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PLoS pathogens, ISSN 1553-7374, 11/2013, Volume 9, Issue 11, pp. e1003773 - e1003773
.... Here we show that airway epithelia, the primary target of influenza A virus, produce both IFN I and III upon infection, and that induction of both depends on the RIG-I/MAVS pathway... 
Parasitology | Life Sciences & Biomedicine | Microbiology | Science & Technology | Virology | Epithelial Cells - metabolism | Influenza A virus - genetics | Respiratory Mucosa - virology | Interferon Regulatory Factor-7 - genetics | Interferon Type I - immunology | Interferon Regulatory Factor-3 - genetics | Interleukins - metabolism | Orthomyxoviridae Infections - genetics | Respiratory Mucosa - pathology | Interleukins - genetics | Interleukins - immunology | Respiratory Mucosa - immunology | Adaptor Proteins, Signal Transducing - immunology | Interferon Type I - metabolism | Influenza A virus - immunology | Membrane Proteins - metabolism | Interferon Regulatory Factor-3 - immunology | Nerve Tissue Proteins - immunology | Membrane Proteins - genetics | Orthomyxoviridae Infections - metabolism | Epithelial Cells - pathology | Membrane Proteins - immunology | Interferon Regulatory Factor-7 - immunology | Interferon Regulatory Factor-7 - metabolism | Nerve Tissue Proteins - genetics | Mice, Knockout | Nerve Tissue Proteins - metabolism | Animals | Influenza A virus - metabolism | Epithelial Cells - immunology | Epithelial Cells - virology | Adaptor Proteins, Signal Transducing - genetics | Interferon Regulatory Factor-3 - metabolism | Interferon Type I - genetics | Mice | Respiratory Mucosa - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Orthomyxoviridae Infections - immunology | Epithelial cells | Influenza | Physiological aspects | Host-parasite relationships | Interferon | Genetic aspects | Genetic transcription | Research | Health aspects | Airway (Medicine) | Index Medicus | Interleukins/metabolism | Nerve Tissue Proteins/immunology | Orthomyxoviridae Infections/genetics | Orthomyxoviridae Infections/metabolism | Membrane Proteins/genetics | Adaptor Proteins, Signal Transducing/genetics | Interferon Regulatory Factor-7/genetics | Interleukins/immunology | Membrane Proteins/immunology | Life Sciences | Orthomyxoviridae Infections/immunology | Influenza A virus/genetics | Nerve Tissue Proteins/metabolism | Respiratory Mucosa/immunology | Immunology | Interferon Type I/immunology | Epithelial Cells/immunology | Epithelial Cells/virology | Interferon Regulatory Factor-7/immunology | Epithelial Cells/metabolism | Interferon Regulatory Factor-3/immunology | Respiratory Mucosa/pathology | Influenza A virus/immunology | Interleukins/genetics | Interferon Regulatory Factor-3/genetics | Influenza A virus/metabolism | Adaptor Proteins, Signal Transducing/metabolism | Epithelial Cells/pathology | Adaptor Proteins, Signal Transducing/immunology | Interferon Type I/genetics | Interferon Regulatory Factor-3/metabolism | Membrane Proteins/metabolism | Nerve Tissue Proteins/genetics | Interferon Regulatory Factor-7/metabolism | Interferon Type I/metabolism | Respiratory Mucosa/metabolism | Respiratory Mucosa/virology | Cytokines | Genes | Rodents | Genomics | Genomes | Kinases | Experiments | Viral infections
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 07/2011, Volume 333, Issue 6044, pp. 843 - 850
Current flu vaccines provide only limited coverage against seasonal strains of influenza viruses... 
Influenza A virus | RESEARCH ARTICLES | Vaccination | Cardiopulmonary resuscitation | Antibodies | Viruses | Orthomyxoviridae | Infections | Epitopes | H3N2 subtype influenza A virus | Crystal structure | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Orthomyxoviridae Infections - prevention & control | Antibody Specificity | Humans | Molecular Sequence Data | Antigens, Viral - genetics | Crystallography, X-Ray | Neutralization Tests | Hemagglutinin Glycoproteins, Influenza Virus - immunology | Hemagglutinin Glycoproteins, Influenza Virus - genetics | Epitopes - immunology | Antibodies, Neutralizing - immunology | Conserved Sequence | Influenza A Virus, H7N7 Subtype - immunology | Influenza A virus - immunology | Influenza, Human - therapy | Antibodies, Monoclonal - immunology | Amino Acid Sequence | Hemagglutinin Glycoproteins, Influenza Virus - chemistry | Models, Molecular | Antigens, Viral - chemistry | Antibodies, Monoclonal - isolation & purification | Influenza A Virus, H3N2 Subtype - immunology | Antibodies, Viral - isolation & purification | Antibodies, Neutralizing - isolation & purification | Antigens, Viral - immunology | Animals | Influenza Vaccines - immunology | Antibodies, Viral - immunology | Protein Conformation | Mice | Influenza A Virus, H7N7 Subtype - genetics | Mutation | Binding Sites, Antibody | Influenza, Human - prevention & control | Orthomyxoviridae Infections - immunology | Influenza, Human - immunology | Influenza viruses | Influenza vaccines | Crystals | Monoclonal antibodies | Physiological aspects | Research | Properties | Structure | Vaccines | Influenza | Public health | Virology | Index Medicus | fusion | peptide | avian influenza | hemagglutinin | recognition | monoclonal-antibodies | season | vaccination | subtypes
Journal Article
Nature (London), ISSN 1476-4687, 09/2012, Volume 489, Issue 7417, pp. 526 - 532
.... Here we report the isolation and characterization of an antibody called C05, which neutralizes strains from multiple subtypes of influenza A virus, including H1, H2 and H3... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Influenza A Virus, H1N1 Subtype - immunology | Orthomyxoviridae Infections - prevention & control | Complementarity Determining Regions - genetics | Influenza A virus - chemistry | Cross Reactions - genetics | Molecular Sequence Data | Crystallography, X-Ray | Antibody Specificity - genetics | Hemagglutinin Glycoproteins, Influenza Virus - immunology | Epitopes - immunology | Antibodies, Neutralizing - immunology | Antibody Specificity - immunology | Complementarity Determining Regions - chemistry | Conserved Sequence | Influenza A virus - immunology | Binding Sites | Hemagglutinin Glycoproteins, Influenza Virus - chemistry | Enzyme-Linked Immunosorbent Assay | Models, Molecular | Antigens, Viral - chemistry | Antibodies, Neutralizing - genetics | Cross Reactions - immunology | Influenza A Virus, H3N2 Subtype - immunology | Mutation - genetics | Antigens, Viral - immunology | Animals | Influenza A Virus, H3N2 Subtype - chemistry | Influenza Vaccines - immunology | Antibodies, Neutralizing - chemistry | Antibodies, Viral - chemistry | Complementarity Determining Regions - immunology | Antibodies, Viral - immunology | Protein Conformation | Epitopes - chemistry | Influenza A Virus, H1N1 Subtype - chemistry | Mice | Influenza A virus - classification | Orthomyxoviridae Infections - virology | Antibodies, Viral - genetics | Orthomyxoviridae Infections - immunology | Influenza viruses | Agglutinins | Viruses | Complementarity-determining regions | Research | Observations | Inactivation | Proteins | Infections | Binding sites | Index Medicus
Journal Article
Nature (London), ISSN 1476-4687, 04/2008, Volume 453, Issue 7195, pp. 667 - 671
Journal Article
The Journal of infectious diseases, ISSN 1537-6613, 07/2014, Volume 210, Issue 1, pp. 126 - 137
Background. We estimate vaccine effectiveness (VE) against both influenza A/subtypes and B/lineages in Canada for the 2011-2012 trivalent inactivated influenza vaccine (TIV... 
Influenza vaccines | Viral vaccines | Influenza A virus | Comorbidity | Sentinel surveillance | Vaccine components | Specimens | Viruses | Inactivated vaccines | H3N2 subtype influenza A virus | Influenza A subtype | Influenza B lineage | Influenza | Vaccine effectiveness | Vaccines and immunisation | Trivalent influenza vaccine | Infectious Diseases | Immunology | Life Sciences & Biomedicine | Microbiology | Science & Technology | Influenza Vaccines - administration & dosage | Humans | Influenza A virus - genetics | Middle Aged | Child, Preschool | Molecular Sequence Data | Antigens, Viral - genetics | Infant | Male | Hemagglutinin Glycoproteins, Influenza Virus - immunology | Case-Control Studies | Hemagglutinin Glycoproteins, Influenza Virus - genetics | Hemagglutination Inhibition Tests | Young Adult | Influenza B virus - genetics | Vaccination - methods | Canada - epidemiology | Aged, 80 and over | Adult | Female | Influenza A virus - immunology | Influenza, Human - virology | Influenza B virus - immunology | Child | Influenza B virus - classification | Influenza B virus - isolation & purification | Influenza, Human - epidemiology | Treatment Outcome | Influenza A virus - isolation & purification | Sequence Analysis, DNA | Antigens, Viral - immunology | Influenza Vaccines - immunology | Adolescent | Aged | Influenza A virus - classification | Influenza, Human - prevention & control | Influenza, Human - immunology | Care and treatment | Analysis | Research | Health aspects | Sentinel health events | Index Medicus | Abridged Index Medicus
Journal Article
Nature immunology, ISSN 1529-2916, 02/2019, Volume 20, Issue 3, pp. 362 - 372
The present vaccine against influenza virus has the inevitable risk of antigenic discordance between the vaccine and the circulating strains, which diminishes vaccine efficacy... 
Life Sciences & Biomedicine | Immunology | Science & Technology | Influenza A Virus, H1N1 Subtype - immunology | Orthomyxoviridae Infections - prevention & control | Antibodies, Neutralizing - administration & dosage | Influenza Vaccines - administration & dosage | Nanoparticles - chemistry | Humans | Influenza A Virus, H1N1 Subtype - physiology | Hemagglutinin Glycoproteins, Influenza Virus - immunology | Antibodies, Neutralizing - immunology | B-Lymphocytes - virology | Female | Influenza, Human - virology | Influenza A Virus, H1N1 Subtype - metabolism | Hemagglutinin Glycoproteins, Influenza Virus - chemistry | Immunization | Cross Reactions - immunology | B-Lymphocytes - drug effects | Animals | B-Lymphocytes - immunology | Influenza Vaccines - immunology | Influenza Vaccines - chemistry | Antibodies, Viral - immunology | Cross Reactions - drug effects | Mice, Inbred BALB C | Influenza, Human - prevention & control | Orthomyxoviridae Infections - virology | Orthomyxoviridae Infections - immunology | Influenza, Human - immunology | Viral antibodies | Nanoparticles | Influenza vaccines | Influenza viruses | Composition | Immune response | Antibodies | Glycoproteins | Research | B cells | Health aspects | Immunological research | Antigens | Discordance | Admixtures | Viruses | Vaccines | Immunodominance | Lymphocytes B | Influenza | Monoclonal antibodies | Hemagglutinins | Avidity | Strains (organisms) | Index Medicus
Journal Article
The Journal of infectious diseases, ISSN 0022-1899, 1/2009, Volume 199, Issue 2, pp. 159 - 167
Background. We estimated the effectiveness of inactivated influenza vaccines for the prevention of laboratoryconfirmed, medically attended influenza during 3... 
Influenza vaccines | Reverse transcriptase polymerase chain reaction | Vaccination | Viruses | Orthomyxoviridae | Preventive medicine | Older adults | Epidemiology | Diseases | Age groups | Influenza A Virus, H1N1 Subtype - immunology | Influenza Vaccines - administration & dosage | Influenza A Virus, H1N1 Subtype - classification | Wisconsin - epidemiology | Humans | Influenza A virus - genetics | Middle Aged | Child, Preschool | Male | Influenza A Virus, H3N2 Subtype - genetics | Case-Control Studies | Young Adult | Influenza B virus - genetics | Influenza A Virus, H1N1 Subtype - isolation & purification | Influenza A Virus, H3N2 Subtype - isolation & purification | Adult | Female | Influenza A virus - immunology | Influenza, Human - virology | Influenza B virus - immunology | Seasons | Child | Influenza A Virus, H1N1 Subtype - genetics | Influenza B virus - classification | Influenza A Virus, H3N2 Subtype - classification | Influenza B virus - isolation & purification | Influenza, Human - epidemiology | Treatment Outcome | Influenza A virus - isolation & purification | Influenza A Virus, H3N2 Subtype - immunology | Reverse Transcriptase Polymerase Chain Reaction | Vaccines, Inactivated - immunology | Influenza Vaccines - immunology | Vaccines, Inactivated - administration & dosage | Adolescent | Aged | Influenza A virus - classification | Influenza, Human - prevention & control | Population Surveillance | Prevention | Demographic aspects | Influenza | Distribution | Dosage and administration | Research | Index Medicus | Abridged Index Medicus
Journal Article
Nature immunology, ISSN 1529-2916, 02/2017, Volume 18, Issue 4, pp. 456 - 463
.... Little is known regarding B cell and antibody ID despite its importance in immunity to viruses and other pathogens... 
Life Sciences & Biomedicine | Immunology | Science & Technology | Immunodominant Epitopes - immunology | Virus Diseases - virology | Hemagglutinin Glycoproteins, Influenza Virus - immunology | Antibodies, Viral - blood | Host-Pathogen Interactions - immunology | Orthomyxoviridae Infections - genetics | CD4-Positive T-Lymphocytes - immunology | Influenza A virus - immunology | Virus Diseases - genetics | B-Lymphocytes - metabolism | Hemagglutinin Glycoproteins, Influenza Virus - chemistry | Immunization | Virus Diseases - immunology | Immunodominant Epitopes - chemistry | CD4-Positive T-Lymphocytes - metabolism | Models, Molecular | Antigens, Viral - chemistry | Viruses - immunology | Lymph Nodes - immunology | Antigens, Viral - immunology | Animals | B-Lymphocytes - immunology | Host-Pathogen Interactions - genetics | Antibodies, Viral - immunology | Immunologic Memory | Protein Conformation | Mice | Genetic Background | Orthomyxoviridae Infections - immunology | Antigen-antibody reactions | Genetic aspects | Immune response | Host-virus relationships | Viral proteins | Health aspects | Index Medicus | Viral | Antibodies | B-Lymphocytes | Viruses | Immunologi inom det medicinska området | Mikrobiologi inom det medicinska området | Molecular | genetics | CD4-Positive T-Lymphocytes | Orthomyxoviridae Infections | immunology | Immunology in the medical area | Hemagglutinin Glycoproteins | Virus Diseases | chemistry | Antigens | Influenza Virus | blood | Lymph Nodes | Host-Pathogen Interactions | Microbiology in the medical area | Influenza A virus | virology | metabolism | Models | Immunodominant Epitopes
Journal Article