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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2009, Volume 106, Issue 49, pp. 20842 - 20846
Journal Article
Nature Medicine, ISSN 1078-8956, 02/2017, Volume 23, Issue 2, pp. 174 - 184
Low-grade, chronic inflammation has been associated with many diseases of aging, but the mechanisms responsible for producing this inflammation remain unclear.... 
MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | INTERLEUKIN-18 LEVELS | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | CARDIOVASCULAR-DISEASE | RECEPTOR | ESSENTIAL-HYPERTENSION | PROTEINS | T-CELLS | AGE | CELL BIOLOGY | Toll-Like Receptor 5 - genetics | Humans | Middle Aged | Oxidative Stress - immunology | Transcriptome | Immunoblotting | Male | Purinergic P1 Receptor Antagonists - pharmacology | Young Adult | Toll-Like Receptor 8 - immunology | Aging - immunology | Toll-Like Receptor 6 - immunology | Aging - genetics | Calcium-Binding Proteins - immunology | Interleukin-1beta - metabolism | Aged, 80 and over | Caffeine - pharmacology | Hypertension - genetics | Intracellular Signaling Peptides and Proteins - genetics | Interleukin 1 Receptor Antagonist Protein - immunology | Carotid Intima-Media Thickness | Mortality | Neutrophils - drug effects | Hypertension - immunology | Nucleotides - metabolism | Toll-Like Receptor 5 - immunology | Monocytes - drug effects | Regression Analysis | Phenotype | Mice | Calcium-Binding Proteins - genetics | Metabolomics | Pulse Wave Analysis | Neutrophil Activation - drug effects | Cytidine - pharmacology | Interleukin 1 Receptor Antagonist Protein - genetics | Intracellular Signaling Peptides and Proteins - immunology | Cytidine - analogs & derivatives | CARD Signaling Adaptor Proteins - genetics | Toll-Like Receptor 6 - genetics | Adult | Female | Blood Pressure - drug effects | Blood Platelets - drug effects | Macrophages - immunology | Cytokines - immunology | CARD Signaling Adaptor Proteins - immunology | Cell Line | Vascular Stiffness - genetics | Cytokines - metabolism | Oxidative Stress - genetics | Interleukin-1beta - immunology | Adenine - pharmacology | Inflammation - immunology | Inflammasomes - genetics | Vascular Stiffness - immunology | Animals | Inflammasomes - immunology | Toll-Like Receptor 8 - genetics | Inflammation - genetics | Aged | Platelet Activation - drug effects | Genetic aspects | Immune response | Gene expression | Health aspects | Aging | Inflammation | Immune system
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 29, pp. 12077 - 12087
The NLRP3 inflammasome is a multiprotein complex that regulates the activation of caspase-1 leading to the maturation of the proinflammatory cytokines IL-1... 
SHOCK | ALZHEIMERS-DISEASE | INTERLEUKIN-1-BETA | BIOCHEMISTRY & MOLECULAR BIOLOGY | TOLL-LIKE RECEPTORS | ATP BINDING | RELEASE | NUCLEAR TRANSLOCATION | URIC-ACID | NALP3 INFLAMMASOME | CELL-DEATH | Inflammasomes - metabolism | Pyroptosis - drug effects | Interleukin-1beta - agonists | Mitochondrial Proteins - genetics | Protein Transport - drug effects | Chloride Channels - genetics | Interleukin-1beta - genetics | Mice, 129 Strain | Inflammasomes - drug effects | RNA Interference | Interleukin-1beta - metabolism | Mitochondrial Proteins - metabolism | Bone Marrow Cells - immunology | Bone Marrow Cells - drug effects | Macrophages - immunology | Interleukin-1beta - secretion | Cell Line | Chloride Channels - antagonists & inhibitors | Lipopolysaccharides - toxicity | Bone Marrow Cells - cytology | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Mice, Inbred C57BL | Mitochondrial Proteins - antagonists & inhibitors | Cells, Cultured | Macrophages - cytology | Mice, Knockout | Chloride Channels - metabolism | Macrophages - metabolism | Animals | Signal Transduction - drug effects | Active Transport, Cell Nucleus - drug effects | Inflammasomes - immunology | Macrophages - drug effects | RAW 264.7 Cells | Mice | Macrophage Activation - drug effects | Bone Marrow Cells - metabolism | lipopolysaccharide (LPS) | CLIC4 | Immunology | chloride channel | inflammasome | macrophage | NLRP3 | IL-1β | CLIC1
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 02/2017, Volume 114, Issue 8, pp. E1395 - E1404
Journal Article
Journal of Dental Research, ISSN 0022-0345, 8/2013, Volume 92, Issue 8, pp. 735 - 739
Oxidative stress is associated with age-related reactions. The anti-oxidative effects of a reduced form of co-enzyme Q10 (rCoQ10) suppress oxidative stress,... 
coenzyme Q10 | aging | preclinical drug evaluation | inflammasomes | periodontium | oxidative stress | RAT PERIODONTITIS | MODEL | LEVEL | SALIVARY | DAMAGE | ANTIOXIDANT | INFLAMMATION | DENTISTRY, ORAL SURGERY & MEDICINE | STRESS | Interleukin-1beta - drug effects | Isoenzymes - analysis | Deoxyguanosine - blood | Age Factors | NLR Family, Pyrin Domain-Containing 3 Protein | Rats, Inbred F344 | Aging - drug effects | Tartrate-Resistant Acid Phosphatase | Alveolar Process - drug effects | Actins - drug effects | Male | Deoxyguanosine - analysis | Vitamins - pharmacology | Ubiquinone - pharmacology | Gingiva - pathology | Gingiva - drug effects | Inflammasomes - drug effects | Ubiquinone - blood | Electron Transport Chain Complex Proteins - pharmacology | Periodontium - pathology | Models, Animal | Periodontium - drug effects | Cytoskeletal Proteins - drug effects | Deoxyguanosine - analogs & derivatives | Carrier Proteins | DNA Damage - drug effects | Acid Phosphatase - analysis | Receptors, Cytoplasmic and Nuclear - drug effects | Ubiquinone - analogs & derivatives | Alveolar Process - pathology | Rats | Antioxidants - pharmacology | Random Allocation | Animals | Apoptosis Regulatory Proteins | Caspase 1 - drug effects | CARD Signaling Adaptor Proteins | Oxidative Stress - drug effects | Osteoclasts - drug effects | NF-kappa B - drug effects
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 09/2017, Volume 140, pp. 64 - 72
Toll-like receptor (TLR) 4-independent recognition of lipopolysaccharide (LPS) in the cytosol by inflammatory caspases leads to non-canonical inflammasome... 
Inflammatory caspases | Interleukin-1beta (IL-1β) | Synthetic anti-endotoxin peptides | Pyroptosis | Cytoplasmic lipopolysaccharide (LPS) | DEFENSE | RECEPTOR | NLRP3 INFLAMMASOME | RELEASE | NONCANONICAL INFLAMMASOME ACTIVATION | IMMUNE-RESPONSES | CASPASES | TARGETS | PHARMACOLOGY & PHARMACY | IL-1-BETA | Interleukin-1beta (IL-1 beta) | Inflammasomes - metabolism | Pyroptosis - drug effects | Monocytes - cytology | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Cytoplasm - metabolism | Monocytes - metabolism | Monocytes - immunology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Macrophages - secretion | Inflammasomes - drug effects | Interleukin-1beta - metabolism | Myeloid Cells - immunology | Myeloid Cells - drug effects | Toll-Like Receptor 4 - antagonists & inhibitors | Macrophages - immunology | Interleukin-1beta - secretion | Cell Survival - drug effects | Lipopolysaccharides - toxicity | Peptides - chemistry | Cells, Cultured | Keratinocytes - secretion | Sulfonamides - pharmacology | Toll-Like Receptor 4 - metabolism | Keratinocytes - immunology | Peptides - pharmacology | Monocytes - drug effects | Endotoxins - antagonists & inhibitors | Macrophages - metabolism | Myeloid Cells - secretion | Keratinocytes - drug effects | Keratinocytes - metabolism | Inflammasomes - immunology | Cell Line, Tumor | Myeloid Cells - metabolism | Macrophages - drug effects | Macrophage Activation - drug effects | Cytoplasm - drug effects | Cell Line, Transformed | Endotoxins - toxicity | Chromosomal proteins | Peptides | Interleukins | Cell death | Pharmacy | Septic shock | Skin | Macrophages | Mitogens | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2015, Volume 290, Issue 9, pp. 5926 - 5939
In the past decade, the increasing amount of nanoparticles (NP) and nanomaterials used in multiple applications led the scientific community to investigate the... 
NANOSILVER | INHIBITION | IL-1-BETA RELEASE | ER STRESS | CASPASE-4 | BIOCHEMISTRY & MOLECULAR BIOLOGY | IRE1 | PYROPTOSIS | RECEPTORS | NF-KAPPA-B | CELL-DEATH | Inflammasomes - metabolism | Apoptosis - drug effects | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Caspase 1 - metabolism | Monocytes - metabolism | Proteolysis - drug effects | Inflammasomes - drug effects | RNA Interference | Cell Death - drug effects | Metal Nanoparticles - ultrastructure | Interleukin-1beta - secretion | Microscopy, Electron, Transmission | Endoplasmic Reticulum Stress - drug effects | Metal Nanoparticles - chemistry | Cells, Cultured | Silver - chemistry | Enzyme Activation - drug effects | Blotting, Western | Monocytes - drug effects | Carrier Proteins - genetics | Microscopy, Confocal | Activating Transcription Factor 6 - metabolism | Metal Nanoparticles - toxicity | Carrier Proteins - metabolism | Cell Line, Tumor | Index Medicus | Inflammasomes | Activating Transcription Factor 6 | Interleukin-1beta | Life Sciences | Silver | Monocytes | Proteolysis | Endoplasmic Reticulum Stress | Cell Death | Caspase 1 | Enzyme Activation | Apoptosis | Metal Nanoparticles | Carrier Proteins | Silver Nanoparticles | Caspase 1 (CASP1) | NLRP-3 Inflammasome | Pyroptosis | Caspase | Inflammasome | Endoplasmic Reticulum Stress (ER Stress) | Nanotechnology | Cell Biology | Caspase 4
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 50, pp. 20437 - 20448
Advanced glycation end products (AGEs) are adducts formed on proteins by glycation with reducing sugars, such as glucose, and tend to form and accumulate under... 
BIOCHEMISTRY & MOLECULAR BIOLOGY | macrophage | RECEPTOR | FACTOR-KAPPA-B | CELL-DEATH | glycation | innate immunity | inflammasome | INSULIN-RESISTANCE | DISEASE | NLRP3 | INFLUENZA-VIRUS | ACTIVATED PROTEIN-KINASES | NLRP3-INFLAMMASOME ACTIVATION | EXPRESSION | AGE | Inflammasomes - metabolism | Reactive Oxygen Species - metabolism | Caspase 1 - metabolism | Interleukin-1beta - genetics | Lipopolysaccharides - antagonists & inhibitors | Inflammasomes - drug effects | Interleukin-1beta - metabolism | Bone Marrow Cells - immunology | Bone Marrow Cells - drug effects | Interleukin-6 - metabolism | Macrophages - immunology | Biomarkers - metabolism | Lipopolysaccharides - toxicity | Specific Pathogen-Free Organisms | Immunity, Innate - drug effects | Interleukin-6 - genetics | Bone Marrow Cells - cytology | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Mice, Inbred C57BL | Cells, Cultured | Macrophages - cytology | Down-Regulation - drug effects | Gene Expression Regulation - drug effects | Macrophages - metabolism | Animals | Signal Transduction - drug effects | Caspase 1 - genetics | Glycation End Products, Advanced - metabolism | Inflammasomes - immunology | Genes, Reporter - drug effects | Macrophages - drug effects | Mice | Macrophage Activation - drug effects | Bone Marrow Cells - metabolism | Immunology
Journal Article
Pharmacological Research, ISSN 1043-6618, 09/2015, Volume 99, pp. 101 - 115
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2016, Volume 291, Issue 7, pp. 3254 - 3267
Hepatitis C virus (HCV) relies on host lipids and lipid droplets for replication and morphogenesis. The accumulation of lipid droplets in infected hepatocytes... 
TARGET | liver injury | OXIDATIVE STRESS | SREBP | hepatitis virus | CHOLESTEROL | INTERLEUKIN-1-BETA | BIOCHEMISTRY & MOLECULAR BIOLOGY | lipid metabolism | NLRP3 inflammasome | DROPLETS | inflammation | PATHWAY | inflammasome | FATTY-ACID | CASPASES | INFECTION | EXPRESSION | Hepatitis C, Chronic - pathology | Inflammasomes - metabolism | Cytoskeletal Proteins - antagonists & inhibitors | Cytoskeletal Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Golgi Apparatus - drug effects | Humans | Hepatitis C, Chronic - virology | Non-alcoholic Fatty Liver Disease - etiology | Caspase 1 - metabolism | Host-Pathogen Interactions - drug effects | Intracellular Signaling Peptides and Proteins - metabolism | Protein Transport - drug effects | Sterol Regulatory Element Binding Protein 1 - agonists | RNA Interference | Hepacivirus - physiology | Sterol Regulatory Element Binding Protein 2 - metabolism | Endopeptidases - metabolism | Carrier Proteins - antagonists & inhibitors | Serine Endopeptidases - chemistry | Cysteine Proteinase Inhibitors - pharmacology | Cell Line, Tumor | Hepatocytes - virology | Sterol Regulatory Element Binding Protein 2 - agonists | Hepatitis C, Chronic - metabolism | Hepatitis C, Chronic - physiopathology | Hepatocytes - pathology | Golgi Apparatus - pathology | Hepatocytes - metabolism | Golgi Apparatus - virology | Caspase 1 - chemistry | Proteolysis - drug effects | Endopeptidases - chemistry | Inflammasomes - drug effects | Enzyme Induction - drug effects | Cytoskeletal Proteins - metabolism | Membrane Proteins - metabolism | Hepatocytes - drug effects | Sterol Regulatory Element Binding Protein 1 - metabolism | Hepacivirus - drug effects | Proprotein Convertases - metabolism | Proprotein Convertases - chemistry | Carrier Proteins - genetics | Carrier Proteins - metabolism | Caspase 1 - genetics | CARD Signaling Adaptor Proteins | Lipogenesis - drug effects | Golgi Apparatus - metabolism | Serine Endopeptidases - metabolism | Microbiology
Journal Article