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Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 6/2014, Volume 111, Issue 22, pp. 8107 - 8112
The source, timing, and geographical origin of the 1918–1920 pandemic influenza A virus have remained tenaciously obscure for nearly a century, as have the reasons for its unusual severity among young adults... 
H1N1 subtype influenza A virus | Pandemics | Influenza A virus | Swine | Mortality | Childhood | Antibodies | Viruses | Immunity | Age groups | Pathogenicity | Cohort immunity | Phylogeny | Reassortment | Virulence | UNITED-STATES | MORTALITY | reassortment | ORIGINAL ANTIGENIC SIN | NEUTRALIZING ANTIBODIES | MULTIDISCIPLINARY SCIENCES | HUMAN SERA | PATTERNS | cohort immunity | pathogenicity | RESPONSES | DIFFERENT AGES | virulence | phylogeny | INFECTION | EPIDEMIOLOGY | Influenza A Virus, H1N1 Subtype - immunology | Reassortant Viruses - pathogenicity | Humans | Influenza A virus - genetics | Reassortant Viruses - genetics | Disease Resistance - immunology | Influenza A Virus, H5N1 Subtype - genetics | Influenza A Virus, H3N2 Subtype - genetics | Influenza A Virus, H3N8 Subtype - genetics | Influenza A Virus, H3N8 Subtype - pathogenicity | Influenza A Virus, H7N9 Subtype - immunology | Genetic Variation | Reassortant Viruses - immunology | Influenza A Virus, H7N9 Subtype - pathogenicity | Influenza A virus - pathogenicity | Influenza, Human - mortality | Adult | Influenza A virus - immunology | Influenza, Human - virology | Child | Influenza A Virus, H1N1 Subtype - genetics | Influenza A Virus, H3N2 Subtype - pathogenicity | Influenza Pandemic, 1918-1919 - mortality | Birds | Influenza A Virus, H1N1 Subtype - pathogenicity | Influenza A Virus, H3N2 Subtype - immunology | Biological Evolution | Animals | Influenza A Virus, H3N8 Subtype - immunology | Influenza A Virus, H5N1 Subtype - immunology | Influenza A Virus, H5N1 Subtype - pathogenicity | Aged | Influenza A Virus, H7N9 Subtype - genetics | Causes of | Epidemics | United States | Swine influenza | Biological Sciences
Journal Article
Clinical chemistry (Baltimore, Md.), ISSN 1530-8561, 2009, Volume 55, Issue 8, pp. 1555 - 1558
.... We also developed an additional real-time RTPCR that can discriminate the novel H1N1 from other swine and human H I subtype viruses. RESULTS... 
MEDICAL LABORATORY TECHNOLOGY | Influenza A Virus, H2N2 Subtype - isolation & purification | Molecular Diagnostic Techniques - methods | Influenza A Virus, H1N1 Subtype - classification | Humans | DNA, Viral - analysis | Influenza A Virus, H5N1 Subtype - classification | Influenza A Virus, H5N1 Subtype - genetics | Influenza A Virus, H3N2 Subtype - genetics | Molecular Diagnostic Techniques - economics | Influenza A Virus, H5N1 Subtype - isolation & purification | Reverse Transcriptase Polymerase Chain Reaction - economics | RNA, Viral - genetics | Influenza A Virus, H1N1 Subtype - isolation & purification | Influenza A Virus, H3N2 Subtype - isolation & purification | Time Factors | Base Sequence | Reverse Transcriptase Polymerase Chain Reaction - methods | Sensitivity and Specificity | Influenza, Human - diagnosis | Influenza, Human - virology | RNA, Viral - isolation & purification | Influenza A Virus, H1N1 Subtype - genetics | Influenza A Virus, H3N2 Subtype - classification | RNA, Viral - analysis | Influenza A Virus, H2N2 Subtype - classification | Orthomyxoviridae Infections - diagnosis | Animals | Influenza A Virus, H2N2 Subtype - genetics | DNA, Viral - genetics | Orthomyxoviridae Infections - virology | Swine - virology | Influenza viruses | Polymerase chain reaction | Usage | Swine influenza | Causes of | Genetic aspects | Research | Diagnosis | Health aspects | Viruses | Mathematical models | Microbiology | Swine flu | Laboratories | Influenza A Virus, H3N2 Subtype | Influenza A Virus, H2N2 Subtype | Influenza A Virus, H5N1 Subtype | Reverse Transcriptase Polymerase Chain Reaction | Virology | Life Sciences | Microbiology and Parasitology | Molecular Diagnostic Techniques | Swine | RNA, Viral | Influenza, Human | Influenza A Virus, H1N1 Subtype | Orthomyxoviridae Infections | DNA, Viral | Brief Communications
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2010, Volume 328, Issue 5985, pp. 1529 - 1529
Journal Article
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2008, Volume 105, Issue 11, pp. 4381 - 4386
... genetics and the pathogenicity of the viruses determined. Viruses containing NS1... 
Proteins | H1N1 subtype influenza A virus | Lungs | Influenza A virus | Virulence | Viruses | Orthomyxoviridae | Amino acids | H5N1 subtype influenza A virus | Genetic mutation | PDZ domains | Influenza reverse genetics | PDZ ligand | H5N1 influenza | Mouse model for influenza | 1918 PANDEMIC VIRUS | ACTIVATION | BETA INDUCTION | MULTIDISCIPLINARY SCIENCES | PRE-MESSENGER-RNAS | NUCLEAR EXPORT | A-VIRUS | INTERFERON | IN-VIVO | mouse model for influenza | INFECTED-CELLS | influenza reverse genetics | V-PROTEIN | Interferons - biosynthesis | Lung Diseases - metabolism | Virulence Factors - genetics | Humans | Molecular Sequence Data | Influenza A Virus, H5N1 Subtype - genetics | Viral Nonstructural Proteins - chemistry | Recombination, Genetic - genetics | Female | Influenza A Virus, H5N1 Subtype - metabolism | Influenza A Virus, H1N1 Subtype - genetics | Influenza A Virus, H1N1 Subtype - metabolism | Disease Models, Animal | Amino Acid Sequence | Cell Line | Viral Nonstructural Proteins - genetics | Influenza A Virus, H1N1 Subtype - pathogenicity | Virulence Factors - chemistry | Mutation - genetics | Animals | Dogs | Influenza A Virus, H5N1 Subtype - chemistry | Influenza A Virus, H5N1 Subtype - pathogenicity | Viral Nonstructural Proteins - metabolism | Virulence Factors - metabolism | Influenza A Virus, H1N1 Subtype - chemistry | Mice | Mice, Inbred BALB C | Lung Diseases - pathology | Ligand binding (Biochemistry) | Viral proteins | Influenza | Influence | Models | Genetic aspects | Virulence (Microbiology) | Research | Properties | Biological Sciences
Journal Article
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2011, Volume 108, Issue 34, pp. 14264 - 14269
.... To identify molecular determinants that allowed efficient transmission of the pandemic H1N1 virus among humans, we evaluated the direct-contact and respiratory-droplet transmissibility in ferrets... 
H1N1 subtype influenza A virus | Polysaccharides | Receptors | Pandemics | Disease transmission | Influenza A virus | Swine | Viruses | Orthomyxoviridae | Transmission efficiency | Influenza A | Viral genes | Zoonosis | PIGS | PB2 | influenza A | viral genes | SPECIFICITY | MULTIDISCIPLINARY SCIENCES | POLYMERASE | HUMANS | zoonosis | A VIRUS | PATHOGENESIS | SWINE INFLUENZA | REASSORTMENT | Respiratory System - pathology | Tropism | Receptors, Virus - metabolism | Genome, Viral - genetics | Influenza A Virus, H1N1 Subtype - physiology | Neuraminidase - metabolism | Substrate Specificity | Hemagglutinin Glycoproteins, Influenza Virus - metabolism | Ferrets - virology | Polysaccharides - metabolism | Orthomyxoviridae Infections - epidemiology | Respiratory System - virology | Animals | Orthomyxoviridae Infections - transmission | Influenza A Virus, H1N1 Subtype - enzymology | Protein Binding | Recombination, Genetic - genetics | Kinetics | Seasons | Influenza A Virus, H1N1 Subtype - genetics | Orthomyxoviridae Infections - virology | Virus Replication - physiology | Influenza viruses | Swine influenza | Erythrocytes | Physiological aspects | Development and progression | Genetic aspects | Ferrets | Health aspects | Life Sciences | Microbiology and Parasitology | Virology | Biological Sciences
Journal Article
Virology (New York, N.Y.), ISSN 0042-6822, 2012, Volume 422, Issue 1, pp. 151 - 160
... (tr_SOIV) inheriting genes from classical swine, avian and human influenza viruses. Of those twenty-one tr_SOIV, thirteen were of A(H1N1), one of A(H1N2), and seven of A(H3N2) subtype... 
Infectious Disease | Triple reassortants | Swine origin influenza viruses | PIGS | PATHOGENESIS | TRANSMISSION | PROTEIN | VIROLOGY | A VIRUSES | PB1-F2 | INFECTION | PREVALENCE | Influenza A Virus, H1N1 Subtype - immunology | Influenza A Virus, H1N1 Subtype - classification | United States | Humans | Neuraminidase - genetics | Reassortant Viruses - genetics | Hemagglutinin Glycoproteins, Influenza Virus - immunology | Influenza A Virus, H3N2 Subtype - genetics | Phylogeny | Hemagglutinin Glycoproteins, Influenza Virus - genetics | Neuraminidase - immunology | Genetic Variation | Influenza A Virus, H1N2 Subtype - genetics | Antigens, Viral | Influenza A Virus, H1N1 Subtype - isolation & purification | Influenza A Virus, H3N2 Subtype - isolation & purification | Base Sequence | Influenza, Human - virology | Influenza A Virus, H1N1 Subtype - genetics | Genome, Viral | Influenza A Virus, H3N2 Subtype - classification | Influenza, Human - epidemiology | Influenza A Virus, H1N2 Subtype - immunology | Influenza A Virus, H3N2 Subtype - immunology | Reassortant Viruses - isolation & purification | Sequence Analysis, DNA | Molecular Epidemiology | Influenza A Virus, H1N2 Subtype - isolation & purification | Influenza A Virus, H1N2 Subtype - classification | Influenza viruses | Genetic research | Genetic aspects | Swine | Influenza | Genes | Analysis | Infection | Pathogens | Genetic analysis | Swine influenza
Journal Article
Virology (New York, N.Y.), ISSN 0042-6822, 2007, Volume 362, Issue 2, pp. 271 - 282
...Introduction Aquatic birds are thought to be the reservoir for genetic diversity of influenza A viruses, and the source for transmission to other animal... 
Infectious Disease | PB2 | Transcription/replication | Influenza A virus | Host-range | host-range | RNA REPLICATION | REASSORTANT VIRUSES | transcription/replication | AMINO-ACID | HIGH VIRULENCE | VIROLOGY | GENES | H5N1 VIRUSES | RECEPTOR SPECIFICITY | REVERSE GENETICS | MOLECULAR-BASIS | BINDING | influenza A virus | Influenza A Virus, H5N1 Subtype - physiology | Humans | Influenza A virus - genetics | Influenza A Virus, H1N1 Subtype - physiology | Cercopithecus aethiops | Molecular Sequence Data | Chloramphenicol O-Acetyltransferase - genetics | Influenza A Virus, H5N1 Subtype - genetics | Influenza A Virus, H3N2 Subtype - genetics | Viral Proteins - metabolism | Transcription, Genetic | Influenza A Virus, H1N1 Subtype - genetics | Genes, Reporter | Cell Line | Chloramphenicol O-Acetyltransferase - analysis | Influenza A virus - physiology | Promoter Regions, Genetic | RNA, Viral - biosynthesis | Viral Plaque Assay | Viral Proteins - genetics | Ribonucleoproteins - metabolism | Sequence Analysis, DNA | Protein Interaction Mapping | Animals | Virus Replication | Chickens | RNA Polymerase I | Influenza A Virus, H3N2 Subtype - physiology | COS Cells | Proteins | Control | Influenza | Influenza A Virus, H3N2 Subtype | Influenza A Virus, H5N1 Subtype | Viral Proteins | Life Sciences | Influenza A Virus, H1N1 Subtype | Promoter Regions (Genetics) | Ribonucleoproteins | Chloramphenicol O-Acetyltransferase | Virology | Microbiology and Parasitology | RNA, Viral | Plaque Assay
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 11/2014, Volume 111, Issue 44, pp. 15798 - 15803
Journal Article