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PLoS pathogens, ISSN 1553-7374, 11/2013, Volume 9, Issue 11, pp. e1003773 - e1003773
.... Here we show that airway epithelia, the primary target of influenza A virus, produce both IFN I and III upon infection, and that induction of both depends on the RIG-I/MAVS pathway... 
Parasitology | Life Sciences & Biomedicine | Microbiology | Science & Technology | Virology | Epithelial Cells - metabolism | Influenza A virus - genetics | Respiratory Mucosa - virology | Interferon Regulatory Factor-7 - genetics | Interferon Type I - immunology | Interferon Regulatory Factor-3 - genetics | Interleukins - metabolism | Orthomyxoviridae Infections - genetics | Respiratory Mucosa - pathology | Interleukins - genetics | Interleukins - immunology | Respiratory Mucosa - immunology | Adaptor Proteins, Signal Transducing - immunology | Interferon Type I - metabolism | Influenza A virus - immunology | Membrane Proteins - metabolism | Interferon Regulatory Factor-3 - immunology | Nerve Tissue Proteins - immunology | Membrane Proteins - genetics | Orthomyxoviridae Infections - metabolism | Epithelial Cells - pathology | Membrane Proteins - immunology | Interferon Regulatory Factor-7 - immunology | Interferon Regulatory Factor-7 - metabolism | Nerve Tissue Proteins - genetics | Mice, Knockout | Nerve Tissue Proteins - metabolism | Animals | Influenza A virus - metabolism | Epithelial Cells - immunology | Epithelial Cells - virology | Adaptor Proteins, Signal Transducing - genetics | Interferon Regulatory Factor-3 - metabolism | Interferon Type I - genetics | Mice | Respiratory Mucosa - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Orthomyxoviridae Infections - immunology | Epithelial cells | Influenza | Physiological aspects | Host-parasite relationships | Interferon | Genetic aspects | Genetic transcription | Research | Health aspects | Airway (Medicine) | Index Medicus | Interleukins/metabolism | Nerve Tissue Proteins/immunology | Orthomyxoviridae Infections/genetics | Orthomyxoviridae Infections/metabolism | Membrane Proteins/genetics | Adaptor Proteins, Signal Transducing/genetics | Interferon Regulatory Factor-7/genetics | Interleukins/immunology | Membrane Proteins/immunology | Life Sciences | Orthomyxoviridae Infections/immunology | Influenza A virus/genetics | Nerve Tissue Proteins/metabolism | Respiratory Mucosa/immunology | Immunology | Interferon Type I/immunology | Epithelial Cells/immunology | Epithelial Cells/virology | Interferon Regulatory Factor-7/immunology | Epithelial Cells/metabolism | Interferon Regulatory Factor-3/immunology | Respiratory Mucosa/pathology | Influenza A virus/immunology | Interleukins/genetics | Interferon Regulatory Factor-3/genetics | Influenza A virus/metabolism | Adaptor Proteins, Signal Transducing/metabolism | Epithelial Cells/pathology | Adaptor Proteins, Signal Transducing/immunology | Interferon Type I/genetics | Interferon Regulatory Factor-3/metabolism | Membrane Proteins/metabolism | Nerve Tissue Proteins/genetics | Interferon Regulatory Factor-7/metabolism | Interferon Type I/metabolism | Respiratory Mucosa/metabolism | Respiratory Mucosa/virology | Cytokines | Genes | Rodents | Genomics | Genomes | Kinases | Experiments | Viral infections
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 4/2012, Volume 109, Issue 16, pp. 6247 - 6252
Influenza viruses are the cause of yearly epidemics and occasional pandemics that represent a significant challenge to public health... 
Proteins | Molecules | Influenza A virus | RNA | Molecular interactions | Antivirals | Viruses | Orthomyxoviridae | Cytotoxicity | Inhibitory concentration 50 | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Small Molecule Libraries - pharmacology | Influenza A Virus, H3N2 Subtype - drug effects | Humans | Influenza A virus - genetics | RNA Replicase - metabolism | Drug Resistance, Viral | Influenza A Virus, H3N2 Subtype - metabolism | Green Fluorescent Proteins - genetics | Influenza A Virus, H3N2 Subtype - genetics | Protein Subunits - metabolism | Influenza B virus - genetics | Protein Binding - drug effects | HEK293 Cells | Inhibitory Concentration 50 | Influenza B virus - drug effects | Influenza A Virus, H1N1 Subtype - genetics | Influenza A Virus, H1N1 Subtype - metabolism | Vero Cells | Oseltamivir - pharmacology | Protein Structure, Tertiary | Cell Line | Cell Survival - drug effects | Green Fluorescent Proteins - metabolism | Antiviral Agents - pharmacology | Cells, Cultured | Models, Molecular | Influenza A Virus, H1N1 Subtype - drug effects | Microscopy, Confocal | Animals | Influenza A virus - metabolism | RNA Replicase - chemistry | Cell Line, Tumor | Influenza B virus - metabolism | Protein Subunits - chemistry | Influenza A virus - drug effects | Influenza viruses | Disease transmission | Viral genetics | Transferases | Physiological aspects | Genetic aspects | Research | Health aspects | Index Medicus | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 05/2014, Volume 111, Issue 22, pp. E2241 - E2250
Journal Article
PLoS pathogens, ISSN 1553-7374, 04/2013, Volume 9, Issue 4, pp. e1003256 - e1003256
Influenza A virus (IAV) triggers a contagious and potentially lethal respiratory disease... 
Parasitology | Life Sciences & Biomedicine | Microbiology | Science & Technology | Virology | Epithelial Cells - metabolism | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Caspase 1 - metabolism | Male | Tripartite Motif Proteins | Lung - virology | RNA Interference | Respiratory Mucosa - immunology | HEK293 Cells | Cytoskeletal Proteins - metabolism | Lung - metabolism | Toll-Like Receptor 3 - genetics | DEAD-box RNA Helicases - metabolism | Influenza A Virus, H1N1 Subtype - metabolism | Macrophages - immunology | DEAD Box Protein 58 | Respiratory Mucosa - cytology | Signal Transduction | Cells, Cultured | Ubiquitin-Protein Ligases - metabolism | Ferrets | Toll-Like Receptor 3 - metabolism | Transcription Factors - metabolism | Carrier Proteins - genetics | DEAD-box RNA Helicases - genetics | Animals | Carrier Proteins - metabolism | Interferon-beta - metabolism | Caspase 1 - genetics | CARD Signaling Adaptor Proteins | Viral Nonstructural Proteins - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Index Medicus | Cytoskeletal Proteins | Toll-Like Receptor 3 | Interferon-beta | Lung | Macrophages | Life Sciences | Influenza A Virus, H1N1 Subtype | Caspase 1 | Carrier Proteins | Viral Nonstructural Proteins | DEAD-box RNA Helicases | Inflammasomes | Respiratory Mucosa | Epithelial Cells | Ubiquitin-Protein Ligases | Microbiology and Parasitology | Adaptor Proteins, Signal Transducing | Transcription Factors | Proteins | Medical research | Experiments | Respiratory diseases | Influenza
Journal Article
Journal of virology, ISSN 0022-538X, 06/2010, Volume 84, Issue 17, pp. 8433 - 8445
Journal Article
Journal Article