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Science, ISSN 0036-8075, 8/2011, Volume 333, Issue 6044, pp. 843 - 850
Current flu vaccines provide only limited coverage against seasonal strains of influenza viruses. The identification of V H 1-69 antibodies that broadly... 
Influenza A virus | RESEARCH ARTICLES | Vaccination | Cardiopulmonary resuscitation | Antibodies | Viruses | Orthomyxoviridae | Infections | Epitopes | H3N2 subtype influenza A virus | Crystal structure | FUSION | HEMAGGLUTININ | RECOGNITION | AVIAN INFLUENZA | SUBTYPES | MULTIDISCIPLINARY SCIENCES | VACCINATION | MONOCLONAL-ANTIBODIES | PEPTIDE | SEASON | Orthomyxoviridae Infections - prevention & control | Antibody Specificity | Humans | Molecular Sequence Data | Antigens, Viral - genetics | Crystallography, X-Ray | Neutralization Tests | Hemagglutinin Glycoproteins, Influenza Virus - immunology | Hemagglutinin Glycoproteins, Influenza Virus - genetics | Epitopes - immunology | Antibodies, Neutralizing - immunology | Conserved Sequence | Influenza A Virus, H7N7 Subtype - immunology | Influenza A virus - immunology | Influenza, Human - therapy | Antibodies, Monoclonal - immunology | Amino Acid Sequence | Hemagglutinin Glycoproteins, Influenza Virus - chemistry | Models, Molecular | Antigens, Viral - chemistry | Antibodies, Monoclonal - isolation & purification | Influenza A Virus, H3N2 Subtype - immunology | Antibodies, Viral - isolation & purification | Antibodies, Neutralizing - isolation & purification | Antigens, Viral - immunology | Animals | Influenza Vaccines - immunology | Antibodies, Viral - immunology | Protein Conformation | Mice | Influenza A Virus, H7N7 Subtype - genetics | Mutation | Binding Sites, Antibody | Influenza, Human - prevention & control | Orthomyxoviridae Infections - immunology | Influenza, Human - immunology | Influenza viruses | Influenza vaccines | Crystals | Monoclonal antibodies | Physiological aspects | Research | Properties | Structure | Vaccines | Influenza | Public health | Virology | Index Medicus | fusion | peptide | avian influenza | hemagglutinin | recognition | monoclonal-antibodies | season | vaccination | subtypes
Journal Article
Journal Article
Science, ISSN 0036-8075, 8/2011, Volume 333, Issue 6044, pp. 850 - 856
The isolation of broadly neutralizing antibodies against influenza A viruses has been a long-sought goal for therapeutic approaches and vaccine design. Using a... 
Influenza A virus | RESEARCH ARTICLES | Vaccination | Blood donation | Antibodies | Plasma cells | Viruses | Cultured cells | Cultural groups | Infections | Monomers | MEMBRANE-FUSION | B-CELLS | SITE | COMPLEX | EPITOPE | SEQUENCES | SUBTYPES | MULTIDISCIPLINARY SCIENCES | VIRUS HEMAGGLUTININ | MONOCLONAL-ANTIBODIES | RECEPTOR-BINDING | Influenza A Virus, H1N1 Subtype - immunology | Orthomyxoviridae Infections - prevention & control | Antibody Specificity | Humans | Protein Multimerization | Molecular Sequence Data | Crystallography, X-Ray | Hemagglutinin Glycoproteins, Influenza Virus - immunology | Immunoglobulin Variable Region - immunology | Epitopes - immunology | Antibodies, Neutralizing - immunology | Influenza A virus - immunology | Influenza B virus - immunology | Orthomyxoviridae Infections - therapy | Protein Structure, Secondary | Cells, Cultured | Models, Molecular | Glycosylation | Ferrets | Antibodies, Viral - isolation & purification | Antibodies, Neutralizing - isolation & purification | Cross Reactions | Antigens, Viral - immunology | Animals | Hydrophobic and Hydrophilic Interactions | Immunization, Passive | Antibodies, Viral - immunology | Mice | Orthomyxoviridae Infections - immunology | Influenza, Human - immunology | Plasma Cells - immunology | Influenza viruses | Influenza vaccines | Monoclonal antibodies | Research | Properties | Vaccines | Influenza | Public health | Virology | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 09/2012, Volume 489, Issue 7417, pp. 526 - 532
Immune recognition of protein antigens relies on the combined interaction of multiple antibody loops, which provide a fairly large footprint and constrain the... 
HIV-1 | SYSTEM | POTENT NEUTRALIZATION | EPITOPE | HEMAGGLUTININ | RECOGNITION | STRUCTURAL BASIS | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | BINDING-SITE | BROAD | Influenza A Virus, H1N1 Subtype - immunology | Orthomyxoviridae Infections - prevention & control | Complementarity Determining Regions - genetics | Influenza A virus - chemistry | Cross Reactions - genetics | Molecular Sequence Data | Crystallography, X-Ray | Antibody Specificity - genetics | Hemagglutinin Glycoproteins, Influenza Virus - immunology | Epitopes - immunology | Antibodies, Neutralizing - immunology | Antibody Specificity - immunology | Complementarity Determining Regions - chemistry | Conserved Sequence | Influenza A virus - immunology | Binding Sites | Hemagglutinin Glycoproteins, Influenza Virus - chemistry | Enzyme-Linked Immunosorbent Assay | Models, Molecular | Antigens, Viral - chemistry | Antibodies, Neutralizing - genetics | Cross Reactions - immunology | Influenza A Virus, H3N2 Subtype - immunology | Mutation - genetics | Antigens, Viral - immunology | Animals | Influenza A Virus, H3N2 Subtype - chemistry | Influenza Vaccines - immunology | Antibodies, Neutralizing - chemistry | Antibodies, Viral - chemistry | Complementarity Determining Regions - immunology | Antibodies, Viral - immunology | Protein Conformation | Epitopes - chemistry | Influenza A Virus, H1N1 Subtype - chemistry | Mice | Influenza A virus - classification | Orthomyxoviridae Infections - virology | Antibodies, Viral - genetics | Orthomyxoviridae Infections - immunology | Influenza viruses | Agglutinins | Viruses | Complementarity-determining regions | Research | Observations | Inactivation | Proteins | Infections | Binding sites | Index Medicus
Journal Article
PLoS Pathogens, ISSN 1553-7366, 11/2013, Volume 9, Issue 11, pp. e1003773 - e1003773
Interferons (IFNs) are a group of cytokines with a well-established antiviral function. They can be induced by viral infection, are secreted and bind to... 
CELLS | DEFENSE | VIRUS-INFECTION | DISTINCT | RIG-I | MICROBIOLOGY | IRF-7 | ANTIVIRAL RESPONSE | VIROLOGY | GENE | SIGNALING PATHWAY | ADAPTER PROTEIN | PARASITOLOGY | Epithelial Cells - metabolism | Influenza A virus - genetics | Respiratory Mucosa - virology | Interferon Regulatory Factor-7 - genetics | Interferon Type I - immunology | Interferon Regulatory Factor-3 - genetics | Interleukins - metabolism | Orthomyxoviridae Infections - genetics | Respiratory Mucosa - pathology | Interleukins - genetics | Interleukins - immunology | Respiratory Mucosa - immunology | Adaptor Proteins, Signal Transducing - immunology | Interferon Type I - metabolism | Influenza A virus - immunology | Membrane Proteins - metabolism | Interferon Regulatory Factor-3 - immunology | Nerve Tissue Proteins - immunology | Membrane Proteins - genetics | Orthomyxoviridae Infections - metabolism | Epithelial Cells - pathology | Membrane Proteins - immunology | Interferon Regulatory Factor-7 - immunology | Interferon Regulatory Factor-7 - metabolism | Nerve Tissue Proteins - genetics | Mice, Knockout | Nerve Tissue Proteins - metabolism | Animals | Influenza A virus - metabolism | Epithelial Cells - immunology | Epithelial Cells - virology | Adaptor Proteins, Signal Transducing - genetics | Interferon Regulatory Factor-3 - metabolism | Interferon Type I - genetics | Mice | Respiratory Mucosa - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Orthomyxoviridae Infections - immunology | Epithelial cells | Influenza | Physiological aspects | Host-parasite relationships | Interferon | Genetic aspects | Genetic transcription | Research | Health aspects | Airway (Medicine) | Index Medicus | Interleukins/metabolism | Nerve Tissue Proteins/immunology | Orthomyxoviridae Infections/genetics | Orthomyxoviridae Infections/metabolism | Membrane Proteins/genetics | Adaptor Proteins, Signal Transducing/genetics | Interferon Regulatory Factor-7/genetics | Interleukins/immunology | Membrane Proteins/immunology | Life Sciences | Orthomyxoviridae Infections/immunology | Influenza A virus/genetics | Nerve Tissue Proteins/metabolism | Respiratory Mucosa/immunology | Immunology | Interferon Type I/immunology | Epithelial Cells/immunology | Epithelial Cells/virology | Interferon Regulatory Factor-7/immunology | Epithelial Cells/metabolism | Interferon Regulatory Factor-3/immunology | Respiratory Mucosa/pathology | Influenza A virus/immunology | Interleukins/genetics | Interferon Regulatory Factor-3/genetics | Influenza A virus/metabolism | Adaptor Proteins, Signal Transducing/metabolism | Epithelial Cells/pathology | Adaptor Proteins, Signal Transducing/immunology | Interferon Type I/genetics | Interferon Regulatory Factor-3/metabolism | Membrane Proteins/metabolism | Nerve Tissue Proteins/genetics | Interferon Regulatory Factor-7/metabolism | Interferon Type I/metabolism | Respiratory Mucosa/metabolism | Respiratory Mucosa/virology | Cytokines | Genes | Rodents | Genomics | Genomes | Kinases | Experiments | Viral infections
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2014, Volume 111, Issue 22, pp. 8107 - 8112
The source, timing, and geographical origin of the 1918–1920 pandemic influenza A virus have remained tenaciously obscure for nearly a century, as have the... 
H1N1 subtype influenza A virus | Pandemics | Influenza A virus | Swine | Mortality | Childhood | Antibodies | Viruses | Immunity | Age groups | Pathogenicity | Cohort immunity | Phylogeny | Reassortment | Virulence | UNITED-STATES | MORTALITY | reassortment | ORIGINAL ANTIGENIC SIN | NEUTRALIZING ANTIBODIES | MULTIDISCIPLINARY SCIENCES | HUMAN SERA | PATTERNS | cohort immunity | pathogenicity | RESPONSES | DIFFERENT AGES | virulence | phylogeny | INFECTION | EPIDEMIOLOGY | Influenza A Virus, H1N1 Subtype - immunology | Reassortant Viruses - pathogenicity | Humans | Influenza A virus - genetics | Reassortant Viruses - genetics | Disease Resistance - immunology | Influenza A Virus, H5N1 Subtype - genetics | Influenza A Virus, H3N2 Subtype - genetics | Influenza A Virus, H3N8 Subtype - genetics | Influenza A Virus, H3N8 Subtype - pathogenicity | Influenza A Virus, H7N9 Subtype - immunology | Genetic Variation | Reassortant Viruses - immunology | Influenza A Virus, H7N9 Subtype - pathogenicity | Influenza A virus - pathogenicity | Influenza, Human - mortality | Adult | Influenza A virus - immunology | Influenza, Human - virology | Child | Influenza A Virus, H1N1 Subtype - genetics | Influenza A Virus, H3N2 Subtype - pathogenicity | Influenza Pandemic, 1918-1919 - mortality | Birds | Influenza A Virus, H1N1 Subtype - pathogenicity | Influenza A Virus, H3N2 Subtype - immunology | Biological Evolution | Animals | Influenza A Virus, H3N8 Subtype - immunology | Influenza A Virus, H5N1 Subtype - immunology | Influenza A Virus, H5N1 Subtype - pathogenicity | Aged | Influenza A Virus, H7N9 Subtype - genetics | Causes of | Epidemics | United States | Swine influenza | Phylogenetics | Pathogenesis | Avian flu | Index Medicus | Biological Sciences
Journal Article
Nature Immunology, ISSN 1529-2908, 03/2017, Volume 18, Issue 4, pp. 456 - 463
Immunodominance (ID) defines the hierarchical immune response to competing antigens in complex immunogens. Little is known regarding B cell and antibody ID... 
ANTIGENIC SIN RESPONSES | IMMUNE-RESPONSE | HEMAGGLUTININ | MEMORY | INFECTION | GENERATION | MICE | IMMUNOLOGY | ANTIBODY-RESPONSE | MONOCLONAL-ANTIBODIES | INFLUENZA-VIRUSES | Immunodominant Epitopes - immunology | Virus Diseases - virology | Hemagglutinin Glycoproteins, Influenza Virus - immunology | Antibodies, Viral - blood | Host-Pathogen Interactions - immunology | Orthomyxoviridae Infections - genetics | CD4-Positive T-Lymphocytes - immunology | Influenza A virus - immunology | Virus Diseases - genetics | B-Lymphocytes - metabolism | Hemagglutinin Glycoproteins, Influenza Virus - chemistry | Immunization | Virus Diseases - immunology | Immunodominant Epitopes - chemistry | CD4-Positive T-Lymphocytes - metabolism | Models, Molecular | Antigens, Viral - chemistry | Viruses - immunology | Lymph Nodes - immunology | Antigens, Viral - immunology | Animals | B-Lymphocytes - immunology | Host-Pathogen Interactions - genetics | Antibodies, Viral - immunology | Immunologic Memory | Protein Conformation | Mice | Genetic Background | Orthomyxoviridae Infections - immunology | Antigen-antibody reactions | Genetic aspects | Immune response | Host-virus relationships | Viral proteins | Health aspects | Index Medicus | Viral | Antibodies | B-Lymphocytes | Viruses | Immunologi inom det medicinska området | Mikrobiologi inom det medicinska området | Molecular | genetics | CD4-Positive T-Lymphocytes | Orthomyxoviridae Infections | immunology | Immunology in the medical area | Hemagglutinin Glycoproteins | Virus Diseases | chemistry | Antigens | Influenza Virus | blood | Lymph Nodes | Host-Pathogen Interactions | Microbiology in the medical area | Influenza A virus | virology | metabolism | Models | Immunodominant Epitopes
Journal Article