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Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 6/2014, Volume 111, Issue 22, pp. 8107 - 8112
The source, timing, and geographical origin of the 1918–1920 pandemic influenza A virus have remained tenaciously obscure for nearly a century, as have the reasons for its unusual severity among young adults... 
H1N1 subtype influenza A virus | Pandemics | Influenza A virus | Swine | Mortality | Childhood | Antibodies | Viruses | Immunity | Age groups | Pathogenicity | Cohort immunity | Phylogeny | Reassortment | Virulence | UNITED-STATES | MORTALITY | reassortment | ORIGINAL ANTIGENIC SIN | NEUTRALIZING ANTIBODIES | MULTIDISCIPLINARY SCIENCES | HUMAN SERA | PATTERNS | cohort immunity | pathogenicity | RESPONSES | DIFFERENT AGES | virulence | phylogeny | INFECTION | EPIDEMIOLOGY | Influenza A Virus, H1N1 Subtype - immunology | Reassortant Viruses - pathogenicity | Humans | Influenza A virus - genetics | Reassortant Viruses - genetics | Disease Resistance - immunology | Influenza A Virus, H5N1 Subtype - genetics | Influenza A Virus, H3N2 Subtype - genetics | Influenza A Virus, H3N8 Subtype - genetics | Influenza A Virus, H3N8 Subtype - pathogenicity | Influenza A Virus, H7N9 Subtype - immunology | Genetic Variation | Reassortant Viruses - immunology | Influenza A Virus, H7N9 Subtype - pathogenicity | Influenza A virus - pathogenicity | Influenza, Human - mortality | Adult | Influenza A virus - immunology | Influenza, Human - virology | Child | Influenza A Virus, H1N1 Subtype - genetics | Influenza A Virus, H3N2 Subtype - pathogenicity | Influenza Pandemic, 1918-1919 - mortality | Birds | Influenza A Virus, H1N1 Subtype - pathogenicity | Influenza A Virus, H3N2 Subtype - immunology | Biological Evolution | Animals | Influenza A Virus, H3N8 Subtype - immunology | Influenza A Virus, H5N1 Subtype - immunology | Influenza A Virus, H5N1 Subtype - pathogenicity | Aged | Influenza A Virus, H7N9 Subtype - genetics | Causes of | Epidemics | United States | Swine influenza | Biological Sciences
Journal Article
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2008, Volume 105, Issue 11, pp. 4381 - 4386
... genetics and the pathogenicity of the viruses determined. Viruses containing NS1... 
Proteins | H1N1 subtype influenza A virus | Lungs | Influenza A virus | Virulence | Viruses | Orthomyxoviridae | Amino acids | H5N1 subtype influenza A virus | Genetic mutation | PDZ domains | Influenza reverse genetics | PDZ ligand | H5N1 influenza | Mouse model for influenza | 1918 PANDEMIC VIRUS | ACTIVATION | BETA INDUCTION | MULTIDISCIPLINARY SCIENCES | PRE-MESSENGER-RNAS | NUCLEAR EXPORT | A-VIRUS | INTERFERON | IN-VIVO | mouse model for influenza | INFECTED-CELLS | influenza reverse genetics | V-PROTEIN | Interferons - biosynthesis | Lung Diseases - metabolism | Virulence Factors - genetics | Humans | Molecular Sequence Data | Influenza A Virus, H5N1 Subtype - genetics | Viral Nonstructural Proteins - chemistry | Recombination, Genetic - genetics | Female | Influenza A Virus, H5N1 Subtype - metabolism | Influenza A Virus, H1N1 Subtype - genetics | Influenza A Virus, H1N1 Subtype - metabolism | Disease Models, Animal | Amino Acid Sequence | Cell Line | Viral Nonstructural Proteins - genetics | Influenza A Virus, H1N1 Subtype - pathogenicity | Virulence Factors - chemistry | Mutation - genetics | Animals | Dogs | Influenza A Virus, H5N1 Subtype - chemistry | Influenza A Virus, H5N1 Subtype - pathogenicity | Viral Nonstructural Proteins - metabolism | Virulence Factors - metabolism | Influenza A Virus, H1N1 Subtype - chemistry | Mice | Mice, Inbred BALB C | Lung Diseases - pathology | Ligand binding (Biochemistry) | Viral proteins | Influenza | Influence | Models | Genetic aspects | Virulence (Microbiology) | Research | Properties | Biological Sciences
Journal Article
Trends in immunology, ISSN 1471-4906, 2009, Volume 30, Issue 12, pp. 574 - 584
..., but its pathogenesis remains an enigma. Comparison of the virology and pathogenesis of human seasonal influenza viruses (H3N2 and H1N1... 
Allergy and Immunology | BRONCHIAL EPITHELIAL-CELLS | CYTOKINE RESPONSES | DENDRITIC CELLS | I INTERFERON RESPONSE | LOWER RESPIRATORY-TRACT | ACUTE LUNG INJURY | PROINFLAMMATORY CYTOKINES | IMMUNOLOGY | STRAND RNA VIRUSES | HONG-KONG | H1N1 VIRUS | Influenza A Virus, H1N1 Subtype - immunology | Tumor Necrosis Factor-alpha - metabolism | Influenza, Human - pathology | Orthomyxoviridae Infections - physiopathology | Humans | Influenza A Virus, H3N2 Subtype - pathogenicity | Influenza A Virus, H1N1 Subtype - pathogenicity | Influenza, Human - epidemiology | Immunity, Innate | Influenza A Virus, H3N2 Subtype - immunology | Respiratory Distress Syndrome, Adult - immunology | Animals | Influenza A Virus, H5N1 Subtype - immunology | Interferons - metabolism | Influenza A Virus, H5N1 Subtype - pathogenicity | Mice | Influenza, Human - physiopathology | Orthomyxoviridae Infections - immunology | Influenza, Human - immunology | Avian influenza | Influenza viruses | Immune response | Health aspects | Analysis | Infections | Pandemics | Mutation | Respiratory distress syndrome | Genes | Influenza A Virus, H3N2 Subtype | Respiratory Distress Syndrome, Adult | Interferons | Influenza A Virus, H5N1 Subtype | Tumor Necrosis Factor-alpha | Virology | Life Sciences | Microbiology and Parasitology | Influenza, Human | Influenza A Virus, H1N1 Subtype | Orthomyxoviridae Infections | influenza | cytokine | H5N1 | macrophage | pandemic | innate immune response
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2010, Volume 328, Issue 5985, pp. 1529 - 1529
Journal Article
Nature (London), ISSN 1476-4687, 2012, Volume 484, Issue 7395, pp. 519 - 523
The 2009 H1N1 influenza pandemic showed the speed with which a novel respiratory virus can spread and the ability of a generally mild infection to induce severe morbidity and mortality in a subset of the population... 
PATHOGENESIS | WEST NILE VIRUS | INFECTION | PROTEINS | MULTIDISCIPLINARY SCIENCES | Analysis | Mortality | Swine influenza | United Kingdom | Research | Morbidity | Membrane proteins | Pathology | Pandemics | Lymphocytes | Viruses | Genomes | Avian flu | Blood | Viral infections | Apoptosis
Journal Article
PloS one, ISSN 1932-6203, 04/2013, Volume 8, Issue 4, p. e61397
The two glycosylation sites (Asn142 and Asn177) were observed in the HA of most human seasonal influenza A/H1N1 viruses, while none in pandemic H1N1/2009 influenza A (pH1N1) viruses... 
SITE | H5N1 | N-LINKED GLYCOSYLATION | MULTIDISCIPLINARY SCIENCES | GLYCOPROTEINS | CLEAVAGE | RECEPTOR-BINDING | Influenza A Virus, H1N1 Subtype - immunology | Humans | Molecular Sequence Data | Hemagglutinin Glycoproteins, Influenza Virus - immunology | Hemagglutinin Glycoproteins, Influenza Virus - genetics | Lung - virology | Virulence - genetics | Swine | Inflammation Mediators - metabolism | Female | Lung - metabolism | Influenza A Virus, H1N1 Subtype - genetics | Influenza A Virus, H1N1 Subtype - metabolism | Antibodies, Monoclonal - immunology | Cytokines - immunology | Inflammation Mediators - immunology | Amino Acid Sequence | Hemagglutinin Glycoproteins, Influenza Virus - chemistry | Lung - pathology | Cytokines - metabolism | Orthomyxoviridae Infections - metabolism | Models, Molecular | Influenza A Virus, H1N1 Subtype - pathogenicity | Glycosylation | Chick Embryo | Hemagglutinin Glycoproteins, Influenza Virus - metabolism | Animals | Virus Replication | Erythrocytes - virology | Weight Loss | Antibodies, Viral - immunology | Mice | Mutation | Orthomyxoviridae Infections - virology | Lung - immunology | Orthomyxoviridae Infections - immunology | Avian influenza | Lectins | Physiological aspects | Virulence (Microbiology) | Research | Risk factors | Veterinary colleges | Pandemics | Laboratories | Virulence | Viruses | Veterinary medicine | Avian flu | Proteins | Antigenicity | Hemagglutinins | Genetics | Alveoli | Pathogens | Gene expression | Embryos | Mutants | Pathogenicity | Mutagenesis | Lungs | Swine flu | Site-directed mutagenesis | Influenza | Affinity | Recombinants
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 11/2014, Volume 111, Issue 44, pp. 15798 - 15803
Journal Article