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Xenobiotica, ISSN 1366-5928, 09/2014, Volume 45, Issue 2, pp. 177 - 187
Abstract 1. Regulation of hepatic metabolism or transport may lead to increase in drug clearance and compromise efficacy or safety. In this study,... 
cryopreserved human hepatocytes | sandwich culture | drug-drug interactions | hepatic transporters | induction | Cytochrome P450 | Cryopreserved human hepatocytes | Drug-drug interactions | Induction | Sandwich culture | Hepatic transporters | Pharmacology & Pharmacy | Toxicology | Life Sciences & Biomedicine | Science & Technology | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Cytochrome P-450 CYP1A2 Inducers - pharmacology | Humans | Organic Anion Transporters - chemistry | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Drug Discovery - methods | Organic Cation Transporter 1 - metabolism | Structure-Activity Relationship | Neoplasm Proteins - metabolism | Organic Anion Transporters - metabolism | ATP-Binding Cassette Transporters - chemistry | Cytochrome P-450 CYP2B6 Inducers - pharmacology | ATP-Binding Cassette Transporters - metabolism | ATP-Binding Cassette, Sub-Family B, Member 1 - chemistry | Cell Culture Techniques | Cytochrome P-450 CYP1A2 Inducers - chemistry | Hepatocytes - drug effects | Multidrug Resistance-Associated Proteins - chemistry | Neoplasm Proteins - chemistry | Organic Cation Transporter 1 - chemistry | Cytochrome P-450 CYP2B6 Inducers - chemistry | Cytochrome P-450 CYP3A Inducers - pharmacology | Cytochrome P-450 CYP3A - metabolism | Cytochrome P-450 CYP3A Inducers - chemistry | Solute Carrier Organic Anion Transporter Family Member 1b1 | Multidrug Resistance-Associated Proteins - metabolism | Hepatocytes - enzymology | Index Medicus
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 09/2012, Volume 122, Issue 9, pp. 3271 - 3280
Journal Article
Cancer research (Chicago, Ill.), ISSN 1538-7445, 02/2011, Volume 71, Issue 4, pp. 1263 - 1271
The tumor microenvironment includes a complex network of immune T-cell subpopulations. In this study, we systematically analyzed the balance between cytotoxic... 
Life Sciences & Biomedicine | Oncology | Science & Technology | Th1 Cells - pathology | Th1 Cells - physiology | Prognosis | Th2 Cells - physiology | Tissue Array Analysis | Colorectal Neoplasms - genetics | Humans | Gene Expression Regulation, Neoplastic | Carcinoma - mortality | Gene Expression Profiling | Th2 Cells - immunology | Th1 Cells - immunology | Colorectal Neoplasms - diagnosis | Lymphocytes, Tumor-Infiltrating - physiology | T-Lymphocytes, Cytotoxic - pathology | Th1 Cells - metabolism | Th17 Cells - metabolism | Forkhead Transcription Factors - metabolism | Microarray Analysis | T-Lymphocytes, Helper-Inducer - immunology | Lymphocytes, Tumor-Infiltrating - metabolism | T-Lymphocytes, Helper-Inducer - pathology | Interleukin-4 - genetics | Th2 Cells - pathology | Th17 Cells - pathology | Colorectal Neoplasms - mortality | T-Lymphocytes, Cytotoxic - immunology | Th17 Cells - physiology | T-Lymphocytes, Helper-Inducer - metabolism | Carcinoma - immunology | Interleukin-4 - metabolism | Carcinoma - diagnosis | Forkhead Transcription Factors - genetics | Th2 Cells - metabolism | T-Lymphocytes, Cytotoxic - physiology | T-Lymphocytes, Helper-Inducer - physiology | Colorectal Neoplasms - immunology | Lymphocytes, Tumor-Infiltrating - pathology | T-Lymphocytes, Cytotoxic - metabolism | Survival Analysis | Th17 Cells - immunology | Carcinoma - genetics | Cohort Studies | Lymphocytes, Tumor-Infiltrating - immunology | Index Medicus
Journal Article
Immunity (Cambridge, Mass.), ISSN 1074-7613, 10/2015, Volume 43, Issue 4, pp. 690 - 702
The differentiation of CD4+ helper T cell subsets with diverse effector functions is accompanied by changes in metabolism required to meet their bioenergetic... 
Life Sciences & Biomedicine | Immunology | Science & Technology | Lymphocytic choriomeningitis virus - immunology | T-Lymphocyte Subsets - immunology | T-Lymphocyte Subsets - cytology | NFATC Transcription Factors - physiology | Th1 Cells - immunology | Interleukin-2 Receptor alpha Subunit - physiology | Mechanistic Target of Rapamycin Complex 1 | T-Lymphocytes, Helper-Inducer - virology | Th1 Cells - metabolism | Interleukin-2 - physiology | T-Lymphocytes, Helper-Inducer - immunology | Cell Division | T-Lymphocytes, Helper-Inducer - cytology | TOR Serine-Threonine Kinases - physiology | Calcium Signaling | Specific Pathogen-Free Organisms | T-Lymphocytes, Helper-Inducer - metabolism | Mice, Inbred C57BL | Oxygen Consumption | Transcription Factors - biosynthesis | Proto-Oncogene Proteins c-akt - physiology | Transcription Factors - genetics | Multiprotein Complexes - physiology | Animals | Cell Cycle | T-Lymphocyte Subsets - metabolism | Glucose - metabolism | Glycolysis | Signal Transduction - physiology | Th1 Cells - cytology | Enzyme Activation | Apoptosis | Positive Regulatory Domain I-Binding Factor 1 | Virus diseases | Physiological aspects | Glucose metabolism | Interleukins | T cells | Proteins | Flow cytometry | Scholarships & fellowships | Transcription factors | Cytokines | Lymphocytes | Cell cycle | Kinases | Metabolism | Gene expression | Viral infections | Index Medicus
Journal Article
Archives of toxicology, ISSN 1432-0738, 11/2014, Volume 90, Issue 2, pp. 291 - 304
The tumour suppressor gene TP53 is mutated in more than 50 % of human tumours, making it one of the most important cancer genes. We have investigated the role... 
Benzo[ a ]pyrene | Biomedicine | Environmental Health | Occupational Medicine/Industrial Medicine | Cytochrome P450 | Carcinogen metabolism | DNA adducts | Pharmacology/Toxicology | Tumour suppressor p53 | Biomedicine general | Benzo[a]pyrene | Life Sciences & Biomedicine | Toxicology | Science & Technology | DNA Damage - drug effects | Cell Survival - drug effects | Cytochrome P-450 CYP1B1 - genetics | Inactivation, Metabolic | Polycyclic Aromatic Hydrocarbons - pharmacokinetics | Benzo(a)pyrene - toxicity | Polycyclic Aromatic Hydrocarbons - toxicity | Humans | Tumor Suppressor Protein p53 - metabolism | Cytochrome P-450 CYP1B1 - metabolism | NAD(P)H Dehydrogenase (Quinone) - genetics | Cytochrome P-450 CYP1A1 - metabolism | HCT116 Cells - drug effects | Tumor Suppressor Protein p53 - genetics | Carcinogens - toxicity | DNA Adducts | Basic Helix-Loop-Helix Transcription Factors - metabolism | Cytochrome P-450 Enzyme Inducers - poisoning | DNA Damage - genetics | NAD(P)H Dehydrogenase (Quinone) - metabolism | Receptors, Aryl Hydrocarbon - metabolism | Cytochrome P-450 Enzyme Inducers - pharmacology | Toxicity Tests | Cytochrome P-450 Enzyme Inducers - toxicity | Metabolites | Benzopyrene | Analysis | Cytochrome P-450 | Physiological aspects | Tumor proteins | Xenobiotics | Cells | Cytochrome | Carcinogens | Polycyclic aromatic hydrocarbons | Tumors | Index Medicus | Toxicokinetics and Metabolism | Cell Survival | HCT116 Cells | Polycyclic Aromatic Hydrocarbons | Benzo(a)pyrene | NAD(P)H Dehydrogenase (Quinone) | Journal Article | Cytochrome P-450 Enzyme Inducers | Tumor Suppressor Protein p53 | Research Support, Non-U.S. Gov't | Cytochrome P-450 CYP1B1 | Cytochrome P-450 CYP1A1 | DNA Damage | Receptors, Aryl Hydrocarbon | Basic Helix-Loop-Helix Transcription Factors
Journal Article
Antimicrobial agents and chemotherapy, ISSN 0066-4804
Journal
PloS one, ISSN 1932-6203, 09/2015, Volume 10, Issue 9, pp. e0138875 - e0138875
To investigate the auto-induction of cytochrome P450 (CYP450) by Chloroxoquinoline (CXL), a novel anticancer drug. Three experiments related to the induction... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Cytochrome P-450 CYP1A2 Inducers - pharmacology | Cells, Cultured | Male | Cytochrome P-450 CYP1A2 - metabolism | Rats, Sprague-Dawley | Quinolines - pharmacology | Cytochrome P-450 CYP1A2 Inducers - pharmacokinetics | Quinolines - pharmacokinetics | Animals | Cytochrome P-450 CYP3A Inducers - pharmacology | Cytochrome P-450 CYP3A - genetics | Cytochrome P-450 CYP3A - metabolism | Cytochrome P-450 CYP1A2 - genetics | Cytochrome P-450 CYP3A Inducers - pharmacokinetics | Enzyme Induction - drug effects | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Kinetics | Hepatocytes - drug effects | Hepatocytes - enzymology | Complications and side effects | Chemotherapy | Cytochrome P-450 | Physiological aspects | Quinoline | Genetic aspects | Dosage and administration | Research | Cancer | Cytochrome | CYP1A protein | Life assessment | mRNA | Cancer therapies | Toxicology | Metabolites | Rodents | Pretreatment | Inducers | Caffeine | Enzymes | Cytochrome P450 | Rats | Pharmacology | Liquid chromatography | FDA approval | Metabolism | Gene expression | High-performance liquid chromatography | Polymerase chain reaction | Studies | Pathology | Hepatocytes | Pharmacy | In vivo methods and tests | Pharmaceuticals | Index Medicus
Journal Article
Antiviral chemistry & chemotherapy, ISSN 0956-3202, 1990
Journal