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Cancer cell, ISSN 1535-6108, 2006, Volume 10, Issue 5, pp. 375 - 388
BCL-2 proteins are critical for cell survival and are overexpressed in many tumors... 
CELLCYCLE | PROGRAMMED CELL-DEATH | CANCER-CELLS | STEM-CELLS | PROAPOPTOTIC ACTIVITY | ONCOLOGY | X-L | ACUTE MYELOGENOUS LEUKEMIA | IN-VIVO | MITOCHONDRIAL-MEMBRANE | BCL-2 FAMILY-MEMBERS | BH3-ONLY PROTEINS | RNA, Small Interfering - genetics | bcl-2-Associated X Protein - chemistry | Humans | Leukemia, Myeloid, Acute - metabolism | Nitrophenols - metabolism | bcl-2 Homologous Antagonist-Killer Protein - genetics | Piperazines - metabolism | Neoplasm Proteins - metabolism | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Biphenyl Compounds - metabolism | Biphenyl Compounds - therapeutic use | Recombinant Fusion Proteins - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Nitrophenols - therapeutic use | Hematopoietic Stem Cells - physiology | Leukemia, Myeloid, Acute - drug therapy | Proto-Oncogene Proteins c-bcl-2 - chemistry | Dimerization | bcl-2-Associated X Protein - genetics | Protein Structure, Tertiary | Cell Line | bcl-2-Associated X Protein - metabolism | Piperazines - therapeutic use | Animals | Sulfonamides - therapeutic use | Myeloid Cell Leukemia Sequence 1 Protein | Sulfonamides - metabolism | Recombinant Fusion Proteins - genetics | Protein Conformation | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Mice | Apoptosis - physiology | Drug Resistance, Neoplasm - physiology | Proto-Oncogene Proteins c-bcl-2 - genetics | RNA, Small Interfering - metabolism | Proteins | Oncology, Experimental | Lung cancer | Bone marrow | Transplantation | Lymphomas | Research | Hematopoietic stem cells | Cancer | Apoptosis
Journal Article
Molecular cell, ISSN 1097-2765, 2011, Volume 43, Issue 3, pp. 432 - 448
.... It also forms upon Smac-mimetic (SM) treatment without involvement of autocrine TNF. Ripoptosome assembly requires RIP1's kinase activity and can stimulate caspase-8-mediated apoptosis as well as caspase-independent necrosis... 
CASPASE INHIBITORS | TUMOR-NECROSIS-FACTOR | LIGASE ACTIVITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | ALPHA-DEPENDENT APOPTOSIS | TRAIL-INDUCED APOPTOSIS | TNF-ALPHA | CHEMOTHERAPEUTIC DRUGS | NF-KAPPA-B | CELL-DEATH | CELL BIOLOGY | CASP8 and FADD-Like Apoptosis Regulating Protein - physiology | Apoptosis - drug effects | Inhibitor of Apoptosis Proteins - genetics | Humans | Caspase 8 - metabolism | Nuclear Pore Complex Proteins - chemistry | Caspase 8 - chemistry | Inhibitor of Apoptosis Proteins - physiology | Nuclear Pore Complex Proteins - physiology | Antineoplastic Agents - pharmacology | CASP8 and FADD-Like Apoptosis Regulating Protein - metabolism | Fas-Associated Death Domain Protein - physiology | RNA-Binding Proteins - physiology | Signal Transduction | CASP8 and FADD-Like Apoptosis Regulating Protein - genetics | Nuclear Pore Complex Proteins - metabolism | RNA-Binding Proteins - chemistry | Fas-Associated Death Domain Protein - metabolism | Etoposide - pharmacology | Mitochondria - metabolism | Caspase 8 - physiology | Fas-Associated Death Domain Protein - chemistry | Cell Line, Tumor | Ligands | Apoptosis - physiology | DNA Damage | Enzyme Activation | RNA-Binding Proteins - metabolism | Ubiquitin | Green design | Oncology, Experimental | Internet service providers | Research | Sustainable development | Cancer
Journal Article
Journal Article
Oncogene, ISSN 1476-5594, 2003, Volume 22, Issue 20, pp. 3138 - 3151
... to apoptosis and by reprogramming their proliferation and survival pathways during melanoma progression... 
Drug resistance | Cancer therapy | Chemotherapeutic targets | Apoptosis | Skin cancer | WILD-TYPE P53 | skin cancer | PROTEIN-KINASE-B | BIOCHEMISTRY & MOLECULAR BIOLOGY | apoptosis | MALIGNANT-MELANOMA | DIFFERENTIATION-ASSOCIATED GENE-7 | CELL BIOLOGY | PROGRAMMED CELL-DEATH | cancer therapy | HUMAN METASTATIC MELANOMA | ONCOLOGY | chemotherapeutic targets | SMALL-MOLECULE INHIBITORS | IN-VIVO | GENETICS & HEREDITY | drug resistance | CYTOCHROME-C RELEASE | NF-KAPPA-B | Caspase 9 | Skin Neoplasms - drug therapy | Apoptosis - drug effects | Microtubule-Associated Proteins - metabolism | Humans | NF-kappa B - metabolism | Microtubule-Associated Proteins - drug effects | Proto-Oncogene Proteins c-bcl-2 - metabolism | Caspases - metabolism | PTEN Phosphohydrolase | Melanocytes - drug effects | Neoplasm Proteins | Caspases - drug effects | Antineoplastic Agents - pharmacology | Cell Survival - physiology | Skin Neoplasms - pathology | Apoptotic Protease-Activating Factor 1 | Cell Survival - drug effects | Tumor Suppressor Proteins - metabolism | Inhibitor of Apoptosis Proteins | Signal Transduction | Mitochondria - metabolism | Melanoma - pathology | Mitochondria - drug effects | Disease Progression | Animals | Proteins - metabolism | Melanoma - drug therapy | Proto-Oncogene Proteins c-bcl-2 - drug effects | Proteins - drug effects | Apoptosis - physiology | Phosphoric Monoester Hydrolases - metabolism | Tumor Suppressor Protein p14ARF - metabolism | Drug Resistance, Neoplasm - physiology | NF-kappa B - drug effects | Tumor Suppressor Protein p14ARF - drug effects
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2012, Volume 287, Issue 15, pp. 12455 - 12468
Autophagy and apoptosis are two evolutionarily conserved processes that regulate cell fate in response to cytotoxic stress... 
PROGRAMMED CELL-DEATH | INHIBITION | BECLIN-1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIF-1 | MITOCHONDRIA | DEGRADATION | MEDIATED CLEAVAGE | MACROAUTOPHAGY | CHLOROQUINE | SPHINGOSINE KINASE | Death Domain Receptor Signaling Adaptor Proteins - physiology | Autophagy-Related Proteins | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Sequestosome-1 Protein | Humans | Protein Multimerization | Caspase 3 - metabolism | Caspase 8 - metabolism | Leukemia, Myeloid, Acute | Autophagy | Heat-Shock Proteins - genetics | Cell Membrane - metabolism | Tumor Cells, Cultured | Pyrazoles - pharmacology | Cell Survival - drug effects | Hydrazines - pharmacology | Lysosome-Associated Membrane Glycoproteins - metabolism | Heat-Shock Proteins - metabolism | Cells, Cultured | Fas-Associated Death Domain Protein - metabolism | Ubiquitin-Conjugating Enzymes - genetics | Mitochondria - metabolism | Mitochondria - drug effects | Gene Knockout Techniques | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Protein Transport | Cell Membrane - enzymology | Phosphotransferases (Alcohol Group Acceptor) - antagonists & inhibitors | Animals | Autophagy-Related Protein 5 | Ubiquitin-Conjugating Enzymes - metabolism | Adaptor Proteins, Signal Transducing - genetics | Protein Binding | Mice | Enzyme Activation | Adaptor Proteins, Signal Transducing - metabolism | Apoptosis | Caspase-8 | Bortezomib | Cell Death | Caspase | Sphingolipid | SKI-I | p62 | Sequestosome 1 | Atg5 | Cell Biology
Journal Article
The EMBO Journal, ISSN 0261-4189, 07/2011, Volume 30, Issue 14, pp. 2779 - 2792
Mitochondrial outer membrane permeabilization is a watershed event in the process of apoptosis, which is tightly regulated by a series of pro‐ and anti... 
MOMP | ageing | BH3 domain | yeast | mitochondrial apoptosis | Ageing | OXIDATIVE-STRESS | BUDDING YEAST | ADENINE-NUCLEOTIDE TRANSLOCATOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | BCL-2 FAMILY PROTEINS | SACCHAROMYCES-CEREVISIAE | CELL-DEATH | PERMEABILITY TRANSITION | CELL BIOLOGY | BAX-EXPRESSION | CYCLOPHILIN-D | CYTOCHROME-C RELEASE | RNA, Small Interfering - genetics | Immunoprecipitation | Saccharomyces cerevisiae - genetics | Humans | Lung Neoplasms - metabolism | Phosphate Transport Proteins - metabolism | bcl-X Protein - genetics | Molecular Sequence Data | Peptide Fragments - pharmacology | Mitochondrial Proteins - genetics | Bone Neoplasms - metabolism | Saccharomyces cerevisiae - metabolism | Flow Cytometry | Mitochondria - genetics | Mitochondrial Proteins - metabolism | Membrane Potential, Mitochondrial | Apoptosis Regulatory Proteins - genetics | Bone Neoplasms - genetics | Tumor Cells, Cultured | Phosphate Transport Proteins - genetics | bcl-2-Associated X Protein - genetics | Lung Neoplasms - genetics | Proto-Oncogene Proteins - pharmacology | Amino Acid Sequence | Signal Transduction | Saccharomyces cerevisiae Proteins - antagonists & inhibitors | RNA, Messenger - genetics | bcl-2-Associated X Protein - metabolism | Mitochondria - metabolism | Saccharomyces cerevisiae Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Apoptosis Regulatory Proteins - metabolism | Sequence Homology, Amino Acid | Animals | Cell Cycle | Apoptosis Regulatory Proteins - antagonists & inhibitors | Saccharomyces cerevisiae Proteins - metabolism | Mice | bcl-X Protein - metabolism | Apoptosis | Proteins | Mitochondria | Yeast
Journal Article
Cell host & microbe, ISSN 1931-3128, 2018, Volume 24, Issue 5, pp. 689 - 702.e7
... (FADD, RIPK1, RIPK3, and caspase 8) and autophagy (ATG5, ATG7, and SQSTM1) proteins. Genetic or pharmacological inhibition of autophagy induction, but not autophagy-mediated... 
caspase 8 | autophagy | HIV | CD4+ T cell | SMAC mimetics | apoptosis | XIAP | Fas | RIPK1 | BIRC2 | CD4+ T cell | CD4(+) T-CELLS | MICROBIOLOGY | DEATH | HUMAN-IMMUNODEFICIENCY-VIRUS | REPLICATION | INHIBITION | VIROLOGY | DNA | RESISTANCE | HIV-1 INFECTION | TYPE-1 | PROTEINS | PARASITOLOGY | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | HIV-1 - pathogenicity | Apoptosis - drug effects | Autophagy-Related Protein 7 - metabolism | Cyclohexanes - pharmacology | Humans | Caspase 8 - metabolism | Autophagy - physiology | Intracellular Signaling Peptides and Proteins - metabolism | Autophagy - drug effects | CD4-Positive T-Lymphocytes - immunology | HIV Infections - immunology | HIV-1 - physiology | Mitochondrial Proteins - metabolism | Baculoviral IAP Repeat-Containing 3 Protein - metabolism | Cell Death | Indoles - pharmacology | Inhibitor of Apoptosis Proteins - metabolism | Sequestosome-1 Protein - metabolism | Cell Line | HIV-1 - drug effects | Dipeptides - pharmacology | Fas-Associated Death Domain Protein - metabolism | Ubiquitin-Protein Ligases - metabolism | Benzoquinones - pharmacology | Pyrroles - pharmacology | Apoptosis Regulatory Proteins | X-Linked Inhibitor of Apoptosis Protein - metabolism | Autophagy-Related Protein 5 - metabolism | Apoptosis - physiology | Beclin-1 - metabolism | Proteins | Medical colleges | Trout | Communicable diseases | T cells | HIV (Viruses) | Health aspects | HIV infection | Apoptosis
Journal Article
Clinical cancer research, ISSN 1078-0432, 04/2011, Volume 17, Issue 8, pp. 2140 - 2148
Purpose: EML4-ALK (echinoderm microtubule-associated protein-like 4 anaplastic lymphoma kinase... 
ANAPLASTIC LYMPHOMA KINASE | NPM-ALK | GEFITINIB | ONCOLOGY | SURVIVIN | EML4-ALK FUSION GENE | STAT3 | CELL-CYCLE ARREST | MUTATIONS | IDENTIFICATION | EGFR | NIH 3T3 Cells | Oncogene Proteins, Fusion - metabolism | Cell Proliferation | Apoptosis - drug effects | Inhibitor of Apoptosis Proteins - genetics | Protein-Tyrosine Kinases - metabolism | Humans | Lung Neoplasms - metabolism | Immunoblotting | Lung Neoplasms - pathology | Proto-Oncogene Proteins c-akt - genetics | Neoplasms, Experimental - pathology | Protein-Tyrosine Kinases - genetics | Transfection | Bcl-2-Like Protein 11 | RNA Interference | Cell Transformation, Neoplastic - genetics | Mitogen-Activated Protein Kinase 1 - genetics | Neoplasms, Experimental - genetics | Apoptosis Regulatory Proteins - genetics | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Female | Inhibitor of Apoptosis Proteins - metabolism | Membrane Proteins - metabolism | Proto-Oncogene Proteins c-akt - metabolism | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Lung Neoplasms - genetics | Proto-Oncogene Proteins - metabolism | Membrane Proteins - genetics | Proto-Oncogene Proteins - genetics | Pyrimidines - pharmacology | Receptor Protein-Tyrosine Kinases - metabolism | Apoptosis Regulatory Proteins - metabolism | Animals | Signal Transduction - drug effects | Mice, Nude | Oncogene Proteins, Fusion - genetics | Cell Line, Tumor | Mice | Neoplasms, Experimental - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism
Journal Article
Molecular cell, ISSN 1097-2765, 2008, Volume 30, Issue 1, pp. 11 - 25
Apoptosis in response to TRAIL or TNF requires the activation of initiator caspases, which then activate the effector caspases that dismantle cells and cause death... 
SYSBIO | CELLCYCLE | EFFECTOR-CASPASE ACTIVATION | PROTEIN | X-LINKED INHIBITOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | SMAC/DIABLO RELEASE | DEGRADATION | BAX | DEATH | CYTOCHROME-C RELEASE | MITOCHONDRIAL RELEASE | OLIGOMERIZATION | CELL BIOLOGY | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Mathematics | Mitochondrial Proteins - genetics | Recombinant Fusion Proteins - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Caspases - metabolism | RNA Interference | Mitochondrial Proteins - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Models, Theoretical | Mitochondria - metabolism | Membrane Potentials - physiology | TNF-Related Apoptosis-Inducing Ligand - metabolism | X-Linked Inhibitor of Apoptosis Protein - genetics | Poly(ADP-ribose) Polymerases - metabolism | Poly(ADP-ribose) Polymerases - genetics | X-Linked Inhibitor of Apoptosis Protein - metabolism | Recombinant Fusion Proteins - genetics | Luminescent Proteins - genetics | Signal Transduction - physiology | Apoptosis - physiology | Enzyme Activation | HeLa Cells | Proto-Oncogene Proteins c-bcl-2 - genetics | TNF-Related Apoptosis-Inducing Ligand - genetics | Luminescent Proteins - metabolism | Analysis | Apoptosis | Bcl-2 | proteasome | TRAIL | biological modeling | FRET reporter | apoptosis | XIAP | TNF | caspase | computational
Journal Article