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Journal Article
Clinical and Experimental Pharmacology and Physiology, ISSN 0305-1870, 07/2004, Volume 31, Issue 7, pp. 424 - 428
SUMMARY 1. 5-Hydroxytryptamine (5-HT) modulates the motility and secretion of the gastrointestinal tract. To examine the direct effect of 5-HT on the... 
colon | ion secretion | 5-hydroxytryptamine | short-circuit current | 5-HT4 receptor | receptor | 5‐hydroxytryptamine | short‐circuit current | 5‐HT | Short-circuit current | Ion secretion | Colon | 5-HT | CELLS | PHYSIOLOGY | RELEASE | MUCOSA | DISTAL COLON | PHARMACOLOGY & PHARMACY | SEROTONIN | ELECTROLYTE TRANSPORT | CYSTIC-FIBROSIS | CL-SECRETION | 5-HT4 RECEPTORS | Cystic Fibrosis Transmembrane Conductance Regulator - antagonists & inhibitors | Free Radical Scavengers - pharmacology | 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid - pharmacology | Diuretics - pharmacology | Epithelial Cells - drug effects | Colon - drug effects | Rats | Male | Sodium - metabolism | Serotonin - pharmacology | Serotonin Antagonists - pharmacology | Sodium-Potassium-Chloride Symporters - metabolism | Rats, Sprague-Dawley | Bumetanide - pharmacology | Colon - metabolism | Indomethacin - pharmacology | Ion Channels - antagonists & inhibitors | Serotonin Receptor Agonists - pharmacology | Animals | Biological Transport - drug effects | Tetrodotoxin - pharmacology | Colon, drug effects | Serotonin, pharmacology | Tetrodotoxin, pharmacology | 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid, pharmacology | Bumetanide, pharmacology | Ion Channels, antagonists and inhibitors | Sodium-Potassium-Chloride Symporters, metabolism | Sodium, metabolism | Colon, metabolism | Biological Transport, drug effects | Epithelial Cells, drug effects | Cystic Fibrosis Transmembrane Conductance Regulator, antagonists and inhibitors | Diuretics, pharmacology | Free Radical Scavengers, pharmacology | Indomethacin, pharmacology | Serotonin Antagonists, pharmacology | Serotonin Agonists, pharmacology
Journal Article
Journal Article
Journal Article
The Journal of Physiology, ISSN 0022-3751, 05/2004, Volume 556, Issue 3, pp. 875 - 886
A role for myoendothelial gap junctions (MEGJs) has been proposed in the action of the vasodilator endothelium-derived hyperpolarizing factor (EDHF). EDHF... 
SMOOTH-MUSCLE | PHYSIOLOGY | MESENTERIC-ARTERIES | POTASSIUM CHANNELS | ENDOTHELIUM-DEPENDENT HYPERPOLARIZATION | HYPERTENSIVE RATS | GUINEA-PIG | CONNEXIN EXPRESSION | CORONARY-ARTERIES | SMALL-CONDUCTANCE | EDHF-TYPE RELAXATIONS | Catalase - pharmacology | Endothelium, Vascular - cytology | Immunohistochemistry | Rats, Inbred WKY | Male | Peptide Fragments - pharmacology | Apamin - pharmacology | Endothelium, Vascular - physiology | 8,11,14-Eicosatrienoic Acid - analogs & derivatives | Phenylephrine - pharmacology | Arteries - physiology | Charybdotoxin - pharmacology | Vasodilation - physiology | 8,11,14-Eicosatrienoic Acid - pharmacology | Connexins - pharmacology | Myocytes, Smooth Muscle - drug effects | Hydroxocobalamin - pharmacology | Ouabain - pharmacology | Connexins - chemistry | Pyrazoles - pharmacology | Membrane Potentials - drug effects | NG-Nitroarginine Methyl Ester - pharmacology | Acetylcholine - pharmacology | Biological Factors - physiology | Myocytes, Smooth Muscle - physiology | Rats | Arteries - drug effects | Barium - pharmacology | Femoral Artery - drug effects | Microscopy, Electron | Indomethacin - pharmacology | Connexin 26 | Gap Junctions - ultrastructure | Patch-Clamp Techniques | Animals | Gap Junctions - physiology | Models, Biological | Femoral Artery - physiology | Vasodilation - drug effects | In Vitro Techniques | Research Papers
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2018, Volume 13, Issue 7, p. e0199009
Pain and inflammation are complex clinical conditions that are present in a wide variety of disorders. Most drugs used to treat pain and inflammation have... 
INDUCED PAW EDEMA | AQUEOUS EXTRACT | ACTIVATION | PAIN | SENSITIZATION | DOCKING | MULTIDISCIPLINARY SCIENCES | MOUSE | FORMALIN TEST | RECEPTORS | ANALGESIA | Analgesics - pharmacology | Hindlimb | Ondansetron - pharmacology | Male | Nociceptive Pain - chemically induced | Nociceptive Pain - drug therapy | Arachidonic Acid - administration & dosage | Formaldehyde | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Nociceptive Pain - metabolism | Acetic Acid | Dexamethasone - pharmacology | Analgesics - chemical synthesis | Nociception - drug effects | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Histamine - administration & dosage | Disease Models, Animal | Cyclooxygenase 2 Inhibitors - chemical synthesis | NG-Nitroarginine Methyl Ester - pharmacology | Cyclooxygenase 2 Inhibitors - pharmacology | Cyclooxygenase 2 - chemistry | Prostaglandins - biosynthesis | Edema - drug therapy | Hydrazones - chemical synthesis | Inflammation | Indomethacin - pharmacology | Hydrazones - pharmacology | Edema - metabolism | Croton Oil - administration & dosage | Animals | Nociceptive Pain - physiopathology | Cyclooxygenase 2 - metabolism | Mice | Molecular Docking Simulation | Edema - chemically induced | Edema - pathology | Carrageenan - administration & dosage | Care and treatment | Pain | Analysis | Dosage and administration | Research | Nonsteroidal anti-inflammatory drugs | Risk factors | Quality of life | Animal models | Automation | Pain perception | Antiinflammatory agents | Inflammatory response | Cotton | Metabolism | Arachidonic acid | Molecular docking | Organic chemistry | Histamine | Side effects | Prostaglandins | Acids | Analgesics | Cyclooxygenase-2 | Carrageenan | Acetic acid
Journal Article
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, ISSN 0363-6119, 02/2009, Volume 296, Issue 2, pp. 289 - 298
Mitochondria affect cerebrovascular tone by activation of mitochondrial ATP-sensitive K+ (KATP) channels and generation of reactive oxygen species (ROS).... 
Depolarization | Zucker obese rats | Mitochondrial ATP-sensitive potassium channels | Diazoxide | PROTEIN-KINASE-C | METABOLIC SYNDROME | ACTIVATION | PHYSIOLOGY | mitochondrial ATP-sensitive potassium channels | DILATION | CALCIUM INFLUX | diazoxide | depolarization | ENDOTHELIAL-CELLS | NITRIC-OXIDE | DYSFUNCTION | POTASSIUM | CA2+ SPARKS | Free Radical Scavengers - pharmacology | Propionates - pharmacology | Mitochondria - enzymology | Diazoxide - pharmacology | Reactive Oxygen Species - metabolism | Muscle, Smooth, Vascular - metabolism | Endothelium, Vascular - drug effects | Male | Metalloporphyrins - pharmacology | Muscle, Smooth, Vascular - physiopathology | Cerebral Arteries - drug effects | Dose-Response Relationship, Drug | Potassium Channels - metabolism | Potassium Channels, Calcium-Activated - metabolism | Nitro Compounds - pharmacology | Nitric Oxide Synthase Type III - metabolism | Potassium Channel Blockers - pharmacology | Superoxide Dismutase - metabolism | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | NG-Nitroarginine Methyl Ester - pharmacology | Vasodilator Agents - pharmacology | Succinate Dehydrogenase - antagonists & inhibitors | Endothelium, Vascular - physiopathology | Enzyme Inhibitors - pharmacology | Insulin Resistance | Rats | Cerebral Arteries - physiopathology | Obesity - physiopathology | Mitochondria - metabolism | Mitochondria - drug effects | Indomethacin - pharmacology | Cyclooxygenase Inhibitors - pharmacology | Nitric Oxide Synthase Type III - antagonists & inhibitors | Obesity - metabolism | Peptides - pharmacology | Rats, Zucker | Animals | Cerebral Arteries - metabolism | Endothelium, Vascular - metabolism | Succinate Dehydrogenase - metabolism | Vasodilation - drug effects | Nitric Oxide - metabolism | Neurohumoral Control of Cardiovascular Function
Journal Article
Pharmacology, Biochemistry and Behavior, ISSN 0091-3057, 01/2013, Volume 103, Issue 3, pp. 678 - 683
Journal Article
Journal of Ethnopharmacology, ISSN 0378-8741, 09/2016, Volume 191, pp. 29 - 40
( ) is used in southern Brazilian folk medicine to treat gastric problems, as well as for its analgesic and anti-inflammatory properties. To evaluate the... 
Prostaglandins | Antioxidant | Phenolic compounds | Nitric oxide | Anti-ulcer | Glutathione | CATALASE | CHEMISTRY, MEDICINAL | INDUCED GASTRIC-LESIONS | ANTI-HELICOBACTER-PYLORI | APPLE PEEL POLYPHENOLS | INVOLVEMENT | STEM BARK | PLANT SCIENCES | IN-VITRO | INHIBITION | INTEGRATIVE & COMPLEMENTARY MEDICINE | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | Plant Extracts - chemistry | Gallic Acid - pharmacology | Rats, Wistar | Plant Extracts - pharmacology | Solvents - chemistry | Polyphenols - pharmacology | Stomach Ulcer - pathology | Helicobacter pylori - drug effects | Stomach - metabolism | Chromatography, High Pressure Liquid | Flavonols - isolation & purification | Plant Bark - chemistry | Dose-Response Relationship, Drug | Sulfonic Acids - chemistry | Euphorbia - chemistry | Spectrometry, Mass, Electrospray Ionization | Anti-Ulcer Agents - pharmacology | Female | Phytotherapy | Methanol - chemistry | Stomach - drug effects | Stomach Ulcer - prevention & control | Disease Models, Animal | Gallic Acid - isolation & purification | Stomach Ulcer - chemically induced | Ellagic Acid - pharmacology | Polyphenols - isolation & purification | Stomach Ulcer - metabolism | Stomach - pathology | Ethanol | Ellagic Acid - isolation & purification | Plant Extracts - isolation & purification | Anti-Bacterial Agents - isolation & purification | Antioxidants - pharmacology | Ethnopharmacology | Animals | Anti-Ulcer Agents - chemistry | Signal Transduction - drug effects | Antioxidants - isolation & purification | Polyphenols - chemistry | Benzothiazoles - chemistry | Anti-Bacterial Agents - pharmacology | Anti-Ulcer Agents - isolation & purification | Flavonols - pharmacology | Indomethacin | Plants, Medicinal
Journal Article