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Nature, ISSN 0028-0836, 09/2008, Volume 455, Issue 7211, pp. 416 - 420
Translation initiation, the rate- limiting step of the universal process of protein synthesis, proceeds through sequential, tightly regulated steps. In... 
MESSENGER-RNA TRANSLATION | BACTERIA | BOOTSTRAP | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | MOVEMENT | FMET-TRNA(FMET) | TERMINATION | BINDING | RIBOSOMAL-SUBUNIT | Ribosome Subunits - chemistry | RNA, Transfer, Met - ultrastructure | Ribosomes - metabolism | Crystallography, X-Ray | Multiprotein Complexes - genetics | Thermus thermophilus - ultrastructure | Guanosine Triphosphate - metabolism | Peptide Chain Initiation, Translational | RNA, Messenger - metabolism | RNA, Transfer, Met - genetics | Multiprotein Complexes - metabolism | Thermus thermophilus - genetics | Prokaryotic Initiation Factor-1 - chemistry | Guanosine Triphosphate - chemistry | Prokaryotic Initiation Factor-1 - ultrastructure | Prokaryotic Initiation Factor-2 - chemistry | Prokaryotic Initiation Factor-2 - ultrastructure | Thermus thermophilus - enzymology | RNA, Messenger - genetics | RNA, Transfer, Met - metabolism | Ribosomes - chemistry | Models, Molecular | Prokaryotic Initiation Factor-1 - genetics | Cryoelectron Microscopy | Multiprotein Complexes - ultrastructure | Multiprotein Complexes - chemistry | Ribosomes - ultrastructure | RNA, Transfer, Met - chemistry | Ribosome Subunits - ultrastructure | Prokaryotic Initiation Factor-1 - metabolism | Prokaryotic Initiation Factor-2 - metabolism | Protein Conformation | RNA, Messenger - chemistry | Ribosome Subunits - metabolism | Prokaryotic Initiation Factor-2 - genetics | Physiological aspects | Protein biosynthesis | Research | RNA | Ribosomal proteins | Genetic translation | Proteins | Bacteria | Statistical analysis | Methods | Crystal structure | Prokaryotic Initiation Factor-1 | Prokaryotic Initiation Factor-2 | Multiprotein Complexes | Biochemistry, Molecular Biology | Ribosomes | Cellular Biology | RNA, Transfer, Met | Thermus thermophilus | Life Sciences | Ribosome Subunits | RNA, Messenger | Guanosine Triphosphate
Journal Article
Molecular Cell, ISSN 1097-2765, 08/2017, Volume 67, Issue 3, pp. 447 - 456.e7
After having translated short upstream open reading frames, ribosomes can re-initiate translation on the same mRNA. This process, referred to as re-initiation,... 
eIF2D | ligatin | start codon recognition | translation initiation | DENR | ribosomal recycling | translation regulation | translation re-initiation | MCT-1 | initiator tRNA | P-SITE | EUKARYOTIC TRANSLATION INITIATION | 40S RIBOSOMAL-SUBUNIT | OPEN READING FRAMES | MESSENGER-RNA | UPSTREAM | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SEQUENCE | CRYO-EM STRUCTURE | PROTEIN-SYNTHESIS | CELL BIOLOGY | Oncogene Proteins - genetics | Ribosome Subunits, Small, Eukaryotic - chemistry | Eukaryotic Initiation Factor-2 - chemistry | Humans | Multiprotein Complexes | Crystallography, X-Ray | Structure-Activity Relationship | RNA, Messenger - metabolism | Cell Cycle Proteins - chemistry | Transfection | HEK293 Cells | Cell Cycle Proteins - genetics | Eukaryotic Initiation Factor-2 - metabolism | RNA, Transfer - genetics | Transcription Initiation, Genetic | Nucleic Acid Conformation | RNA, Transfer - chemistry | Binding Sites | Ribosome Subunits, Small, Eukaryotic - genetics | Eukaryotic Initiation Factors - chemistry | Eukaryotic Initiation Factors - genetics | Eukaryotic Initiation Factors - metabolism | Oncogene Proteins - chemistry | RNA, Transfer - metabolism | RNA, Messenger - genetics | Cell Cycle Proteins - metabolism | Oncogene Proteins - metabolism | Cryoelectron Microscopy | Eukaryotic Initiation Factor-2 - genetics | Transcription Initiation Site | Protein Binding | Protein Conformation | RNA, Messenger - chemistry | Molecular Docking Simulation | Mutation | Ribosome Subunits, Small, Eukaryotic - metabolism | RNA | Molecular biology | Binding proteins | Genetic translation | Protein binding
Journal Article
2003, illustrated edition, ISBN 9780415289207, xix, 294
Scholars of classical history and literature have far more than a century accepted "initiation" as a tool for understanding a variety of obscure rituals and... 
Initiation rites | Greek literature | Religious aspects | Greece Religious life and customs | Initiation rites in literature | History | History and criticism
Book
2004, ISBN 9781551302478, xvi, 179
Media attention has recently raised public awareness of hazing rituals, generating curiosity, interest and debate about hazing as an initiation practice.... 
Initiations (into trades, societies, etc.) | Sociological aspects | Social aspects | Hazing | Sports | Canada | Sports - Social aspects | Social Science | Sports - Sociological aspects | Electronic books
Book
Molecular Cell, ISSN 1097-2765, 07/2016, Volume 63, Issue 2, pp. 206 - 217
mRNA translation initiation in eukaryotes requires the cooperation of a dozen eukaryotic initiation factors (eIFs) forming several complexes, which leads to... 
ribosome | eukaryotic translation initiation | eIF3 peripheral subunits | cryo-EM | eIF3 | PROTEIN DHX29 | EUKARYOTIC TRANSLATION INITIATION | MOLECULAR-DYNAMICS | INHIBITION | SCANNING MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | PURIFICATION | RIBOSOMAL-SUBUNITS | CELL-PROLIFERATION | ELECTRON-MICROGRAPHS | 43S PREINITIATION COMPLEX | CELL BIOLOGY | Protein Subunits | Protein Biosynthesis | Eukaryotic Initiation Factor-2 - chemistry | Eukaryotic Initiation Factor-3 - chemistry | Humans | Multiprotein Complexes | Ribosomes - metabolism | Structure-Activity Relationship | RNA, Messenger - metabolism | Eukaryotic Initiation Factor-2 - metabolism | Eukaryotic Initiation Factor-1 - chemistry | Eukaryotic Initiation Factor-1 - metabolism | Nucleic Acid Conformation | RNA, Transfer - chemistry | Binding Sites | Rabbits | RNA, Transfer - metabolism | RNA, Messenger - genetics | Ribosomes - chemistry | Models, Molecular | Eukaryotic Initiation Factor-3 - metabolism | Codon, Initiator | Animals | beta-Globins - metabolism | Protein Binding | Protein Conformation | RNA, Messenger - chemistry | beta-Globins - chemistry | RNA | Genetic translation | Analysis | Biochemistry, Molecular Biology | Ribosomes | Eukaryotic Initiation Factor-1 | Eukaryotic Initiation Factor-2 | Eukaryotic Initiation Factor-3 | RNA, Transfer | beta-Globins | Life Sciences | Molecular biology | RNA, Messenger
Journal Article
Journal Article
Cell, ISSN 0092-8674, 2007, Volume 128, Issue 2, pp. 257 - 267
Assembly of the eIF4E/eIF4G complex has a central role in the regulation of gene expression at the level of translation initiation. This complex is regulated... 
FACTOR EIF-4E | HUMAN-DISEASE | MALIGNANT-TRANSFORMATION | CAP-DEPENDENT TRANSLATION | MESSENGER-RNA CAP | BIOCHEMISTRY & MOLECULAR BIOLOGY | BINDING PROTEIN EIF4E | EUKARYOTIC TRANSLATION | SECONDARY STRUCTURE | MTOR INHIBITORS | CANCER-THERAPY | CELL BIOLOGY | Protein Binding - genetics | Humans | Nitro Compounds - chemistry | Eukaryotic Initiation Factor-4E - metabolism | Peptide Fragments - pharmacology | Eukaryotic Initiation Factor-4G - drug effects | Eukaryotic Initiation Factor-4G - metabolism | Fluorescence Polarization Immunoassay - methods | Thiazoles - isolation & purification | Antineoplastic Agents - isolation & purification | Cell Transformation, Neoplastic - genetics | Protein Binding - drug effects | Nitro Compounds - pharmacology | Antineoplastic Agents - pharmacology | Protein Biosynthesis - genetics | Gene Expression Regulation, Neoplastic - drug effects | Eukaryotic Initiation Factor-4E - genetics | Peptide Fragments - genetics | Gene Expression Regulation, Neoplastic - genetics | RNA, Messenger - drug effects | Drug Evaluation, Preclinical - methods | Oncogenes - genetics | Peptide Fragments - metabolism | Jurkat Cells | RNA, Messenger - genetics | Hydrazones | Models, Molecular | Antineoplastic Agents - chemistry | Cell Transformation, Neoplastic - metabolism | Eukaryotic Initiation Factor-4E - drug effects | Nitro Compounds - isolation & purification | Animals | Cell Line, Tumor | Oncogenes - drug effects | Feedback, Physiological - drug effects | Protein Biosynthesis - drug effects | Thiazoles - chemistry | Eukaryotic Initiation Factor-4G - genetics | Mice | Thiazoles - pharmacology | Cell Transformation, Neoplastic - drug effects | Feedback, Physiological - physiology | Cell Line, Transformed | Peptide Fragments | Protein Biosynthesis | Gene Expression Regulation, Neoplastic | Eukaryotic Initiation Factor-4E | Chemical Sciences | Fluorescence Polarization Immunoassay | Life Sciences | Thiazoles | Drug Evaluation, Preclinical | Feedback, Biochemical | Oncogenes | Analytical chemistry | Biochemistry, Molecular Biology | Antineoplastic Agents | Organic chemistry | Eukaryotic Initiation Factor-4G | Cell Transformation, Neoplastic | Nitro Compounds | Protein Binding | RNA, Messenger
Journal Article
The EMBO Journal, ISSN 0261-4189, 01/2003, Volume 22, Issue 2, pp. 193 - 204
Translation initiation factor 1A (eIF1A) is predicted to bind in the decoding site of the 40S ribosome and has been implicated in recruitment of the... 
translation | ribosomes | eIF1A | GCN4 | eIF3 | eIF2 | EIF2 | EIF3 | Translation | EIF1A | Ribosomes | PROTEIN | RNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSLATION INITIATION | SACCHAROMYCES-CEREVISIAE | CELL BIOLOGY | YEAST | GENE | IF2 | EIF2-ALPHA | MODULATION | Eukaryotic Initiation Factor-5 - chemistry | Protein Biosynthesis | Eukaryotic Initiation Factor-2 - chemistry | Eukaryotic Initiation Factor-3 - chemistry | Saccharomyces cerevisiae - genetics | Ribosomes - metabolism | Peptide Chain Initiation, Translational | Recombinant Fusion Proteins - metabolism | Peptide Initiation Factors - chemistry | Saccharomyces cerevisiae - metabolism | Eukaryotic Initiation Factor-2 - metabolism | Eukaryotic Initiation Factor-3 - genetics | Binding Sites | Eukaryotic Initiation Factor-3 - metabolism | Eukaryotic Initiation Factor-1 | Recombinant Fusion Proteins - chemistry | Saccharomyces cerevisiae Proteins - genetics | Eukaryotic Initiation Factor-5 - metabolism | Macromolecular Substances | Peptide Initiation Factors - metabolism | Peptide Initiation Factors - genetics | Two-Hybrid System Techniques | Eukaryotic Initiation Factor-5 - genetics | Phenotype | Eukaryotic Initiation Factor-2 - genetics | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Recombinant Fusion Proteins - genetics | Protein Conformation | Saccharomyces cerevisiae Proteins - chemistry
Journal Article
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 513, Issue 7516, pp. 105 - 109
In BRAF(V600)-mutant tumours, most mechanisms of resistance to drugs that target the BRAF and/or MEK kinases rely on reactivation of the RAS-RAF-MEK-ERK... 
MESSENGER-RNA TRANSLATION | SILVESTROL | MELANOMA | INITIATION | RAF | MULTIDISCIPLINARY SCIENCES | ACQUIRED-RESISTANCE | LEUKEMIA-CELLS | MODEL | FEEDBACK INHIBITION | Triterpenes - pharmacology | Humans | Eukaryotic Initiation Factor-4E - metabolism | Eukaryotic Initiation Factor-4G - metabolism | Eukaryotic Initiation Factor-4F - metabolism | Melanoma - genetics | Protein Binding - drug effects | Female | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Cell Death - drug effects | Phosphorylation - drug effects | Eukaryotic Initiation Factor-4F - antagonists & inhibitors | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Melanoma - pathology | Sulfonamides - pharmacology | Eukaryotic Initiation Factor-4A - antagonists & inhibitors | Drug Synergism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | MAP Kinase Signaling System - drug effects | Eukaryotic Initiation Factor-4F - chemistry | Signal Transduction - drug effects | Proto-Oncogene Proteins B-raf - genetics | Colonic Neoplasms - pathology | Melanoma - drug therapy | Cell Line, Tumor | Mice | Protein Kinase Inhibitors - pharmacology | Eukaryotic Initiation Factor-4A - metabolism | Drug Resistance, Neoplasm - drug effects | Thyroid Neoplasms - pathology | Antimitotic agents | Pharmaceutical research | Vemurafenib | Protein research | Research | Antineoplastic agents | Drug resistance | Phosphorylation | Biopsy | Melanoma | Mutation | Metastasis | Cancer therapies | Tumors | Cancer | Cell and Molecular Biology | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Cell- och molekylärbiologi | Medicinska och farmaceutiska grundvetenskaper
Journal Article