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1. Full Text In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses
by Itoh, Yasushi and Shinya, Kyoko and Kiso, Maki and Watanabe, Tokiko and Sakoda, Yoshihiro and Hatta, Masato and Muramoto, Yukiko and Tamura, Daisuke and Sakai-Tagawa, Yuko and Noda, Takeshi and Sakabe, Saori and Imai, Masaki and Hatta, Yasuko and Watanabe, Shinji and Li, Chengjun and Yamada, Shinya and Fujii, Ken and Murakami, Shin and Imai, Hirotaka and Kakugawa, Satoshi and Ito, Mutsumi and Takano, Ryo and Iwatsuki-Horimoto, Kiyoko and Shimojima, Masayuki and Horimoto, Taisuke and Goto, Hideo and Takahashi, Kei and Makino, Akiko and Ishigaki, Hirohito and Nakayama, Misako and Okamatsu, Masatoshi and Takahashi, Kazuo and Warshauer, David and Shult, Peter A and Saito, Reiko and Suzuki, Hiroshi and Furuta, Yousuke and Yamashita, Makoto and Mitamura, Keiko and Nakano, Kunio and Nakamura, Morio and Brockman-Schneider, Rebecca and Mitamura, Hiroshi and Yamazaki, Masahiko and Sugaya, Norio and Suresh, M and Ozawa, Makoto and Neumann, Gabriele and Gern, James and Kida, Hiroshi and Ogasawara, Kazumasa and Kawaoka, Yoshihiro
Nature, ISSN 0028-0836, 08/2009, Volume 460, Issue 7258, pp. 1021 - 1025
Influenza A viruses cause recurrent outbreaks at local or global scale with potentially severe consequences for human health and the global economy. Recently,... 
CELLS | TRANSMISSION | A VIRUSES | MULTIDISCIPLINARY SCIENCES | INFECTION | MODEL | RESISTANT INFLUENZA | Macaca fascicularis - immunology | Swine Diseases - virology | Humans | Influenza A Virus, H1N1 Subtype - physiology | Male | Neutralization Tests | Ferrets - virology | Swine, Miniature - virology | Lung - virology | Primate Diseases - pathology | Female | Cell Line | Antiviral Agents - pharmacology | Lung - pathology | Swine Diseases - pathology | Influenza A Virus, H1N1 Subtype - pathogenicity | HN Protein - metabolism | Influenza A Virus, H1N1 Subtype - drug effects | Primate Diseases - virology | Animals | Orthomyxoviridae Infections - transmission | Virus Replication | Influenza A Virus, H1N1 Subtype - enzymology | Dogs | Antibodies, Viral - immunology | Mice | Mice, Inbred BALB C | Orthomyxoviridae Infections - virology | Swine - virology | Lung - immunology | Macaca fascicularis - virology | Orthomyxoviridae Infections - immunology | Influenza viruses | Genetic aspects | Properties | Swine influenza | Scanning electron microscopy | Cytokines | Swine flu | Influenza | Viruses | Avian flu
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2. Full Text Oseltamivir-resistant influenza virus A (H1N1), Europe, 2007-08 season
by Meijer, A and Lackenby, A and Hungnes, O and Lina, B and Werf, S. van der and Schweiger, B and Opp, M and Paget, J and Kassteele, J. van de and Hay, A and Zambon, M and European Influenza Surveillance Scheme and on behalf of the European Influenza Surveillance Scheme
Emerging Infectious Diseases, ISSN 1080-6040, 2009, Volume 15, Issue 4, pp. 552 - 560
In Europe, the 2007-08 winter season was dominated by influenza virus A (H1N1) circulation through week 7, followed by influenza B virus from week 8 onward.... 
Antiviral Agents - pharmacology | Influenza A Virus, H1N1 Subtype - classification | Hemagglutinins, Viral - genetics | Humans | Enzyme Inhibitors - pharmacology | Europe - epidemiology | Neuraminidase - genetics | Influenza, Human - epidemiology | Communicable Diseases, Emerging - epidemiology | Phylogeny | Influenza A Virus, H1N1 Subtype - drug effects | Drug Resistance, Viral - genetics | Influenza A Virus, H1N1 Subtype - enzymology | Genes, Viral | Communicable Diseases, Emerging - drug therapy | Influenza, Human - virology | Neuraminidase - antagonists & inhibitors | Influenza, Human - drug therapy | Mutation | Seasons | Communicable Diseases, Emerging - virology | Influenza A Virus, H1N1 Subtype - genetics | Oseltamivir - pharmacology | Population Surveillance - methods | Influenza viruses | Causes of | Research | Health aspects | Influenza | Distribution | Life Sciences | Biochemistry, Molecular Biology
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3. Full Text Hemagglutinin–neuraminidase balance confers respiratory-droplet transmissibility of the pandemic H1N1 influenza virus in ferrets
by Hui-Ling Yen and Chi-Hui Liang and Chung-Yi Wu and Heather L. Forrest and Angela Ferguson and Ka-Tim Choy and Jeremy Jones and Diana Dik-Yan Wong and Peter Pak-Hang Cheung and Che-Hsiung Hsu and Olive T. Li and Kit M. Yuen and Renee W. Y. Chan and Leo L. M. Poon and Michael C. W. Chan and John M. Nicholls and Scott Krauss and Chi-Huey Wong and Yi Guan and Robert G. Webster and Richard J. Webby and Malik Peiris
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2011, Volume 108, Issue 34, pp. 14264 - 14269
A novel reassortant derived from North American triple-reassortant (TRsw) and Eurasian swine (EAsw) influenza viruses acquired sustained human-to-human... 
H1N1 subtype influenza A virus | Polysaccharides | Receptors | Pandemics | Disease transmission | Influenza A virus | Swine | Viruses | Orthomyxoviridae | Transmission efficiency | Influenza A | Viral genes | Zoonosis | PIGS | PB2 | influenza A | viral genes | SPECIFICITY | MULTIDISCIPLINARY SCIENCES | POLYMERASE | HUMANS | zoonosis | A VIRUS | PATHOGENESIS | SWINE INFLUENZA | REASSORTMENT | Respiratory System - pathology | Tropism | Receptors, Virus - metabolism | Genome, Viral - genetics | Influenza A Virus, H1N1 Subtype - physiology | Neuraminidase - metabolism | Substrate Specificity | Hemagglutinin Glycoproteins, Influenza Virus - metabolism | Ferrets - virology | Polysaccharides - metabolism | Orthomyxoviridae Infections - epidemiology | Respiratory System - virology | Animals | Orthomyxoviridae Infections - transmission | Influenza A Virus, H1N1 Subtype - enzymology | Protein Binding | Recombination, Genetic - genetics | Kinetics | Seasons | Influenza A Virus, H1N1 Subtype - genetics | Orthomyxoviridae Infections - virology | Virus Replication - physiology | Influenza viruses | Swine influenza | Erythrocytes | Physiological aspects | Development and progression | Genetic aspects | Ferrets | Health aspects | Life Sciences | Microbiology and Parasitology | Virology | Biological Sciences
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4. Full Text Surveillance for Neuraminidase Inhibitor Resistance among Human Influenza A and B Viruses Circulating Worldwide from 2004 to 2008
by Tiffany G. Sheu and Varough M. Deyde and Margaret Okomo-Adhiambo and Rebecca J. Garten and Xiyan Xu and Rick A. Bright and Eboneé N. Butler and Teresa R. Wallis and Alexander I. Klimov and Larisa V. Gubareva
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 09/2008, Volume 52, Issue 9, pp. 3284 - 3292
Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit... 
IMMUNOCOMPROMISED CHILD | ASSAY | ACTIVE-SITE | ZANAMIVIR | SUSCEPTIBILITY NETWORK | ADAMANTANE RESISTANCE | POSITION STATEMENT | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | MUTATIONS | REDUCED SENSITIVITY | OSELTAMIVIR | Cell Line | Influenza B virus - enzymology | Antiviral Agents - pharmacology | Influenza A Virus, H3N2 Subtype - enzymology | Global Health | Influenza A Virus, H3N2 Subtype - drug effects | Antiviral Agents - therapeutic use | Oseltamivir - therapeutic use | Humans | Drug Resistance, Viral | Neuraminidase - genetics | Influenza, Human - epidemiology | Influenza A Virus, H3N2 Subtype - genetics | Influenza A Virus, H1N1 Subtype - drug effects | Influenza B virus - genetics | Animals | Influenza A Virus, H1N1 Subtype - enzymology | Influenza, Human - virology | Neuraminidase - antagonists & inhibitors | Influenza B virus - drug effects | Seasons | Influenza A Virus, H1N1 Subtype - genetics | Population Surveillance | Oseltamivir - pharmacology | Antiviral Agents
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5. Full Text Influenza virus resistance to neuraminidase inhibitors
by Samson, Mélanie and Pizzorno, Andrés and Abed, Yacine and Boivin, Guy
Antiviral Research, ISSN 0166-3542, 05/2013, Volume 98, Issue 2, pp. 174 - 185
In addition to immunization programs, antiviral agents can play a major role for the control of seasonal influenza epidemics and may also provide prophylactic... 
Resistance | Oseltamivir | Neuraminidase inhibitors | Influenza | Antivirals | Zanamivir | REDUCED SUSCEPTIBILITY | ACTIVE-SITE | B VIRUS | CLINICAL PHARMACOKINETICS | PANDEMIC H1N1 2009 | A VIRUS | IN-VITRO | VIROLOGY | IMMUNOCOMPROMISED PATIENTS | OSELTAMIVIR-RESISTANT | PHARMACOLOGY & PHARMACY | ZANAMIVIR RESISTANCE | Antiviral Agents - pharmacology | Humans | Drug Resistance, Viral | Enzyme Inhibitors - pharmacology | Viral Proteins - genetics | Zanamivir - pharmacology | Viral Proteins - antagonists & inhibitors | Influenza A Virus, H1N1 Subtype - drug effects | Viral Proteins - metabolism | Animals | Influenza A Virus, H1N1 Subtype - enzymology | Influenza, Human - virology | Neuraminidase - antagonists & inhibitors | Influenza, Human - drug therapy | Influenza A Virus, H1N1 Subtype - genetics | Oseltamivir - pharmacology | Influenza viruses
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6. Full Text Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants
by Martin, Stephen R and Gamblin, Steven J and Collins, Patrick J and Skehel, John J and Lin, Yi Pu and Hay, Alan J and Russell, Rupert J and Haire, Lesley F and Walker, Philip A and Liu, Junfeng
Nature, ISSN 0028-0836, 06/2008, Volume 453, Issue 7199, pp. 1258 - 1261
The potential impact of pandemic influenza makes effective measures to limit the spread and morbidity of virus infection a public health priority. Antiviral... 
A H5N1 | IN-VITRO | REPLICATION | VARIANTS | ZANAMIVIR | MULTIDISCIPLINARY SCIENCES | DRUG DESIGN | SENSITIVITY | SIALIC-ACID | INFECTION | INHIBITORS | Influenza A Virus, H5N1 Subtype - enzymology | Humans | Molecular Conformation | Drug Resistance, Viral | Neuraminidase - genetics | Crystallography, X-Ray | Influenza A Virus, H5N1 Subtype - genetics | Oseltamivir - chemistry | Enzyme Inhibitors - chemistry | Neuraminidase - chemistry | Influenza, Human - virology | Binding Sites | Influenza A Virus, H1N1 Subtype - genetics | Oseltamivir - pharmacology | Enzyme Inhibitors - metabolism | Enzyme Inhibitors - pharmacology | Models, Molecular | Neuraminidase - metabolism | Zanamivir - pharmacology | Influenza A Virus, H5N1 Subtype - drug effects | Influenza A Virus, H1N1 Subtype - drug effects | Mutation - genetics | Oseltamivir - metabolism | Influenza A Virus, H1N1 Subtype - enzymology | Protein Binding | Neuraminidase - antagonists & inhibitors | Kinetics | Influenza viruses | Properties | Microbial mutation | Proteins | Enzymes | Hydrogen bonds | Amino acids | Mutation | Drug resistance | Avian flu | Crystal structure
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7. Full Text Functional Balance of the Hemagglutinin and Neuraminidase Activities Accompanies the Emergence of the 2009 H1N1 Influenza Pandemic
by Rui Xu and Xueyong Zhu and Ryan McBride and Corwin M. Nycholat and Wenli Yu and James C. Paulson and Ian A. Wilson
Journal of Virology, ISSN 0022-538X, 09/2012, Volume 86, Issue 17, pp. 9221 - 9232
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A VIRUS | PATHOGENESIS | SWINE INFLUENZA | TRANSMISSION | COMBINATIONS | RECEPTOR-BINDING PROPERTIES | VIROLOGY | SPECIFICITY | HUMANS | STRUCTURAL-CHARACTERIZATION | HA | Pandemics | Receptors, Virus - metabolism | Swine Diseases - virology | Humans | Neuraminidase - genetics | Viral Proteins - metabolism | Hemagglutinin Glycoproteins, Influenza Virus - genetics | Swine | Neuraminidase - chemistry | Polysaccharides - chemistry | Influenza, Human - virology | Influenza A Virus, H1N1 Subtype - genetics | Influenza A Virus, H1N1 Subtype - metabolism | Hemagglutinin Glycoproteins, Influenza Virus - chemistry | Influenza, Human - metabolism | Orthomyxoviridae Infections - metabolism | Orthomyxoviridae Infections - veterinary | Viral Proteins - chemistry | Swine Diseases - metabolism | Neuraminidase - metabolism | Viral Proteins - genetics | Influenza, Human - epidemiology | Hemagglutinin Glycoproteins, Influenza Virus - metabolism | Polysaccharides - metabolism | Animals | Receptors, Virus - chemistry | Influenza A Virus, H1N1 Subtype - enzymology | Protein Binding | Kinetics | Orthomyxoviridae Infections - virology | Virus-Cell Interactions
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8. Full Text The PB2 Subunit of the Influenza Virus RNA Polymerase Affects Virulence by Interacting with the Mitochondrial Antiviral Signaling Protein and Inhibiting Expression of Beta Interferon
by Katy M. Graef and Frank T. Vreede and Yuk-Fai Lau and Amber W. McCall and Simon M. Carr and Kanta Subbarao and Ervin Fodor
Journal of Virology, ISSN 0022-538X, 09/2010, Volume 84, Issue 17, pp. 8433 - 8445
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SINGLE AMINO-ACID | A VIRUS | PA SUBUNIT | H5N1 | REPLICATION | VIROLOGY | HUMAN-CELLS | HOST-RANGE | HEPATITIS-C-VIRUS | MICE | ADAPTER PROTEIN | Influenza A Virus, H5N1 Subtype - enzymology | Influenza A Virus, H2N2 Subtype - enzymology | Humans | Influenza A virus - genetics | RNA Replicase - metabolism | Virulence | Molecular Sequence Data | Influenza A Virus, H5N1 Subtype - genetics | Viral Proteins - metabolism | Influenza A virus - pathogenicity | Interferon-beta - genetics | Female | Influenza, Human - virology | Influenza A Virus, H1N1 Subtype - genetics | Amino Acid Sequence | Influenza, Human - metabolism | RNA Replicase - genetics | Viral Proteins - chemistry | Down-Regulation | Mice, Inbred C57BL | Viral Proteins - genetics | Influenza A Virus, H1N1 Subtype - pathogenicity | Influenza A Virus, H2N2 Subtype - pathogenicity | Influenza A virus - enzymology | Host-Pathogen Interactions | Sequence Alignment | Animals | Interferon-beta - metabolism | Influenza A Virus, H1N1 Subtype - enzymology | RNA Replicase - chemistry | Influenza, Human - genetics | Adaptor Proteins, Signal Transducing - genetics | Influenza A Virus, H2N2 Subtype - genetics | Protein Binding | Influenza A Virus, H5N1 Subtype - pathogenicity | Mice | Adaptor Proteins, Signal Transducing - metabolism | Cellular Response to Infection
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9. Full Text Characterization of H7N9 influenza A viruses isolated from humans
by Watanabe, Tokiko and Kiso, Maki and Fukuyama, Satoshi and Nakajima, Noriko and Imai, Masaki and Yamada, Shinya and Murakami, Shin and Yamayoshi, Seiya and Iwatsuki-Horimoto, Kiyoko and Sakoda, Yoshihiro and Takashita, Emi and McBride, Ryan and Noda, Takeshi and Hatta, Masato and Imai, Hirotaka and Zhao, Dongming and Kishida, Noriko and Shirakura, Masayuki and De Vries, Robert P and Shichinohe, Shintaro and Okamatsu, Masatoshi and Tamura, Tomokazu and Tomita, Yuriko and Fujimoto, Naomi and Goto, Kazue and Katsura, Hiroaki and Kawakami, Eiryo and Ishikawa, Izumi and Watanabe, Shinji and Ito, Mutsumi and Sakai-Tagawa, Yuko and Sugita, Yukihiko and Uraki, Ryuta and Yamaji, Reina and Eisfeld, Amie J and Zhong, Gongxun and Fan, Shufang and Ping, Jihui and Maher, Eileen A and Hanson, Anthony and Uchida, Yuko and Saito, Takehiko and Ozawa, Makoto and Neumann, Gabriele and Kida, Hiroshi and Odagiri, Takato and Paulson, James C and Hasegawa, Hideki and Tashiro, Masato and Kawaoka, Yoshihiro
Nature, ISSN 0028-0836, 2013, Volume 501, Issue 7468, pp. 551 - 555
Avian influenza A viruses rarely infect humans; however, when human infection and subsequent human-to-human transmission occurs, worldwide outbreaks... 
APRIL 2013 | IN-VITRO | TRANSMISSION | AVIAN H5N1 | H5N1 VIRUS | HEMAGGLUTININ | MULTIDISCIPLINARY SCIENCES | FERRETS | INFECTION | RECEPTOR SPECIFICITY | MOLECULAR-BASIS | Influenza A virus - chemistry | DNA-Directed RNA Polymerases - antagonists & inhibitors | Humans | Chickens - virology | Male | Monkey Diseases - pathology | Ferrets - virology | Swine, Miniature - virology | Madin Darby Canine Kidney Cells | Influenza A virus - pathogenicity | Female | Influenza, Human - virology | Influenza, Human - drug therapy | Quail - virology | Virus Replication - drug effects | Antiviral Agents - pharmacology | Orthomyxoviridae Infections - pathology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Monkey Diseases - virology | Models, Molecular | Influenza A virus - isolation & purification | Influenza A Virus, H1N1 Subtype - drug effects | Animals | Orthomyxoviridae Infections - transmission | Influenza A Virus, H1N1 Subtype - enzymology | Dogs | Neuraminidase - antagonists & inhibitors | Mice | Mice, Inbred BALB C | Influenza A virus - drug effects | Orthomyxoviridae Infections - virology | Swine - virology | Macaca fascicularis - virology | Avian influenza viruses | Physiological aspects | Pathology | Genetic aspects | Research
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10. Full Text Structural Characterization of the 1918 Influenza Virus H1N1 Neuraminidase
by Xiaojin Xu and Xueyong Zhu and Raymond A. Dwek and James Stevens and Ian A. Wilson
Journal of Virology, ISSN 0022-538X, 11/2008, Volume 82, Issue 21, pp. 10493 - 10501
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IN-VITRO | COMPLEX | DESIGN | PANDEMIC VIRUS | VIROLOGY | HEMAGGLUTININ | CRYSTAL-STRUCTURE | GENES | CALCIUM | LATTICE-TRANSLOCATION DEFECTS | SIALIC-ACID | Gene Expression | Influenza A Virus, H1N1 Subtype - enzymology | Humans | Neuraminidase - chemistry | Models, Molecular | Baculoviridae - genetics | Crystallography, X-Ray | Binding Sites | Zanamivir - metabolism | Structure and Assembly
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11. Full Text Oseltamivir-resistant influenza A(H1N1) pdm09 viruses, United States, 2013–14
by Okomo-Adhiambo, Margaret and Fry, Alicia M and Su, Su and Nguyen, Ha T and Elal, Anwar Abd and Negron, Elizabeth and Hand, Julie and Garten, Rebecca J and Barnes, John and Xiyan, Xu and Villanueva, Julie M and Gubareva, Larisa V and 2013-14 US Influenza Antiviral and 2013–14 US Influenza Antiviral Working Group
Emerging Infectious Diseases, ISSN 1080-6040, 2015, Volume 21, Issue 1, pp. 136 - 141
We report characteristics of oseltamivir-resistant influenza A(H1N1)pdm09 viruses and patients infected with these viruses in the United States. During... 
INFECTIOUS DISEASES | PANDEMIC H1N1 2009 | IMMUNOLOGY | United States - epidemiology | Antiviral Agents - pharmacology | Prevalence | Humans | Middle Aged | Drug Resistance, Viral | Neuraminidase - genetics | Viral Proteins - genetics | Influenza, Human - epidemiology | Male | Phylogeny | Influenza A Virus, H1N1 Subtype - drug effects | Young Adult | Influenza A Virus, H1N1 Subtype - enzymology | Adolescent | Adult | Female | Influenza, Human - virology | Influenza, Human - drug therapy | Influenza A Virus, H1N1 Subtype - genetics | Oseltamivir - pharmacology | Avian influenza | Oseltamivir phosphate | United States | Patient outcomes | Medical care | Forecasts and trends | Drug therapy | influenza | influenza A(H1N1)pdm09 viruses | viruses | neuraminidase inhibition | Dispatch | pyrosequencing | resistance | Oseltamivir-Resistant Influenza A(H1N1)pdm09 Viruses, United States, 2013–14 | H275Y mutation | neuraminidase | influenza virus | zanamivir | oseltamivir
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