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Immunological Reviews, ISSN 0105-2896, 07/2013, Volume 254, Issue 1, pp. 78 - 101
Systemic chronic immune activation is considered today as the driving force of CD 4 + T‐cell depletion and acquired immunodeficiency syndrome ( AIDS ). A... 
SIV | pathogenesis | HIV | inflammation | immune activation | natural hosts | Immune activation | Inflammation | Pathogenesis | Natural hosts | LONG-TERM NONPROGRESSORS | RECEIVING ANTIRETROVIRAL THERAPY | AFRICAN-GREEN MONKEYS | CD4(+) T-CELLS | NONPATHOGENIC SIV INFECTION | NECROSIS-FACTOR-ALPHA | IMMUNOLOGY | PLASMACYTOID DENDRITIC CELLS | SIMIAN IMMUNODEFICIENCY VIRUS | LYMPHOID-TISSUE | INFECTED SOOTY MANGABEYS | HIV-1 - metabolism | Lymphoid Tissue - virology | HIV Infections - virology | Humans | Viral Proteins - immunology | Lymphocyte Depletion | Lymphoid Tissue - immunology | CD4-Positive T-Lymphocytes - immunology | HIV Infections - immunology | HIV-1 - immunology | Lymphocyte Activation - immunology | Simian Acquired Immunodeficiency Syndrome - virology | Animals | Simian Acquired Immunodeficiency Syndrome - immunology | Virus Replication | CD4-Positive T-Lymphocytes - virology | HIV (Viruses) | T cells | HIV infection | Lymphoid Tissue/immunology | HIV-1/immunology | HIV Infections/immunology | HIV-1/metabolism | Lymphoid Tissue/virology | Virology | Life Sciences | Simian Acquired Immunodeficiency Syndrome/virology | Microbiology and Parasitology | Immunology | CD4-Positive T-Lymphocytes/immunology | Lymphocyte Activation/immunology | HIV Infections/virology | CD4-Positive T-Lymphocytes/virology | Simian Acquired Immunodeficiency Syndrome/immunology | Viral Proteins/immunology
Journal Article
Annual Review of Medicine, ISSN 0066-4219, 02/2011, Volume 62, Issue 1, pp. 141 - 155
Although antiretroviral therapy for HIV infection prevents AIDS-related complications and prolongs life, it does not fully restore health. Long-term treated... 
CD28 | frailty | CD38 | CMV | telomere | MEDICINE, RESEARCH & EXPERIMENTAL | LIFE-SPAN | MYOCARDIAL-INFARCTION | CYTOMEGALOVIRUS-INFECTION | HUMAN-IMMUNODEFICIENCY-VIRUS | REPLICATIVE SENESCENCE | T-CELL RESPONSES | REVERSE-TRANSCRIPTASE INHIBITORS | KIDNEY-FUNCTION | IMMUNE ACTIVATION | COMBINATION ANTIRETROVIRAL THERAPY | Immune System - virology | Humans | Mitochondrial Diseases - immunology | T-Lymphocytes - virology | HIV Infections - immunology | Neoplasms - virology | Aging - immunology | Cardiovascular Diseases - virology | Aging - genetics | Anti-HIV Agents - therapeutic use | Metabolic Syndrome - immunology | Intra-Abdominal Fat - immunology | Intra-Abdominal Fat - virology | Liver Diseases - immunology | Liver Diseases - virology | Bone Diseases - virology | Mitochondrial Diseases - virology | Inflammation - virology | Treatment Outcome | Inflammation - immunology | Bone Diseases - immunology | Antiretroviral Therapy, Highly Active | Kidney Diseases - immunology | Cardiovascular Diseases - immunology | Neoplasms - immunology | HIV Infections - complications | Metabolic Syndrome - virology | HIV Infections - drug therapy | Kidney Diseases - virology | Nervous System Diseases - virology | T-Lymphocytes - immunology | Nervous System Diseases - immunology | Anti-HIV Agents - immunology | Prevention | Aging | Physiological aspects | Telomeres | Care and treatment | HIV infection
Journal Article
European Journal of Immunology, ISSN 0014-2980, 12/2017, Volume 47, Issue 12, pp. 2113 - 2123
We and others have demonstrated that adipose tissue is a reservoir for HIV. Evaluation of the mechanisms responsible for viral persistence may lead to ways of... 
CD4 T cell | Fat | Adipose tissue | HIV | PD‐1 | HIV persistence | PD-1 | IMMUNE CELLS | RESIDENT | REG CELLS | IMMUNOLOGY | OBESITY | INSULIN-RESISTANCE | INFLAMMATION | REGULATORY T-CELLS | PPAR-GAMMA | ACCUMULATION | LYMPHOCYTE-ACTIVATION | Disease Reservoirs - virology | Humans | Middle Aged | Male | Adipose Tissue - immunology | Host-Pathogen Interactions - immunology | CD4-Positive T-Lymphocytes - immunology | Adipose Tissue - metabolism | HIV Infections - immunology | Flow Cytometry | Aged, 80 and over | Adult | Female | CD4-Positive T-Lymphocytes - virology | Antiviral Agents - therapeutic use | HIV-1 - drug effects | Adipose Tissue - virology | HIV Infections - virology | CD4-Positive T-Lymphocytes - metabolism | Programmed Cell Death 1 Receptor - metabolism | Cellular Microenvironment - immunology | HIV-1 - immunology | Aged | Programmed Cell Death 1 Receptor - immunology | HIV Infections - metabolism | Adipose tissues | Highly active antiretroviral therapy | Antiviral agents | Medical research | Medicine, Experimental | T cells | HIV (Viruses) | HIV infection | Antiretroviral drugs | Memory cells | Immunological memory | PD-1 protein | Immunomodulation | CD8 antigen | Helper cells | Activation | Lymphocytes T | Infections | Patients | Antiretroviral therapy | CD4 antigen | CD69 antigen | Cell activation | Antiretroviral agents | Lymphocytes | Human immunodeficiency virus--HIV | Reservoirs | Histocompatibility antigen HLA | Programmed Cell Death 1 Receptor/immunology | CD4-Positive T-Lymphocytes/metabolism | HIV-1/immunology | Adipose Tissue/immunology | HIV Infections/immunology | HIV-1/drug effects | Life Sciences | Host-Pathogen Interactions/immunology | HIV Infections/metabolism | Immunology | Adipose Tissue/metabolism | Cellular Microenvironment/immunology | Adipose Tissue/virology | Virology | Disease Reservoirs/virology | Microbiology and Parasitology | Antiviral Agents/therapeutic use | CD4-Positive T-Lymphocytes/immunology | HIV Infections/virology | CD4-Positive T-Lymphocytes/virology | Programmed Cell Death 1 Receptor/metabolism
Journal Article
Cell Host & Microbe, ISSN 1931-3128, 06/2016, Volume 19, Issue 6, pp. 788 - 799
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2012, Volume 7, Issue 10, p. e47542
Background: Mortality in the first months of antiretroviral therapy (ART) is a significant clinical problem in sub-Saharan Africa. To date, no post-mortem... 
AUTOPSY | RECONSTITUTION INFLAMMATORY SYNDROME | SUB-SAHARAN AFRICA | TUBERCULOSIS | MULTIDISCIPLINARY SCIENCES | HIV-POSITIVE PATIENTS | DISEASE | ADULTS | COHORT | EARLY MORTALITY | PATHOLOGY | Liver - virology | Tuberculosis, Pulmonary - microbiology | Liver - pathology | Kidney - pathology | Humans | Middle Aged | Male | Tuberculosis, Pulmonary - drug therapy | Bacterial Infections - virology | Liver - drug effects | Autopsy | HIV Infections - mortality | Lymph Nodes - drug effects | Bacterial Infections - microbiology | Bone Marrow - drug effects | Bone Marrow - virology | Kidney - drug effects | Bacterial Infections - drug therapy | HIV Infections - virology | Tuberculosis, Pulmonary - pathology | Tuberculosis, Pulmonary - mortality | Bacterial Infections - pathology | Lung - drug effects | Biopsy, Needle | Kidney - virology | Bacterial Infections - mortality | Mycobacterium tuberculosis - growth & development | Lymph Nodes - pathology | Mycobacterium tuberculosis - drug effects | Cause of Death | HIV - drug effects | Lung - virology | Immune Reconstitution Inflammatory Syndrome - virology | HIV Infections - pathology | Adult | Female | Skin - virology | Skin - pathology | Lung - pathology | South Africa - epidemiology | Lymph Nodes - virology | Immune Reconstitution Inflammatory Syndrome - mortality | HIV - growth & development | Antiretroviral Therapy, Highly Active | Immune Reconstitution Inflammatory Syndrome - pathology | Bone Marrow - pathology | Immune Reconstitution Inflammatory Syndrome - drug therapy | HIV Infections - drug therapy | Skin - drug effects | Tuberculosis, Pulmonary - virology | Antiviral agents | Bacterial infections | Mycobacterium tuberculosis | Dosage and administration | Diagnosis | Research | Drug therapy | Risk factors | Reproductive health | Health sciences | Therapy | Laboratories | Liver | Systematic review | Infections | Cerebrospinal fluid | Drug resistance | Lymph nodes | Acquired immune deficiency syndrome--AIDS | Antiretroviral agents | Human immunodeficiency virus--HIV | Bone marrow | Bacteria | Ultrasound | Spleen | Autopsies | Kidneys | Internal medicine | Mortality | Immune reconstitution | Inflammation | Patients | Antiretroviral therapy | Medicine | Hospitals | Tuberculosis | Infectious diseases | Lungs | Biopsy | Death | Fatalities | Adults | Skin | Bone | Kidney transplantation | Lymph | Acquired immune deficiency syndrome | AIDS | HIV | Human immunodeficiency virus
Journal Article
Science Translational Medicine, ISSN 1946-6234, 05/2010, Volume 2, Issue 32, pp. 32ra36 - ra36
Journal Article
PLoS Pathogens, ISSN 1553-7366, 2015, Volume 11, Issue 9, p. e1005153
Two of the crucial aspects of human immunodeficiency virus (HIV) infection are (i) viral persistence in reservoirs (precluding viral eradication) and (ii)... 
LONG-TERM NONPROGRESSORS | MESSENGER-RNA EXPRESSION | MICROBIOLOGY | NECROSIS-FACTOR-ALPHA | HUMAN-IMMUNODEFICIENCY-VIRUS | HUMAN ADIPOCYTES | VIROLOGY | ACTIVE ANTIRETROVIRAL THERAPY | SIVMAC251 INFECTION | IMMUNE ACTIVATION | METABOLIC-DISORDERS | MEMORY T-CELLS | PARASITOLOGY | Simian Acquired Immunodeficiency Syndrome - metabolism | HIV - physiology | Stromal Cells - pathology | Coculture Techniques | Humans | Middle Aged | Macaca fascicularis | Male | HIV - immunology | Adipose Tissue - immunology | CD4-Positive T-Lymphocytes - pathology | CD4-Positive T-Lymphocytes - immunology | Simian Immunodeficiency Virus - isolation & purification | Adipose Tissue - metabolism | HIV Infections - immunology | Simian Acquired Immunodeficiency Syndrome - virology | Macrophages - virology | HIV Infections - pathology | Stromal Cells - virology | Adult | Female | Panniculitis - immunology | Disease Reservoirs | CD4-Positive T-Lymphocytes - virology | Simian Acquired Immunodeficiency Syndrome - pathology | Macrophages - immunology | Simian Immunodeficiency Virus - immunology | Macrophages - pathology | Adipose Tissue - virology | HIV Infections - virology | Stromal Cells - metabolism | Adipose Tissue - pathology | CD4-Positive T-Lymphocytes - metabolism | Cells, Cultured | Stromal Cells - immunology | HIV - isolation & purification | Immunity, Innate | Panniculitis - virology | Simian Immunodeficiency Virus - physiology | Host-Pathogen Interactions | Macrophages - metabolism | Animals | Simian Acquired Immunodeficiency Syndrome - immunology | Aged | Panniculitis - pathology | Panniculitis - metabolism | HIV Infections - metabolism | Adipose tissues | Host-virus relationships | HIV (Viruses) | Simian immunodeficiency virus | Observations | Health aspects | Life Sciences | Human health and pathology | Antiretroviral drugs | Lymphatic system | Mortality | Infections | Inflammation | Adipocytes | Metabolism | Experiments | HIV | Lymphocytes | Rodents | Deoxyribonucleic acid | DNA | Human immunodeficiency virus | Drug therapy
Journal Article