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Molecular Medicine Reports, ISSN 1791-2997, 06/2018, Volume 17, Issue 6, pp. 7672 - 7682
Journal Article
Journal Article
FEBS Letters, ISSN 0014-5793, 2009, Volume 583, Issue 19, pp. 3265 - 3268
We recently reported that diacylglycerol kinase (DGK) α enhanced tumor necrosis factor-α (TNF-α)-induced activation of nuclear factor-κB (NF-κB). However, the... 
Protein kinase Cζ | Phosphorylation | Tumor necrosis factor-α | Diacylglycerol kinase | Nuclear factor-κB | inhibitor of NF-κB | IKK | DGK | PKC | diacylglycerol kinase | siRNA | small interfering RNA | green fluorescent protein | IκB kinase | GFP | IκB | nuclear factor-κB | NF-κB | TNF-α | tumor necrosis factor-α | protein kinase C
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 1782, Volume 289, Issue 21, pp. 14996 - 15004
NF-kappa B is an important transcription factor in the immune system, and aberrant NF-kappa B activity contributes to malignant diseases and autoimmunity. In T... 
ACTIVATION | HOMEOSTASIS | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | LYMPHOMA | ALPHA | PP2A | IDENTIFICATION | TYROSINE-PHOSPHATASE | OKADAIC ACID | MALT1 | Gene Expression - genetics | I-kappa B Proteins - immunology | Humans | NF-kappa B - immunology | Protein Kinase C-theta | NF-kappa B - metabolism | I-kappa B Proteins - metabolism | Protein Phosphatase 2 - immunology | Isoenzymes - immunology | Signal Transduction - immunology | Lymphocyte Activation - immunology | Interleukin-2 - immunology | I-kappa B Kinase - metabolism | RNA Interference | T-Lymphocytes - metabolism | Isoenzymes - metabolism | Protein Kinase C - metabolism | Gene Expression - immunology | Receptors, Antigen, T-Cell - immunology | Phosphorylation - immunology | Interleukin-2 - metabolism | NF-KappaB Inhibitor alpha | Receptors, Antigen, T-Cell - metabolism | Jurkat Cells | Cells, Cultured | Protein Phosphatase 2 - genetics | Protein Kinase C - immunology | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Interleukin-2 - genetics | Protein Phosphatase 2 - metabolism | I-kappa B Kinase - immunology | T-Lymphocytes - immunology | Signaling | Signal Transduction | T Cell | Serine | Nuclear Factor-κB (NF-κB) | NF-κB Transcription Factor | T Cell Receptor | IL-2 | PPP2R5C | Phosphoprotein Phosphatase | B56γ | Threonine Protein Phosphatase
Journal Article
Molecular Biology of the Cell, ISSN 1059-1524, 07/2011, Volume 22, Issue 13, pp. 2144 - 2156
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2013, Volume 288, Issue 18, pp. 12852 - 12865
This study was carried out to explore the molecular mechanism for down-regulation of TRPC6 expression in the reactive oxygen species (ROS)/PKC signaling in... 
GLOMERULAR MESANGIAL CELLS | TUMOR-NECROSIS-FACTOR | OXIDATIVE STRESS | ACTIVATION | MECHANISM | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOWN-REGULATION | TRPC6 CHANNEL | PROLIFERATION | FACTOR-ALPHA | Protein Kinase C - genetics | Transcription, Genetic - drug effects | Oxidants - pharmacology | Tetradecanoylphorbol Acetate - pharmacology | Humans | NF-kappa B p50 Subunit - genetics | Transcription Factor RelA - genetics | Gene Knockdown Techniques | Kidney - metabolism | Carcinogens - pharmacology | Protein Kinase C - metabolism | Response Elements - physiology | TRPC Cation Channels - genetics | Hydroxamic Acids - pharmacology | Cell Line | Histone Deacetylase 2 - genetics | TRPC6 Cation Channel | NF-kappa B p50 Subunit - metabolism | TRPC Cation Channels - biosynthesis | Histone Deacetylase 2 - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Hydrogen Peroxide - pharmacology | Gene Expression Regulation - physiology | Kidney - cytology | Protein Kinase C - antagonists & inhibitors | Gene Expression Regulation - drug effects | Transcription, Genetic - physiology | Transcription Factor RelA - metabolism | Histone Deacetylase Inhibitors - pharmacology | Histone Deacetylase 2 - metabolism | Carbazoles - pharmacology | NF-κB | Reactive Oxygen Species (ROS) | Signal Transduction | Calcium | Ion Channels | TRP Channels | Hydrogen Peroxide
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2012, Volume 7, Issue 11, p. e49321
Constitutive activation of nuclear factor kappa B (NF-kappa B) has been linked with carcinogenesis and cancer progression, including metastasis,... 
EPITHELIAL-MESENCHYMAL TRANSITION | SURVIVAL | BREAST-CANCER CELLS | APOPTOSIS | CIRCUITRY | METASTASIS | INHIBITION | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | DRUG-RESISTANCE | EXPRESSION | Cell Line | NF-KappaB Inhibitor alpha | Protein Binding - genetics | Biocatalysis | Signal Transduction | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Humans | Repressor Proteins - genetics | NF-kappa B - metabolism | I-kappa B Proteins - metabolism | Promoter Regions, Genetic - genetics | Down-Regulation - genetics | Cross-Linking Reagents - metabolism | Chromatin Immunoprecipitation | I-kappa B Kinase - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Models, Biological | Proteolysis | Transglutaminases - metabolism | Transcription, Genetic | GTP-Binding Proteins | Proteasome Endopeptidase Complex - metabolism | Repressor Proteins - metabolism | Hypoxia-inducible factor 1 | Transcription factors | Transcription | Epithelial cells | Gene regulation | Radiation | Chemoresistance | Activation | Metastasis | Drug resistance | Cancer therapies | Carcinogenesis | Metastases | Ovarian cancer | Proteins | Genotype & phenotype | Carcinogens | Repressors | Inhibition | Hypoxia-inducible factors | NF-κB protein | Breast cancer | Inflammation | Tumor necrosis factor-α | Transglutaminase 2 | Molecular modelling | Stem cells | Proteasomes | Radiation tolerance | Hypoxia | RelA protein | Binding sites | Cancer | Tumors
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 08/2008, Volume 28, Issue 33, pp. 8246 - 8256
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2004, Volume 101, Issue 15, pp. 5634 - 5639
Journal Article
Biochemical Journal, ISSN 0264-6021, 09/2004, Volume 382, Issue 2, pp. 393 - 409
Two members of the NF-kappaB (nuclear factor kappaB)/Rel transcription factor family, NF-kappaB1 and NF-kappaB2, are produced as precursor proteins, NF-kappaB1... 
IκB kinase (IKK) | p100 | Tumour progression locus-2 (TPL-2) | Nuclear factor κB (NF-κB) | p105 | Toll-like receptor (TLR) | nuclear factor kappa B (NF-kappa B) | TRCP UBIQUITIN LIGASE | I kappa B kinase (IKK) | BIOCHEMISTRY & MOLECULAR BIOLOGY | P105 REQUIRES PHOSPHORYLATION | ALLERGIC AIRWAY INFLAMMATION | KINASE KINASE KINASE | P50 SUBUNIT | GLYCINE-RICH REGION | TUMOR-NECROSIS-FACTOR | TOLL-LIKE RECEPTORS | tumour progression locus-2 (TPL-2) | NF-KAPPA-B | SIGNAL-TRANSDUCTION PATHWAY | TNF, tumour necrosis factor | GC, germinal centre | NEMO, nuclear factor κB essential modulator | MAP 3-kinase, MAP kinase kinase kinase | BAFF, B-cell activating factor | ERK, extracellular-signal-regulated kinase | Fn14, fibroblast-growth-factor-inducible 14 | ABIN, A20-binding inhibitor of nuclear factor κB | GM-CSF, granulocyte–macrophage colony-stimulating factor | GSK, glycogen synthase kinase | Dif, Dorsal-related immunity factor | EBNA1, EBV nuclear antigen 1 | BMDM, bone-marrow-derived macrophage | NF-κB, nuclear factor κB | SCF, Skp1 | Imd, immune deficiency | F-box | IL, interleukin | MAP kinase, mitogen-activated protein kinase | EBV, Epstein–Barr virus | LPS, lipopolysaccharide | IFNβ, interferon-β | IκB, inhibitor of nuclear factor κB | TRAF, TNF-receptor-associated factor | TLR, Toll-like receptor | DC, dendritic cell | IKK, IκB kinase | GRR, glycine-rich region | Review | JNK, c-Jun N-terminal kinase | PGRP-LC, peptidoglycan recognition protein LC | ERK kinase | RANKL, receptor activator of NF-κB ligand | LTβR, lymphotoxin-β receptor | MIP, macrophage inflammatory protein | DD, death domain | HTLV-1, human T-cell leukaemia virus type 1 | MEK, MAP kinase | COX-2, cyclo-oxygenase-2 | TH2, T-helper 2 | TH1, T-helper 1 | LMP1, latent membrane protein 1 | TPL-2, tumour progression locus-2 | TWEAK, TNF-like weak inducer of apoptosis | Cul1 | PEST region, polypeptide sequence enriched in proline (P), glutamic acid (E), serine (S) and threonine (T) | RHD, Rel homology domain | nuclear factor κB (NF-κB) | NIK, NF-κB-inducing kinase | MEF, mouse embryo fibroblast | βTrCP, β-transducin repeat-containing protein
Journal Article
International Immunopharmacology, ISSN 1567-5769, 11/2013, Volume 17, Issue 3, pp. 638 - 650
Neutrophils play a critical role in the host defense against bacterial and fungal infections, but their inappropriate activation also contributes to tissue... 
Signaling | Receptors | Inflammation | Kinases | Neutrophils | ACTIVATED PROTEIN-KINASE | COLONY-STIMULATING FACTOR | LEUKOCYTE ADHESION DEFICIENCY | IMMUNOLOGY | SRC-FAMILY KINASES | HUMAN POLYMORPHONUCLEAR LEUKOCYTES | HIGH-AFFINITY RECEPTOR | TUMOR-NECROSIS-FACTOR | TOLL-LIKE RECEPTORS | PHARMACOLOGY & PHARMACY | BETA-GAMMA-SUBUNITS | NF-KAPPA-B | Signal Transduction - immunology | Animals | Receptors, Cell Surface - immunology | Humans | Neutrophils - immunology | Selectins - immunology | Mycoses | Lectins | Fc receptors | Integrins | FcR, Fc-receptor | GPI, glycosylphosphatidylinositol anchor | CLEC, C-type lectin | OSCAR, osteoclast-associated receptor | PKB, protein kinase B | DAG, diacyl-glycerol | Tyk2, tyrosine protein kinase 2 | VCAM-1, vascular cell adhesion molecule 1 | ICAM-1, intercellular adhesion molecule 1 | FADD, Fas-associated protein with death domain | IκB, inhibitor of NF-κB | GM-CSF, granulocyte | MyD88, myeloid differentiation protein 88 | TNF, tumor necrosis factor | LTβ, lymphotoxin β | TRADD, TNFR1-associated death domain protein | Abl, Abelson leukemia proto-oncogene | SLP-76, SH2 domain-containing leukocyte protein of 76 kDa | CALDAG-GEFI, calcium and DAG-regulated guanine nucleotide exchange factor I | IL, interleukin | Src, Rous sarcoma virus proto-oncogene | IRF, IFN regulatory factor | RIG, retinoic acid-inducible gene | PLC, phospholipase C | TCR, T-cell receptor | IKK, IκB kinase | ITAM, immunoreceptor tyrosine-based activation motif | CARD, caspase activation and recruitment domain | IP3, inositol-tris-phosphate | CHO, Chinese hamster ovary cells | MKK, MAP kinase kinase | fMLP, formly-Met-Leu-Phe | TRAF, TNF receptor-associated factor | MIP, macrophage inflammatory protein | Rac, Ras-related C3 botulinum toxin substrate | monocyte colony-stimulating factor | PIP3, phosphatidylinositol-3-phosphate | VLA-4, very late antigen 4 (α4β1 integrin) | PAF, platelet activating factor | STAT, signal transducer and activator of transcription | TAK, TGFβ-activated kinase 1 | Mac-1, macrophage antigen 1 (αMβ2 integrin) | FcRγ, Fc-receptor γ-chain | Asc, apoptosis-associated speck-like protein containing a CARD | cIAP, cellular inhibitor of apoptosis | BCR, B-cell receptor | Fgr, Gardner–Rasheed feline sarcoma proto-oncogene | VASP, vasodilator-stimulated phosphoprotein | Hck, hematopoietic cell kinase | TGFβ, transforming growth factor β | Rap, Ras-related protein | SHP-1, SH2 domain-containing protein tyrosine phosphatase 1 | Syk, spleen tyrosine kinase | GPCR, G protein-coupled receptor | G-CSF, granulocyte colony-stimulating factor | TREM, triggering receptor expressed on myeloid cells | DISC, death-inducing signaling complex | MDL-1, myeloid DAP12-associating lectin 1 | C3G, Crk SH3 domain-binding guanine nucleotide exchange factor (RapGEF1) | NF-κB, nuclear factor κB | ERM, ezrin-radixin-moesin | Epac1, exchange protein activated by cyclic AMP 1 | LTB4, leukotriene B4 | Mcl, macrophage C-type lectin | SAP130, Sin3A-associated protein of 130 kDa | SH2, Src-homology 2 domain | MAP kinase, mitogen-activated protein kinase | PSGL-1, P-selectin glycoprotein ligand | PI3K, phoshoinositide-3-kinase | ADAP, adhesion and degranulation promoting adapter protein (Fyb, SLAP-130) | NLRP3, NOD-like receptor family, pyrin domain containing 3 | MDA5, melanoma differentiation-associated protein 5 | TLR, Toll-like receptor | GRK, GPCR kinase | LAD, leukocyte adhesion deficiency | MAPKAP-kinase, MAP kinase-associated protein kinase | ZAP-70, ζ-chain-associated protein of 70 kDa | TRAIL, TNF-related apoptosis-inducing ligand | JNK, c-Jun N-terminal kinase | LFA-1, lymphocyte function-associated receptor 1 (αLβ2 integrin) | ROS, reactive oxygen species | RIP3, receptor-interacting serine-threonine protein kinase 3 | DAP12, DNAX activating protein 12 | IFN, interferon | PIR, paired immunoglobulin-like receptor | PKC, protein kinase C | PAK, p21-activated kinase | ESL-1, E-selectin ligand 1 | GAP, GTPase activating protein | ERK, extracellular signal-regulated kinase | SOCS, suppressor of cytokine signaling | JAK, Janus kinase | RANK, receptor activator of NF-κB | IRAK, IL-1 receptor-associated kinase | NOD, nucleotide-binding oligomerization domain containing protein | CEACAM3, carcinoembryonic antigen-related cell adhesion molecule 3 (CD66b)
Journal Article