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Apoptosis (London), ISSN 1573-675X, 2017, Volume 22, Issue 7, pp. 898 - 919
Inhibitors of apoptosis (IAPs) are a family of proteins that play a significant role in the control of programmed cell death (PCD... 
Chemotherapy resistance | Intrinsic apoptotic pathway | Combination therapy | Extrinsic apoptotic pathway | Inhibitors of apoptosis proteins | HEPATOCELLULAR-CARCINOMA CELLS | X-LINKED INHIBITOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | EFFICIENTLY INDUCES APOPTOSIS | ORALLY-ACTIVE ANTAGONIST | ACUTE MYELOID-LEUKEMIA | CELL BIOLOGY | CELL LUNG-CANCER | SMAC MIMETIC BIRINAPANT | TRAIL-INDUCED APOPTOSIS | THORACIC RADIATION-THERAPY | NF-KAPPA-B | Apoptosis - drug effects | Inhibitor of Apoptosis Proteins - genetics | Humans | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Mitochondrial Proteins - antagonists & inhibitors | Apoptosis - genetics | Mitochondrial Proteins - genetics | X-Linked Inhibitor of Apoptosis Protein - genetics | Neoplasms - drug therapy | Drug Resistance, Neoplasm - genetics | Neoplasms - genetics | Inhibitor of Apoptosis Proteins - antagonists & inhibitors | Neoplasms - pathology | Intracellular Signaling Peptides and Proteins - genetics | TNF-Related Apoptosis-Inducing Ligand - genetics | Proteins | Viral antibodies | Chemotherapy | Antibodies | Metastasis | Drug resistance | Cancer | Apoptosis | Biotechnology | XIAP protein | Infections | Metastases | Anticancer properties | Analogs | Mitochondria | Antagonism | Cell cycle | Cell survival | Mortality | Caspase | Survivin | Tumor cell lines | Survival | DIABLO protein | Inhibitors | Reviews | Cell death | TRAIL protein | Review
Journal Article
Nature (London), ISSN 1476-4687, 2018, Volume 562, Issue 7725, pp. 69 - 75
Primary liver cancer represents a major health problem. It comprises hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC), which differ... 
PATHOGENESIS | HEPATOCELLULAR-CARCINOMA | READ ALIGNMENT | HEPATOCYTES | DNA | INFLAMMATION | PACKAGE | MULTIDISCIPLINARY SCIENCES | FRAMEWORK | BINDING | DISCOVERY | Humans | Tumor Microenvironment | Apoptosis - genetics | Hepatocytes - pathology | Male | Gene Expression Profiling | Genes, myc | Hepatocytes - metabolism | Proto-Oncogene Proteins c-akt - genetics | DNA-Binding Proteins - metabolism | Carcinoma, Hepatocellular - genetics | DNA Transposable Elements - genetics | Female | Liver Neoplasms - pathology | Cell Differentiation | Cell Lineage - genetics | Disease Models, Animal | Cyclin-Dependent Kinase Inhibitor p16 - deficiency | Cytokines - metabolism | Liver Neoplasms - genetics | Carcinogenesis - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | T-Box Domain Proteins - genetics | T-Box Domain Proteins - metabolism | Transcription Factors - metabolism | Cholangiocarcinoma - pathology | Animals | Epigenesis, Genetic - genetics | Carcinoma, Hepatocellular - pathology | Cholangiocarcinoma - genetics | Mosaicism | Mice | Necrosis - genetics | Genes, ras | Liver cancer | Research | Carcinogenesis | Oncology, Experimental | Apoptosis | Cancer | Animal models | Cytokines | Liver | Hepatocellular carcinoma | Genomes | Metastasis | Risk analysis | Gene expression | Risk factors | Metastases | Hepatocytes | Morphology | DNA methylation | Tumorigenesis | Bioinformatics | Cholangiocarcinoma | Deoxyribonucleic acid--DNA | Tumors | T-Box Domain Proteins/metabolism | Hepatocytes/pathology | DNA-Binding Proteins/metabolism | Life Sciences | Cholangiocarcinoma/pathology | Transcription Factors/metabolism | Necrosis/genetics | Cytokines/metabolism | Epigenesis, Genetic/genetics | Cyclin-Dependent Kinase Inhibitor p16/deficiency | Carcinoma, Hepatocellular/pathology | DNA Transposable Elements/genetics | Cell Lineage/genetics | T-Box Domain Proteins/genetics | Transcription Factors/genetics | Apoptosis/genetics | Proto-Oncogene Proteins c-akt/genetics | Liver Neoplasms/genetics | Cholangiocarcinoma/genetics | Liver Neoplasms/pathology | DNA-Binding Proteins/genetics | Hepatocytes/metabolism | Carcinoma, Hepatocellular/genetics | Carcinogenesis/genetics
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 08/2010, Volume 285, Issue 35, pp. 27487 - 27498
The S100B-p53 protein complex was discovered in C8146A malignant melanoma, but the consequences of this interaction required further study... 
WILD-TYPE P53 | UV-RADIATION | CANCER-CELLS | P53-MEDIATED APOPTOSIS | P53-INDUCED APOPTOSIS | CARCINOMA-CELLS | MDM2 GENE | DIFFERENTIAL EXPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-SUPPRESSOR PROTEIN | PIFITHRIN-ALPHA | RNA, Small Interfering - genetics | Caspase 9 - genetics | Caspase 9 - metabolism | Inhibitor of Apoptosis Proteins - genetics | Membrane Potential, Mitochondrial - radiation effects | Humans | Caspase 3 - metabolism | Cell Survival - genetics | Multiprotein Complexes - genetics | Nerve Growth Factors - metabolism | fas Receptor - metabolism | Death Domain Receptor Signaling Adaptor Proteins | Multiprotein Complexes - metabolism | RNA, Messenger - biosynthesis | Phosphorylation - genetics | S100 Proteins - genetics | Ultraviolet Rays | Caspase 3 - genetics | fas Receptor - genetics | Biomarkers, Tumor - metabolism | Membrane Potential, Mitochondrial - genetics | Inhibitor of Apoptosis Proteins - metabolism | S100 Calcium Binding Protein beta Subunit | Down-Regulation | S100 Proteins - metabolism | Melanoma - pathology | Enzyme Activation - radiation effects | Phosphorylation - radiation effects | RNA, Neoplasm - biosynthesis | Nerve Growth Factors - genetics | Cell Line, Tumor | RNA, Neoplasm - genetics | Biomarkers, Tumor - genetics | Mutation | Transcription, Genetic - genetics | Enzyme Activation - genetics | Caspase 8 - metabolism | Gene Expression Regulation, Neoplastic | Transcription, Genetic - radiation effects | Cytochromes c - genetics | Tumor Suppressor Protein p53 - genetics | Caspase 8 - genetics | Melanoma - genetics | Melanoma - metabolism | Cytochromes c - metabolism | RNA, Messenger - genetics | Tumor Suppressor Protein p53 - metabolism | Cell Survival - radiation effects | Carrier Proteins - genetics | Carrier Proteins - metabolism | Apoptosis | Molecular Bases of Disease | S100 Proteins | Calcium-binding Proteins | S100B | Cell Biology | p53 | Protein-Protein Interactions | Tumor Suppressor
Journal Article
The EMBO Journal, ISSN 0261-4189, 07/2011, Volume 30, Issue 14, pp. 2779 - 2792
Mitochondrial outer membrane permeabilization is a watershed event in the process of apoptosis, which is tightly regulated by a series of pro‐ and anti... 
MOMP | ageing | BH3 domain | yeast | mitochondrial apoptosis | Ageing | OXIDATIVE-STRESS | BUDDING YEAST | ADENINE-NUCLEOTIDE TRANSLOCATOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | BCL-2 FAMILY PROTEINS | SACCHAROMYCES-CEREVISIAE | CELL-DEATH | PERMEABILITY TRANSITION | CELL BIOLOGY | BAX-EXPRESSION | CYCLOPHILIN-D | CYTOCHROME-C RELEASE | RNA, Small Interfering - genetics | Immunoprecipitation | Saccharomyces cerevisiae - genetics | Humans | Lung Neoplasms - metabolism | Phosphate Transport Proteins - metabolism | bcl-X Protein - genetics | Molecular Sequence Data | Peptide Fragments - pharmacology | Mitochondrial Proteins - genetics | Bone Neoplasms - metabolism | Saccharomyces cerevisiae - metabolism | Flow Cytometry | Mitochondria - genetics | Mitochondrial Proteins - metabolism | Membrane Potential, Mitochondrial | Apoptosis Regulatory Proteins - genetics | Bone Neoplasms - genetics | Tumor Cells, Cultured | Phosphate Transport Proteins - genetics | bcl-2-Associated X Protein - genetics | Lung Neoplasms - genetics | Proto-Oncogene Proteins - pharmacology | Amino Acid Sequence | Signal Transduction | Saccharomyces cerevisiae Proteins - antagonists & inhibitors | RNA, Messenger - genetics | bcl-2-Associated X Protein - metabolism | Mitochondria - metabolism | Saccharomyces cerevisiae Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Apoptosis Regulatory Proteins - metabolism | Sequence Homology, Amino Acid | Animals | Cell Cycle | Apoptosis Regulatory Proteins - antagonists & inhibitors | Saccharomyces cerevisiae Proteins - metabolism | Mice | bcl-X Protein - metabolism | Apoptosis | Proteins | Mitochondria | Yeast
Journal Article
Clinical cancer research, ISSN 1078-0432, 04/2011, Volume 17, Issue 8, pp. 2140 - 2148
Purpose: EML4-ALK (echinoderm microtubule-associated protein-like 4 anaplastic lymphoma kinase... 
ANAPLASTIC LYMPHOMA KINASE | NPM-ALK | GEFITINIB | ONCOLOGY | SURVIVIN | EML4-ALK FUSION GENE | STAT3 | CELL-CYCLE ARREST | MUTATIONS | IDENTIFICATION | EGFR | NIH 3T3 Cells | Oncogene Proteins, Fusion - metabolism | Cell Proliferation | Apoptosis - drug effects | Inhibitor of Apoptosis Proteins - genetics | Protein-Tyrosine Kinases - metabolism | Humans | Lung Neoplasms - metabolism | Immunoblotting | Lung Neoplasms - pathology | Proto-Oncogene Proteins c-akt - genetics | Neoplasms, Experimental - pathology | Protein-Tyrosine Kinases - genetics | Transfection | Bcl-2-Like Protein 11 | RNA Interference | Cell Transformation, Neoplastic - genetics | Mitogen-Activated Protein Kinase 1 - genetics | Neoplasms, Experimental - genetics | Apoptosis Regulatory Proteins - genetics | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Female | Inhibitor of Apoptosis Proteins - metabolism | Membrane Proteins - metabolism | Proto-Oncogene Proteins c-akt - metabolism | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Lung Neoplasms - genetics | Proto-Oncogene Proteins - metabolism | Membrane Proteins - genetics | Proto-Oncogene Proteins - genetics | Pyrimidines - pharmacology | Receptor Protein-Tyrosine Kinases - metabolism | Apoptosis Regulatory Proteins - metabolism | Animals | Signal Transduction - drug effects | Mice, Nude | Oncogene Proteins, Fusion - genetics | Cell Line, Tumor | Mice | Neoplasms, Experimental - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism
Journal Article
BMC cancer, ISSN 1471-2407, 04/2009, Volume 9, Issue 1, pp. 125 - 125
Background: Similarly to other tumor types, an imbalance between unrestrained cell proliferation and impaired apoptosis appears to be a major unfavorable feature of hepatocellular carcinoma (HCC... 
SMAC/DIABLO | OVEREXPRESSION | SURVIVIN EXPRESSION | ONCOLOGY | CHRONIC LIVER-DISEASE | XIAP | APOLLON | X-LINKED-INHIBITOR | XAF1 | PROGRESSION | BALANCE | Immunohistochemistry | Prognosis | Follow-Up Studies | Microtubule-Associated Proteins - genetics | Inhibitor of Apoptosis Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Male | Intracellular Signaling Peptides and Proteins - metabolism | Mitochondrial Proteins - genetics | Neoplasm Proteins - metabolism | Mitochondrial Proteins - metabolism | Carcinoma, Hepatocellular - genetics | Aged, 80 and over | Adult | Female | Liver Neoplasms - pathology | Inhibitor of Apoptosis Proteins - metabolism | Neoplasm Proteins - genetics | Intracellular Signaling Peptides and Proteins - genetics | Liver Neoplasms - genetics | Kaplan-Meier Estimate | Chi-Square Distribution | Reverse Transcriptase Polymerase Chain Reaction | X-Linked Inhibitor of Apoptosis Protein - genetics | Analysis of Variance | Adaptor Proteins, Signal Transducing - genetics | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | X-Linked Inhibitor of Apoptosis Protein - metabolism | Aged | Adaptor Proteins, Signal Transducing - metabolism | Apoptosis | Carcinoma, Hepatocellular - metabolism | Control | Care and treatment | Usage | Genetic aspects | Research | Hepatoma | Gene expression | Health aspects
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2014, Volume 289, Issue 41, pp. 28660 - 28675
The cadmium-transformed human lung bronchial epithelial BEAS-2B cells exhibit a property of apoptosis resistance as compared with normal non-transformed BEAS-2B cells... 
TARGET | OVEREXPRESSION | BCL-2 | OXIDATIVE STRESS | ACTIVATION | TRANSCRIPTION FACTOR NRF2 | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | AUTOPHAGY | P62 | BINDING | Neoplasm Transplantation | RNA, Small Interfering - genetics | RNA-Binding Proteins - genetics | NF-E2-Related Factor 2 - antagonists & inhibitors | Superoxide Dismutase - genetics | Epithelial Cells - metabolism | Reactive Oxygen Species - metabolism | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Epithelial Cells - drug effects | Humans | Lung Neoplasms - metabolism | Gene Expression Regulation, Neoplastic | bcl-X Protein - genetics | Apoptosis - genetics | Lung Neoplasms - pathology | Male | Cell Transformation, Neoplastic - chemically induced | Green Fluorescent Proteins - genetics | Bronchi - drug effects | Proto-Oncogene Proteins c-bcl-2 - metabolism | Cell Transformation, Neoplastic - genetics | Bronchi - metabolism | NF-E2-Related Factor 2 - genetics | Autophagy - genetics | Bronchi - pathology | Genes, Reporter | Superoxide Dismutase - metabolism | RNA-Binding Proteins - antagonists & inhibitors | Lung Neoplasms - genetics | Cell Line | Green Fluorescent Proteins - metabolism | Cadmium - toxicity | Signal Transduction | Catalase - genetics | Epithelial Cells - pathology | Cell Transformation, Neoplastic - metabolism | Catalase - metabolism | Animals | Mice, Nude | NF-E2-Related Factor 2 - metabolism | Mice | Cell Transformation, Neoplastic - pathology | bcl-X Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | RNA-Binding Proteins - metabolism | RNA, Small Interfering - metabolism | Index Medicus | Cadmium | Reactive Oxygen Species (ROS) | Nuclear Factor 2 (Erythroid-derived 2-like Factor) (NFE2L2) (Nrf2) | Autophagy | Carcinogenesis | p62 | Cell Biology | Apoptosis
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