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1. Full Text HIF Hydroxylase Pathways in Cardiovascular Physiology and Medicine
by Bishop, Tammie and Ratcliffe, Peter J
Circulation research, ISSN 0009-7330, 06/2015, Volume 117, Issue 1, pp. 65 - 79
hypoxia | dioxygenases | prolyl hydroxylases | hypoxia inducible factor | Cardiac & Cardiovascular Systems | Peripheral Vascular Disease | Life Sciences & Biomedicine | Hematology | Cardiovascular System & Cardiology | Science & Technology | Adaptation, Physiological | Polycythemia - genetics | Heart Defects, Congenital - embryology | Cardiovascular Diseases - drug therapy | Heart - embryology | Humans | Hypoxia-Inducible Factor-Proline Dioxygenases - antagonists & inhibitors | Cardiovascular Diseases - enzymology | Oxygen - metabolism | Hypoxia - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - deficiency | Hypoxia-Inducible Factor-Proline Dioxygenases - deficiency | Cell Hypoxia | Repressor Proteins - physiology | Basic Helix-Loop-Helix Transcription Factors - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Heart Defects, Congenital - enzymology | Von Hippel-Lindau Tumor Suppressor Protein - genetics | Mixed Function Oxygenases - physiology | Von Hippel-Lindau Tumor Suppressor Protein - metabolism | Basic Helix-Loop-Helix Transcription Factors - deficiency | Basic Helix-Loop-Helix Transcription Factors - genetics | Hypoxia-Inducible Factor-Proline Dioxygenases - physiology | Cardiovascular Diseases - metabolism | Hydroxylation | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Hypoxia-Inducible Factor-Proline Dioxygenases - genetics | Hypertension, Pulmonary - metabolism | Cardiovascular System - enzymology | Animals | Iron - physiology | Polycythemia - enzymology | Cardiovascular System - metabolism | Ischemic Preconditioning, Myocardial | Protein Isoforms | Mice | Protein Processing, Post-Translational | Altitude | Index Medicus | Hypoxia | oxygen sensing | HIF | 2-oxoglutarate oxygenase | hydroxylase
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2. Full Text The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A
by Segura, Inmaculada and Lange, Christian and Knevels, Ellen and Moskalyuk, Anastasiya and Pulizzi, Rocco and Eelen, Guy and Chaze, Thibault and Tudor, Cicerone and Boulegue, Cyril and Holt, Matthew and Daelemans, Dirk and Matondo, Mariette and Ghesquière, Bart and Giugliano, Michele and Ruiz de Almodovar, Carmen and Dewerchin, Mieke and Carmeliet, Peter
Cell reports (Cambridge), ISSN 2211-1247, 03/2016, Volume 14, Issue 11, pp. 2653 - 2667
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Rats, Wistar | Humans | Dendritic Spines - metabolism | Hypoxia-Inducible Factor-Proline Dioxygenases - antagonists & inhibitors | Amino Acids, Dicarboxylic - pharmacology | Oxygen - metabolism | Cell Hypoxia | Tubulin - metabolism | Synapses - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | HEK293 Cells | Von Hippel-Lindau Tumor Suppressor Protein - genetics | Filamins - genetics | Von Hippel-Lindau Tumor Suppressor Protein - antagonists & inhibitors | Von Hippel-Lindau Tumor Suppressor Protein - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Cells, Cultured | Hypoxia-Inducible Factor-Proline Dioxygenases - genetics | Filamins - antagonists & inhibitors | Rats | Hippocampus - cytology | Mice, Knockout | Up-Regulation - drug effects | Hippocampus - metabolism | Filamins - metabolism | Animals | Hypoxia-Inducible Factor-Proline Dioxygenases - metabolism | Cell Line, Tumor | Mice | Index Medicus | Up-Regulation/drug effects | Hippocampus/cytology | Hypoxia-Inducible Factor-Proline Dioxygenases/antagonists & inhibitors | Tubulin/metabolism | Dendritic Spines/metabolism | Hypoxia-Inducible Factor 1, alpha Subunit/genetics | Oxygen/metabolism | Synapses/metabolism | Von Hippel-Lindau Tumor Suppressor Protein/antagonists & inhibitors | Life Sciences | Filamins/genetics | Hypoxia-Inducible Factor-Proline Dioxygenases/genetics | Filamins/metabolism | Hypoxia-Inducible Factor-Proline Dioxygenases/metabolism | Von Hippel-Lindau Tumor Suppressor Protein/metabolism | Amino Acids, Dicarboxylic/pharmacology | Von Hippel-Lindau Tumor Suppressor Protein/genetics | Hippocampus/metabolism | Filamins/antagonists & inhibitors | Hypoxia-Inducible Factor 1, alpha Subunit/metabolism
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3. Full Text Hypoxia‐inducible factor 1‐alpha does not regulate osteoclastogenesis but enhances bone resorption activity via prolyl‐4‐hydroxylase 2
by Hulley, Philippa A and Bishop, Tammie and Vernet, Aude and Schneider, Jurgen E and Edwards, James R and Athanasou, Nick A and Knowles, Helen J
The Journal of pathology, ISSN 0022-3417, 07/2017, Volume 242, Issue 3, pp. 322 - 333
hypoxia‐inducible factor (HIF) | differentiation | PHD2 | osteoclast | bone resorption | hypoxia-inducible factor (HIF) | Pathology | Oncology | Life Sciences & Biomedicine | Science & Technology | Bone Resorption - physiopathology | Osteogenesis - physiology | Humans | RNA, Messenger - metabolism | Hypoxia-Inducible Factor-Proline Dioxygenases - deficiency | Leukocytes, Mononuclear - pathology | Animals | Cell Adhesion - physiology | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Female | Mice | Hypoxia-Inducible Factor 1, alpha Subunit - physiology | Osteoclasts - physiology | Cell Differentiation - physiology | Cancellous Bone - physiology | Prolyl Hydroxylases - physiology | Bone resorption | Bones | Hydroxylases | RNA | Density | Analysis | Osteoprogenitor cells | Hypoxia-inducible factor 1 | Activation | Bone (trabecular) | CD14 antigen | Osteolysis | Osteoblasts | Angiogenesis | Biomedical materials | Hypoxia-inducible factor 1a | Mineralization | Bone marrow | Biocompatibility | Inhibition | Coupling | Hypoxia-inducible factors | Enzymes | Hydroxylase | Gene expression | Diseases | Osteoclastogenesis | Monocytes | Bone mass | Glycolysis | Hypoxia | Osteoclasts | Differentiation | Index Medicus | Original Papers | Original Paper
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4. Full Text Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR
by Walton, Zandra E and Patel, Chirag H and Brooks, Rebekah C and Yu, Yongjun and Ibrahim-Hashim, Arig and Riddle, Malini and Porcu, Alessandra and Jiang, Tianying and Ecker, Brett L and Tameire, Feven and Koumenis, Constantinos and Weeraratna, Ashani T and Welsh, David K and Gillies, Robert and Alwine, James C and Zhang, Lin and Powell, Jonathan D and Dang, Chi V
Cell (Cambridge), ISSN 0092-8674, 06/2018, Volume 174, Issue 1, pp. 72 - 87.e32
hypoxia | circadian | acidity | RHEB | mTOR | cancer | hypoxia-inducible factor | clock | lysosome | pH | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors | Phosphoproteins - antagonists & inhibitors | Ras Homolog Enriched in Brain Protein - metabolism | Amino Acids, Dicarboxylic - pharmacology | Phosphoproteins - metabolism | Tuberous Sclerosis Complex 2 Protein - genetics | Cell Hypoxia | CLOCK Proteins - metabolism | Lysosomes - metabolism | RNA Interference | T-Lymphocytes - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Eukaryotic Initiation Factors | Culture Media - chemistry | Tuberous Sclerosis Complex 2 Protein - deficiency | Circadian Clocks - drug effects | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Carrier Proteins - antagonists & inhibitors | Cells, Cultured | Mechanistic Target of Rapamycin Complex 1 - antagonists & inhibitors | Transcriptome - drug effects | Phosphoproteins - genetics | Mechanistic Target of Rapamycin Complex 1 - metabolism | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Signal Transduction - drug effects | T-Lymphocytes - cytology | Mice | Cell Cycle Proteins | Hydrogen-Ion Concentration | RNA, Small Interfering - metabolism | Medical colleges | Genetic transcription | T cells | Analysis | Index Medicus | hypoxia inducible factor
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5. Full Text Reactive oxygen species in the control of hypoxia-inducible factor-mediated gene expression
by Kietzmann, Thomas and Görlach, Agnes
Seminars in cell & developmental biology, ISSN 1084-9521, 2005, Volume 16, Issue 4, pp. 474 - 486
Hypoxia | Reactive oxygen species | Oxygen sensing | HIF | NADPH oxidase | Life Sciences & Biomedicine | Developmental Biology | Science & Technology | Cell Biology | Hypoxia - enzymology | Reactive Oxygen Species - metabolism | Hypoxia-Inducible Factor 1 - chemistry | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Humans | Hypoxia-Inducible Factor 1 - physiology | Gene Expression Regulation - physiology | Hypoxia - metabolism | Hypoxia-Inducible Factor 1 - genetics | Animals | Reactive Oxygen Species - chemistry | Hypoxia-Inducible Factor 1, alpha Subunit - chemistry | Signal Transduction - physiology | Hypoxia-Inducible Factor 1, alpha Subunit - biosynthesis | Hypoxia-Inducible Factor 1, alpha Subunit - physiology | Hypoxia-Inducible Factor 1 - biosynthesis | Index Medicus
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6. Full Text Atorvastatin attenuates paraquat poisoning-induced epithelial-mesenchymal transition via downregulating hypoxia-inducible factor-1 alpha
by Du, Jiang and Zhu, Yong and Meng, Xiaoxiao and Xie, Hui and Wang, Jinfeng and Zhou, Zhigang and Wang, Ruilan
Life sciences (1973), ISSN 0024-3205, 11/2018, Volume 213, pp. 126 - 133
Atorvastatin | Hypoxia-inducible factor | Epithelial-mesenchymal transition | Paraquat | Pulmonary fibrosis | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Hypoxia-Inducible Factor 1, alpha Subunit - drug effects | A549 Cells | Cell Line | Cadherins - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Atorvastatin - metabolism | Humans | Rats | Epithelial-Mesenchymal Transition - drug effects | Male | Atorvastatin - pharmacology | Hypoxia-Inducible Factor 1 - metabolism | Rats, Sprague-Dawley | Paraquat - adverse effects | Animals | Signal Transduction - drug effects | Lung Injury - metabolism | Hypoxia | Hypoxia-Inducible Factor 1 - drug effects | Lung - metabolism | Pulmonary Fibrosis - metabolism | Lung Injury - drug therapy | Pulmonary Fibrosis - drug therapy | Zonula Occludens-1 Protein - metabolism | Herbicides | Medical colleges | Respiratory tract diseases | Poisoning | Stem cells | Antilipemic agents | Vimentin | Cell culture | Hypoxia-inducible factor 1 | Mesenchyme | Toxicity | E-cadherin | Hypoxia-inducible factor 1a | Attenuation | Catenin | Statins | Hypoxia-inducible factors | Lung diseases | Markers | Pharmacology | Gene expression | Chemical compounds | Zonula occludens-1 protein | Cell lines | Fibrosis | Index Medicus
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7. Full Text Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis
by Madsen, Chris D and Pedersen, Jesper T and Venning, Freja A and Singh, Lukram Babloo and Moeendarbary, Emad and Charras, Guillaume and Cox, Thomas R and Sahai, Erik and Erler, Janine T
EMBO reports, ISSN 1469-221X, 10/2015, Volume 16, Issue 10, pp. 1394 - 1408
hypoxia | PHD2 | cancer‐associated fibroblasts | tumour invasion and metastasis | tumour stiffness | cancer-associated fibroblasts | Cell Adhesion Molecules - genetics | Breast - cytology | Fibroblasts - physiology | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Neoplasm Invasiveness | Humans | Hypoxia-Inducible Factor-Proline Dioxygenases - genetics | Mammary Neoplasms, Experimental - physiopathology | Hypoxia-Inducible Factor-Proline Dioxygenases - antagonists & inhibitors | Amino Acids, Dicarboxylic - pharmacology | Hypoxia-Inducible Factor-Proline Dioxygenases - deficiency | Cell Hypoxia | Cell Movement - drug effects | Neoplasm Metastasis | Animals | Myosin Type II - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Hypoxia-Inducible Factor-Proline Dioxygenases - metabolism | Mammary Neoplasms, Experimental - pathology | Female | Mice | Tumor Cells, Cultured | Stromal Cells - physiology | Organ Culture Techniques | Fibroblasts | Hypoxia | Metastasis | Tumors | Index Medicus | Signal Transduction | Cell Adhesion, Polarity & Cytoskeleton | Cancer
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