Articles

Search Articles

Advanced search
Help

Catalogue

Articles

Databases

X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (88342) 88342
Publication (12400) 12400
Book Review (840) 840
Book Chapter (466) 466
Conference Proceeding (136) 136
Newsletter (90) 90
Book / eBook (80) 80
Dissertation (54) 54
Government Document (20) 20
Newspaper Article (11) 11
Data Set (10) 10
Reference (4) 4
Magazine Article (3) 3
Paper (3) 3
Web Resource (2) 2
Presentation (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
humans (53973) 53973
animals (49978) 49978
index medicus (48305) 48305
apoptosis (30768) 30768
mice (23586) 23586
biochemistry & molecular biology (23317) 23317
cell biology (17797) 17797
male (16885) 16885
apoptosis - drug effects (15737) 15737
rats (15305) 15305
expression (14886) 14886
cell line, tumor (13480) 13480
female (13437) 13437
cells, cultured (13042) 13042
cancer (12449) 12449
activation (11567) 11567
oncology (11413) 11413
enzyme inhibitors - pharmacology (11325) 11325
proteins (10419) 10419
neurosciences (9974) 9974
signal transduction (9950) 9950
phosphorylation (9487) 9487
apoptosis - physiology (8996) 8996
cell line (8464) 8464
oxidative stress (7756) 7756
analysis (7661) 7661
article (7481) 7481
gene expression (7478) 7478
signal transduction - drug effects (7366) 7366
research (7360) 7360
physiology (7260) 7260
pharmacology & pharmacy (6805) 6805
cells (6669) 6669
dose-response relationship, drug (6311) 6311
physiological aspects (6080) 6080
inhibition (5943) 5943
in-vitro (5926) 5926
antineoplastic agents - pharmacology (5864) 5864
rats, sprague-dawley (5685) 5685
inflammation (5526) 5526
cell survival - drug effects (5500) 5500
blotting, western (5491) 5491
cell proliferation (5474) 5474
research article (5463) 5463
cell proliferation - drug effects (5447) 5447
gene-expression (5375) 5375
mice, inbred c57bl (5359) 5359
inhibitors (5274) 5274
signal transduction - physiology (5158) 5158
health aspects (5126) 5126
kinases (5106) 5106
in-vivo (5060) 5060
biophysics (4914) 4914
endocrinology & metabolism (4846) 4846
growth (4780) 4780
cell cycle (4665) 4665
immunology (4650) 4650
nf-kappa-b (4621) 4621
medicine (4620) 4620
biochemistry (4526) 4526
proliferation (4524) 4524
tumor cells, cultured (4510) 4510
protein (4480) 4480
disease models, animal (4457) 4457
caspases - metabolism (4442) 4442
inhibitor (4338) 4338
transfection (4338) 4338
rodents (4263) 4263
multidisciplinary sciences (4208) 4208
time factors (4159) 4159
cell death (4108) 4108
death (3968) 3968
hematology (3834) 3834
genetic aspects (3757) 3757
care and treatment (3680) 3680
down-regulation (3658) 3658
reactive oxygen species - metabolism (3616) 3616
biology (3608) 3608
cell-death (3576) 3576
pathway (3517) 3517
rna, messenger - metabolism (3512) 3512
up-regulation (3502) 3502
immunohistochemistry (3487) 3487
protein kinase inhibitors - pharmacology (3444) 3444
differentiation (3426) 3426
tumors (3420) 3420
enzyme activation (3403) 3403
enzymes (3379) 3379
science (3364) 3364
angiogenesis (3342) 3342
mice, knockout (3290) 3290
rats, wistar (3248) 3248
protein binding (3215) 3215
neurons - drug effects (3171) 3171
chemistry, medicinal (3125) 3125
mutation (3114) 3114
medicine, research & experimental (3093) 3093
nf-kappa b - metabolism (3079) 3079
rna interference (3049) 3049
neurology (3021) 3021
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (88388) 88388
Chinese (133) 133
Japanese (78) 78
French (55) 55
Spanish (25) 25
Polish (19) 19
Russian (16) 16
German (9) 9
Portuguese (9) 9
Korean (3) 3
Czech (2) 2
Dutch (2) 2
Arabic (1) 1
Hungarian (1) 1
Italian (1) 1
Serbian (1) 1
Ukrainian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


1. Full Text Targeting IAP proteins for therapeutic intervention in cancer
by Fulda, Simone and Vucic, Domagoj
Nature Reviews Drug Discovery, ISSN 1474-1776, 02/2012, Volume 11, Issue 2, pp. 109 - 124
Evasion of apoptosis is one of the crucial acquired capabilities used by cancer cells to fend off anticancer therapies. Inhibitor of apoptosis (IAP) proteins... 
HUMAN PROSTATE-CANCER | IRRADIATION-INDUCED APOPTOSIS | MITOCHONDRIA-DERIVED ACTIVATOR | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | PHARMACOLOGY & PHARMACY | TRAIL-INDUCED APOPTOSIS | ACUTE MYELOID-LEUKEMIA | PROGNOSTIC-SIGNIFICANCE | X-LINKED-INHIBITOR | NF-KAPPA-B | RENAL-CELL CARCINOMA | XIAP ANTISENSE OLIGONUCLEOTIDE | Oligodeoxyribonucleotides, Antisense - pharmacology | X-Linked Inhibitor of Apoptosis Protein - drug effects | Apoptosis - drug effects | Humans | Oligodeoxyribonucleotides, Antisense - therapeutic use | Antineoplastic Agents - therapeutic use | Inhibitor of Apoptosis Proteins - physiology | Neoplasms - drug therapy | Animals | Cell Death - physiology | Signal Transduction - drug effects | Inhibitor of Apoptosis Proteins - antagonists & inhibitors | Inhibitor of Apoptosis Proteins - drug effects | Signal Transduction - physiology | Antineoplastic Agents - pharmacology | Apoptosis - physiology | Cell Death - drug effects | Drug Therapy, Combination | X-Linked Inhibitor of Apoptosis Protein - physiology | Physiological aspects | Research | Gene expression | Cancer cells | Apoptosis
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
2. Full Text The Ripoptosome, a Signaling Platform that Assembles in Response to Genotoxic Stress and Loss of IAPs
by Tenev, Tencho and Bianchi, Katiuscia and Darding, Maurice and Broemer, Meike and Langlais, Claudia and Wallberg, Fredrik and Zachariou, Anna and Lopez, Juanita and MacFarlane, Marion and Cain, Kelvin and Meier, Pascal
Molecular Cell, ISSN 1097-2765, 08/2011, Volume 43, Issue 3, pp. 432 - 448
A better understanding of the mechanisms through which anticancer drugs exert their effects is essential to improve combination therapies. While studying how... 
CASPASE INHIBITORS | TUMOR-NECROSIS-FACTOR | LIGASE ACTIVITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | ALPHA-DEPENDENT APOPTOSIS | TRAIL-INDUCED APOPTOSIS | TNF-ALPHA | CHEMOTHERAPEUTIC DRUGS | NF-KAPPA-B | CELL-DEATH | CELL BIOLOGY | CASP8 and FADD-Like Apoptosis Regulating Protein - physiology | Apoptosis - drug effects | Inhibitor of Apoptosis Proteins - genetics | Humans | Caspase 8 - metabolism | Nuclear Pore Complex Proteins - chemistry | Caspase 8 - chemistry | Inhibitor of Apoptosis Proteins - physiology | Nuclear Pore Complex Proteins - physiology | Antineoplastic Agents - pharmacology | CASP8 and FADD-Like Apoptosis Regulating Protein - metabolism | Fas-Associated Death Domain Protein - physiology | RNA-Binding Proteins - physiology | Signal Transduction | CASP8 and FADD-Like Apoptosis Regulating Protein - genetics | Nuclear Pore Complex Proteins - metabolism | RNA-Binding Proteins - chemistry | Fas-Associated Death Domain Protein - metabolism | Etoposide - pharmacology | Mitochondria - metabolism | Caspase 8 - physiology | Fas-Associated Death Domain Protein - chemistry | Cell Line, Tumor | Ligands | Apoptosis - physiology | DNA Damage | Enzyme Activation | RNA-Binding Proteins - metabolism | Ubiquitin | Green design | Oncology, Experimental | Internet service providers | Research | Sustainable development | Cancer
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
3. Full Text The inhibitors of apoptosis (IAPs) as cancer targets
by Hunter, Allison M and LaCasse, Eric C and Korneluk, Robert G
Apoptosis, ISSN 1360-8185, 9/2007, Volume 12, Issue 9, pp. 1543 - 1568
Apoptosis has been accepted as a fundamental component in the pathogenesis of cancer, in addition to other human diseases including neurodegeneration, coronary... 
Biochemistry, general | TNFR | TRAF | Oncology | NFkB | Virology | Cell Biology | Biomedicine | Cancer Research | IAPs | Caspases | Smac | Knock out mice | Apoptosis | Cancer | NEURONAL APOPTOSIS | X-LINKED INHIBITOR | SERINE-PROTEASE OMI/HTRA2 | MITOCHONDRIA-DERIVED ACTIVATOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | knock out mice | INDUCED PROXIMITY MODEL | apoptosis | CELL BIOLOGY | CELL LUNG-CANCER | SPINAL MUSCULAR-ATROPHY | IN-VIVO | cancer | CYTOCHROME-C RELEASE | caspases | CASPASE ACTIVATION | Caspases - physiology | Proto-Oncogene Proteins c-bcl-2 - physiology | Apoptosis - drug effects | Inhibitor of Apoptosis Proteins - genetics | Humans | Neoplasm Proteins - physiology | Serine Endopeptidases - physiology | Neoplasm Proteins - antagonists & inhibitors | Inhibitor of Apoptosis Proteins - physiology | X-Linked Inhibitor of Apoptosis Protein - antagonists & inhibitors | Neoplasms - genetics | Inhibitor of Apoptosis Proteins - antagonists & inhibitors | Oligonucleotides, Antisense - therapeutic use | Intracellular Signaling Peptides and Proteins - therapeutic use | Mitochondrial Proteins - therapeutic use | Peptide Termination Factors - physiology | Mitochondrial Proteins - physiology | Neoplasm Proteins - therapeutic use | Microtubule-Associated Proteins - antagonists & inhibitors | Caspase Inhibitors | High-Temperature Requirement A Serine Peptidase 2 | Neoplasms - drug therapy | Animals | Protein Kinases - physiology | Checkpoint Kinase 1 | Enzyme Activation | Genetic Vectors | Intracellular Signaling Peptides and Proteins - physiology | Proteins | Cancer therapies
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
4. Full Text cIAPs Block Ripoptosome Formation, a RIP1/Caspase-8 Containing Intracellular Cell Death Complex Differentially Regulated by cFLIP Isoforms
by Feoktistova, Maria and Geserick, Peter and Kellert, Beate and Dimitrova, Diana Panayotova and Langlais, Claudia and Hupe, Mike and Cain, Kelvin and MacFarlane, Marion and Häcker, Georg and Leverkus, Martin
Molecular Cell, ISSN 1097-2765, 08/2011, Volume 43, Issue 3, pp. 449 - 463
The intracellular regulation of cell death pathways by cIAPs has been enigmatic. Here we show that loss of cIAPs promotes the spontaneous formation of an... 
TOLL-LIKE RECEPTOR-3 | KAPPA-B ACTIVATION | GENOTOXIC STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOTHELIAL-CELLS | ALPHA-DEPENDENT APOPTOSIS | TNF-ALPHA | MEDIATED APOPTOSIS | HUMAN KERATINOCYTES | SIGNALING COMPLEX | INNATE IMMUNITY | CELL BIOLOGY | Tumor Necrosis Factor-alpha - metabolism | CASP8 and FADD-Like Apoptosis Regulating Protein - physiology | RNA-Binding Proteins - physiology | Signal Transduction | Nuclear Pore Complex Proteins - metabolism | Humans | Caspase 8 - metabolism | Receptors, Tumor Necrosis Factor, Type I - metabolism | Caspase 8 - physiology | Toll-Like Receptor 3 - metabolism | Inhibitor of Apoptosis Proteins - physiology | Protein Isoforms - physiology | Toll-Like Receptor 3 - physiology | Nuclear Pore Complex Proteins - physiology | Cell Line, Tumor | Apoptosis - physiology | CASP8 and FADD-Like Apoptosis Regulating Protein - metabolism | RNA-Binding Proteins - metabolism | Cell death | Biochemistry | Universities and colleges
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
5. Full Text A Smac mimetic rescue screen reveals roles for inhibitor of apoptosis proteins in tumor necrosis factor-α signaling
by Gaither, Alex and Porter, Dale and Yao, Yao and Borawski, Jason and Yang, Guang and Donovan, Jerry and Sage, David and Slisz, Joanna and Tran, Mary and Straub, Christopher and Ramsey, Tim and Iourgenko, Vadim and Huang, Alan and Chen, Yan and Schlegel, Robert and Labow, Mark and Fawell, Stephen and Sellers, William R and Zawel, Leigh
Cancer Research, ISSN 0008-5472, 12/2007, Volume 67, Issue 24, pp. 11493 - 11498
Smac mimetic compounds targeting the inhibitor of apoptosis proteins (UP) baculoviral LAP repeat-3 domain are presumed to reduce the threshold for apoptotic... 
SMAC/DIABLO | ACTIVATION | C-IAP1 | EVENTS | ONCOLOGY | CASPASES | BIOLOGY | IAPS | XIAP | CHEMORESISTANCE | CANCER | RNA, Small Interfering - genetics | Signal Transduction | Apoptosis - drug effects | Humans | Mitochondrial Proteins - physiology | Inhibitor of Apoptosis Proteins - physiology | X-Linked Inhibitor of Apoptosis Protein - genetics | Cell Death | Tumor Necrosis Factor-alpha - physiology | Cell Line, Tumor | Conserved Sequence | RNA, Neoplasm - genetics | Female | Apoptosis - physiology | Ovarian Neoplasms | Intracellular Signaling Peptides and Proteins - physiology | Oligopeptides - pharmacology | RNA Interference - physiology | X-Linked Inhibitor of Apoptosis Protein - physiology
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
6. Full Text Clinical impact of clonal and subclonal TP53, SF3B1, BIRC3, NOTCH1, and ATM mutations in chronic lymphocytic leukemia
by Nadeu, Ferran and Delgado, Julio and Royo, Cristina and Baumann, Tycho and Stankovic, Tatjana and Pinyol, Magda and Jares, Pedro and Navarro, Alba and Martín-García, David and Beà, Sílvia and Salaverria, Itziar and Oldreive, Ceri and Aymerich, Marta and Suárez-Cisneros, Helena and Rozman, Maria and Villamor, Neus and Colomer, Dolors and López-Guillermo, Armando and González, Marcos and Alcoceba, Miguel and Terol, Maria José and Colado, Enrique and Puente, Xose S and López-Otín, Carlos and Enjuanes, Anna and Campo, Elías
Blood, ISSN 0006-4971, 04/2016, Volume 127, Issue 17, pp. 2122 - 2130
Genomic studies have revealed the complex clonal heterogeneity of chronic lymphocytic leukemia (CLL). The acquisition and selection of genomic aberrations may... 
SURVIVAL | TRIAL | GENOMIC LANDSCAPE | EVOLUTION | THERAPY | HIGH-THROUGHPUT | HIGH-RISK | RECURRENT MUTATIONS | IN-SITU HYBRIDIZATION | DNA-SEQUENCING DATA | HEMATOLOGY | Prognosis | Inhibitor of Apoptosis Proteins - genetics | Humans | Middle Aged | Neoplasm Proteins - physiology | Male | Baculoviral IAP Repeat-Containing 3 Protein | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Ubiquitin-Protein Ligases - physiology | Inhibitor of Apoptosis Proteins - physiology | Tumor Suppressor Protein p53 - physiology | Young Adult | Genes, p53 | DNA Mutational Analysis | Aged, 80 and over | Adult | Female | Clone Cells | Phosphoproteins - physiology | Neoplasm Proteins - genetics | Time-to-Treatment | Kaplan-Meier Estimate | Treatment Outcome | Neoplastic Stem Cells | Phosphoproteins - genetics | RNA Splicing Factors - genetics | Ataxia Telangiectasia Mutated Proteins - physiology | Disease Progression | Leukemia, Lymphocytic, Chronic, B-Cell - therapy | RNA Splicing Factors - physiology | Aged | Mutation | Ataxia Telangiectasia Mutated Proteins - genetics | Receptor, Notch1 - genetics | Ubiquitin-Protein Ligases - genetics | Receptor, Notch1 - physiology | Evolution, Molecular | Lymphoid Neoplasia
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
7. Full Text Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family
by Salvesen, Guy S and Scott, Fiona L and Eckelman, Brendan P
EMBO reports, ISSN 1469-221X, 10/2006, Volume 7, Issue 10, pp. 988 - 994
Several of the inhibitor of apoptosis protein (IAP) family members regulate apoptosis in response to various cellular assaults. Some members are also involved... 
protease | apoptosis | BIR | caspase | exosite | ML-IAP | X-LINKED INHIBITOR | SPECIFICITY | UBIQUITIN LIGASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CASPASE INHIBITION | CELL-DEATH | CELL BIOLOGY | STRUCTURAL BASIS | BIR DOMAIN | NMR STRUCTURE | MOLECULAR-MECHANISMS | Amino Acid Sequence | Genes, X-Linked - physiology | Humans | Models, Molecular | Molecular Sequence Data | Caspase Inhibitors | Inhibitor of Apoptosis Proteins - physiology | Sequence Homology, Amino Acid | Glutathione Transferase - genetics | Inhibitor of Apoptosis Proteins - chemistry | Models, Biological | X-Linked Inhibitor of Apoptosis Protein - chemistry | Recombinant Fusion Proteins - genetics | X-Linked Inhibitor of Apoptosis Protein - physiology | Proteins | Enzymes | Cellular biology | Apoptosis | Review
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
8. Full Text Recruitment of the Linear Ubiquitin Chain Assembly Complex Stabilizes the TNF-R1 Signaling Complex and Is Required for TNF-Mediated Gene Induction
by Haas, Tobias L and Emmerich, Christoph H and Gerlach, Björn and Schmukle, Anna C and Cordier, Stefanie M and Rieser, Eva and Feltham, Rebecca and Vince, James and Warnken, Uwe and Wenger, Till and Koschny, Ronald and Komander, David and Silke, John and Walczak, Henning
Molecular Cell, ISSN 1097-2765, 12/2009, Volume 36, Issue 5, pp. 831 - 844
TNF is a key inflammatory cytokine. Using a modified tandem affinity purification approach, we identified HOIL-1 and HOIP as functional components of... 
PROTEINS | MOLIMMUNO | SIGNALING | NECROSIS-FACTOR RECEPTOR | ACTIVATION | STRUCTURAL BASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CONJUGATING ENZYME | POLYUBIQUITIN CHAINS | KINASE RIP | APOPTOSIS PROTEINS | CELL-SURVIVAL | NF-KAPPA-B | NEMO | CELL BIOLOGY | Cell Line | Signal Transduction | Inhibitor of Apoptosis Proteins - genetics | Humans | TNF Receptor-Associated Factor 2 - genetics | Gene Expression Regulation | Ubiquitin - metabolism | JNK Mitogen-Activated Protein Kinases - metabolism | NF-kappa B - metabolism | TNF Receptor-Associated Factor 2 - physiology | Receptors, Tumor Necrosis Factor, Type I - metabolism | Ubiquitin-Protein Ligases - physiology | Inhibitor of Apoptosis Proteins - physiology | TNF Receptor-Associated Death Domain Protein - genetics | Animals | U937 Cells | Tumor Necrosis Factor-alpha - physiology | Mice | GTPase-Activating Proteins - genetics | HeLa Cells | Ubiquitin-Protein Ligases - genetics | Intracellular Signaling Peptides and Proteins - genetics | Apoptosis | Ubiquitin | Employee recruitment | Ligases | Oncology, Experimental | Analysis | Universities and colleges | Research | Cancer
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights