes | Vasodilators | Blood vessels | Glycerol | Fatty acids | Pulmonary hypertension | Glycerin | Cannabinoids | Dilatation | Dimethyl sulfoxide | Hydrolases | Indomethacin | Index Medicus
Journal Article
Chemical Research in Toxicology, ISSN 0893-228X, 09/2008, Volume 21, Issue 9, pp. 1814 - 1822
In vitro covalent binding assessments of drugs have been useful in providing retrospective insights into the association between drug metabolism and a... 
ACYL GLUCURONIDES | CHEMISTRY, MEDICINAL | PROTEIN | RAT | REACTIVE METABOLITES | TIENILIC ACID | HEPATIC-NECROSIS | BIOACTIVATION | IDENTIFICATION | CHEMISTRY, MULTIDISCIPLINARY | MASS-SPECTROMETRY | TOXICOLOGY | HUMAN URINE | Buspirone - chemistry | Raloxifene Hydrochloride - pharmacology | Thiazoles - metabolism | Acetaminophen - metabolism | Humans | Microsomes, Liver - metabolism | Indomethacin - metabolism | Simvastatin - pharmacology | Diclofenac - chemistry | Thiazines - metabolism | Propranolol - pharmacology | Toxicity Tests - methods | Binding Sites | Simvastatin - metabolism | Microsomes, Liver - chemistry | Indomethacin - pharmacology | Paroxetine - metabolism | Raloxifene Hydrochloride - metabolism | Triazoles - metabolism | Ticrynafen - metabolism | Paroxetine - pharmacology | Diclofenac - metabolism | Paroxetine - chemistry | Diphenhydramine - pharmacology | Diclofenac - pharmacology | Triazoles - chemistry | Buspirone - metabolism | Ticrynafen - pharmacology | Structure-Activity Relationship | Buspirone - pharmacology | Hepatocytes - metabolism | Dose-Response Relationship, Drug | Carbamazepine - chemistry | Diphenhydramine - metabolism | Acetaminophen - pharmacology | Microsomes, Liver - drug effects | Propranolol - metabolism | Carbamazepine - metabolism | Thiazines - pharmacology | Molecular Structure | Drug Evaluation, Preclinical | Hepatocytes - drug effects | Carbamazepine - pharmacology | Simvastatin - chemistry | Acetaminophen - chemistry | Ticrynafen - chemistry | Propranolol - chemistry | Diphenhydramine - chemistry | Thiazines - chemistry | Triazoles - pharmacology | Indomethacin - chemistry | Thiazoles - chemistry | Thiazoles - pharmacology | Raloxifene Hydrochloride - chemistry | Index Medicus
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 01/2017, Volume 794, pp. 209 - 215
N-arachidonoyl glycine (NAGLY), is the endogenous lipid that activates the G protein-couple receptor 18 (GPR18) with vasodilatory activity in resistance... 
Na+/Ca2+ exchanger | Vasorelaxation | Nitric oxide | N-arachidonoyl glycine | Hypotensive | Ca | exchanger | ANANDAMIDE-INDUCED VASORELAXATION | RAT | IDENTIFICATION | VASCULAR ENDOTHELIUM | CORONARY-ARTERIES | SMALL MESENTERIC-ARTERY | CANNABINOID RECEPTOR | ENDOTHELIAL-CELLS | PHARMACOLOGY & PHARMACY | ABNORMAL-CANNABIDIOL | GPR18 | Glycine - analogs & derivatives | Kidney - blood supply | Rats, Wistar | Capsaicin - pharmacology | Anisoles - pharmacology | Cyclohexanes - pharmacology | Endothelium, Vascular - drug effects | Male | Thiourea - pharmacology | Quinoxalines - pharmacology | Phenylephrine - pharmacology | Regional Blood Flow - drug effects | Piperidines - pharmacology | Oxadiazoles - pharmacology | Blood Pressure - drug effects | Pyrazoles - pharmacology | NG-Nitroarginine Methyl Ester - pharmacology | Kidney - drug effects | Rats | Capsaicin - analogs & derivatives | Arachidonic Acids - pharmacology | Hypertension - physiopathology | Hypertension - metabolism | Carbachol - pharmacology | Animals | Cyclic GMP - metabolism | Glycine - pharmacology | Endothelium, Vascular - metabolism | Anilides - pharmacology | Endothelium, Vascular - pathology | Potassium Channels, Calcium-Activated - antagonists & inhibitors | Vasodilation - drug effects | Nitric Oxide - metabolism | Thiourea - analogs & derivatives | Medical colleges | Dilatation | Vasodilators | Blood vessels | Indomethacin | Glycine | Endothelium | Index Medicus
Journal Article
Journal of Urology, The, ISSN 0022-5347, 2013, Volume 190, Issue 2, pp. 746 - 756
Journal Article
Life Sciences, ISSN 0024-3205, 10/2016, Volume 163, pp. 1 - 10
Journal Article
Gastroenterology, ISSN 0016-5085, 2000, Volume 118, Issue 6, pp. 1149 - 1156
Circulating levels of angiotensin II (ANGII), a powerful vasoconstrictor factor, are frequently increased in chronic liver diseases. In these conditions,... 
FAT-STORING CELLS | RAT-LIVER | GLOMERULAR MESANGIAL CELLS | DEPENDENT CONTRACTILITY | NITRIC-OXIDE | GROWTH-FACTOR | ITO CELLS | GASTROENTEROLOGY & HEPATOLOGY | SMOOTH-MUSCLE CELLS | PORTAL-HYPERTENSION | ALDOSTERONE SYSTEM | Receptor, Angiotensin, Type 1 | Receptors, Angiotensin - metabolism | Receptor, Angiotensin, Type 2 | Antihypertensive Agents - pharmacology | Iodine Radioisotopes | Liver - enzymology | Humans | Penicillamine - analogs & derivatives | Sodium Nitrite - pharmacology | Liver - drug effects | Thymidine - pharmacology | Nitric Oxide Donors - pharmacology | Radioligand Assay | Thymidine - metabolism | NG-Nitroarginine Methyl Ester - pharmacology | Vasoconstrictor Agents - pharmacology | Dinoprostone - pharmacology | Angiotensin II - pharmacology | Angiotensin II - metabolism | Cell Size - drug effects | Penicillamine - pharmacology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Losartan - pharmacology | Rats | Imidazoles - pharmacology | Cell Division - drug effects | Indomethacin - pharmacology | Cyclooxygenase Inhibitors - pharmacology | Animals | Vasoconstrictor Agents - metabolism | Liver - cytology | Pyridines - pharmacology | Mitogen-Activated Protein Kinases - metabolism | Cell research | Liver diseases | Platelet-derived growth factor | Prostaglandins E | Nitric oxide | Angiotensin | Physiological aspects | Bookbinding | DNA synthesis | Peptide hormones | Protein kinases | Index Medicus | Abridged Index Medicus
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 11/2007, Volume 152, Issue 5, pp. 699 - 708
Background and purpose: Studies in isolated preparations of vascular tissue (mainly resistance vessels) provide evidence that anandamide exerts vasorelaxation.... 
vasorelaxation | anandamide | rat aorta | Rat aorta | Vasorelaxation | Anandamide | PHARMACOLOGICAL CHARACTERIZATION | SENSORY NERVES MEDIATE | OXIDATIVE-METABOLISM | PROSTANOID RECEPTORS | CANNABINOID RECEPTOR | ISOLATED MESENTERIC-ARTERY | HYPERPOLARIZING FACTOR | PROSTAGLANDIN E-2 ETHANOLAMIDE | VANILLOID RECEPTORS | CARDIOVASCULAR FUNCTION | PHARMACOLOGY & PHARMACY | Cannabinoid Receptor Modulators - pharmacology | Rats, Wistar | Capsaicin - pharmacology | Bornanes - pharmacology | Endothelium, Vascular - drug effects | Male | Peptide Fragments - pharmacology | Receptor, Cannabinoid, CB2 - antagonists & inhibitors | Apamin - pharmacology | Aorta, Abdominal - drug effects | Endothelium, Vascular - physiology | Dose-Response Relationship, Drug | Piperidines - pharmacology | Charybdotoxin - pharmacology | Benzamides - pharmacology | Vasodilation - physiology | Isoindoles - pharmacology | Endocannabinoids | Carbamates - pharmacology | Pyrazoles - pharmacology | NG-Nitroarginine Methyl Ester - pharmacology | Nitric Oxide - biosynthesis | Calcitonin Gene-Related Peptide - pharmacology | Nitric Oxide - antagonists & inhibitors | Rats | Capsaicin - analogs & derivatives | Aorta, Abdominal - physiology | Sulfonamides - pharmacology | Arachidonic Acids - pharmacology | Indomethacin - pharmacology | Pyrazoles - administration & dosage | Animals | Polyunsaturated Alkamides - pharmacology | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Vasodilation - drug effects | In Vitro Techniques | Index Medicus | Research Papers
Journal Article
Pharmacological Research, ISSN 1043-6618, 12/2014, Volume 90, pp. 25 - 35
Journal Article
Neuropharmacology, ISSN 0028-3908, 2005, Volume 48, Issue 5, pp. 658 - 672
To date, two cannabinoid receptors have been identified, CB1 and CB2. Activation of these receptors with non-selective cannabinoid receptor agonists reduces... 
CB2 | Rotarod | GW405833 | Radioligand binding | Incisional pain | Catalepsy | Anxiety | Cannabinoid | Pharmacokinetics | Inflammatory pain | Neuropathic pain | ACTIVATION | ANTIHYPERALGESIC ACTIVITY | MICE DEFICIENT | cannabinoid | radioligand binding | NEUROSCIENCES | RAT MODEL | incisional pain | catalepsy | anxiety | CB2 RECEPTORS | neuropathic pain | INHIBITION | pharmacokinetics | inflammatory pain | PHARMACOLOGY & PHARMACY | rotarod | EXPRESSION | CANNABINOIDS | Analgesics - pharmacology | Cricetulus | Receptor, Cannabinoid, CB2 - agonists | Humans | Catalepsy - metabolism | Male | Benzoxazines | Pain - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Dose-Response Relationship, Drug | Time Factors | Inflammation - drug therapy | Reaction Time - drug effects | Behavior, Animal - drug effects | Indoles - pharmacology | Cyclohexanols - pharmacology | Anxiety - metabolism | Ataxia - metabolism | Cyclic AMP - metabolism | Immunosuppressive Agents - pharmacology | CHO Cells | Disease Models, Animal | Cricetinae | Morpholines - pharmacology | Rats | gamma-Aminobutyric Acid - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Psychomotor Performance - drug effects | Rats, Sprague-Dawley | Indomethacin - pharmacology | Mice, Knockout | Naphthalenes - pharmacology | Binding, Competitive - drug effects | Receptor, Cannabinoid, CB2 - metabolism | Pain Measurement - methods | Animals | Cyclohexanecarboxylic Acids - pharmacology | Indoles - pharmacokinetics | Mice | Morpholines - pharmacokinetics | Amines - pharmacology | Receptor, Cannabinoid, CB2 - deficiency | Care and treatment | Pain | Analysis | Physiological aspects | Ataxia | Models | Chemical properties | Index Medicus
Journal Article
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 11/2005, Volume 146, Issue 6, pp. 834 - 845
In the spontaneously hypertensive rat (SHR) and aging Wistar–Kyoto rats (WKY), acetylcholine releases an endothelium‐derived contracting factor (EDCF) produced... 
TP receptors | spontaneously hypertensive rat | prostaglandins | Endothelium‐dependent contractions | endoperoxide | prostacyclin | Endoperoxide | Prostaglandins | Prostacyclin | Spontaneously hypertensive rat | Endothelium-dependent contractions | PROSTAGLANDIN-E SYNTHASE | CELLS | CYCLOOXYGENASE-2 | SPONTANEOUSLY HYPERTENSIVE-RATS | PLATELET-AGGREGATION | VASOCONSTRICTOR PROSTANOIDS | H-2 | VASCULAR SMOOTH-MUSCLE | ARTERIES | PHARMACOLOGY & PHARMACY | EXPRESSION | endothelium-dependent contractions | Prostaglandins - pharmacology | Rats, Inbred WKY | Nitrobenzenes - pharmacology | Salicylates - pharmacology | Aorta, Thoracic - drug effects | Prostaglandins I - metabolism | Rats, Inbred SHR | Vasoconstrictor Agents - pharmacology | Acetylcholine - pharmacology | Endothelium, Vascular - physiopathology | Enzyme Inhibitors - pharmacology | Aorta, Thoracic - metabolism | Rats | Imidazoles - pharmacology | Aorta, Thoracic - physiopathology | Sulfonamides - pharmacology | Vasoconstriction - drug effects | Hypertension - physiopathology | Indomethacin - pharmacology | Cyclooxygenase Inhibitors - pharmacology | Animals | 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology | Prostaglandins I - pharmacology | Prostaglandins - classification | In Vitro Techniques | Thromboxane A2 - secretion | Prostaglandins - metabolism | Index Medicus | Papers
Journal Article