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1. Full Text Contemporary H3N2 influenza viruses have a glycosylation site that alters binding of antibodies elicited by egg-adapted vaccine strains
by Zost, Seth J and Parkhouse, Kaela and Gumina, Megan E and Kim, Kangchon and Perez, Sebastian Diaz and Wilson, Patrick C and Treanor, John J and Sant, Andrea J and Cobey, Sarah and Hensley, Scott E
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2017, Volume 114, Issue 47, pp. 12578 - 12583
H3N2 viruses continuously acquire mutations in the hemagglutinin (HA) glycoprotein that abrogate binding of human antibodies. During the 2014-2015 influenza... 
Vaccine | Antibody | Hemagglutinin | Influenza | influenza | UNITED-STATES | MDCK CELLS | antibody | HEALTH-CARE PERSONNEL | hemagglutinin | MULTIDISCIPLINARY SCIENCES | H7N9 INFLUENZA | ANTIGENIC DRIFT | MONOCLONAL-ANTIBODY | A(H3N2) VIRUSES | vaccine | EMBRYONATED EGGS | IMMUNE HISTORY | Immunogenicity, Vaccine | Hemagglutinin Glycoproteins, Influenza Virus - chemistry | Antibodies, Viral - metabolism | Humans | Antigens, Viral - chemistry | Antigens, Viral - genetics | Neutralization Tests | Glycosylation | Ovum - virology | Hemagglutinin Glycoproteins, Influenza Virus - immunology | Influenza A Virus, H3N2 Subtype - genetics | Ferrets | Influenza A Virus, H3N2 Subtype - immunology | Hemagglutinin Glycoproteins, Influenza Virus - genetics | Antigens, Viral - immunology | Animals | Influenza Vaccines - immunology | Chickens | Influenza Vaccines - chemistry | Influenza, Human - virology | Mutation | Influenza, Human - prevention & control | Influenza viruses | Usage | Gene mutations | Glycoproteins | Genetic aspects | Research | Vaccines | Biological Sciences
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2. Full Text Low 2012-13 influenza vaccine effectiveness associated with mutation in the egg-adapted H3N2 vaccine strain not antigenic drift in circulating viruses
by Skowronski, Danuta M and Janjua, Naveed Z and De Serres, Gaston and Sabaiduc, Suzana and Eshaghi, Alireza and Dickinson, James A and Fonseca, Kevin and Winter, Anne-Luise and Gubbay, Jonathan B and Krajden, Mel and Petric, Martin and Charest, Hugues and Bastien, Nathalie and Kwindt, Trijntje L and Mahmud, Salaheddin M and Van Caeseele, Paul and Li, Yan
PLoS ONE, ISSN 1932-6203, 03/2014, Volume 9, Issue 3, p. e92153
Background: Influenza vaccine effectiveness (VE) is generally interpreted in the context of vaccine match/mismatch to circulating strains with evolutionary... 
CANADA | METAANALYSIS | EVOLUTION | HEMAGGLUTININ | EFFICACY | SUBSTITUTIONS | MULTIDISCIPLINARY SCIENCES | RECEPTOR | PANDEMIC H1N1 VACCINE | SENTINEL SURVEILLANCE NETWORK | CHILDREN | Influenza Vaccines - administration & dosage | Humans | Middle Aged | Child, Preschool | Molecular Sequence Data | Infant | Male | Hemagglutinin Glycoproteins, Influenza Virus - immunology | Influenza A Virus, H3N2 Subtype - genetics | Case-Control Studies | Hemagglutinin Glycoproteins, Influenza Virus - genetics | Young Adult | Influenza A Virus, H3N2 Subtype - isolation & purification | Aged, 80 and over | Adult | Female | Influenza, Human - virology | Seasons | Child | Infant, Newborn | Immunization | Influenza A Virus, H3N2 Subtype - immunology | Mutation - genetics | Canada | Influenza Vaccines - immunology | Influenza, Human - genetics | Adolescent | Protein Conformation | Aged | DNA, Viral - genetics | Influenza, Human - prevention & control | Influenza, Human - immunology | Influenza viruses | Influenza vaccines | Control | Genetic aspects | Influenza | Antigens | Antigenic drift | Amino acids | Viruses | Systematic review | Genetic diversity | Vaccines | Disease prevention | Antigenicity | Influenza A | Drift | Mutation | Strains (organisms)
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3. Full Text Enhanced Genetic Characterization of Influenza A(H3N2) Viruses and Vaccine Effectiveness by Genetic Group, 2014-2015
by Flannery, Brendan and Zimmerman, Richard K and Gubareva, Larisa V and Garten, Rebecca J and Chung, Jessie R and Nowalk, Mary Patricia and Jackson, Michael L and Jackson, Lisa A and Monto, Arnold S and Ohmit, Suzanne E and Belongia, Edward A and McLean, Huong Q and Gaglani, Manjusha and Piedra, Pedro A and Mishin, Vasiliy P and Chesnokov, Anton P and Spencer, Sarah and Thaker, Swathi N and Barnes, John R and Foust, Angie and Sessions, Wendy and Xu, Xiyan and Katz, Jacqueline and Fry, Alicia M
Journal of Infectious Diseases, ISSN 0022-1899, 10/2016, Volume 214, Issue 7, pp. 1010 - 1019
Background. During the 2014-2015 US influenza season, expanded genetic characterization of circulating influenza A(H3N2) viruses was used to assess the impact... 
influenza | vaccine effectiveness | influenza vaccine | pyrosequencing | genetic characterization | UNITED-STATES | INFECTIOUS DISEASES | HEMAGGLUTININ | PROTECTION | FEBRUARY | MICROBIOLOGY | IMMUNOLOGY | RECOMMENDATIONS | SEASONAL INFLUENZA | TEST-NEGATIVE DESIGN | Genetic Drift | Influenza Vaccines - administration & dosage | Influenza A Virus, H3N2 Subtype - classification | United States | Humans | Middle Aged | Child, Preschool | Infant | Male | Treatment Outcome | Influenza A Virus, H3N2 Subtype - genetics | Influenza A Virus, H3N2 Subtype - immunology | Hemagglutinin Glycoproteins, Influenza Virus - genetics | Genetic Variation | Young Adult | Influenza Vaccines - immunology | Adolescent | Aged, 80 and over | Adult | Female | Influenza, Human - virology | Aged | High-Throughput Nucleotide Sequencing | Influenza, Human - prevention & control | Influenza vaccines | Influenza viruses | Genetics | Usage | Research | Diagnosis | Major and Brief Reports | Editor's Choice
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4. Full Text Genesis and pathogenesis of the 1918 pandemic H1N1 influenza A virus
by Michael Worobey and Guan-Zhu Han and Andrew Rambaut
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2014, Volume 111, Issue 22, pp. 8107 - 8112
The source, timing, and geographical origin of the 1918–1920 pandemic influenza A virus have remained tenaciously obscure for nearly a century, as have the... 
H1N1 subtype influenza A virus | Pandemics | Influenza A virus | Swine | Mortality | Childhood | Antibodies | Viruses | Immunity | Age groups | Pathogenicity | Cohort immunity | Phylogeny | Reassortment | Virulence | UNITED-STATES | MORTALITY | reassortment | ORIGINAL ANTIGENIC SIN | NEUTRALIZING ANTIBODIES | MULTIDISCIPLINARY SCIENCES | HUMAN SERA | PATTERNS | cohort immunity | pathogenicity | RESPONSES | DIFFERENT AGES | virulence | phylogeny | INFECTION | EPIDEMIOLOGY | Influenza A Virus, H1N1 Subtype - immunology | Reassortant Viruses - pathogenicity | Humans | Influenza A virus - genetics | Reassortant Viruses - genetics | Disease Resistance - immunology | Influenza A Virus, H5N1 Subtype - genetics | Influenza A Virus, H3N2 Subtype - genetics | Influenza A Virus, H3N8 Subtype - genetics | Influenza A Virus, H3N8 Subtype - pathogenicity | Influenza A Virus, H7N9 Subtype - immunology | Genetic Variation | Reassortant Viruses - immunology | Influenza A Virus, H7N9 Subtype - pathogenicity | Influenza A virus - pathogenicity | Influenza, Human - mortality | Adult | Influenza A virus - immunology | Influenza, Human - virology | Child | Influenza A Virus, H1N1 Subtype - genetics | Influenza A Virus, H3N2 Subtype - pathogenicity | Influenza Pandemic, 1918-1919 - mortality | Birds | Influenza A Virus, H1N1 Subtype - pathogenicity | Influenza A Virus, H3N2 Subtype - immunology | Biological Evolution | Animals | Influenza A Virus, H3N8 Subtype - immunology | Influenza A Virus, H5N1 Subtype - immunology | Influenza A Virus, H5N1 Subtype - pathogenicity | Aged | Influenza A Virus, H7N9 Subtype - genetics | Causes of | Epidemics | United States | Swine influenza | Biological Sciences
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5. Full Text Recent H3N2 Viruses Have Evolved Specificity for Extended, Branched Human-type Receptors, Conferring Potential for Increased Avidity
by Peng, Wenjie and de Vries, Robert P and Grant, Oliver C and Thompson, Andrew J and McBride, Ryan and Tsogtbaatar, Buyankhishig and Lee, Peter S and Razi, Nahid and Wilson, Ian A and Woods, Robert J and Paulson, James C
Cell Host & Microbe, ISSN 1931-3128, 01/2017, Volume 21, Issue 1, pp. 23 - 34
Human and avian influenza viruses recognize different sialic acid-containing receptors, referred to as human-type (NeuAcα2-6Gal) and avian-type (NeuAcα2-3Gal),... 
sialoside microarray | chemo-enzymatic synthesis | poly-N-acetyl-lactosamine | bidentate binding | hemagglutinin | airway | influenza virus | receptor specificity | extended branched glycans | H3N2 | MDCK CELLS | ENTRY | RECOGNITION | MICROBIOLOGY | BINDING SPECIFICITY | TRANSMISSION | EVOLUTION | VIROLOGY | GLYCAN ARRAY | HEMAGGLUTININS | HUMAN INFLUENZA-VIRUSES | INFECTION | PARASITOLOGY | Cell Line | Galactans - metabolism | Influenza A Virus, H3N8 Subtype - metabolism | Species Specificity | Receptors, Virus - metabolism | Humans | Influenza A Virus, H3N2 Subtype - metabolism | Influenza A Virus, H3N2 Subtype - genetics | Hemagglutinin Glycoproteins, Influenza Virus - metabolism | N-Acetylneuraminic Acid - metabolism | Molecular Dynamics Simulation | Polysaccharides - metabolism | Animals | Dogs | HEK293 Cells | Madin Darby Canine Kidney Cells | Virus Attachment | Influenza A Virus, H5N1 Subtype - metabolism | Influenza A Virus, H1N1 Subtype - genetics | Influenza A Virus, H1N1 Subtype - metabolism | Avian influenza | Polysaccharides | Physiological aspects | Lectins | Avian influenza viruses | Research institutes | Molecular biology | Health aspects | Organic acids
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6. Full Text The Global Circulation of Seasonal Influenza a (H3N2) Viruses
by Colin A. Russell and Terry C. Jones and Ian G. Barr and Nancy J. Cox and Rebecca J. Garten and Vicky Gregory and Ian D. Gust and Alan W. Hampson and Alan J. Hay and Aeron C. Hurt and Jan C. de Jong and Anne Kelso and Alexander I. Klimov and Tsutomu Kageyama and Naomi Komadina and Alan S. Lapedes and Yi P. Lin and Ana Mosterin and Masatsugu Obuchi and Takato Odagiri and Albert D. M. E. Osterhaus and Guus F. Rimmelzwaan and Michael W. Shaw and Eugene Skepner and Klaus Stohr and Masato Tashiro and Ron A. M. Fouchier and Derek J. Smith
Science, ISSN 0036-8075, 4/2008, Volume 320, Issue 5874, pp. 340 - 346
Antigenic and genetic analysis of the hemagglutinin of ∼13,000 human influenza A (H3N2) viruses from six continents during 2002-2007 revealed that there was... 
Epidemics | Tropical regions | Vaccination | Phylogenetics | Viruses | Evolution | Evolutionary genetics | Research Articles | Temperate regions | Seeding | H3N2 subtype influenza A virus | INFECTIONS | EVOLUTION | MULTIDISCIPLINARY SCIENCES | SURVEILLANCE | HIERARCHIES | EPIDEMICS | REASSORTMENT | BRAZIL | REVEALS | Antigenic Variation | Influenza A Virus, H3N2 Subtype - classification | Humans | Europe - epidemiology | Influenza, Human - epidemiology | Hemagglutinin Glycoproteins, Influenza Virus - immunology | Influenza A Virus, H3N2 Subtype - genetics | Phylogeny | Asia, Southeastern - epidemiology | Influenza A Virus, H3N2 Subtype - immunology | Forecasting | Hemagglutinin Glycoproteins, Influenza Virus - genetics | Oceania | Asia - epidemiology | South America - epidemiology | Influenza A Virus, H3N2 Subtype - isolation & purification | Disease Outbreaks | Influenza, Human - virology | Influenza Vaccines | North America - epidemiology | Seasons | Population Surveillance | Evolution, Molecular | Influenza viruses | Influenza vaccines | Disease transmission | Distribution | Environmental aspects | Influence | Research | Natural history | Evolutionary biology | Microbiology | Influenza
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7. Full Text A predictive fitness model for influenza
by Łuksza, Marta and Lässig, Michael
Nature, ISSN 0028-0836, 2014, Volume 507, Issue 7490, pp. 57 - 61
The seasonal human influenza A/H3N2 virus undergoes rapid evolution, which produces significant year-to-year sequence turnover in the population of circulating... 
A VIRUS | ASEXUAL EVOLUTION | CLONAL INTERFERENCE | POSITIVE SELECTION | BENEFICIAL MUTATIONS | MULTIDISCIPLINARY SCIENCES | LINKED GLYCOSYLATION | SEASONAL INFLUENZA | EVOLUTIONARY DYNAMICS | ANTIGENIC SITES | RECEPTOR-BINDING | Humans | Hemagglutinin Glycoproteins, Influenza Virus - immunology | Influenza A Virus, H3N2 Subtype - genetics | Hemagglutinin Glycoproteins, Influenza Virus - genetics | Epitopes - immunology | Time Factors | Genes, Viral - genetics | Computer Simulation | Influenza, Human - virology | Genetics, Population | Hemagglutinin Glycoproteins, Influenza Virus - chemistry | Influenza A Virus, H3N2 Subtype - classification | Genetic Fitness - immunology | Genetic Fitness - physiology | Influenza, Human - epidemiology | Epitopes - genetics | Influenza A Virus, H3N2 Subtype - immunology | Mutation - genetics | Models, Immunological | Influenza A Virus, H3N2 Subtype - chemistry | Influenza Vaccines - immunology | Genetic Fitness - genetics | Influenza Vaccines - genetics | Influenza Vaccines - chemistry | Evolution, Molecular | Influenza, Human - immunology | Trees | Influenza | Population | Mutation | Seasons | Evolution & development | Methods
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8. Full Text Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans
by Rebecca J. Garten and C. Todd Davis and Colin A. Russell and Bo Shu and Stephen Lindstrom and Amanda Balish and Wendy M. Sessions and Xiyan Xu and Eugene Skepner and Varough Deyde and Margaret Okomo-Adhiambo and Larisa Gubareva and John Barnes and Catherine B. Smith and Shannon L. Emery and Michael J. Hillman and Pierre Rivailler and James Smagala and Miranda de Graaf and David F. Burke and Ron A. M. Fouchier and Claudia Pappas and Celia M. Alpuche-Aranda and Hugo López-Gatell and Hiram Olivera and Irma López and Christopher A. Myers and Dennis Faix and Patrick J. Blair and Cindy Yu and Kimberly M. Keene and P. David Dotson and David Boxrud and Anthony R. Sambol and Syed H. Abid and Kirsten St. George and Tammy Bannerman and Amanda L. Moore and David J. Stringer and Patricia Blevins and Gail J. Demmler-Harrison and Michele Ginsberg and Paula Kriner and Steve Waterman and Sandra Smole and Hugo F. Guevara and Edward A. Belongia and Patricia A. Clark and Sara T. Beatrice and Ruben Donis and Jacqueline Katz and Lyn Finelli and Carolyn B. Bridges and Michael Shaw and Daniel B. Jernigan and Timothy M. Uyeki and Derek J. Smith and Alexander I. Klimov and Nancy J. Cox
Science, ISSN 0036-8075, 7/2009, Volume 325, Issue 5937, pp. 197 - 201
Since its identification in April 2009, an A(H1N1) virus containing a unique combination of gene segments from both North American and Eurasian swine lineages... 
H1N1 subtype influenza A virus | Maps | Pandemics | Influenza A virus | Swine | Environmental laboratories | Viruses | Orthomyxoviridae | Reports | Genomes | Public health | A VIRUS | UNITED-STATES | PIGS | TRANSMISSION | EVOLUTION | PATHOGENICITY | PHYLOGENETIC ANALYSIS | MULTIDISCIPLINARY SCIENCES | INFECTION | EMERGENCE | NORTH-AMERICA | Influenza A Virus, H1N1 Subtype - immunology | Viral Matrix Proteins - genetics | Influenza A Virus, H1N1 Subtype - classification | Swine Diseases - virology | Humans | Influenza A virus - genetics | Neuraminidase - genetics | Reassortant Viruses - genetics | Antigens, Viral - genetics | Hemagglutinin Glycoproteins, Influenza Virus - immunology | Influenza A Virus, H3N2 Subtype - genetics | Phylogeny | Hemagglutinin Glycoproteins, Influenza Virus - genetics | Genetic Variation | Hemagglutination Inhibition Tests | Influenza A Virus, H1N1 Subtype - isolation & purification | Disease Outbreaks | Genes, Viral | Influenza, Human - virology | Influenza A Virus, H1N1 Subtype - genetics | Genome, Viral | Hemagglutinin Glycoproteins, Influenza Virus - chemistry | Orthomyxoviridae Infections - veterinary | Viral Nonstructural Proteins - genetics | Influenza, Human - epidemiology | Antigens, Viral - immunology | Animals | Antibodies, Viral - immunology | Mutation | Orthomyxoviridae Infections - virology | Evolution, Molecular | Influenza, Human - immunology | Influenza viruses | Genetic aspects | Research | Health aspects | Swine influenza
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9. Full Text Origins and evolutionary dynamics of H3N2 canine influenza virus
by Zhu, Henan and Hughes, Joseph and Murcia, Pablo R
Journal of Virology, ISSN 0022-538X, 2015, Volume 89, Issue 10, pp. 5406 - 5418
Influenza A viruses (IAVs) are maintained mainly in wild birds, and despite frequent spillover infections of avian IAVs into mammals, only a small number of... 
A VIRUS | EQUINE INFLUENZA | TRANSMISSION | VIROLOGY | AVIAN-LIKE | PHYLOGENETIC ANALYSIS | SWINE | DOGS | GENETIC-CHARACTERIZATION | H1N1 | EXPERIMENTAL-INFECTION | Reassortant Viruses - pathogenicity | Humans | Databases, Genetic | Reassortant Viruses - genetics | Influenza A Virus, H5N1 Subtype - genetics | Influenza A Virus, H3N2 Subtype - genetics | Phylogeny | Influenza A Virus, H5N1 Subtype - isolation & purification | Influenza A Virus, H3N2 Subtype - isolation & purification | Time Factors | Influenza, Human - virology | Dog Diseases - virology | Genome, Viral | Orthomyxoviridae Infections - veterinary | Influenza A Virus, H3N2 Subtype - pathogenicity | Selection, Genetic | Viral Proteins - genetics | Birds | Host Specificity | Reassortant Viruses - isolation & purification | Animals | Dogs | Influenza in Birds - virology | Influenza A Virus, H5N1 Subtype - pathogenicity | Mutation | Orthomyxoviridae Infections - virology | Evolution, Molecular
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10. Full Text Evolution of Novel Reassortant A/H3N2 Influenza Viruses in North American Swine and Humans, 2009–2011
by Martha I. Nelson and Amy L. Vincent and Pravina Kitikoon and Edward C. Holmes and Marie R. Gramer
Journal of Virology, ISSN 0022-538X, 08/2012, Volume 86, Issue 16, pp. 8872 - 8878
Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
UNITED-STATES | PIGS | ORIGIN | CANADA | VIROLOGY | A VIRUSES | OUTBREAK | PANDEMIC H1N1 2009 | REVEALS | Viral Matrix Proteins - genetics | Influenza A Virus, H3N2 Subtype - classification | Orthomyxoviridae Infections - veterinary | Swine Diseases - virology | Humans | Neuraminidase - genetics | Reassortant Viruses - genetics | Viral Proteins - genetics | Influenza A Virus, H3N2 Subtype - genetics | North America | Reassortant Viruses - isolation & purification | Sequence Analysis, DNA | Hemagglutinin Glycoproteins, Influenza Virus - genetics | Animals | Influenza A Virus, H3N2 Subtype - isolation & purification | Swine | Influenza, Human - virology | Orthomyxoviridae Infections - virology | Evolution, Molecular | Reassortant Viruses - classification | Genetic Diversity and Evolution
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