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Gastroenterology, ISSN 0016-5085, 2011, Volume 140, Issue 1, pp. 221 - 230.e3
Background & Aims Anti–tumor necrosis factor (TNF)α antibodies are effective in treating patients with Crohn's disease whereas soluble TNFα receptors have not... 
Gastroenterology and Hepatology | Autoimmunity | IBD | Inflammatory Response | Type 2 Macrophage | MONOCLONAL-ANTIBODY | POLYMORPHISM | ACTIVE CROHNS-DISEASE | INFLAMMATORY-BOWEL-DISEASE | ACCENT-I | DOUBLE-BLIND | PLACEBO-CONTROLLED TRIAL | TNF-ALPHA | INFLIXIMAB | GASTROENTEROLOGY & HEPATOLOGY | T-LYMPHOCYTES | Cell Proliferation | Certolizumab Pegol | Humans | Lectins, C-Type - immunology | Anti-Inflammatory Agents - immunology | Caspase 3 - immunology | Antibodies, Monoclonal, Humanized | Lymphocyte Activation - immunology | Immunoglobulin Fc Fragments - immunology | Etanercept | Infliximab | Immunoglobulin G - immunology | T-Lymphocytes - drug effects | Leukocytes, Mononuclear - immunology | Tumor Necrosis Factor-alpha - immunology | Immunoglobulin G - pharmacology | Immunosuppressive Agents - pharmacology | Antibodies, Monoclonal - immunology | Macrophages - immunology | Cytokines - immunology | Polyethylene Glycols - pharmacology | Leukocytes, Mononuclear - drug effects | Anti-Inflammatory Agents - pharmacology | Cells, Cultured | Cytokines - secretion | Crohn Disease - immunology | Receptors, Cell Surface - immunology | Immunoglobulin Fab Fragments - pharmacology | Mannose-Binding Lectins - immunology | Receptors, Fc - immunology | Immunosuppressive Agents - immunology | Lymphocyte Activation - drug effects | Caspase 3 - analysis | T-Lymphocytes - immunology | Immunoglobulin Fab Fragments - immunology | Adalimumab | Receptors, Tumor Necrosis Factor - immunology | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Apoptosis
Journal Article
Journal of Immunology, ISSN 0022-1767, 04/2014, Volume 192, Issue 7, pp. 3111 - 3120
Psoriasis is a common and chronic inflammatory skin disease in which T cells play a key role. Effective treatment heals the skin without scarring, but... 
VULGARIS LESIONS | INTERFERON-GAMMA | RESIDENT | IFN-GAMMA | DOUBLE-BLIND | ULTRAVIOLET-B | UVB PHOTOTHERAPY | MONOCLONAL-ANTIBODY | SKIN | IMMUNOLOGY | CD8(+) T-CELLS | Receptors, CCR6 - immunology | Antigens, CD - immunology | Humans | Middle Aged | Interleukin-17 - immunology | Immunologic Memory - radiation effects | Ustekinumab | Antibodies, Monoclonal - therapeutic use | Dermatologic Agents - therapeutic use | Transcriptome - immunology | Transcriptome - radiation effects | Immunologic Memory - drug effects | Antigens, CD - genetics | Interleukins - metabolism | Antigens, CD - metabolism | Receptors, Interleukin - metabolism | Young Adult | Interleukins - genetics | Flow Cytometry | Ultraviolet Rays | Infliximab | T-Lymphocytes - metabolism | Integrin alpha Chains - immunology | Interleukins - immunology | Receptors, CCR6 - metabolism | Adult | Immunologic Memory - immunology | Psoriasis - immunology | Epidermis - metabolism | Epidermis - pathology | Antibodies, Monoclonal, Humanized - therapeutic use | Psoriasis - drug therapy | Receptors, Interleukin - immunology | Interleukin-17 - genetics | Psoriasis - radiotherapy | Integrin alpha Chains - metabolism | Transcriptome - drug effects | Reverse Transcriptase Polymerase Chain Reaction | Receptors, Interleukin - genetics | Interleukin-17 - metabolism | Microscopy, Confocal | Models, Immunological | Epidermis - immunology | Receptors, CCR6 - genetics | T-Lymphocytes - immunology | Aged | Integrin alpha Chains - genetics | Clinical and Human Immunology
Journal Article
Clinical Immunology, ISSN 1521-6616, 2011, Volume 139, Issue 2, pp. 164 - 176
Abstract The impact of anti-TNF therapy on systemic immune responses in patients has not been clearly defined. Here, we examined Th1/Th2/Th17 cytokine... 
Allergy and Immunology | Inflammatory bowel disease | Psoriasis | Immunotherapy | TNF-blockade | T cell responses | Cytokine | RHEUMATOID-ARTHRITIS | PATHWAYS | SURVIVAL | RECEPTOR | FACTOR-ALPHA BLOCKADE | ANKYLOSING-SPONDYLITIS | IMMUNOLOGY | PATHOGENESIS | TUMOR-NECROSIS-FACTOR | IMMUNE ACTIVATION | Leukocytes, Mononuclear - metabolism | Skin - metabolism | Humans | Inflammatory Bowel Diseases - immunology | Middle Aged | Antibodies, Monoclonal - therapeutic use | Male | Antigens, CD - genetics | Blood - metabolism | Antigens, CD - metabolism | CD4-Positive T-Lymphocytes - immunology | Young Adult | Inflammation - metabolism | Lymphocyte Activation - immunology | Etanercept | T-Lymphocytes - metabolism | T-Lymphocyte Subsets - drug effects | T-Lymphocytes - drug effects | Gene Expression - immunology | Psoriasis - metabolism | Tumor Necrosis Factor-alpha - immunology | Aged, 80 and over | Cytokines - genetics | B-Lymphocytes - metabolism | Inflammatory Bowel Diseases - drug therapy | Psoriasis - immunology | B-Lymphocytes - cytology | Leukocytes, Mononuclear - drug effects | Psoriasis - drug therapy | Receptors, Antigen, T-Cell - metabolism | Antibodies, Monoclonal - pharmacology | Bacterial Toxins - immunology | CD4-Positive T-Lymphocytes - metabolism | Adolescent | T-Lymphocytes - immunology | Viral Matrix Proteins - immunology | Adalimumab | T-Lymphocyte Subsets - immunology | Gene Expression - drug effects | T-Lymphocyte Subsets - cytology | Blood - immunology | Inflammatory Bowel Diseases - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Receptors, Tumor Necrosis Factor - therapeutic use | Antibodies, Monoclonal, Humanized | Enterotoxins - immunology | Infliximab | Inflammation - drug therapy | Leukocytes, Mononuclear - immunology | Immunoglobulin G - pharmacology | Adult | Female | Cytokines - blood | Skin - immunology | Cytokines - metabolism | CD4-Positive T-Lymphocytes - cytology | Blood - drug effects | Immunoglobulin G - therapeutic use | Treatment Outcome | Inflammation - immunology | Superantigens - immunology | T-Lymphocytes - cytology | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Lymphocyte Activation - drug effects | T-Lymphocyte Subsets - metabolism | Aged | Cell Proliferation - drug effects | CD4-Positive T-Lymphocytes - drug effects | Skin - drug effects | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Inflammation | T cells | Gastrointestinal diseases
Journal Article
Journal of Immunology Research, ISSN 2314-8861, 11/2014, Volume 2014, pp. 385352 - 12
TNFα plays an important role in autoimmune pathogenesis and is the main therapeutic target of rheumatoid arthritis. However, its underlying mechanism is not... 
RESPONSES | CYTOKINES | INHIBITION | THERAPY | INTERLEUKIN-17 | INFLAMMATION | REGULATORY T-CELLS | ANTIBODY | CHEMOKINE | IMMUNOLOGY | EXPRESSION | Tumor Necrosis Factor-alpha - metabolism | Arthritis, Rheumatoid - blood | Receptors, Tumor Necrosis Factor, Type I - immunology | Humans | Middle Aged | Synovial Fluid - metabolism | Antibodies, Monoclonal - therapeutic use | Immunoblotting | Male | Monocytes - metabolism | Antibodies, Blocking - pharmacology | Monocytes - immunology | Receptors, Tumor Necrosis Factor, Type I - metabolism | Receptors, Tumor Necrosis Factor, Type II - immunology | CD4-Positive T-Lymphocytes - immunology | Th17 Cells - drug effects | Infliximab | Th17 Cells - metabolism | Arthritis, Rheumatoid - drug therapy | Interleukin-1beta - metabolism | Receptors, Tumor Necrosis Factor, Type II - metabolism | Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism | Tumor Necrosis Factor-alpha - immunology | Female | Phosphorylation - immunology | Synovial Fluid - cytology | Interleukin-6 - metabolism | Nuclear Receptor Subfamily 1, Group F, Member 3 - genetics | STAT3 Transcription Factor - metabolism | Antirheumatic Agents - therapeutic use | Nuclear Receptor Subfamily 1, Group F, Member 3 - immunology | CD4-Positive T-Lymphocytes - metabolism | Cells, Cultured | Interleukin-1beta - immunology | Reverse Transcriptase Polymerase Chain Reaction | Synovial Fluid - immunology | Cell Differentiation - immunology | Cell Differentiation - drug effects | Antibodies, Blocking - immunology | Interleukin-6 - immunology | Th17 Cells - immunology | Aged | STAT3 Transcription Factor - immunology | Arthritis, Rheumatoid - immunology | Tumor Necrosis Factor-alpha - antagonists & inhibitors
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 01/2018, Volume 9, Issue 1, pp. 25 - 11
Although anti-tumor necrosis factor (TNF) agents are highly effective in the treatment of psoriasis, 2-5% of treated patients develop psoriasis-like skin... 
RHEUMATOID-ARTHRITIS | TUMOR-NECROSIS-FACTOR | SYSTEMIC-LUPUS-ERYTHEMATOSUS | DENDRITIC CELL-DIFFERENTIATION | PLAQUE PSORIASIS | MULTIDISCIPLINARY SCIENCES | FOLLOW-UP | CLINICAL-FEATURES | T-CELLS | FACTOR-ALPHA | IFN-ALPHA | Tumor Necrosis Factor-alpha - metabolism | Dendritic Cells - immunology | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Crohn Disease - metabolism | Antibodies, Monoclonal - therapeutic use | Male | Infliximab - therapeutic use | Interferon Type I - immunology | Adalimumab - adverse effects | Young Adult | Infliximab - adverse effects | T-Lymphocytes - metabolism | Autoimmunity - immunology | T-Lymphocytes - drug effects | Tumor Necrosis Factor-alpha - immunology | Interferon Type I - metabolism | Adult | Dendritic Cells - drug effects | Female | Cytokines - genetics | Antibodies, Monoclonal - immunology | Dendritic Cells - metabolism | Cytokines - immunology | Psoriasis - immunology | Adalimumab - immunology | Cytokines - metabolism | Cells, Cultured | Infliximab - immunology | Crohn Disease - immunology | Adalimumab - therapeutic use | Animals | Crohn Disease - drug therapy | Psoriasis - chemically induced | Adolescent | Interferon Type I - genetics | T-Lymphocytes - immunology | Aged | Mice, Inbred BALB C | Autoimmunity - drug effects | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Psoriasis | Dendritic cells | Pathogenesis | Lymphocytes T | Inflammation | Patients | Anticancer properties | Tumor necrosis factor | Lymphocytes | Tumor necrosis factor-TNF | Skin diseases | Skin | Interferon | Lesions
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2016, Volume 11, Issue 12, p. e0167757
TNF-alpha has a central role in the development and maintenance of psoriatic plaques, and its serum levels correlate with disease activity. Anti-TNF-alpha... 
RHEUMATOID-ARTHRITIS | THERAPY | DENDRITIC CELLS | MULTIDISCIPLINARY SCIENCES | PHASE-III | DISEASE | NECROSIS-FACTOR-ALPHA | RANDOMIZED CONTROLLED-TRIAL | INFLIXIMAB | ETANERCEPT | GENE POLYMORPHISMS | Humans | Middle Aged | Tumor Necrosis Factor-alpha - blood | Anti-Inflammatory Agents - immunology | Male | Dermatologic Agents - therapeutic use | Monocytes - immunology | Infliximab - therapeutic use | Leukocytes, Mononuclear - immunology | Receptors, Tumor Necrosis Factor - blood | Tumor Necrosis Factor-alpha - immunology | Anti-Inflammatory Agents - therapeutic use | Antibodies - immunology | Adult | Female | Psoriasis - blood | Psoriasis - immunology | Adalimumab - immunology | Leukocytes, Mononuclear - drug effects | Psoriasis - drug therapy | Infliximab - immunology | Monocytes - drug effects | Adalimumab - therapeutic use | Etanercept - immunology | Antibodies - blood | Aged | Dermatologic Agents - immunology | Receptors, Tumor Necrosis Factor - immunology | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Cohort Studies | Etanercept - therapeutic use | Drugs | Pathogenesis | Antibodies | Amino acids | Leukocytes (mononuclear) | Systematic review | Cell adhesion & migration | Receptors | Etanercept | Infliximab | Lymphocytes | Surgery | Modulation | Peripheral blood mononuclear cells | Tumor necrosis factor-TNF | Life sciences | Drug dosages | Plaques | Immunoglobulins | Psoriasis | Cytokines | Dendritic cells | Dermatology | Inflammation | Dentistry | Tumor necrosis factor-α | Patients | Medicine | Serum levels | Monocytes | Rheumatoid arthritis | Morphology | Monoclonal antibodies | TNF inhibitors | Plasma levels
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 10/2009, Volume 119, Issue 10, pp. 3011 - 3023
Cytokines orchestrate the tumor-promoting interplay between malignant cells and the immune system. In many experimental and human cancers, the cytokine... 
RHEUMATOID-ARTHRITIS | MEDICINE, RESEARCH & EXPERIMENTAL | TGF-BETA | INTERLEUKIN-17 FAMILY | IN-VIVO | GROWTH | IL-17-PRODUCING T-CELLS | FACTOR RECEPTOR P55 | PHASE-II | NECROSIS-FACTOR-ALPHA | NF-KAPPA-B | Humans | Tumor Necrosis Factor-alpha - genetics | Interleukin-17 - immunology | Antibodies, Monoclonal - therapeutic use | Gene Expression Profiling | Chimera - genetics | CD4-Positive T-Lymphocytes - immunology | Interleukin-23 - genetics | Ovarian Neoplasms - genetics | Chimera - immunology | Interleukin-2 Receptor alpha Subunit - genetics | Infliximab | Microarray Analysis | Tumor Necrosis Factor-alpha - immunology | Anti-Inflammatory Agents - therapeutic use | Female | Ovarian Neoplasms - drug therapy | Disease Models, Animal | Interleukin-2 Receptor alpha Subunit - immunology | Receptors, Interleukin - immunology | Mice, Inbred C57BL | Receptors, Tumor Necrosis Factor, Type I | Interleukin-17 - genetics | Clinical Trials as Topic | Receptors, Interleukin - genetics | Interleukin-23 - immunology | Mice, Knockout | Animals | Signal Transduction - physiology | Mice | Ovarian Neoplasms - immunology | Interleukin-2 Receptor alpha Subunit | Signal Transduction | Anti-Inflammatory Agents | Interleukin-23 | Receptors, Interleukin | Antibodies, Monoclonal | Tumor Necrosis Factor-alpha | Life Sciences | Immunology | CD4-Positive T-Lymphocytes | Interleukin-17 | Ovarian Neoplasms | Chimera
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 05/2009, Volume 119, Issue 5, pp. 1167 - 1177
The incidence of tuberculosis is increased during treatment of autoimmune diseases with anti-TNF antibodies. This is a significant clinical complication, but... 
RHEUMATOID-ARTHRITIS | MEDICINE, RESEARCH & EXPERIMENTAL | IN-VIVO BLOCKADE | TUMOR-NECROSIS-FACTOR | CHILDHOOD TUBERCULOSIS | ALVEOLAR MACROPHAGES | ANKYLOSING-SPONDYLITIS | GRANULYSIN-DERIVED PEPTIDES | FACTOR ANTAGONISTS | CHIMERIC MONOCLONAL-ANTIBODY | FACTOR-ALPHA | T-Lymphocyte Subsets - immunology | Tumor Necrosis Factor-alpha - metabolism | CD8-Positive T-Lymphocytes - cytology | Leukocytes, Mononuclear - metabolism | T-Lymphocyte Subsets - cytology | Vesicular Transport Proteins - metabolism | Humans | Middle Aged | Mycobacterium tuberculosis - immunology | Complement System Proteins - immunology | Antibodies, Monoclonal - therapeutic use | Male | Monocytes - immunology | Interferon-gamma - metabolism | Arthritis, Rheumatoid - metabolism | Infliximab | Leukocytes, Mononuclear - immunology | Tumor Necrosis Factor-alpha - immunology | CD8-Positive T-Lymphocytes - metabolism | Adult | Female | Perforin | Antirheumatic Agents - therapeutic use | Monocytes - microbiology | Pore Forming Cytotoxic Proteins - metabolism | Blood Cell Count | Immunotherapy - adverse effects | Tuberculosis - immunology | Arthritis, Rheumatoid - therapy | Immunity, Cellular - immunology | T-Lymphocyte Subsets - metabolism | Autoimmune Diseases - therapy | Antibodies, Monoclonal - metabolism | CD8-Positive T-Lymphocytes - immunology | Cytotoxicity, Immunologic - immunology | Tumor Necrosis Factor-alpha - antagonists & inhibitors
Journal Article
British Journal of Dermatology, ISSN 0007-0963, 02/2014, Volume 170, Issue 2, pp. 261 - 273
Journal Article
Journal of Immunology, ISSN 0022-1767, 03/2018, Volume 200, Issue 6, pp. 2038 - 2045
Journal Article
Rheumatology, ISSN 1462-0324, 01/2018, Volume 57, Issue 1, pp. 164 - 174
Abstract Objective The aim of this study was to assess the therapeutic effects of biological DMARDs (bDMARDs) on the diversity of immune cell phenotypes in... 
plasmablasts | biologic DMARDs | rheumatoid arthritis | T follicular helper cells | immunophenotype | CYTOKINES | DENDRITIC CELLS | RHEUMATOLOGY | B-CELLS | INHIBITION | MEMORY | ROLES | INTERLEUKIN-6 RECEPTOR BLOCKADE | T-Lymphocyte Subsets - immunology | Dendritic Cells - immunology | Humans | Middle Aged | Antibodies, Monoclonal - therapeutic use | Male | Infliximab - therapeutic use | Case-Control Studies | Immunoglobulin D - immunology | T-Lymphocytes, Regulatory - immunology | Arthritis, Rheumatoid - drug therapy | T-Lymphocytes, Helper-Inducer - immunology | Female | Retrospective Studies | Certolizumab Pegol - therapeutic use | Antirheumatic Agents - therapeutic use | Tumor Necrosis Factor Receptor Superfamily, Member 7 - immunology | Antibodies, Monoclonal, Humanized - therapeutic use | Immunophenotyping | Adalimumab - therapeutic use | Autoantibodies - immunology | B-Lymphocytes - immunology | Abatacept - therapeutic use | Th17 Cells - immunology | Aged | Arthritis, Rheumatoid - immunology | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Etanercept - therapeutic use | CD27 antigen | Flow cytometry | Memory cells | Phenotypes | Immunological memory | Autoantibodies | Dendritic cells | Helper cells | Lymphocytes T | Immunoglobulin D | Patients | Lymphocytes B | Tumor necrosis factor | Rheumatoid arthritis | Peripheral blood
Journal Article