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Immunity, ISSN 1074-7613, 02/2012, Volume 36, Issue 2, pp. 215 - 227
Interleukin-1β (IL-1β) is a potent inflammatory cytokine that is usually cleaved and activated by inflammasome-associated caspase-1. To determine whether IL-1β... 
STERILE INFLAMMATORY RESPONSE | PROGRAMMED NECROSIS | CASPASE-8 | IL-1-BETA | NLRP3 INFLAMMASOME | TNF-ALPHA | IMMUNOLOGY | NF-KAPPA-B | CIAP1 | NALP3 INFLAMMASOME | CELL-DEATH | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | X-Linked Inhibitor of Apoptosis Protein - deficiency | Inflammasomes - metabolism | Reactive Oxygen Species - metabolism | Inhibitor of Apoptosis Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Caspase 1 - metabolism | Baculoviral IAP Repeat-Containing 3 Protein | Mitochondrial Proteins - agonists | Carrier Proteins - agonists | Inhibitor of Apoptosis Proteins - deficiency | Molecular Mimicry | Interleukin-1beta - metabolism | Inhibitor of Apoptosis Proteins - antagonists & inhibitors | Inhibitor of Apoptosis Proteins - metabolism | Macrophages - immunology | Macrophages - cytology | X-Linked Inhibitor of Apoptosis Protein - genetics | Mice, Knockout | Ubiquitin-Protein Ligases | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Inflammasomes - immunology | X-Linked Inhibitor of Apoptosis Protein - metabolism | Macrophages - drug effects | Mice | Apoptosis | Proteins | Interleukins | Genes | Membranes | Mammals | Immune system | Caspase-8 | DIABLO protein | Cell activation | IAP protein | Reactive oxygen species | Interleukin 1 | Toll-like receptors | XIAP protein | Inflammation | Macrophages | Caspase-1 | Index Medicus
Journal Article
Molecular Cell, ISSN 1097-2765, 08/2011, Volume 43, Issue 3, pp. 432 - 448
A better understanding of the mechanisms through which anticancer drugs exert their effects is essential to improve combination therapies. While studying how... 
CASPASE INHIBITORS | TUMOR-NECROSIS-FACTOR | LIGASE ACTIVITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | ALPHA-DEPENDENT APOPTOSIS | TRAIL-INDUCED APOPTOSIS | TNF-ALPHA | CHEMOTHERAPEUTIC DRUGS | NF-KAPPA-B | CELL-DEATH | CELL BIOLOGY | CASP8 and FADD-Like Apoptosis Regulating Protein - physiology | Apoptosis - drug effects | Inhibitor of Apoptosis Proteins - genetics | Humans | Caspase 8 - metabolism | Nuclear Pore Complex Proteins - chemistry | Caspase 8 - chemistry | Inhibitor of Apoptosis Proteins - physiology | Nuclear Pore Complex Proteins - physiology | Antineoplastic Agents - pharmacology | CASP8 and FADD-Like Apoptosis Regulating Protein - metabolism | Fas-Associated Death Domain Protein - physiology | RNA-Binding Proteins - physiology | Signal Transduction | CASP8 and FADD-Like Apoptosis Regulating Protein - genetics | Nuclear Pore Complex Proteins - metabolism | RNA-Binding Proteins - chemistry | Fas-Associated Death Domain Protein - metabolism | Etoposide - pharmacology | Mitochondria - metabolism | Caspase 8 - physiology | Fas-Associated Death Domain Protein - chemistry | Cell Line, Tumor | Ligands | Apoptosis - physiology | DNA Damage | Enzyme Activation | RNA-Binding Proteins - metabolism | Ubiquitin | Green design | Oncology, Experimental | Internet service providers | Research | Sustainable development | Cancer | Index Medicus
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 04/2011, Volume 17, Issue 8, pp. 2140 - 2148
Purpose: EML4-ALK (echinoderm microtubule-associated protein-like 4 anaplastic lymphoma kinase) was recently identified as a transforming fusion gene in... 
ANAPLASTIC LYMPHOMA KINASE | NPM-ALK | GEFITINIB | ONCOLOGY | SURVIVIN | EML4-ALK FUSION GENE | STAT3 | CELL-CYCLE ARREST | MUTATIONS | IDENTIFICATION | EGFR | NIH 3T3 Cells | Oncogene Proteins, Fusion - metabolism | Cell Proliferation | Apoptosis - drug effects | Inhibitor of Apoptosis Proteins - genetics | Protein-Tyrosine Kinases - metabolism | Humans | Lung Neoplasms - metabolism | Immunoblotting | Lung Neoplasms - pathology | Proto-Oncogene Proteins c-akt - genetics | Neoplasms, Experimental - pathology | Protein-Tyrosine Kinases - genetics | Transfection | Bcl-2-Like Protein 11 | RNA Interference | Cell Transformation, Neoplastic - genetics | Mitogen-Activated Protein Kinase 1 - genetics | Neoplasms, Experimental - genetics | Apoptosis Regulatory Proteins - genetics | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Female | Inhibitor of Apoptosis Proteins - metabolism | Membrane Proteins - metabolism | Proto-Oncogene Proteins c-akt - metabolism | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Lung Neoplasms - genetics | Proto-Oncogene Proteins - metabolism | Membrane Proteins - genetics | Proto-Oncogene Proteins - genetics | Pyrimidines - pharmacology | Receptor Protein-Tyrosine Kinases - metabolism | Apoptosis Regulatory Proteins - metabolism | Animals | Signal Transduction - drug effects | Mice, Nude | Oncogene Proteins, Fusion - genetics | Cell Line, Tumor | Mice | Neoplasms, Experimental - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Index Medicus
Journal Article
BMC Cancer, ISSN 1471-2407, 04/2009, Volume 9, Issue 1, pp. 125 - 125
Background: Similarly to other tumor types, an imbalance between unrestrained cell proliferation and impaired apoptosis appears to be a major unfavorable... 
CANCER-CELLS | SMAC/DIABLO | OVEREXPRESSION | SURVIVIN EXPRESSION | ONCOLOGY | CHRONIC LIVER-DISEASE | RENAL-CELL CARCINOMAS | XIAP | X-LINKED-INHIBITOR | XAF1 | GASTRIC ADENOCARCINOMAS | Immunohistochemistry | Prognosis | Follow-Up Studies | Microtubule-Associated Proteins - genetics | Inhibitor of Apoptosis Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Male | Intracellular Signaling Peptides and Proteins - metabolism | Mitochondrial Proteins - genetics | Neoplasm Proteins - metabolism | Mitochondrial Proteins - metabolism | Carcinoma, Hepatocellular - genetics | Aged, 80 and over | Adult | Female | Liver Neoplasms - pathology | Inhibitor of Apoptosis Proteins - metabolism | Neoplasm Proteins - genetics | Intracellular Signaling Peptides and Proteins - genetics | Liver Neoplasms - genetics | Kaplan-Meier Estimate | Chi-Square Distribution | Reverse Transcriptase Polymerase Chain Reaction | X-Linked Inhibitor of Apoptosis Protein - genetics | Analysis of Variance | Adaptor Proteins, Signal Transducing - genetics | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | X-Linked Inhibitor of Apoptosis Protein - metabolism | Aged | Adaptor Proteins, Signal Transducing - metabolism | Apoptosis | Carcinoma, Hepatocellular - metabolism | Control | Care and treatment | Usage | Genetic aspects | Research | Hepatoma | Gene expression | Health aspects | Index Medicus
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 09/2012, Volume 19, Issue 9, pp. 1482 - 1494
Toll-like receptor 3 (TLR3) is a pattern-recognition receptor known to initiate an innate immune response when stimulated by double-stranded RNA (dsRNA).... 
apoptosis | caspase-8 | cancer cells | ubiquitination | Toll-like receptor 3 | RIP1 | HOMOTYPIC INTERACTION MOTIF | CELLS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | IFN-BETA | NECROSIS | TOLL-LIKE RECEPTORS | C-FLIP | TRIF | NF-KAPPA-B | RNA-Binding Proteins - genetics | Apoptosis - drug effects | Inhibitor of Apoptosis Proteins - genetics | Humans | TNF Receptor-Associated Factor 2 - genetics | Caspase 8 - metabolism | Apoptosis - genetics | Baculoviral IAP Repeat-Containing 3 Protein | TNF Receptor-Associated Death Domain Protein - genetics | Caspase 8 - genetics | Nuclear Pore Complex Proteins - genetics | Ubiquitination - drug effects | Inhibitor of Apoptosis Proteins - metabolism | Toll-Like Receptor 3 - genetics | TNF Receptor-Associated Death Domain Protein - metabolism | Nuclear Pore Complex Proteins - metabolism | TNF Receptor-Associated Factor 2 - metabolism | Signal Transduction - genetics | Toll-Like Receptor 3 - metabolism | Ubiquitin-Protein Ligases | Signal Transduction - drug effects | RNA, Double-Stranded - pharmacology | Cell Line, Tumor | RNA-Binding Proteins - metabolism | Ubiquitination - genetics | Index Medicus | Tumor necrosis factor receptors | Immune response | Lung cancer | Double-stranded RNA | TLR3 protein | death receptors | Caspase-8 | FADD protein | Molecular modelling | Toll-like receptors | alpha -Interferon | Ubiquitin-protein ligase | Apoptosis | Original Paper
Journal Article
Molecular Cell, ISSN 1097-2765, 12/2009, Volume 36, Issue 5, pp. 831 - 844
Journal Article
Blood, ISSN 0006-4971, 02/2013, Volume 121, Issue 8, pp. 1403 - 1412
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2010, Volume 285, Issue 35, pp. 27487 - 27498
The S100B-p53 protein complex was discovered in C8146A malignant melanoma, but the consequences of this interaction required further study. When S100B... 
WILD-TYPE P53 | UV-RADIATION | CANCER-CELLS | P53-MEDIATED APOPTOSIS | P53-INDUCED APOPTOSIS | CARCINOMA-CELLS | MDM2 GENE | DIFFERENTIAL EXPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-SUPPRESSOR PROTEIN | PIFITHRIN-ALPHA | RNA, Small Interfering - genetics | Caspase 9 - genetics | Caspase 9 - metabolism | Inhibitor of Apoptosis Proteins - genetics | Membrane Potential, Mitochondrial - radiation effects | Humans | Caspase 3 - metabolism | Cell Survival - genetics | Multiprotein Complexes - genetics | Nerve Growth Factors - metabolism | fas Receptor - metabolism | Death Domain Receptor Signaling Adaptor Proteins | Multiprotein Complexes - metabolism | RNA, Messenger - biosynthesis | Phosphorylation - genetics | S100 Proteins - genetics | Ultraviolet Rays | Caspase 3 - genetics | fas Receptor - genetics | Biomarkers, Tumor - metabolism | Membrane Potential, Mitochondrial - genetics | Inhibitor of Apoptosis Proteins - metabolism | S100 Calcium Binding Protein beta Subunit | Down-Regulation | S100 Proteins - metabolism | Melanoma - pathology | Enzyme Activation - radiation effects | Phosphorylation - radiation effects | RNA, Neoplasm - biosynthesis | Nerve Growth Factors - genetics | Cell Line, Tumor | RNA, Neoplasm - genetics | Biomarkers, Tumor - genetics | Mutation | Transcription, Genetic - genetics | Enzyme Activation - genetics | Caspase 8 - metabolism | Gene Expression Regulation, Neoplastic | Transcription, Genetic - radiation effects | Cytochromes c - genetics | Tumor Suppressor Protein p53 - genetics | Caspase 8 - genetics | Melanoma - genetics | Melanoma - metabolism | Cytochromes c - metabolism | RNA, Messenger - genetics | Tumor Suppressor Protein p53 - metabolism | Cell Survival - radiation effects | Carrier Proteins - genetics | Carrier Proteins - metabolism | Apoptosis | Index Medicus | Molecular Bases of Disease | S100 Proteins | Calcium-binding Proteins | S100B | Cell Biology | p53 | Protein-Protein Interactions | Tumor Suppressor
Journal Article
Blood, ISSN 0006-4971, 04/2016, Volume 127, Issue 17, pp. 2122 - 2130
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2007, Volume 282, Issue 36, pp. 26202 - 26209
X-linked inhibitor of apoptosis (XIAP)-associated factor 1 (XAF1) is a putative tumor suppressor in which expression is significantly reduced in human cancer... 
CANCER-CELLS | SMAC/DIABLO | HYPERMETHYLATION | PROTEIN | XIAP-ASSOCIATED FACTOR-1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOWN-REGULATION | XAF1 EXPRESSION | TRAIL-INDUCED APOPTOSIS | MAMMALIAN-CELLS | UBIQUITIN-PROTEASOME PATHWAY | Microtubule-Associated Proteins - genetics | Apoptosis - drug effects | Inhibitor of Apoptosis Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | Neuronal Apoptosis-Inhibitory Protein - genetics | Ubiquitin - metabolism | Multiprotein Complexes - genetics | Baculoviral IAP Repeat-Containing 3 Protein | Neoplasm Proteins - metabolism | Multiprotein Complexes - metabolism | Tumor Suppressor Proteins - genetics | Inhibitor of Apoptosis Proteins - metabolism | Neoplasm Proteins - genetics | Antiviral Agents - pharmacology | Tumor Suppressor Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Intracellular Signaling Peptides and Proteins | Ubiquitin - genetics | Down-Regulation - drug effects | Neuronal Apoptosis-Inhibitory Protein - metabolism | X-Linked Inhibitor of Apoptosis Protein - genetics | Down-Regulation - physiology | Leupeptins - pharmacology | Mitosis - drug effects | Interferon-beta - pharmacology | Mitosis - physiology | Cysteine Proteinase Inhibitors - pharmacology | Adaptor Proteins, Signal Transducing - genetics | X-Linked Inhibitor of Apoptosis Protein - metabolism | Cell Line, Tumor | Apoptosis - physiology | Adaptor Proteins, Signal Transducing - metabolism | Ubiquitin-Protein Ligases - genetics | Index Medicus
Journal Article