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Science, ISSN 0036-8075, 10/2011, Volume 334, Issue 6054, pp. 376 - 380
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 09/2012, Volume 19, Issue 9, pp. 876 - 883
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 07/2018, Volume 17, Issue 7, pp. 1381 - 1391
Because of their roles in the evasion of apoptosis, inhibitor of apoptosis proteins (IAP) are considered attractive targets for anticancer therapy. Antagonists... 
SMAC-MIMETIC BIRINAPANT | X-LINKED INHIBITOR | SMALL-MOLECULE ANTAGONIST | SOLID TUMORS | ONCOLOGY | STRUCTURAL BASIS | CLINICAL CANDIDATE | PROGNOSTIC MARKER | PHASE-I | IAP PROTEINS | DISCOVERY | Tumor Necrosis Factor-alpha - metabolism | Protein Interaction Domains and Motifs - drug effects | Apoptosis - drug effects | Humans | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Dose-Response Relationship, Drug | Xenograft Model Antitumor Assays | X-Linked Inhibitor of Apoptosis Protein - antagonists & inhibitors | Molecular Mimicry | Animals | Inhibitor of Apoptosis Proteins - chemistry | Inhibitor of Apoptosis Proteins - antagonists & inhibitors | X-Linked Inhibitor of Apoptosis Protein - chemistry | X-Linked Inhibitor of Apoptosis Protein - metabolism | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Inhibitor of Apoptosis Proteins - metabolism | Mice | Disease Models, Animal | Biotechnology | Animal models | Downstream effects | Xenotransplantation | XIAP protein | Antagonists | Drug development | Proteins | Antagonism | Xenografts | NF-κB protein | IAP protein | Melanoma | Caspase | Tumor cell lines | Tumor necrosis factor-α | DIABLO protein | Signaling | Cell death | Peptidomimetics | Cell lines | Caspase-9 | Proteasomes | Cancer | Apoptosis | Tumors
Journal Article
Science, ISSN 0036-8075, 2/2008, Volume 319, Issue 5866, pp. 1092 - 1096
Mammalian telomeres are protected by a six-protein complex: shelterin. Shelterin contains two closely related proteins (TRF1 and TRF2), which recruit various... 
Proteins | Telomeres | Colors | Atomic interactions | Amino acids | Reports | Grants | Electrostatics | Binding sites | Crystal structure | COMPLEX | DNA | INTERACTS | MULTIDISCIPLINARY SCIENCES | POLYMERASE | APOLLO | TIN2 | Humans | Molecular Sequence Data | Telomeric Repeat Binding Protein 1 - metabolism | Crystallography, X-Ray | TATA Box Binding Protein-Like Proteins - metabolism | Telomeric Repeat Binding Protein 1 - chemistry | Telomere-Binding Proteins - genetics | Inhibitor of Apoptosis Proteins - chemistry | TATA Box Binding Protein-Like Proteins - genetics | Tumor Suppressor Proteins - chemistry | TATA Box Binding Protein-Like Proteins - chemistry | Inhibitor of Apoptosis Proteins - metabolism | Nuclear Proteins - genetics | Telomere-Binding Proteins - metabolism | Dimerization | Protein Structure, Tertiary | Amino Acid Sequence | Tumor Suppressor Proteins - metabolism | Protein Structure, Secondary | Telomeric Repeat Binding Protein 2 | Models, Molecular | Mutant Proteins - metabolism | Nuclear Proteins - metabolism | Nuclear Proteins - chemistry | Amino Acid Motifs | Hydrogen Bonding | Mutant Proteins - chemistry | Hydrophobic and Hydrophilic Interactions | Protein Binding | Protein Conformation | Telomere-Binding Proteins - chemistry | Cellular proteins | Evaluation | Thyrotropin releasing factor | Influence | Properties | Protein binding | Protons | Biochemistry
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2013, Volume 288, Issue 18, pp. 13022 - 13035
Journal Article