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Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 08/2016, Volume 113, Issue 32, pp. E4671 - E4680
Journal Article
Journal Article
Nature (London), ISSN 1476-4687, 06/2019, Volume 570, Issue 7761, pp. 338 - 343
Journal Article
Nature (London), ISSN 1476-4687, 06/2017, Volume 546, Issue 7660, pp. 667 - 670
Rotavirus, a leading cause of severe gastroenteritis and diarrhoea in young children, accounts for around 215,000 deaths annually worldwide. Rotavirus... 
Intestines | DEAD-box RNA Helicases | Pyroptosis | Inflammasomes | Rotavirus | Mice, Inbred C57BL | Receptors, G-Protein-Coupled | Male | Epithelial Cells | Immunity, Innate | Journal Article | Research Support, N.I.H., Extramural | Rotavirus Infections | Research Support, U.S. Gov't, Non-P.H.S | Animals | Apoptosis Regulatory Proteins | Research Support, Non-U.S. Gov't | CARD Signaling Adaptor Proteins | Female | Caspase 1 | Mice | RNA, Double-Stranded | Interleukin-18 | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Interleukin-18 - immunology | Intestinal Mucosa - metabolism | Epithelial Cells - metabolism | Inflammasomes - metabolism | Rotavirus - growth & development | Receptors, G-Protein-Coupled - metabolism | Rotavirus - immunology | Caspase 1 - metabolism | Intestines - immunology | Receptors, G-Protein-Coupled - immunology | CARD Signaling Adaptor Proteins - metabolism | RNA, Double-Stranded - metabolism | Rotavirus Infections - virology | DEAD-box RNA Helicases - metabolism | Inflammasomes - chemistry | Inflammasomes - genetics | Apoptosis Regulatory Proteins - metabolism | Rotavirus Infections - immunology | Receptors, G-Protein-Coupled - deficiency | Epithelial Cells - immunology | Epithelial Cells - virology | Intestines - cytology | Epithelial cells | Health aspects | Rotaviruses | Gastroenteritis | Mucosa | Interleukin | Ribosomal DNA | Viruses | Infections | Small intestine | Caspase-1 | DNA helicase | Proteins | Signal transduction | Rodents | Modulation | Children | Feces | Adaptor proteins | Pathogens | Medical research | Cytokines | Maturation | Double-stranded RNA | Diarrhea | Caspase | Ribonucleic acid--RNA | Signaling | Replication | Fatalities | In vivo methods and tests | Interferon | Viral infections | RNA helicase | Index Medicus
Journal Article
Nature immunology, ISSN 1529-2908, 12/2013, Volume 14, Issue 12, pp. 1247 - 1255
The inflammasome adaptor ASC contributes to innate immunity through the activation of caspase-1. Here we found that signaling pathways dependent on the kinases... 
Life Sciences & Biomedicine | Immunology | Science & Technology | Interleukin-18 - immunology | Inflammasomes - metabolism | Cytoskeletal Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Protein-Tyrosine Kinases - metabolism | Dendritic Cells - immunology | Humans | JNK Mitogen-Activated Protein Kinases - immunology | Caspase 1 - metabolism | Immunoblotting | Intracellular Signaling Peptides and Proteins - metabolism | RNA Interference | Bone Marrow Cells - immunology | Phosphorylation - immunology | JNK Mitogen-Activated Protein Kinases - genetics | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | Carrier Proteins - immunology | DNA-Binding Proteins | Tyrosine - immunology | Mice, Knockout | Macrophages - metabolism | Tyrosine - metabolism | Lipopolysaccharides - pharmacology | Mice | Interleukin-18 - metabolism | Intracellular Signaling Peptides and Proteins - immunology | JNK Mitogen-Activated Protein Kinases - metabolism | Caspase 1 - immunology | Protein-Tyrosine Kinases - immunology | Protein-Tyrosine Kinases - genetics | HEK293 Cells | Cytoskeletal Proteins - metabolism | Female | Nuclear Proteins - genetics | Dendritic Cells - metabolism | Macrophages - immunology | Mice, Inbred C57BL | Cells, Cultured | Nuclear Proteins - metabolism | Nuclear Proteins - immunology | Inflammasomes - genetics | Carrier Proteins - genetics | Animals | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | Cytoskeletal Proteins - immunology | CARD Signaling Adaptor Proteins | Inflammasomes - immunology | Macrophages - drug effects | Nigericin - pharmacology | Bone Marrow Cells - metabolism | Tyrosine - genetics | Cellular signal transduction | Inflammation | Genetic aspects | Research | Properties | Phosphotransferases | Index Medicus
Journal Article