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Journal Article
Gastroenterology, ISSN 0016-5085, 2014, Volume 146, Issue 7, pp. 1763 - 1774
Background & Aims The NACHT, LRR, and pyrin domain–containing protein 3 (NLRP3) inflammasome induces inflammation in response to organ injury, but little is... 
Gastroenterology and Hepatology | Innate Immune Response | Immune Regulation | Pancreas | Mouse Model | ACTIVATION | NLRP3 INFLAMMASOME | GPR81 | AGONISTS | GENE | TLR9 | MICE | HEPATOTOXICITY | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | SEVERITY | Liver - pathology | Inflammasomes - metabolism | Receptors, G-Protein-Coupled - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Male | NF-kappa B - metabolism | Monocytes - immunology | Lipopolysaccharides | Liver - immunology | Liver - drug effects | RNA Interference | Interleukin-1beta - metabolism | Toll-Like Receptors - drug effects | Anti-Inflammatory Agents - administration & dosage | Toll-Like Receptors - metabolism | Cytoprotection | Disease Models, Animal | Galactosamine | Chemical and Drug Induced Liver Injury - prevention & control | Anti-Inflammatory Agents - pharmacology | Down-Regulation | Liver - metabolism | Injections, Intraperitoneal | Pancreas - pathology | Pancreas - metabolism | Pancreas - immunology | Toll-Like Receptor 4 - metabolism | Chemical and Drug Induced Liver Injury - immunology | Monocytes - drug effects | Macrophages - metabolism | Signal Transduction - drug effects | Chemical and Drug Induced Liver Injury - metabolism | Sodium Lactate - pharmacology | beta-Arrestins | Mice | Receptors, G-Protein-Coupled - genetics | RNA, Small Interfering - metabolism | Monocytes - metabolism | Pancreatitis - prevention & control | Arrestins - metabolism | Dose-Response Relationship, Drug | Pancreatitis - genetics | Transfection | Inflammasomes - drug effects | Sodium Lactate - administration & dosage | Pancreatitis - immunology | Chemical and Drug Induced Liver Injury - pathology | Chemical and Drug Induced Liver Injury - etiology | Macrophages - immunology | Cell Line | Immunity, Innate - drug effects | Toll-Like Receptor 4 - drug effects | Mice, Inbred C57BL | Pancreas - drug effects | Chemical and Drug Induced Liver Injury - genetics | Pancreatitis - chemically induced | Animals | Carrier Proteins - metabolism | beta-Arrestin 2 | Inflammasomes - immunology | Macrophages - drug effects | Pancreatitis - pathology | Pancreatitis - metabolism | Ceruletide | Lactates | Gastrointestinal diseases | Inflammation | Index Medicus | Abridged Index Medicus
Journal Article
Nature, ISSN 0028-0836, 07/2016, Volume 535, Issue 7610, pp. 153 - 158
Inflammatory caspases (caspases 1, 4, 5 and 11) are activated in response to microbial infection and danger signals. When activated, they cleave mouse and... 
LISTERIA-MONOCYTOGENES | INTERLEUKIN-1-BETA | MULTIDISCIPLINARY SCIENCES | MIXED LINEAGE KINASE | PERFORIN | NLRP3 INFLAMMASOME | INTRACELLULAR BACTERIA | GRANZYMES | CASPASE-1 ACTIVATION | GRANULYSIN | CELL-DEATH | Conserved Sequence - genetics | Inflammasomes - metabolism | Phosphatidylinositol Phosphates - metabolism | Pyroptosis - drug effects | Escherichia coli - drug effects | Humans | Molecular Sequence Data | Neoplasm Proteins - pharmacology | Escherichia coli - cytology | Neoplasm Proteins - metabolism | Escherichia coli - metabolism | Protein Multimerization - genetics | Listeria monocytogenes - metabolism | Cell Membrane - metabolism | Membrane Proteins - metabolism | Listeria monocytogenes - cytology | Porosity - drug effects | Neoplasm Proteins - genetics | Cell Membrane - drug effects | Staphylococcus aureus - metabolism | Amino Acid Sequence | Cell Line | Microbial Viability - drug effects | Membrane Proteins - genetics | Mice, Inbred C57BL | Phosphatidylserines - metabolism | Neoplasm Proteins - chemistry | Cardiolipins - metabolism | Cell Membrane - ultrastructure | Protein Structure, Tertiary - genetics | Microscopy, Electron | Pyroptosis - genetics | Protein Transport | Liposomes - chemistry | Animals | Membrane Proteins - chemistry | Cell Membrane Permeability - drug effects | Staphylococcus aureus - cytology | Liposomes - metabolism | Mice | Mutation | Staphylococcus aureus - drug effects | Listeria monocytogenes - drug effects | Observations | Apoptosis | Proteins | Membranes | Bacterial infections | Immunology | Plasmids | Bacteria | Infections | Cells | Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 2013, Volume 4, Issue 1, pp. 1560 - 1560
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 505, Issue 7484, pp. 509 - 514
The pathway causing CD4 T-cell death in HIV-infected hosts remains poorly understood although apoptosis has been proposed as a key mechanism. We now show that... 
APOPTOSIS | ACTIVATION | HUMAN LYMPHOID-TISSUE | DENDRITIC CELLS | MEMORY | REVERSE TRANSCRIPTION | MULTIDISCIPLINARY SCIENCES | IMMUNODEFICIENCY-VIRUS TYPE-1 | X4 HIV-1 | EX-VIVO | CXCR4-TROPIC HIV-1 | Anti-HIV Agents - pharmacology | Spleen - virology | Inflammation - pathology | Caspase Inhibitors - pharmacology | HIV-1 - pathogenicity | Palatine Tonsil - drug effects | Inflammasomes - metabolism | Humans | Caspase 3 - metabolism | Caspase 1 - metabolism | Male | HIV Infections - enzymology | Spleen - drug effects | CD4-Positive T-Lymphocytes - pathology | Lymph Nodes - enzymology | HIV Infections - immunology | Inflammation - complications | HIV-1 - growth & development | HIV Infections - pathology | Adult | Interleukin-1beta - biosynthesis | Cell Death - drug effects | Interleukin-1beta - secretion | Caspase Inhibitors - administration & dosage | Administration, Oral | HIV-1 - drug effects | CD4-Positive T-Lymphocytes - cytology | Inflammation - virology | Inflammation - immunology | CD4-Positive T-Lymphocytes - secretion | Virus Replication | Protein Precursors - biosynthesis | Inflammasomes - immunology | Palatine Tonsil - virology | HIV Infections - drug therapy | In Vitro Techniques | CD4-Positive T-Lymphocytes - drug effects | Medical research | Cell death | Physiological aspects | Host-parasite relationships | Medicine, Experimental | Research | T cells | Health aspects | HIV infection | Infections | Kinases | Human immunodeficiency virus--HIV | Apoptosis | Immune system | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 10/2015, Volume 526, Issue 7575, pp. 666 - 671
Journal Article
Nature Communications, ISSN 2041-1723, 04/2015, Volume 6, Issue 1, pp. 6734 - 6734
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2014, Volume 111, Issue 16, pp. 6046 - 6051
IFN receptor signaling induces cell-autonomous immunity to infections with intracellular bacterial pathogens. Here, we demonstrate that IFN-inducible guanylate... 
Pathogens | Cell death | Bacteria | Infections | Legionella | Macrophages | Immunity | Cytosol | Vacuoles | Gram negative bacteria | Interferon | Nos2 | Immunity-related GTPases | LEGIONELLA-PNEUMOPHILA INFECTION | IMMUNITY | FLAGELLIN | cell death | RECOGNITION | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | MECHANISMS | interferon | NONCANONICAL INFLAMMASOME ACTIVATION | immunity-related GTPases | VACUOLE | HOST-DEFENSE | TOXOPLASMA-GONDII | Membrane Glycoproteins - metabolism | Apoptosis - drug effects | NADPH Oxidases - metabolism | Cytoplasm - metabolism | Legionella pneumophila - growth & development | Caspases - metabolism | Legionnaires' Disease - microbiology | Salmonella typhimurium - drug effects | Macrophages - microbiology | Salmonella typhimurium - physiology | Mice, Inbred C57BL | Legionella pneumophila - drug effects | Enzyme Activation - drug effects | Mutation - genetics | NADPH Oxidase 2 | Macrophages - metabolism | Animals | Legionnaires' Disease - pathology | Lipopolysaccharides - pharmacology | Legionella pneumophila - physiology | Macrophages - drug effects | Mice | Macrophage Activation - drug effects | Cytoplasm - drug effects | Interferon-gamma - pharmacology | GTP-Binding Proteins - metabolism | Nitric Oxide Synthase Type II - metabolism | Physiological aspects | Protein research | Research | Binding proteins | Apoptosis | Signal transduction | Bacterial proteins | Gram-negative bacteria | Binding sites | Cytoplasm | Index Medicus | Biological Sciences
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 29, pp. 12153 - 12164
Twenty-four hours of fasting is known to blunt activation of the human NLRP3 inflammasome. This effect might be mediated by SIRT3 activation, controlling... 
OBESITY | DEACETYLATION | INSULIN-RESISTANCE | DNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISEASE | STRESS | EXPRESSION | SIRTUIN 3 | TERM CALORIE RESTRICTION | SIGNALING NETWORKS | Inflammasomes - metabolism | Sirtuin 3 - metabolism | Humans | Superoxide Dismutase - antagonists & inhibitors | Mitochondria - immunology | Protein Transport - drug effects | Inflammasomes - drug effects | Protein Processing, Post-Translational - drug effects | RNA Interference | Bone Marrow Cells - immunology | Bone Marrow Cells - drug effects | Macrophages - immunology | Superoxide Dismutase - metabolism | Cell Line | Fasting | Lipopolysaccharides - toxicity | Bone Marrow Cells - cytology | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Mice, Inbred C57BL | Cells, Cultured | Mitochondria - metabolism | Macrophages - cytology | Mitochondria - drug effects | Mice, Knockout | NLR Family, Pyrin Domain-Containing 3 Protein - agonists | Superoxide Dismutase - chemistry | Acetylation - drug effects | Macrophages - metabolism | Animals | Inflammasomes - immunology | Macrophages - drug effects | Enzyme Activation | Macrophage Activation - drug effects | Bone Marrow Cells - metabolism | Protein Multimerization - drug effects | Index Medicus | Immunology | sirtuin | mtDNA | inflammasome | mitochondria | NLRP3 | reactive oxygen species (ROS) | superoxide dismutase (SOD)
Journal Article
Journal of Immunology, ISSN 0022-1767, 04/2014, Volume 192, Issue 7, pp. 3259 - 3268
Adjuvants are an essential component of modern vaccines and used for their ability to elicit immunity to coadministered Ags. Many adjuvants in clinical... 
T-CELL RESPONSES | HUMAN NEUTROPHILS | DENDRITIC CELLS | NLRP3 INFLAMMASOME | IMMUNOLOGY | THERAPEUTIC VACCINES | PARTICULATE VACCINE ADJUVANTS | NALP3 INFLAMMASOME | ANTIGEN DELIVERY | INNATE IMMUNITY | TUMOR-ANTIGEN | Interleukin-18 - immunology | Inflammasomes - metabolism | Dendritic Cells - immunology | Humans | Tumor Necrosis Factor-alpha - genetics | Lymphocyte Activation - immunology | Interleukin-1beta - metabolism | Adenosine Triphosphate - metabolism | Tumor Necrosis Factor-alpha - immunology | Macrophages, Peritoneal - drug effects | Cell Survival - drug effects | Antigen-Presenting Cells - metabolism | Antigen-Presenting Cells - drug effects | Phospholipids - immunology | Immunity - immunology | Macrophages, Peritoneal - immunology | Saponins - immunology | Phospholipids - pharmacology | Blotting, Western | Mice, Knockout | Microscopy, Confocal | Macrophages - metabolism | Signal Transduction - drug effects | Cholesterol - pharmacology | Killer Cells, Natural - drug effects | Mice | Killer Cells, Natural - metabolism | Macrophages, Peritoneal - metabolism | Lysosomes - immunology | Interleukin-18 - metabolism | Saponins - pharmacology | Adjuvants, Immunologic - pharmacology | Cholesterol - immunology | Tumor Necrosis Factor-alpha - deficiency | Immunity - drug effects | Signal Transduction - immunology | Lysosomes - metabolism | Inflammasomes - drug effects | Killer Cells, Natural - immunology | Dendritic Cells - drug effects | Receptors, Tumor Necrosis Factor - deficiency | Dendritic Cells - metabolism | Macrophages - immunology | Receptors, Tumor Necrosis Factor - genetics | Lysosomes - drug effects | Mice, Inbred C57BL | Interleukin-1beta - immunology | Adenosine Triphosphate - immunology | Cell Survival - immunology | Antigen-Presenting Cells - immunology | Animals | Lymphocyte Activation - drug effects | Inflammasomes - immunology | Macrophages - drug effects | Receptors, Tumor Necrosis Factor - immunology | Drug Combinations | Index Medicus | Abridged Index Medicus
Journal Article
JOURNAL OF CELL SCIENCE, ISSN 0021-9533, 07/2013, Volume 126, Issue 13, pp. 2903 - 2913
Journal Article