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Bioimpacts, ISSN 2228-5660, 12/2018, Volume 8, Issue Suppl 1, pp. S1 - S129
Journal Article
Nature medicine, ISSN 1546-170X, 2016, Volume 22, Issue 5, pp. 547 - 556
...). Here we demonstrate that patient-specific human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs... 
MEDICINE, RESEARCH & EXPERIMENTAL | OXIDATIVE STRESS | RISK-FACTORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEXRAZOXANE | INDUCED CARDIOMYOPATHY | MATURATION | MUSCLE GENE-EXPRESSION | CELL BIOLOGY | HEART | INHIBITION | ANTHRACYCLINE-INDUCED CARDIOTOXICITY | SURVIVORS | Mitochondria, Heart - metabolism | Reactive Oxygen Species - metabolism | Antibiotics, Antineoplastic - pharmacology | Apoptosis - drug effects | Calcium - metabolism | Humans | Middle Aged | Transcriptome | Antibiotics, Antineoplastic - adverse effects | Mitochondria, Heart - drug effects | Membrane Potential, Mitochondrial - drug effects | Flow Cytometry | Adult | Female | Real-Time Polymerase Chain Reaction | Cardiotoxicity - genetics | DNA Damage - drug effects | Cell Survival - drug effects | Disease Susceptibility | Heart Failure - genetics | Breast Neoplasms - drug therapy | Myocytes, Cardiac - drug effects | Fluorescent Antibody Technique | Myocytes, Cardiac - metabolism | Aged | Polymorphism, Single Nucleotide | Oxidative Stress - drug effects | Induced Pluripotent Stem Cells | Doxorubicin - adverse effects | Doxorubicin - pharmacology | Heart Failure - chemically induced | Complications and side effects | Patient outcomes | Stem cells | Development and progression | Breast cancer | Transplantation | Cardiovascular diseases | Drug therapy | Doxorubicin | Methods | Heart failure | Chemotherapy | Toxicity | Index Medicus
Journal Article
Circulation (New York, N.Y.), ISSN 1524-4539, 2013, Volume 127, Issue 16, pp. 1677 - 1691
.... Here we generated a library of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs... 
arrhythmias, cardiac | stem cells | induced pluripotent stem cells | LONG-QT | INDUCED ARRHYTHMIAS | POLYMORPHIC VENTRICULAR-TACHYCARDIA | CARDIAC & CARDIOVASCULAR SYSTEMS | SUDDEN-DEATH | QT INTERVAL PROLONGATION | DISCOVERY | CHANNEL | MODELS | TORSADE-DE-POINTES | PERIPHERAL VASCULAR DISEASE | MOLECULAR-BASIS | Cardiomyopathy, Dilated - pathology | Embryonic Stem Cells - cytology | Kidney - embryology | Cardiomyopathy, Hypertrophic, Familial - genetics | Humans | Ion Channels - genetics | Verapamil - toxicity | Gene Expression Profiling | HEK293 Cells - drug effects | Cell Line - drug effects | Nicorandil - toxicity | Cell Line - physiology | Myofibrils - ultrastructure | Drug-Related Side Effects and Adverse Reactions - genetics | Cell Differentiation | Induced Pluripotent Stem Cells - cytology | Action Potentials - drug effects | Cardiomyopathy, Dilated - genetics | Drug Evaluation, Preclinical - methods | Genetic Predisposition to Disease | Ion Channels - biosynthesis | Cardiomyopathy, Hypertrophic, Familial - pathology | Cell Size | Kidney - cytology | Long QT Syndrome - pathology | Embryonic Stem Cells - physiology | Embryoid Bodies - drug effects | Patch-Clamp Techniques | Myocytes, Cardiac - drug effects | Quinazolines - toxicity | HEK293 Cells - physiology | Myocytes, Cardiac - physiology | Long QT Syndrome - genetics | Cisapride - toxicity | In Vitro Techniques | Drugs | Usage | Analysis | Heart cells | Stem cells | Product/Service Evaluations | Research | Health aspects | Methods | cardiotoxicity | Induced pluripotent stem cells | arrhythmia
Journal Article
Circulation research, ISSN 0009-7330, 10/2012, Volume 111, Issue 9, pp. 1125 - 1136
Journal Article
Nature cell biology, ISSN 1476-4679, 2015, Volume 17, Issue 8, pp. 994 - 1003
The use of human pluripotent stem cells for in vitro disease modelling and clinical applications requires protocols that convert these cells into relevant adult cell types... 
DIRECTED DIFFERENTIATION | IN-VIVO | MOUSE | DEFINITIVE ENDODERM | GROWTH-FACTOR | HUMAN BLASTOCYSTS | STROMAL CELLS | WNT | CULTURE | LINES | CELL BIOLOGY | Coculture Techniques | Humans | Endothelial Cells - transplantation | Glycogen Synthase Kinase 3 beta | Cell Lineage - drug effects | Dose-Response Relationship, Drug | Human Umbilical Vein Endothelial Cells - physiology | Transfection | Time Factors | Gene Expression Regulation, Developmental | Transcription, Genetic | Myocytes, Smooth Muscle - drug effects | Proto-Oncogene Proteins c-sis - pharmacology | Myocytes, Smooth Muscle - transplantation | Vascular Endothelial Growth Factor A - pharmacology | Endothelial Cells - physiology | Muscle, Smooth, Vascular - physiology | Muscle, Smooth, Vascular - drug effects | Biomarkers - metabolism | Cell Line | Induced Pluripotent Stem Cells - enzymology | Induced Pluripotent Stem Cells - drug effects | Induced Pluripotent Stem Cells - physiology | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Myocytes, Smooth Muscle - enzymology | Induced Pluripotent Stem Cells - transplantation | Myocytes, Smooth Muscle - physiology | Gene Expression Profiling - methods | Muscle, Smooth, Vascular - transplantation | Glycogen Synthase Kinase 3 - metabolism | Mice, SCID | Muscle, Smooth, Vascular - cytology | Metabolomics - methods | Bone Morphogenetic Protein 4 - pharmacology | Phenotype | Animals | Wnt Signaling Pathway - drug effects | Cell Differentiation - drug effects | Mice, Inbred NOD | Protein Kinase Inhibitors - pharmacology | Endothelial Cells - enzymology | Muscle, Smooth, Vascular - enzymology | Neovascularization, Physiologic | Endothelial Cells - drug effects | Usage | Cell research | Growth | Stem cells | Muscle cells | Research | Cell differentiation | Endothelium
Journal Article
Nature (London), ISSN 1476-4687, 2010, Volume 470, Issue 7332, pp. 105 - 109
Studies in embryonic development have guided successful efforts to direct the differentiation of human embryonic and induced pluripotent stem cells (PSCs... 
NEUROGENIN-3 | MULTIDISCIPLINARY SCIENCES | LIVER | ENDODERM | GENERATION | SPECIFICATION | FATE | CULTURE | EFFICIENT DIFFERENTIATION | ENDOCRINE-CELLS | Body Patterning - drug effects | Intestines - drug effects | Wnt Proteins - pharmacology | Embryonic Stem Cells - cytology | Humans | Endoderm - embryology | Intestines - embryology | Organogenesis - drug effects | Intestines - anatomy & histology | Basic Helix-Loop-Helix Transcription Factors - metabolism | Time Factors | Endoderm - cytology | Fibroblast Growth Factor 4 - pharmacology | Cell Culture Techniques | Culture Media - chemistry | Induced Pluripotent Stem Cells - cytology | Basic Helix-Loop-Helix Transcription Factors - genetics | Induced Pluripotent Stem Cells - drug effects | Cells, Cultured | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Microvilli - drug effects | Activins - pharmacology | Embryonic Stem Cells - drug effects | Cell Differentiation - drug effects | Intercellular Signaling Peptides and Proteins - pharmacology | Endoderm - drug effects | Culture Media - pharmacology | Morphogenesis - drug effects | Wnt3 Protein | Wnt3A Protein | Intestines - cytology | Physiological aspects | Intestines | Genetic aspects | Health aspects | Endoderm | Stem cells | Proteins | Studies | posterior endoderm | intestine | FGF | transplantation | colon | drug transport | Wnt | progenitor cell
Journal Article
Journal of molecular and cellular cardiology, ISSN 0022-2828, 2014, Volume 72, pp. 296 - 304
Abstract Background Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs... 
Cardiovascular | Cardiomyocyte maturation | Mitochondria | Tri-iodo-l-thyronine | Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) | Contractile force | CARDIAC & CARDIOVASCULAR SYSTEMS | FUNCTIONAL MATURATION | THYROID-HORMONE | SIZE | LINES | CELL BIOLOGY | PASSIVE STIFFNESS | CARDIAC-HYPERTROPHY | FETAL | DIFFERENTIATION | SECRETION | Tri-iodo-L-thyronine | UP-REGULATION | Calcium - metabolism | Humans | Culture Media, Conditioned - pharmacology | Lung - cytology | Oxidative Phosphorylation - drug effects | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Lung - metabolism | Induced Pluripotent Stem Cells - cytology | Fibroblasts - metabolism | Induced Pluripotent Stem Cells - metabolism | Triiodothyronine - pharmacology | Gene Expression | Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism | Induced Pluripotent Stem Cells - drug effects | Myocytes, Cardiac - cytology | Sarcomeres - drug effects | Sarcomeres - metabolism | Cells, Cultured | Mitochondria - metabolism | Mitochondria - drug effects | Animals | Myocytes, Cardiac - drug effects | Cell Differentiation - drug effects | Fibroblasts - drug effects | Lung - drug effects | Myocytes, Cardiac - metabolism | Fibroblasts - cytology | Mice | Cell Cycle - drug effects | Sarcoplasmic Reticulum Calcium-Transporting ATPases - genetics | Analysis | Stem cells | Heart cells | Index Medicus | Human induced pluripotent stem cells-derived cardiomyocytes (hiPSC-CMs)
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 2012, Volume 7, Issue 1, p. e29597
Human embryonic stem cells (hESC) and induced pluripotent stem cells (iPSC) provide new prospects for studying human neurodevelopment and modeling neurological disease... 
HUMAN ES | INHIBITION | FGF | MULTIDISCIPLINARY SCIENCES | CENTRAL-NERVOUS-SYSTEM | DIFFERENTIATION CAPACITY | PRECURSORS | Oligonucleotide Array Sequence Analysis | Humans | Fibroblast Growth Factor 2 - pharmacology | Neurons - cytology | Gene Expression Profiling | Neural Stem Cells - cytology | Neuroepithelial Cells - cytology | Neuroglia - cytology | Neurons - metabolism | Induced Pluripotent Stem Cells - cytology | Induced Pluripotent Stem Cells - metabolism | Cell Line | Pluripotent Stem Cells - cytology | Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | Pluripotent Stem Cells - metabolism | Transcription Factors - metabolism | Cell Differentiation - drug effects | Fluorescent Antibody Technique | Neuroglia - metabolism | Cell Proliferation - drug effects | Neuroepithelial Cells - metabolism | Epidermal Growth Factor - pharmacology | Neural Stem Cells - metabolism | Cluster Analysis | Medical research | Nervous system diseases | Epidermal growth factor | Neurons | Medicine, Experimental | Fibroblast growth factors | Comparative analysis | Embryonic stem cells | Neurophysiology | Neurosciences | Laboratories | Neurobiology | Embryo cells | Radial glial cells | Nervous system | Biochemistry | Neurodevelopmental disorders | Neuronal-glial interactions | Genotype & phenotype | Fibroblasts | Physiology | Growth factors | Fibroblast growth factor 2 | Fetuses | Embryos | Brain research | Stem cells | Comparative studies | Hindbrain | Bayesian analysis | Pluripotency
Journal Article
Circulation research, ISSN 0009-7330, 02/2009, Volume 104, Issue 4, pp. e30 - e41
Human induced pluripotent stem (iPS) cells hold great promise for cardiovascular research and therapeutic applications, but the ability of human iPS cells to differentiate into functional cardiomyocytes has not yet been demonstrated... 
Action potential | Differentiation | Embryonic stem cells | Induced pluripotent stem cells | Cardiomyocyte | CARDIAC & CARDIOVASCULAR SYSTEMS | differentiation | embryonic stem cells | CARDIAC MYOCYTES | INDUCTION | action potential | LINES | OCT4 | cardiomyocyte | HUMAN FIBROBLASTS | PERIPHERAL VASCULAR DISEASE | induced pluripotent stem cells | GENERATION | HEMATOLOGY | DEVELOP | Embryonic Stem Cells - metabolism | RNA-Binding Proteins - genetics | Cell Proliferation | Homeodomain Proteins - metabolism | Humans | Myocardial Contraction - drug effects | SOXB1 Transcription Factors - metabolism | Action Potentials | Octamer Transcription Factor-3 - genetics | Cell Differentiation - genetics | SOXB1 Transcription Factors - genetics | Time Factors | Cell Line | Nanog Homeobox Protein | Transduction, Genetic | Sarcomeres - metabolism | Pluripotent Stem Cells - physiology | Gene Expression Regulation | Adrenergic beta-Agonists - pharmacology | Embryonic Stem Cells - physiology | Homeodomain Proteins - genetics | Pluripotent Stem Cells - metabolism | Phenotype | Myocytes, Cardiac - drug effects | Embryonic Stem Cells - drug effects | Myocytes, Cardiac - physiology | Isoproterenol - pharmacology | Octamer Transcription Factor-3 - metabolism | Pluripotent Stem Cells - drug effects | Myocytes, Cardiac - metabolism | RNA-Binding Proteins - metabolism
Journal Article
PloS one, ISSN 1932-6203, 2011, Volume 6, Issue 4, p. e18293
Background: The production of cardiomyocytes from human induced pluripotent stem cells (hiPSC... 
DEFINED MEDIUM | MESODERM | MULTIDISCIPLINARY SCIENCES | ENDODERM | CARDIOMYOCYTE DIFFERENTIATION | INDUCTION | LINES | FUNCTIONAL-PROPERTIES | Body Patterning - drug effects | Oxygen - pharmacology | Antigens, CD34 - metabolism | Polyvinyl Alcohol - pharmacology | Humans | Fibroblast Growth Factor 2 - pharmacology | Mesoderm - drug effects | Mesoderm - cytology | Cell Culture Techniques - methods | Embryoid Bodies - metabolism | Embryoid Bodies - cytology | Adult | Induced Pluripotent Stem Cells - cytology | Fibroblasts - metabolism | Induced Pluripotent Stem Cells - metabolism | Cell Line | Insulin - pharmacology | Induced Pluripotent Stem Cells - drug effects | Myocytes, Cardiac - cytology | Transgenes - genetics | Fetal Blood - cytology | Cell Adhesion - drug effects | Bone Morphogenetic Protein 4 - pharmacology | Genetic Vectors - genetics | Embryoid Bodies - drug effects | Animals | Myocytes, Cardiac - drug effects | Cell Differentiation - drug effects | Fibroblasts - drug effects | Culture Media - pharmacology | Myocytes, Cardiac - metabolism | Cell Proliferation - drug effects | Fibroblasts - cytology | Mice | Electrophysiological Phenomena - drug effects | Physiological aspects | Bone morphogenetic proteins | Fibroblast growth factors | Embryonic stem cells | Analysis | Drugs | Neonates | Neuropathology | Variability | Embryo cells | Drug development | Blood | Contraction | Regeneration (physiology) | Alcohols | Engineering | Cord blood | Efficiency | Calcium-binding protein | Fibroblasts | Long QT syndrome | Modelling | Polyvinyl alcohol | Heart diseases | Biomedical engineering | Fibroblast growth factor 2 | CD34 antigen | Bone morphogenetic protein 4 | Oxygen | Anemia | Cardiomyocytes | Insulin | Embryos | Coronary artery disease | Medicine | Regeneration | Troponin | Troponin I | Plasmids | Stem cells | Epigenetics | Mutation | Differentiation | Pluripotency
Journal Article