X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (6682) 6682
Book Review (1804) 1804
Publication (1301) 1301
Book Chapter (89) 89
Conference Proceeding (17) 17
Dissertation (11) 11
Book / eBook (8) 8
Streaming Video (4) 4
Web Resource (3) 3
Magazine Article (2) 2
Data Set (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (5470) 5470
animals (3865) 3865
humans (3577) 3577
immunology (3268) 3268
mice (2414) 2414
inflammasome (2201) 2201
inflammation (2131) 2131
nlrp3 inflammasome (1997) 1997
activation (1765) 1765
inflammasomes - metabolism (1639) 1639
inflammasomes - immunology (1256) 1256
mice, inbred c57bl (1150) 1150
nalp3 inflammasome (1136) 1136
cytokines (1129) 1129
cell biology (1109) 1109
macrophages (1102) 1102
male (1072) 1072
nlr family, pyrin domain-containing 3 protein (1024) 1024
apoptosis (1005) 1005
proteins (1001) 1001
caspase-1 (988) 988
innate immunity (987) 987
signal transduction (962) 962
article (934) 934
female (927) 927
mice, knockout (870) 870
nf-kappa-b (814) 814
biochemistry & molecular biology (804) 804
caspase 1 - metabolism (801) 801
interleukin-1beta - metabolism (787) 787
research (778) 778
immunity, innate (753) 753
dendritic cells (703) 703
expression (702) 702
macrophages - immunology (696) 696
cells, cultured (676) 676
il-1β (669) 669
carrier proteins - metabolism (659) 659
multidisciplinary sciences (657) 657
inflammation - immunology (638) 638
immune response (634) 634
health aspects (629) 629
microbiology (623) 623
cells (603) 603
rodents (585) 585
disease (583) 583
macrophages - metabolism (568) 568
toll-like receptors (568) 568
immunity (552) 552
inflammasomes (552) 552
caspase (546) 546
research article (531) 531
gene expression (530) 530
disease models, animal (528) 528
nlrp3 (520) 520
abridged index medicus (514) 514
cell-death (508) 508
cell death (505) 505
physiological aspects (500) 500
immune system (499) 499
analysis (489) 489
nlr family, pyrin domain-containing 3 protein - metabolism (489) 489
cell line (488) 488
oxidative stress (486) 486
infection (480) 480
interleukin-1beta - immunology (467) 467
carrier proteins - genetics (457) 457
secretion (457) 457
inflammasome activation (436) 436
inflammasomes - genetics (429) 429
pathogenesis (424) 424
cytokines - metabolism (407) 407
infectious diseases (407) 407
bacteria (402) 402
medicine (394) 394
infections (392) 392
inflammation - metabolism (392) 392
medicine, research & experimental (389) 389
genetic aspects (374) 374
carrier proteins - immunology (368) 368
autophagy (365) 365
host-defense (360) 360
protein (345) 345
reactive oxygen species - metabolism (341) 341
interleukin-1beta - genetics (339) 339
biology (335) 335
signal transduction - immunology (322) 322
pathology (317) 317
il-1-beta (315) 315
recognition (313) 313
interleukins (312) 312
pyroptosis (309) 309
receptors (308) 308
review (307) 307
cancer (306) 306
cell activation (300) 300
science (300) 300
kinases (299) 299
receptor (298) 298
adult (294) 294
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (6652) 6652
German (17) 17
Japanese (16) 16
French (11) 11
Chinese (10) 10
Spanish (7) 7
Polish (3) 3
Finnish (2) 2
Russian (2) 2
Czech (1) 1
Danish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Nature Immunology, ISSN 1529-2908, 05/2012, Volume 13, Issue 5, pp. 449 - 456
Intestinal phagocytes transport oral antigens and promote immune tolerance, but their role in innate immune responses remains unclear. Here we found that... 
FLAGELLIN | PATTERN-RECOGNITION | NOD-LIKE RECEPTORS | ACTIVATES CASPASE-1 | MACROPHAGES | INTERLEUKIN-1-BETA | INFLAMMASOME RECEPTORS | INFECTION | NLRP3 INFLAMMASOME | SECRETION | IMMUNOLOGY | Inflammasomes - metabolism | Humans | Receptors, Interleukin-1 - genetics | Salmonella Infections - genetics | Salmonella Infections - immunology | Clonal Anergy | Caspase 1 - metabolism | Monocytes - metabolism | Monocytes - immunology | Intestines - immunology | Host-Pathogen Interactions - immunology | Signal Transduction - immunology | Calcium-Binding Proteins - immunology | Interleukin-1beta - metabolism | Tumor Necrosis Factor-alpha - immunology | Apoptosis Regulatory Proteins - genetics | Pseudomonas - immunology | Toll-Like Receptors - metabolism | Neutrophil Infiltration - immunology | Neutrophils - pathology | Apoptosis Regulatory Proteins - immunology | Flagellin - immunology | Receptors, Interleukin-1 - immunology | Mice, Inbred C57BL | Toll-Like Receptors - immunology | Neutrophils - immunology | Salmonella - genetics | Signal Transduction - genetics | Phagocytes - immunology | Neutrophil Infiltration - genetics | Mice, Knockout | Pseudomonas Infections - immunology | Salmonella - immunology | Animals | Intestines - microbiology | Phagocytes - microbiology | Inflammasomes - immunology | Interleukin-6 - immunology | Interleukin-6 - biosynthesis | Mice | Mice, Inbred BALB C | Tumor Necrosis Factor-alpha - biosynthesis | Calcium-Binding Proteins - genetics | Index Medicus
Journal Article
Nature Immunology, ISSN 1529-2908, 2014, Volume 15, Issue 8, pp. 727 - 737
Journal Article
Immunity, ISSN 1074-7613, 09/2015, Volume 43, Issue 3, pp. 451 - 462
Endoplasmic reticulum (ER) stress is observed in many human diseases, often associated with inflammation. ER stress can trigger inflammation through... 
LISTERIA-MONOCYTOGENES | CYTOCHROME-C | MESSENGER-RNA | BRUCELLA-ABORTUS | INDUCED APOPTOSIS | ER STRESS | THIOREDOXIN-INTERACTING PROTEIN | SECRETION | IMMUNOLOGY | TRANSCRIPTION FACTOR | CELL-DEATH | Caspase 2 - genetics | Inflammasomes - metabolism | Reactive Oxygen Species - metabolism | Brucella abortus - physiology | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | BH3 Interacting Domain Death Agonist Protein - genetics | Caspase 2 - metabolism | Mitochondria - immunology | Endoplasmic Reticulum Stress - genetics | Endoplasmic Reticulum Stress - immunology | Caspase 2 - immunology | Host-Pathogen Interactions - immunology | DNA-Binding Proteins - metabolism | Mitochondria - genetics | Brucella abortus - immunology | Interleukin-1beta - metabolism | Reactive Oxygen Species - immunology | HEK293 Cells | Transcription Factors - immunology | BH3 Interacting Domain Death Agonist Protein - metabolism | Carrier Proteins - immunology | Macrophages - immunology | Macrophages - microbiology | Protein-Serine-Threonine Kinases - metabolism | RNA Interference - immunology | DNA-Binding Proteins - immunology | Endoribonucleases - metabolism | Mice, Inbred C57BL | Cells, Cultured | Interleukin-1beta - immunology | Mitochondria - metabolism | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Regulatory Factor X Transcription Factors | Blotting, Western | Mice, Knockout | Transcription Factors - metabolism | Carrier Proteins - genetics | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Inflammasomes - immunology | BH3 Interacting Domain Death Agonist Protein - immunology | Protein-Serine-Threonine Kinases - immunology | Endoribonucleases - immunology | Medical colleges | Stress (Physiology) | Mitochondrial DNA | Analysis | Cytochrome | Bacterial infections | Dehydrogenases | Infections | Inflammation | Proteins | Studies | Mitochondria | Rodents | Ligands | Endoplasmic reticulum | Deoxyribonucleic acid--DNA | Apoptosis | Index Medicus
Journal Article
Journal Article
Journal of Immunology, ISSN 0022-1767, 03/2014, Volume 192, Issue 6, pp. 2837 - 2845
Inflammation is associated with development of atherosclerosis, and cholesterol crystals (CC) have long been recognized as a hallmark of atherosclerotic... 
ATHEROSCLEROTIC LESIONS | TUMOR-NECROSIS-FACTOR | C5A RECEPTOR | MEMBRANE ATTACK | STERILE INFLAMMATION | EPITHELIAL-CELLS | CARDIOVASCULAR EVENTS | INTERLEUKIN-1-BETA | OXIDATIVE BURST | ANAPHYLATOXINS | IMMUNOLOGY | Inflammasomes - metabolism | Reactive Oxygen Species - metabolism | Complement C1q - immunology | Humans | Complement Pathway, Classical - drug effects | Complement C5a - metabolism | Complement System Proteins - immunology | Caspase 1 - metabolism | Monocytes - metabolism | Caspase 1 - immunology | Macrophage-1 Antigen - immunology | Monocytes - immunology | Interleukin-1beta - genetics | Complement Activation - immunology | Complement C1q - metabolism | Complement System Proteins - metabolism | Inflammasomes - drug effects | Reactive Oxygen Species - immunology | Complement C5 - immunology | Tumor Necrosis Factor-alpha - immunology | Macrophage-1 Antigen - metabolism | Complement Activation - drug effects | Cytokines - immunology | Interleukin-1beta - secretion | Complement C5 - metabolism | Tumor Necrosis Factor-alpha - secretion | Cells, Cultured | Cytokines - secretion | Phagocytosis - immunology | Interleukin-1beta - immunology | Cholesterol - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Monocytes - drug effects | Complement Pathway, Classical - immunology | Microscopy, Confocal | Complement Pathway, Alternative - drug effects | Complement Pathway, Alternative - immunology | Inflammasomes - immunology | Cholesterol - pharmacology | Complement C5a - immunology | Index Medicus | Abridged Index Medicus
Journal Article
Immunity, ISSN 1074-7613, 04/2015, Volume 42, Issue 4, pp. 744 - 755
The microbiota stimulates inflammation, but the signaling pathways and the members of the microbiota involved remain poorly understood. We found that the... 
DEXTRAN SULFATE | IMMUNE-SYSTEM | COLITIS | MACROPHAGES | MICE | INNATE LYMPHOID-CELLS | GUT MICROBIOTA | GERM-FREE | IMMUNOLOGY | PROTEUS-MIRABILIS | BOWEL-DISEASE | Receptors, CCR2 - genetics | Inflammation - pathology | Hemolysin Proteins - immunology | NLR Family, Pyrin Domain-Containing 3 Protein | Proteus Infections - genetics | Receptors, CCR2 - immunology | Hemolysin Proteins - genetics | Salmonella Infections - genetics | Antigens, Ly - genetics | Salmonella Infections - immunology | Symbiosis - immunology | Monocytes - immunology | Interleukin-1beta - genetics | Intestines - immunology | Proteus Infections - pathology | Monocytes - pathology | Carrier Proteins - immunology | Macrophages - immunology | Macrophages - microbiology | Proteus mirabilis - immunology | Monocytes - microbiology | Salmonella Infections - pathology | Inflammation - microbiology | Microbiota - immunology | Macrophages - pathology | Proteus Infections - microbiology | Signal Transduction | Mice, Inbred C57BL | Gene Expression Regulation | Intestines - injuries | Interleukin-1beta - immunology | Inflammation - immunology | Proteus Infections - immunology | Inflammasomes - genetics | Mice, Knockout | Carrier Proteins - genetics | Salmonella - immunology | Animals | Intestines - microbiology | Antigens, Ly - immunology | Inflammasomes - immunology | Inflammation - genetics | Salmonella Infections - microbiology | Mice | Index Medicus
Journal Article
Immunity, ISSN 1074-7613, 07/2013, Volume 39, Issue 1, pp. 123 - 135
The NLRP3 inflammasome plays a major role in innate immune responses by activating caspase-1, resulting in secretion of interleukin-18 (IL-18) and IL-1β.... 
DOUBLE-STRANDED-RNA | ANTIVIRAL RESPONSES | INTRACELLULAR DNA | DENDRITIC CELLS | RECOGNITION | BACTERIAL RNA | CASPASE-1 | INDUCIBLE GENE-I | RIG-I | IMMUNOLOGY | CYTOPLASMIC DNA | Interleukin-18 - immunology | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Cytosol - immunology | Humans | Caspase 1 - metabolism | Immunoblotting | Caspase 1 - immunology | RNA - genetics | RNA Interference | Interleukin-1beta - metabolism | Gene Expression - immunology | HEK293 Cells | Poly I-C - immunology | RNA, Double-Stranded - metabolism | DEAD-box RNA Helicases - metabolism | Carrier Proteins - immunology | Macrophages - immunology | RNA - metabolism | Cell Line | RNA - immunology | Macrophage Activation - immunology | Interleukin-1beta - immunology | Protein Binding - immunology | Reverse Transcriptase Polymerase Chain Reaction | Inflammasomes - genetics | Carrier Proteins - genetics | DEAD-box RNA Helicases - genetics | Microscopy, Confocal | Macrophages - metabolism | Carrier Proteins - metabolism | Inflammasomes - immunology | RNA, Double-Stranded - genetics | RNA, Double-Stranded - immunology | DEAD-box RNA Helicases - immunology | RNA, Bacterial - immunology | Cytosol - metabolism | RNA, Viral - immunology | Interleukin-18 - metabolism | RNA | Biological response modifiers | Proteins | Immunology | Laboratories | Glycerol | Infections | Sensors | Viral infections | Deoxyribonucleic acid--DNA | Immune system | Index Medicus
Journal Article
Journal Article
Journal of Immunology, ISSN 0022-1767, 04/2014, Volume 192, Issue 7, pp. 3259 - 3268
Adjuvants are an essential component of modern vaccines and used for their ability to elicit immunity to coadministered Ags. Many adjuvants in clinical... 
T-CELL RESPONSES | HUMAN NEUTROPHILS | DENDRITIC CELLS | NLRP3 INFLAMMASOME | IMMUNOLOGY | THERAPEUTIC VACCINES | PARTICULATE VACCINE ADJUVANTS | NALP3 INFLAMMASOME | ANTIGEN DELIVERY | INNATE IMMUNITY | TUMOR-ANTIGEN | Interleukin-18 - immunology | Inflammasomes - metabolism | Dendritic Cells - immunology | Humans | Tumor Necrosis Factor-alpha - genetics | Lymphocyte Activation - immunology | Interleukin-1beta - metabolism | Adenosine Triphosphate - metabolism | Tumor Necrosis Factor-alpha - immunology | Macrophages, Peritoneal - drug effects | Cell Survival - drug effects | Antigen-Presenting Cells - metabolism | Antigen-Presenting Cells - drug effects | Phospholipids - immunology | Immunity - immunology | Macrophages, Peritoneal - immunology | Saponins - immunology | Phospholipids - pharmacology | Blotting, Western | Mice, Knockout | Microscopy, Confocal | Macrophages - metabolism | Signal Transduction - drug effects | Cholesterol - pharmacology | Killer Cells, Natural - drug effects | Mice | Killer Cells, Natural - metabolism | Macrophages, Peritoneal - metabolism | Lysosomes - immunology | Interleukin-18 - metabolism | Saponins - pharmacology | Adjuvants, Immunologic - pharmacology | Cholesterol - immunology | Tumor Necrosis Factor-alpha - deficiency | Immunity - drug effects | Signal Transduction - immunology | Lysosomes - metabolism | Inflammasomes - drug effects | Killer Cells, Natural - immunology | Dendritic Cells - drug effects | Receptors, Tumor Necrosis Factor - deficiency | Dendritic Cells - metabolism | Macrophages - immunology | Receptors, Tumor Necrosis Factor - genetics | Lysosomes - drug effects | Mice, Inbred C57BL | Interleukin-1beta - immunology | Adenosine Triphosphate - immunology | Cell Survival - immunology | Antigen-Presenting Cells - immunology | Animals | Lymphocyte Activation - drug effects | Inflammasomes - immunology | Macrophages - drug effects | Receptors, Tumor Necrosis Factor - immunology | Drug Combinations | Index Medicus | Abridged Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 02/2017, Volume 23, Issue 2, pp. 174 - 184
Low-grade, chronic inflammation has been associated with many diseases of aging, but the mechanisms responsible for producing this inflammation remain unclear.... 
MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | INTERLEUKIN-18 LEVELS | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | CARDIOVASCULAR-DISEASE | RECEPTOR | ESSENTIAL-HYPERTENSION | PROTEINS | T-CELLS | AGE | CELL BIOLOGY | Toll-Like Receptor 5 - genetics | Humans | Middle Aged | Oxidative Stress - immunology | Transcriptome | Immunoblotting | Male | Purinergic P1 Receptor Antagonists - pharmacology | Young Adult | Toll-Like Receptor 8 - immunology | Aging - immunology | Toll-Like Receptor 6 - immunology | Aging - genetics | Calcium-Binding Proteins - immunology | Interleukin-1beta - metabolism | Aged, 80 and over | Caffeine - pharmacology | Hypertension - genetics | Intracellular Signaling Peptides and Proteins - genetics | Interleukin 1 Receptor Antagonist Protein - immunology | Carotid Intima-Media Thickness | Mortality | Neutrophils - drug effects | Hypertension - immunology | Nucleotides - metabolism | Toll-Like Receptor 5 - immunology | Monocytes - drug effects | Regression Analysis | Phenotype | Mice | Calcium-Binding Proteins - genetics | Metabolomics | Pulse Wave Analysis | Neutrophil Activation - drug effects | Cytidine - pharmacology | Interleukin 1 Receptor Antagonist Protein - genetics | Intracellular Signaling Peptides and Proteins - immunology | Cytidine - analogs & derivatives | CARD Signaling Adaptor Proteins - genetics | Toll-Like Receptor 6 - genetics | Adult | Female | Blood Pressure - drug effects | Blood Platelets - drug effects | Macrophages - immunology | Cytokines - immunology | CARD Signaling Adaptor Proteins - immunology | Cell Line | Vascular Stiffness - genetics | Cytokines - metabolism | Oxidative Stress - genetics | Interleukin-1beta - immunology | Adenine - pharmacology | Inflammation - immunology | Inflammasomes - genetics | Vascular Stiffness - immunology | Animals | Inflammasomes - immunology | Toll-Like Receptor 8 - genetics | Inflammation - genetics | Aged | Platelet Activation - drug effects | Genetic aspects | Immune response | Gene expression | Health aspects | Aging | Inflammation | Immune system | Index Medicus
Journal Article
Nature Immunology, ISSN 1529-2908, 12/2013, Volume 14, Issue 12, pp. 1247 - 1255
The inflammasome adaptor ASC contributes to innate immunity through the activation of caspase-1. Here we found that signaling pathways dependent on the kinases... 
LISTERIA-MONOCYTOGENES | AIM2 INFLAMMASOME | PROTEIN | INNATE IMMUNE-RESPONSES | MACROPHAGES | KINASE | HOST-DEFENSE | NLRP3 INFLAMMASOME | IMMUNOLOGY | CASPASE-1 ACTIVATION | VIRAL-INFECTION | Interleukin-18 - immunology | Inflammasomes - metabolism | Cytoskeletal Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Protein-Tyrosine Kinases - metabolism | Dendritic Cells - immunology | Humans | JNK Mitogen-Activated Protein Kinases - immunology | Caspase 1 - metabolism | Immunoblotting | Intracellular Signaling Peptides and Proteins - metabolism | RNA Interference | Bone Marrow Cells - immunology | Phosphorylation - immunology | JNK Mitogen-Activated Protein Kinases - genetics | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | Carrier Proteins - immunology | DNA-Binding Proteins | Tyrosine - immunology | Mice, Knockout | Macrophages - metabolism | Tyrosine - metabolism | Lipopolysaccharides - pharmacology | Mice | Interleukin-18 - metabolism | Intracellular Signaling Peptides and Proteins - immunology | JNK Mitogen-Activated Protein Kinases - metabolism | Caspase 1 - immunology | Protein-Tyrosine Kinases - immunology | Protein-Tyrosine Kinases - genetics | HEK293 Cells | Cytoskeletal Proteins - metabolism | Female | Nuclear Proteins - genetics | Dendritic Cells - metabolism | Macrophages - immunology | Mice, Inbred C57BL | Cells, Cultured | Nuclear Proteins - metabolism | Nuclear Proteins - immunology