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Gut, ISSN 0017-5749, 04/2013, Volume 62, Issue 4, pp. 531 - 539
Journal Article
Nature, ISSN 0028-0836, 09/2011, Volume 477, Issue 7364, pp. 330 - 334
Intestinal immune homeostasis depends on a tightly regulated cross talk between commensal bacteria, mucosal immune cells and intestinal epithelial cells... 
APOPTOSIS | REGULATOR | DEATH PATHWAY | NECROPTOSIS | B-CELL | MULTIDISCIPLINARY SCIENCES | NETWORKS | TNF-ALPHA | DEFICIENT MICE | BOWEL-DISEASE | NEMO/IKK-GAMMA | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Colon - enzymology | Epithelial Cells - metabolism | Paneth Cells - pathology | Colitis - pathology | Intracellular Signaling Peptides and Proteins - metabolism | Inflammatory Bowel Diseases - metabolism | Metagenome - physiology | Necrosis | Intracellular Signaling Peptides and Proteins - deficiency | Cysteine Endopeptidases - metabolism | Inflammatory Bowel Diseases - enzymology | Inflammatory Bowel Diseases - pathology | Enteritis - metabolism | Signal Transduction | Colon - pathology | Fas-Associated Death Domain Protein - metabolism | Fas-Associated Death Domain Protein - deficiency | Epithelial Cells - pathology | Enteritis - pathology | Tumor Necrosis Factors - deficiency | Colon - metabolism | Animals | Colitis - enzymology | Myeloid Differentiation Factor 88 - deficiency | Enteritis - enzymology | Colitis - metabolism | Epithelial Cells - enzymology | Mice | Receptor-Interacting Protein Serine-Threonine Kinases - antagonists & inhibitors | Chronic Disease | Myeloid Differentiation Factor 88 - metabolism | Apoptosis | Proteins | Inflammatory bowel disease | Pathogenesis | Colleges & universities | Homeostasis | Colon
Journal Article
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 09/2014, Volume 289, Issue 39, pp. 26847 - 26858
Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, is a group of autoimmune diseases characterized by nonspecific inflammation... 
INFLAMMATORY-BOWEL-DISEASE | CARBON-MONOXIDE | PROTECTIVE ROLE | BIOCHEMISTRY & MOLECULAR BIOLOGY | THERAPEUTIC TARGET | MOUSE MODEL | AIRWAY INFLAMMATION | UP-REGULATION | EXPRESSION | T-CELLS | TH17 CELLS | Forkhead Transcription Factors - immunology | Colon - enzymology | Heme Oxygenase-1 - metabolism | Inflammatory Bowel Diseases - immunology | Interleukin-17 - immunology | Protoporphyrins - pharmacology | Colitis - pathology | Colon - immunology | Membrane Proteins - pharmacology | T-Lymphocytes, Regulatory - pathology | T-Lymphocytes, Regulatory - immunology | Photosensitizing Agents - pharmacology | Forkhead Transcription Factors - metabolism | Inflammatory Bowel Diseases - enzymology | Colitis - chemically induced | Inflammatory Bowel Diseases - pathology | Interleukin-10 - metabolism | Female | Inflammatory Bowel Diseases - chemically induced | Membrane Proteins - metabolism | Hemin - pharmacology | Colitis - immunology | Disease Models, Animal | Th17 Cells - pathology | Acute Disease | Th17 Cells - enzymology | Colon - pathology | Dextran Sulfate - toxicity | Interleukin-17 - metabolism | Animals | Colitis - enzymology | Th17 Cells - immunology | Mice | Mice, Inbred BALB C | Heme Oxygenase-1 - pharmacology | Interleukin-10 - immunology | T-Lymphocytes, Regulatory - enzymology | Immunology | Inflammatory Bowel Disease (IBD) | T Helper Cells | Treg | Heme Oxygenase | Heme Oxygenase-1 | Inflammation | Colitis | Th17
Journal Article
Gastroenterology, ISSN 0016-5085, 2017, Volume 153, Issue 4, pp. 1054 - 1067
Abstract Background Intestinal fibrosis resulting in (sub)obstruction is a common complication of Crohn’s disease (CD). Rho kinases (ROCKs) play multiple roles... 
Gastroenterology and Hepatology | Stenosis | Epithelial-to-Mesenchymal Transition | Colitis | Mesenchymal Cells | APOPTOSIS | CROHNS-DISEASE | MOUSE | AUTOPHAGY | MODEL | PATHWAY | MYOFIBROBLASTS | GASTROENTEROLOGY & HEPATOLOGY | MATRIX-STIFFNESS | PULMONARY-FIBROSIS | Dextran Sulfate | Ileum - pathology | Intestinal Obstruction - enzymology | Myofibroblasts - immunology | Humans | Myofibroblasts - enzymology | Male | Adoptive Transfer | Intestinal Obstruction - chemically induced | Intestinal Obstruction - prevention & control | Ileum - immunology | Autophagy - drug effects | Case-Control Studies | T-Lymphocytes - transplantation | rho-Associated Kinases - antagonists & inhibitors | Ileum - enzymology | Ileum - drug effects | Time Factors | rho-Associated Kinases - metabolism | Inflammatory Bowel Diseases - enzymology | Inflammatory Bowel Diseases - pathology | Inflammatory Bowel Diseases - chemically induced | p38 Mitogen-Activated Protein Kinases - metabolism | Interleukin-6 - metabolism | Disease Models, Animal | Myofibroblasts - pathology | Inflammatory Bowel Diseases - prevention & control | Tissue Culture Techniques | Mice, Inbred C57BL | Intestinal Obstruction - pathology | Myofibroblasts - drug effects | Collagen - metabolism | Animals | Signal Transduction - drug effects | Fibrosis | T-Lymphocytes - immunology | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Matrix Metalloproteinases - metabolism | Care and treatment | Transforming growth factors | Health aspects | Gastrointestinal diseases | Evaluation | Sulfates | T cells | Preventive health services | Dextran | Collagen | Analysis | Resveratrol | Stem cells | Interferon | Medicine, Preventive | Protein kinases | Ulcerative colitis
Journal Article
Journal Article
Redox Biology, ISSN 2213-2317, 12/2015, Volume 6, pp. 135 - 156
Maintaining the redox balance between generation and elimination of reactive oxygen species (ROS) is critical for health. Disturbances such as continuously... 
Inflammatory bowel disease | Chronic granulomatous disease | NADPH oxidase | NOX | Reactive oxygen species (ROS) | DUOX | Hypothyroidism | Genetic disease | CHRONIC GRANULOMATOUS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | REDUCED OXIDATIVE BURST | NADPH OXIDASE ACTIVITY | PLURIPOTENT STEM-CELLS | NEUTROPHIL RESPIRATORY BURST | CONGENITAL HYPOTHYROIDISM | MISSENSE MUTATION | HYDROGEN-PEROXIDE | COPY NUMBER VARIATION | DUAL OXIDASE | Diabetes Mellitus - enzymology | Diabetes Mellitus - pathology | Hypothyroidism - pathology | Reactive Oxygen Species - metabolism | Diabetes Mellitus - genetics | Humans | Granulomatous Disease, Chronic - genetics | Cardiovascular Diseases - enzymology | Cardiovascular Diseases - pathology | Cardiovascular Diseases - genetics | Membrane Proteins - deficiency | NADPH Oxidases - deficiency | Inflammatory Bowel Diseases - enzymology | Inflammatory Bowel Diseases - pathology | Inflammatory Bowel Diseases - genetics | NADPH Oxidases - genetics | Hypothyroidism - enzymology | Hypothyroidism - genetics | Granulomatous Disease, Chronic - pathology | Gene Expression | Oxidation-Reduction | Membrane Proteins - genetics | NADPH Oxidase 2 | NADPH Oxidase 1 | Membrane Glycoproteins - genetics | Granulomatous Disease, Chronic - enzymology | Mutation | Dual Oxidases | Membrane Glycoproteins - deficiency
Journal Article