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Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 6/2014, Volume 111, Issue 22, pp. 8107 - 8112
The source, timing, and geographical origin of the 1918–1920 pandemic influenza A virus have remained tenaciously obscure for nearly a century, as have the reasons for its unusual severity among young adults... 
H1N1 subtype influenza A virus | Pandemics | Influenza A virus | Swine | Mortality | Childhood | Antibodies | Viruses | Immunity | Age groups | Pathogenicity | Cohort immunity | Phylogeny | Reassortment | Virulence | UNITED-STATES | MORTALITY | reassortment | ORIGINAL ANTIGENIC SIN | NEUTRALIZING ANTIBODIES | MULTIDISCIPLINARY SCIENCES | HUMAN SERA | PATTERNS | cohort immunity | pathogenicity | RESPONSES | DIFFERENT AGES | virulence | phylogeny | INFECTION | EPIDEMIOLOGY | Influenza A Virus, H1N1 Subtype - immunology | Reassortant Viruses - pathogenicity | Humans | Influenza A virus - genetics | Reassortant Viruses - genetics | Disease Resistance - immunology | Influenza A Virus, H5N1 Subtype - genetics | Influenza A Virus, H3N2 Subtype - genetics | Influenza A Virus, H3N8 Subtype - genetics | Influenza A Virus, H3N8 Subtype - pathogenicity | Influenza A Virus, H7N9 Subtype - immunology | Genetic Variation | Reassortant Viruses - immunology | Influenza A Virus, H7N9 Subtype - pathogenicity | Influenza A virus - pathogenicity | Influenza, Human - mortality | Adult | Influenza A virus - immunology | Influenza, Human - virology | Child | Influenza A Virus, H1N1 Subtype - genetics | Influenza A Virus, H3N2 Subtype - pathogenicity | Influenza Pandemic, 1918-1919 - mortality | Birds | Influenza A Virus, H1N1 Subtype - pathogenicity | Influenza A Virus, H3N2 Subtype - immunology | Biological Evolution | Animals | Influenza A Virus, H3N8 Subtype - immunology | Influenza A Virus, H5N1 Subtype - immunology | Influenza A Virus, H5N1 Subtype - pathogenicity | Aged | Influenza A Virus, H7N9 Subtype - genetics | Causes of | Epidemics | United States | Swine influenza | Biological Sciences
Journal Article
Clinical chemistry (Baltimore, Md.), ISSN 1530-8561, 2009, Volume 55, Issue 8, pp. 1555 - 1558
.... We also developed an additional real-time RTPCR that can discriminate the novel H1N1 from other swine and human H I subtype viruses. RESULTS... 
MEDICAL LABORATORY TECHNOLOGY | Influenza A Virus, H2N2 Subtype - isolation & purification | Molecular Diagnostic Techniques - methods | Influenza A Virus, H1N1 Subtype - classification | Humans | DNA, Viral - analysis | Influenza A Virus, H5N1 Subtype - classification | Influenza A Virus, H5N1 Subtype - genetics | Influenza A Virus, H3N2 Subtype - genetics | Molecular Diagnostic Techniques - economics | Influenza A Virus, H5N1 Subtype - isolation & purification | Reverse Transcriptase Polymerase Chain Reaction - economics | RNA, Viral - genetics | Influenza A Virus, H1N1 Subtype - isolation & purification | Influenza A Virus, H3N2 Subtype - isolation & purification | Time Factors | Base Sequence | Reverse Transcriptase Polymerase Chain Reaction - methods | Sensitivity and Specificity | Influenza, Human - diagnosis | Influenza, Human - virology | RNA, Viral - isolation & purification | Influenza A Virus, H1N1 Subtype - genetics | Influenza A Virus, H3N2 Subtype - classification | RNA, Viral - analysis | Influenza A Virus, H2N2 Subtype - classification | Orthomyxoviridae Infections - diagnosis | Animals | Influenza A Virus, H2N2 Subtype - genetics | DNA, Viral - genetics | Orthomyxoviridae Infections - virology | Swine - virology | Influenza viruses | Polymerase chain reaction | Usage | Swine influenza | Causes of | Genetic aspects | Research | Diagnosis | Health aspects | Viruses | Mathematical models | Microbiology | Swine flu | Laboratories | Influenza A Virus, H3N2 Subtype | Influenza A Virus, H2N2 Subtype | Influenza A Virus, H5N1 Subtype | Reverse Transcriptase Polymerase Chain Reaction | Virology | Life Sciences | Microbiology and Parasitology | Molecular Diagnostic Techniques | Swine | RNA, Viral | Influenza, Human | Influenza A Virus, H1N1 Subtype | Orthomyxoviridae Infections | DNA, Viral | Brief Communications
Journal Article
Trends in immunology, ISSN 1471-4906, 2009, Volume 30, Issue 12, pp. 574 - 584
..., but its pathogenesis remains an enigma. Comparison of the virology and pathogenesis of human seasonal influenza viruses (H3N2 and H1N1... 
Allergy and Immunology | BRONCHIAL EPITHELIAL-CELLS | CYTOKINE RESPONSES | DENDRITIC CELLS | I INTERFERON RESPONSE | LOWER RESPIRATORY-TRACT | ACUTE LUNG INJURY | PROINFLAMMATORY CYTOKINES | IMMUNOLOGY | STRAND RNA VIRUSES | HONG-KONG | H1N1 VIRUS | Influenza A Virus, H1N1 Subtype - immunology | Tumor Necrosis Factor-alpha - metabolism | Influenza, Human - pathology | Orthomyxoviridae Infections - physiopathology | Humans | Influenza A Virus, H3N2 Subtype - pathogenicity | Influenza A Virus, H1N1 Subtype - pathogenicity | Influenza, Human - epidemiology | Immunity, Innate | Influenza A Virus, H3N2 Subtype - immunology | Respiratory Distress Syndrome, Adult - immunology | Animals | Influenza A Virus, H5N1 Subtype - immunology | Interferons - metabolism | Influenza A Virus, H5N1 Subtype - pathogenicity | Mice | Influenza, Human - physiopathology | Orthomyxoviridae Infections - immunology | Influenza, Human - immunology | Avian influenza | Influenza viruses | Immune response | Health aspects | Analysis | Infections | Pandemics | Mutation | Respiratory distress syndrome | Genes | Influenza A Virus, H3N2 Subtype | Respiratory Distress Syndrome, Adult | Interferons | Influenza A Virus, H5N1 Subtype | Tumor Necrosis Factor-alpha | Virology | Life Sciences | Microbiology and Parasitology | Influenza, Human | Influenza A Virus, H1N1 Subtype | Orthomyxoviridae Infections | influenza | cytokine | H5N1 | macrophage | pandemic | innate immune response
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2010, Volume 328, Issue 5985, pp. 1529 - 1529
Journal Article
Journal Article
2017, First US Edition., ISBN 9781610397674, viii, 332 pages
... I. In this gripping narrative history, Laura Spinney traces the overlooked pandemic to reveal how the virus traveled across the globe, exposing mankind's vulnerability and putting our ingenuity to the test... 
History | Influenza Epidemic, 1918-1919 | Epidemiology | Influenza | Communicable diseases
Book
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2008, Volume 105, Issue 11, pp. 4381 - 4386
The virulence of influenza virus is a multigenic trait. One determinant of virulence is the multifunctional NS1 protein that functions in several ways to defeat the cellular innate immune response... 
Proteins | H1N1 subtype influenza A virus | Lungs | Influenza A virus | Virulence | Viruses | Orthomyxoviridae | Amino acids | H5N1 subtype influenza A virus | Genetic mutation | PDZ domains | Influenza reverse genetics | PDZ ligand | H5N1 influenza | Mouse model for influenza | 1918 PANDEMIC VIRUS | ACTIVATION | BETA INDUCTION | MULTIDISCIPLINARY SCIENCES | PRE-MESSENGER-RNAS | NUCLEAR EXPORT | A-VIRUS | INTERFERON | IN-VIVO | mouse model for influenza | INFECTED-CELLS | influenza reverse genetics | V-PROTEIN | Interferons - biosynthesis | Lung Diseases - metabolism | Virulence Factors - genetics | Humans | Molecular Sequence Data | Influenza A Virus, H5N1 Subtype - genetics | Viral Nonstructural Proteins - chemistry | Recombination, Genetic - genetics | Female | Influenza A Virus, H5N1 Subtype - metabolism | Influenza A Virus, H1N1 Subtype - genetics | Influenza A Virus, H1N1 Subtype - metabolism | Disease Models, Animal | Amino Acid Sequence | Cell Line | Viral Nonstructural Proteins - genetics | Influenza A Virus, H1N1 Subtype - pathogenicity | Virulence Factors - chemistry | Mutation - genetics | Animals | Dogs | Influenza A Virus, H5N1 Subtype - chemistry | Influenza A Virus, H5N1 Subtype - pathogenicity | Viral Nonstructural Proteins - metabolism | Virulence Factors - metabolism | Influenza A Virus, H1N1 Subtype - chemistry | Mice | Mice, Inbred BALB C | Lung Diseases - pathology | Ligand binding (Biochemistry) | Viral proteins | Influenza | Influence | Models | Genetic aspects | Virulence (Microbiology) | Research | Properties | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 11/2014, Volume 111, Issue 44, pp. 15798 - 15803
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2011, Volume 108, Issue 34, pp. 14264 - 14269
.... To identify molecular determinants that allowed efficient transmission of the pandemic H1N1 virus among humans, we evaluated the direct-contact and respiratory-droplet transmissibility in ferrets... 
H1N1 subtype influenza A virus | Polysaccharides | Receptors | Pandemics | Disease transmission | Influenza A virus | Swine | Viruses | Orthomyxoviridae | Transmission efficiency | Influenza A | Viral genes | Zoonosis | PIGS | PB2 | influenza A | viral genes | SPECIFICITY | MULTIDISCIPLINARY SCIENCES | POLYMERASE | HUMANS | zoonosis | A VIRUS | PATHOGENESIS | SWINE INFLUENZA | REASSORTMENT | Respiratory System - pathology | Tropism | Receptors, Virus - metabolism | Genome, Viral - genetics | Influenza A Virus, H1N1 Subtype - physiology | Neuraminidase - metabolism | Substrate Specificity | Hemagglutinin Glycoproteins, Influenza Virus - metabolism | Ferrets - virology | Polysaccharides - metabolism | Orthomyxoviridae Infections - epidemiology | Respiratory System - virology | Animals | Orthomyxoviridae Infections - transmission | Influenza A Virus, H1N1 Subtype - enzymology | Protein Binding | Recombination, Genetic - genetics | Kinetics | Seasons | Influenza A Virus, H1N1 Subtype - genetics | Orthomyxoviridae Infections - virology | Virus Replication - physiology | Influenza viruses | Swine influenza | Erythrocytes | Physiological aspects | Development and progression | Genetic aspects | Ferrets | Health aspects | Life Sciences | Microbiology and Parasitology | Virology | Biological Sciences
Journal Article