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PLoS pathogens, ISSN 1553-7374, 2013, Volume 9, Issue 11, p. e1003773
.... Here we show that airway epithelia, the primary target of influenza A virus, produce both IFN I and III upon infection, and that induction of both depends on the RIG-I/MAVS pathway... 
CELLS | DEFENSE | VIRUS-INFECTION | DISTINCT | RIG-I | MICROBIOLOGY | IRF-7 | ANTIVIRAL RESPONSE | VIROLOGY | GENE | SIGNALING PATHWAY | ADAPTER PROTEIN | PARASITOLOGY | Epithelial Cells - metabolism | Influenza A virus - genetics | Respiratory Mucosa - virology | Interferon Regulatory Factor-7 - genetics | Interferon Type I - immunology | Interferon Regulatory Factor-3 - genetics | Interleukins - metabolism | Orthomyxoviridae Infections - genetics | Respiratory Mucosa - pathology | Interleukins - genetics | Interleukins - immunology | Respiratory Mucosa - immunology | Adaptor Proteins, Signal Transducing - immunology | Interferon Type I - metabolism | Influenza A virus - immunology | Membrane Proteins - metabolism | Interferon Regulatory Factor-3 - immunology | Nerve Tissue Proteins - immunology | Membrane Proteins - genetics | Orthomyxoviridae Infections - metabolism | Epithelial Cells - pathology | Membrane Proteins - immunology | Interferon Regulatory Factor-7 - immunology | Interferon Regulatory Factor-7 - metabolism | Nerve Tissue Proteins - genetics | Mice, Knockout | Nerve Tissue Proteins - metabolism | Animals | Influenza A virus - metabolism | Epithelial Cells - immunology | Epithelial Cells - virology | Adaptor Proteins, Signal Transducing - genetics | Interferon Regulatory Factor-3 - metabolism | Interferon Type I - genetics | Mice | Respiratory Mucosa - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Orthomyxoviridae Infections - immunology | Epithelial cells | Influenza | Physiological aspects | Host-parasite relationships | Interferon | Genetic aspects | Genetic transcription | Research | Health aspects | Airway (Medicine) | Interleukins/metabolism | Nerve Tissue Proteins/immunology | Orthomyxoviridae Infections/genetics | Orthomyxoviridae Infections/metabolism | Membrane Proteins/genetics | Adaptor Proteins, Signal Transducing/genetics | Interferon Regulatory Factor-7/genetics | Interleukins/immunology | Membrane Proteins/immunology | Life Sciences | Orthomyxoviridae Infections/immunology | Influenza A virus/genetics | Nerve Tissue Proteins/metabolism | Respiratory Mucosa/immunology | Immunology | Interferon Type I/immunology | Epithelial Cells/immunology | Epithelial Cells/virology | Interferon Regulatory Factor-7/immunology | Epithelial Cells/metabolism | Interferon Regulatory Factor-3/immunology | Respiratory Mucosa/pathology | Influenza A virus/immunology | Interleukins/genetics | Interferon Regulatory Factor-3/genetics | Influenza A virus/metabolism | Adaptor Proteins, Signal Transducing/metabolism | Epithelial Cells/pathology | Adaptor Proteins, Signal Transducing/immunology | Interferon Type I/genetics | Interferon Regulatory Factor-3/metabolism | Membrane Proteins/metabolism | Nerve Tissue Proteins/genetics | Interferon Regulatory Factor-7/metabolism | Interferon Type I/metabolism | Respiratory Mucosa/metabolism | Respiratory Mucosa/virology | Cytokines | Genes | Rodents | Genomics | Genomes | Kinases | Experiments | Viral infections
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 6/2014, Volume 111, Issue 22, pp. 8107 - 8112
The source, timing, and geographical origin of the 1918–1920 pandemic influenza A virus have remained tenaciously obscure for nearly a century, as have the reasons for its unusual severity among young adults... 
H1N1 subtype influenza A virus | Pandemics | Influenza A virus | Swine | Mortality | Childhood | Antibodies | Viruses | Immunity | Age groups | Pathogenicity | Cohort immunity | Phylogeny | Reassortment | Virulence | UNITED-STATES | MORTALITY | reassortment | ORIGINAL ANTIGENIC SIN | NEUTRALIZING ANTIBODIES | MULTIDISCIPLINARY SCIENCES | HUMAN SERA | PATTERNS | cohort immunity | pathogenicity | RESPONSES | DIFFERENT AGES | virulence | phylogeny | INFECTION | EPIDEMIOLOGY | Influenza A Virus, H1N1 Subtype - immunology | Reassortant Viruses - pathogenicity | Humans | Influenza A virus - genetics | Reassortant Viruses - genetics | Disease Resistance - immunology | Influenza A Virus, H5N1 Subtype - genetics | Influenza A Virus, H3N2 Subtype - genetics | Influenza A Virus, H3N8 Subtype - genetics | Influenza A Virus, H3N8 Subtype - pathogenicity | Influenza A Virus, H7N9 Subtype - immunology | Genetic Variation | Reassortant Viruses - immunology | Influenza A Virus, H7N9 Subtype - pathogenicity | Influenza A virus - pathogenicity | Influenza, Human - mortality | Adult | Influenza A virus - immunology | Influenza, Human - virology | Child | Influenza A Virus, H1N1 Subtype - genetics | Influenza A Virus, H3N2 Subtype - pathogenicity | Influenza Pandemic, 1918-1919 - mortality | Birds | Influenza A Virus, H1N1 Subtype - pathogenicity | Influenza A Virus, H3N2 Subtype - immunology | Biological Evolution | Animals | Influenza A Virus, H3N8 Subtype - immunology | Influenza A Virus, H5N1 Subtype - immunology | Influenza A Virus, H5N1 Subtype - pathogenicity | Aged | Influenza A Virus, H7N9 Subtype - genetics | Causes of | Epidemics | United States | Swine influenza | Biological Sciences
Journal Article
Virology (New York, N.Y.), ISSN 0042-6822, 2007, Volume 362, Issue 2, pp. 271 - 282
...Introduction Aquatic birds are thought to be the reservoir for genetic diversity of influenza A viruses, and the source for transmission to other animal... 
Infectious Disease | PB2 | Transcription/replication | Influenza A virus | Host-range | host-range | RNA REPLICATION | REASSORTANT VIRUSES | transcription/replication | AMINO-ACID | HIGH VIRULENCE | VIROLOGY | GENES | H5N1 VIRUSES | RECEPTOR SPECIFICITY | REVERSE GENETICS | MOLECULAR-BASIS | BINDING | influenza A virus | Influenza A Virus, H5N1 Subtype - physiology | Humans | Influenza A virus - genetics | Influenza A Virus, H1N1 Subtype - physiology | Cercopithecus aethiops | Molecular Sequence Data | Chloramphenicol O-Acetyltransferase - genetics | Influenza A Virus, H5N1 Subtype - genetics | Influenza A Virus, H3N2 Subtype - genetics | Viral Proteins - metabolism | Transcription, Genetic | Influenza A Virus, H1N1 Subtype - genetics | Genes, Reporter | Cell Line | Chloramphenicol O-Acetyltransferase - analysis | Influenza A virus - physiology | Promoter Regions, Genetic | RNA, Viral - biosynthesis | Viral Plaque Assay | Viral Proteins - genetics | Ribonucleoproteins - metabolism | Sequence Analysis, DNA | Protein Interaction Mapping | Animals | Virus Replication | Chickens | RNA Polymerase I | Influenza A Virus, H3N2 Subtype - physiology | COS Cells | Proteins | Control | Influenza | Influenza A Virus, H3N2 Subtype | Influenza A Virus, H5N1 Subtype | Viral Proteins | Life Sciences | Influenza A Virus, H1N1 Subtype | Promoter Regions (Genetics) | Ribonucleoproteins | Chloramphenicol O-Acetyltransferase | Virology | Microbiology and Parasitology | RNA, Viral | Plaque Assay
Journal Article
PloS one, ISSN 1932-6203, 2018, Volume 13, Issue 7, p. e0199260
...) with the fittest lineage of each gene. To characterize the H9N2 variant viruses from 2011 to 2014, 28 H9N2 influenza viruses were isolated from live poultry markets in China from 2011-2014 and were analyzed by genetic and biological characterization... 
A VIRUS | REPLICATION | EVOLUTION | HEMAGGLUTININ | SUBTYPES | PHYLOGENETIC ANALYSIS | MULTIDISCIPLINARY SCIENCES | POULTRY | CHICKENS | INFECTION | H7N9 | Influenza A Virus, H10N8 Subtype - genetics | Humans | Neuraminidase - genetics | Antigens, Viral - genetics | Influenza A Virus, H5N1 Subtype - classification | Influenza A Virus, H5N1 Subtype - genetics | Hemagglutinin Glycoproteins, Influenza Virus - immunology | Influenza in Birds - immunology | Phylogeny | Influenza A Virus, H7N9 Subtype - classification | Influenza A Virus, H10N8 Subtype - classification | Hemagglutinin Glycoproteins, Influenza Virus - genetics | Influenza A Virus, H7N9 Subtype - immunology | Influenza A Virus, H9N2 Subtype - immunology | Neuraminidase - immunology | Neuraminidase - chemistry | Influenza, Human - virology | Poultry Diseases - epidemiology | Influenza A Virus, H10N8 Subtype - immunology | Amino Acid Sequence | Hemagglutinin Glycoproteins, Influenza Virus - chemistry | Gene Expression | Influenza A Virus, H9N2 Subtype - genetics | Antigens, Viral - chemistry | Influenza, Human - epidemiology | Glycosylation | Influenza in Birds - epidemiology | China - epidemiology | Poultry Diseases - virology | Polymorphism, Genetic | Antigens, Viral - immunology | Animals | Influenza A Virus, H5N1 Subtype - immunology | Chickens | Influenza in Birds - virology | Poultry Diseases - immunology | Influenza A Virus, H9N2 Subtype - classification | Influenza A Virus, H7N9 Subtype - genetics | Evolution, Molecular | Influenza, Human - immunology | Avian influenza viruses | Genotype | Genetic aspects | Research | Health aspects | Epidemics | Veterinary colleges | Divergence | Pandemics | Poultry | Genes | Branches | Amino acids | Viruses | Avian flu | Proteins | Antigenicity | Influenza | Airborne infection | HA protein | Genotypes | Binding sites
Journal Article
Journal of virological methods, ISSN 0166-0934, 2005, Volume 126, Issue 1-2, pp. 53 - 63
Three multiplex hemi-nested RT-PCR assays were developed to detect simultaneously 12 RNA respiratory viruses... 
Multiplex RT-PCR assay | Respiratory syncytial virus | Influenza virus | Parainfluenza virus | Human coronavirus | Human metapneumovirus | Rhinovirus | human coronavirus | INFLUENZA-A | BIOCHEMICAL RESEARCH METHODS | rhinovirus | TRACT INFECTIONS | HOSPITALIZED CHILDREN | POLYMERASE-CHAIN-REACTION | VIROLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | PEDIATRIC-PATIENTS | influenza virus | SYNCYTIAL-VIRUS | REVERSE TRANSCRIPTION-PCR | multiplex RT-PCR assay | parainfluenza virus | human metapneumovirus | ENZYME HYBRIDIZATION ASSAY | respiratory syncytial virus | Metapneumovirus - isolation & purification | Humans | Influenza A virus - genetics | Coronavirus OC43, Human - isolation & purification | Influenzavirus C - isolation & purification | Rhinovirus - isolation & purification | Parainfluenza Virus 3, Human - isolation & purification | Metapneumovirus - genetics | Influenza B virus - genetics | Parainfluenza Virus 3, Human - genetics | RNA, Viral - genetics | Reverse Transcriptase Polymerase Chain Reaction - standards | Reverse Transcriptase Polymerase Chain Reaction - methods | Sensitivity and Specificity | Coronavirus 229E, Human - genetics | Coronavirus 229E, Human - isolation & purification | Nasal Cavity - virology | Respiratory Tract Infections - virology | Child | Quality Control | Parainfluenza Virus 4, Human - isolation & purification | RNA Viruses - isolation & purification | Influenza B virus - isolation & purification | Parainfluenza Virus 1, Human - genetics | Parainfluenza Virus 1, Human - isolation & purification | Parainfluenza Virus 4, Human - genetics | RNA Viruses - genetics | RNA, Viral - analysis | Respiratory Syncytial Viruses - isolation & purification | Influenza A virus - isolation & purification | Respiratory Tract Infections - diagnosis | Parainfluenza Virus 2, Human - isolation & purification | Respiratory Syncytial Viruses - genetics | Coronavirus OC43, Human - genetics | Fluorescent Antibody Technique | Parainfluenza Virus 2, Human - genetics | Virus Cultivation | Influenzavirus C - genetics | Rhinovirus - genetics | RNA | Influenza | Analysis
Journal Article
Clinical chemistry (Baltimore, Md.), ISSN 1530-8561, 2009, Volume 55, Issue 8, pp. 1555 - 1558
BACKGROUND: Influenza A viruses are medically important viral pathogens that cause significant mortality and morbidity throughout the world... 
MEDICAL LABORATORY TECHNOLOGY | Influenza A Virus, H2N2 Subtype - isolation & purification | Molecular Diagnostic Techniques - methods | Influenza A Virus, H1N1 Subtype - classification | Humans | DNA, Viral - analysis | Influenza A Virus, H5N1 Subtype - classification | Influenza A Virus, H5N1 Subtype - genetics | Influenza A Virus, H3N2 Subtype - genetics | Molecular Diagnostic Techniques - economics | Influenza A Virus, H5N1 Subtype - isolation & purification | Reverse Transcriptase Polymerase Chain Reaction - economics | RNA, Viral - genetics | Influenza A Virus, H1N1 Subtype - isolation & purification | Influenza A Virus, H3N2 Subtype - isolation & purification | Time Factors | Base Sequence | Reverse Transcriptase Polymerase Chain Reaction - methods | Sensitivity and Specificity | Influenza, Human - diagnosis | Influenza, Human - virology | RNA, Viral - isolation & purification | Influenza A Virus, H1N1 Subtype - genetics | Influenza A Virus, H3N2 Subtype - classification | RNA, Viral - analysis | Influenza A Virus, H2N2 Subtype - classification | Orthomyxoviridae Infections - diagnosis | Animals | Influenza A Virus, H2N2 Subtype - genetics | DNA, Viral - genetics | Orthomyxoviridae Infections - virology | Swine - virology | Influenza viruses | Polymerase chain reaction | Usage | Swine influenza | Causes of | Genetic aspects | Research | Diagnosis | Health aspects | Viruses | Mathematical models | Microbiology | Swine flu | Laboratories | Influenza A Virus, H3N2 Subtype | Influenza A Virus, H2N2 Subtype | Influenza A Virus, H5N1 Subtype | Reverse Transcriptase Polymerase Chain Reaction | Virology | Life Sciences | Microbiology and Parasitology | Molecular Diagnostic Techniques | Swine | RNA, Viral | Influenza, Human | Influenza A Virus, H1N1 Subtype | Orthomyxoviridae Infections | DNA, Viral | Brief Communications
Journal Article
Cell host & microbe, ISSN 1931-3128, 2016, Volume 20, Issue 6, pp. 810 - 821
Constant surveillance of live poultry markets (LPMs) is currently the best way to predict and identify emerging avian influenza viruses (AIVs... 
genesis | prevalence | live poultry markets | H5N6 avian influenza | resassortment | evolution | birds | human infection | HUMAN INFECTION | H7N9 VIRUS | MICROBIOLOGY | SHORT READ ALIGNMENT | HONG-KONG | ORIGIN | LIVE POULTRY MARKETS | VIROLOGY | H9N2 | A(H5N6) VIRUS | A VIRUSES | MIGRATORY BIRDS | PARASITOLOGY | Public Health | Prevalence | Humans | Chickens - virology | Geographic Mapping | Influenza A Virus, H5N1 Subtype - genetics | Influenza A Virus, H9N2 Subtype - pathogenicity | Phylogeny | RNA, Viral - genetics | Genes, Viral - genetics | Poultry - virology | Base Sequence | Influenza A Virus, H7N9 Subtype - pathogenicity | Hemagglutinins | Influenza, Human - virology | Agriculture | Genome, Viral | Influenza A Virus, H5N8 Subtype - pathogenicity | Influenza A Virus, H9N2 Subtype - genetics | Influenza A Virus, H5N8 Subtype - classification | Ducks - virology | Columbidae - virology | Genotype | Influenza, Human - epidemiology | Geese - virology | Influenza in Birds - epidemiology | China - epidemiology | Animals | Epidemiological Monitoring | Influenza in Birds - virology | Neuraminidase | Reassortant Viruses | Influenza A Virus, H5N1 Subtype - pathogenicity | Influenza A Virus, H5N8 Subtype - genetics | Influenza A Virus, H7N9 Subtype - genetics | Cities | Influenza A Virus, H5N8 Subtype - isolation & purification | Evolution, Molecular | Virus diseases | Avian influenza | Cladistic analysis | Analysis | Lectins | Avian influenza viruses | Health aspects
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2015, Volume 112, Issue 2, pp. 548 - 553
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2008, Volume 105, Issue 11, pp. 4381 - 4386
... genetics and the pathogenicity of the viruses determined. Viruses containing NS1... 
Proteins | H1N1 subtype influenza A virus | Lungs | Influenza A virus | Virulence | Viruses | Orthomyxoviridae | Amino acids | H5N1 subtype influenza A virus | Genetic mutation | PDZ domains | Influenza reverse genetics | PDZ ligand | H5N1 influenza | Mouse model for influenza | 1918 PANDEMIC VIRUS | ACTIVATION | BETA INDUCTION | MULTIDISCIPLINARY SCIENCES | PRE-MESSENGER-RNAS | NUCLEAR EXPORT | A-VIRUS | INTERFERON | IN-VIVO | mouse model for influenza | INFECTED-CELLS | influenza reverse genetics | V-PROTEIN | Interferons - biosynthesis | Lung Diseases - metabolism | Virulence Factors - genetics | Humans | Molecular Sequence Data | Influenza A Virus, H5N1 Subtype - genetics | Viral Nonstructural Proteins - chemistry | Recombination, Genetic - genetics | Female | Influenza A Virus, H5N1 Subtype - metabolism | Influenza A Virus, H1N1 Subtype - genetics | Influenza A Virus, H1N1 Subtype - metabolism | Disease Models, Animal | Amino Acid Sequence | Cell Line | Viral Nonstructural Proteins - genetics | Influenza A Virus, H1N1 Subtype - pathogenicity | Virulence Factors - chemistry | Mutation - genetics | Animals | Dogs | Influenza A Virus, H5N1 Subtype - chemistry | Influenza A Virus, H5N1 Subtype - pathogenicity | Viral Nonstructural Proteins - metabolism | Virulence Factors - metabolism | Influenza A Virus, H1N1 Subtype - chemistry | Mice | Mice, Inbred BALB C | Lung Diseases - pathology | Ligand binding (Biochemistry) | Viral proteins | Influenza | Influence | Models | Genetic aspects | Virulence (Microbiology) | Research | Properties | Biological Sciences
Journal Article
Small (Weinheim an der Bergstrasse, Germany), ISSN 1613-6810, 06/2014, Volume 10, Issue 12, pp. 2390 - 2397
Avian influenza viruses (AIV) with good adaptation and various mutations have threatened both human and animals’ health... 
luminescence resonance energy transfer | upconversion | nanoparticles | avian influenza virus detection | GOLD NANOPARTICLES | PHYSICS, CONDENSED MATTER | PHYSICS, APPLIED | HUMAN INFECTION | CYANIDE ANIONS | ASSAY | HEMAGGLUTININ | NANOPHOSPHORS | MATERIALS SCIENCE, MULTIDISCIPLINARY | NANOCRYSTALS | CHEMISTRY, PHYSICAL | NANOSCIENCE & NANOTECHNOLOGY | CHEMISTRY, MULTIDISCIPLINARY | LABEL-FREE DETECTION | DNA | PCR | Fluorescence Resonance Energy Transfer - instrumentation | Humans | Influenza A virus - genetics | Luminescence | Influenza A Virus, H7N2 Subtype - isolation & purification | Hemagglutinin Glycoproteins, Influenza Virus - genetics | Time Factors | Sensitivity and Specificity | Biosensing Techniques - instrumentation | Influenza, Human - diagnosis | Gold | Influenza A Virus, H7N1 Subtype - isolation & purification | Limit of Detection | Influenza A Virus, H7N9 Subtype - isolation & purification | Metal Nanoparticles - chemistry | Influenza A Virus, H7N7 Subtype - isolation & purification | Birds | Influenza A virus - isolation & purification | Influenza A Virus, H7N3 Subtype - isolation & purification | Animals | Influenza, Human - genetics | Influenza in Birds - virology | Biosensing Techniques - methods | Fluorescence Resonance Energy Transfer - methods | Influenza A Virus, H7N9 Subtype - genetics | Influenza A Virus, H7N7 Subtype - genetics | Influenza A Virus, H7N1 Subtype - genetics | Influenza A virus - classification | Influenza A Virus, H7N2 Subtype - genetics | Influenza A Virus, H7N3 Subtype - genetics | Influenza in Birds - diagnosis | Avian influenza | Thiols | Wildlife conservation | Detectors | Lectins | Avian influenza viruses | Fluorescence | Health aspects | Nanoparticles | Influenza | Upconversion | Health | Oligonucleotides | Biosensors | Energy transfer | Erbium
Journal Article