Articles

Search Articles

Advanced search
Help

Catalogue

Articles

Databases

X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (22106) 22106
Publication (2397) 2397
Newsletter (301) 301
Book Review (117) 117
Book Chapter (61) 61
Conference Proceeding (15) 15
Book / eBook (8) 8
Dissertation (8) 8
Magazine Article (4) 4
Newspaper Article (3) 3
Data Set (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
animals (15056) 15056
calcium - metabolism (7028) 7028
rats (6730) 6730
humans (6387) 6387
male (4691) 4691
biochemistry & molecular biology (4564) 4564
inositol phosphates - metabolism (4157) 4157
cells, cultured (3524) 3524
index medicus (3201) 3201
pharmacology & pharmacy (3134) 3134
mice (2986) 2986
kinetics (2983) 2983
signal transduction (2652) 2652
female (2639) 2639
in vitro techniques (2638) 2638
inositol (2618) 2618
inositol 1,4,5-trisphosphate - metabolism (2602) 2602
calcium (2541) 2541
cell biology (2366) 2366
inositol 1,4,5-trisphosphate (2336) 2336
cell line (2187) 2187
neurosciences (2058) 2058
phosphatidylinositols - metabolism (1963) 1963
dose-response relationship, drug (1924) 1924
inositol trisphosphate (1912) 1912
activation (1761) 1761
physiology (1699) 1699
inositol - metabolism (1669) 1669
inositol phosphates (1626) 1626
phosphorylation (1599) 1599
cells (1587) 1587
inositol 1,4,5-trisphosphate receptors (1580) 1580
type c phospholipases - metabolism (1563) 1563
enzyme inhibitors - pharmacology (1384) 1384
time factors (1332) 1332
signal transduction - drug effects (1307) 1307
rats, sprague-dawley (1279) 1279
carbachol - pharmacology (1239) 1239
inositol - pharmacology (1219) 1219
hydrolysis (1205) 1205
inositol 1,4,5-trisphosphate - pharmacology (1183) 1183
research article (1163) 1163
cyclic amp - metabolism (1126) 1126
calcium channels - metabolism (1121) 1121
rats, wistar (1113) 1113
protein-kinase-c (1110) 1110
rats, inbred strains (1101) 1101
receptors (1084) 1084
receptor (1065) 1065
expression (1054) 1054
research (1029) 1029
protein kinase c - metabolism (1028) 1028
release (1005) 1005
physiological aspects (1003) 1003
calcium - pharmacology (986) 986
tumor cells, cultured (986) 986
endocrinology & metabolism (966) 966
inositol phosphates - biosynthesis (955) 955
tetradecanoylphorbol acetate - pharmacology (918) 918
phospholipase-c (915) 915
cell membrane - metabolism (914) 914
biophysics (903) 903
calcium signaling - drug effects (885) 885
calcium - physiology (872) 872
cattle (871) 871
proteins (857) 857
enzyme activation (856) 856
inositol phosphates - pharmacology (844) 844
transfection (837) 837
inositol 1,4,5-trisphosphate receptor (828) 828
pertussis toxin (824) 824
molecular sequence data (823) 823
signal transduction - physiology (812) 812
cytosol - metabolism (795) 795
inhibition (788) 788
adenosine triphosphate - pharmacology (746) 746
amino acid sequence (728) 728
virulence factors, bordetella - pharmacology (727) 727
brain (711) 711
endoplasmic-reticulum (706) 706
intracellular calcium (690) 690
binding (686) 686
rabbits (680) 680
gtp-binding proteins - metabolism (674) 674
analysis (670) 670
phospholipase c (663) 663
inositol 1,4,5-trisphosphate receptors - metabolism (662) 662
multidisciplinary sciences (661) 661
metabolism (659) 659
article (658) 658
cricetinae (640) 640
calcium channels (634) 634
receptors, cytoplasmic and nuclear - metabolism (628) 628
egtazic acid - pharmacology (625) 625
calcium signaling - physiology (618) 618
enzyme activation - drug effects (617) 617
thapsigargin - pharmacology (609) 609
models, biological (607) 607
apoptosis (603) 603
thapsigargin (601) 601
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (22115) 22115
Japanese (99) 99
Russian (51) 51
Chinese (48) 48
French (47) 47
German (47) 47
Italian (25) 25
Spanish (9) 9
Ukrainian (8) 8
Czech (3) 3
Dutch (2) 2
Hungarian (2) 2
Polish (1) 1
Slovak (1) 1
Slovenian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


1. Full Text Intracellular angiotensin II activates rat myometrium
by Deliu, Elena and Tica, Andrei A and Motoc, Dana and Brailoiu, G. Cristina and Brailoiu, Eugen
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 09/2011, Volume 301, Issue 3, pp. C559 - C565
Deliu E, Tica AA, Motoc D, Brailoiu GC, Brailoiu E. Intracellular angiotensin II activates rat myometrium. Am J Physiol Cell Physiol 301: C559-C565, 2011.... 
Calcium imaging | Microinjection | Cytosolic calcium concentration | Endoplasmic reticulum | CYCLIC ADP-RIBOSE | PHYSIOLOGY | ANG-II | LIVER LYSOSOMES | RECEPTOR | microinjection | METABOLIC-CLEARANCE | BLOOD-PRESSURE | UTERINE | CELL BIOLOGY | SIGNAL-TRANSDUCTION | RENAL ENDOSOMES | SMOOTH-MUSCLE-CELLS | calcium imaging | cytosolic calcium concentration | endoplasmic reticulum | Myometrium - drug effects | Type C Phospholipases - metabolism | Brefeldin A - pharmacology | Angiotensin II Type 1 Receptor Blockers - pharmacology | Autophagy - drug effects | Endosomes - metabolism | Angiotensin II Type 2 Receptor Blockers - pharmacology | Macrocyclic Compounds - pharmacology | Saralasin - pharmacology | Endoplasmic Reticulum - drug effects | Estrenes - pharmacology | Myometrium - metabolism | Inositol 1,4,5-Trisphosphate Receptors - antagonists & inhibitors | Ryanodine - pharmacology | Angiotensin II - pharmacology | Pyridines - administration & dosage | Endocytosis - drug effects | Enzyme Inhibitors - pharmacology | Losartan - pharmacology | Saralasin - administration & dosage | Rats | Imidazoles - pharmacology | Piperazines - pharmacology | Rats, Sprague-Dawley | Receptor, Angiotensin, Type 2 - metabolism | Signal Transduction - drug effects | Calcium Signaling - drug effects | Models, Biological | Receptor, Angiotensin, Type 1 - metabolism | Oxazoles - pharmacology | Losartan - administration & dosage | Angiotensin II - administration & dosage | Calcium Signaling - physiology | Endoplasmic Reticulum - metabolism | Imidazoles - administration & dosage | Type C Phospholipases - antagonists & inhibitors | Lysosomes - metabolism | Inositol 1,4,5-Trisphosphate Receptors - metabolism | Pyrrolidinones - pharmacology | Macrolides - pharmacology | NADP - analogs & derivatives | Female | NADP - metabolism | Heparin - pharmacology | Angiotensin II - metabolism | Arsenicals - pharmacology | Cells, Cultured | Sirolimus - pharmacology | Myometrium - cytology | Animals | Egtazic Acid - pharmacology | Uterus - cytology | Signal Transduction - physiology | Pyridines - pharmacology | Carbolines - pharmacology | Myometrium | Cell receptors | Calcium channels | Genetic aspects | Properties | Angiotensin | Receptors and Signal Transduction
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
2. Full Text Glial Cells Dilate and Constrict Blood Vessels: A Mechanism of Neurovascular Coupling
by Metea, Monica R and Newman, Eric A
Journal of Neuroscience, ISSN 0270-6474, 03/2006, Volume 26, Issue 11, pp. 2862 - 2870
Neuronal activity evokes localized changes in blood flow. Although this response, termed neurovascular coupling, is widely used to monitor human brain function... 
Arachidonic acid metabolites | Retina | Calcium | Glia | ATP | Blood flow | arachidonic acid metabolites | NEURONAL-ACTIVITY | 20-HETE | calcium | RAT | ASTROCYTE-MEDIATED CONTROL | CALCIUM WAVES | ARACHIDONIC-ACID | glia | NEUROSCIENCES | HEMODYNAMIC-RESPONSE | retina | NITRIC-OXIDE | blood flow | MULLER CELLS | BRAIN | Arterioles - physiology | Cytochrome P-450 Enzyme Inhibitors | Rats, Long-Evans | Arterioles - enzymology | Nitric Oxide Synthase - physiology | Male | Vasodilation - radiation effects | Retinal Vessels - enzymology | Retinal Vessels - physiology | Hydroxyeicosatetraenoic Acids - biosynthesis | Vasoconstriction - radiation effects | Photolysis | Cyclic N-Oxides - pharmacology | Inositol 1,4,5-Trisphosphate - analogs & derivatives | Eye Proteins - antagonists & inhibitors | Purinergic Antagonists | Signal Transduction - radiation effects | Cytochrome P-450 Enzyme System - physiology | Hydrazines - pharmacology | Rats | Imidazoles - pharmacology | Retinal Vessels - drug effects | Arterioles - drug effects | Vasoconstriction - drug effects | Cytochrome P-450 CYP4A - physiology | Signal Transduction - drug effects | Miconazole - pharmacology | Eye Proteins - physiology | Retinal Vessels - radiation effects | Vasodilation - drug effects | Arterioles - radiation effects | Nitric Oxide - pharmacology | Caproates - pharmacology | Vasomotor System - drug effects | Nitric Oxide Synthase - antagonists & inhibitors | Inositol 1,4,5-Trisphosphate - pharmacology | Adenosine Triphosphate - pharmacology | Vasoconstriction - physiology | 8,11,14-Eicosatrienoic Acid - analogs & derivatives | Proadifen - pharmacology | Nitric Oxide Donors - pharmacology | Vasodilation - physiology | 8,11,14-Eicosatrienoic Acid - pharmacology | NG-Nitroarginine Methyl Ester - pharmacology | Calcium Signaling - radiation effects | Cytochrome P-450 CYP4A - antagonists & inhibitors | Neuroglia - physiology | Nitric Oxide - physiology | Vasomotor System - radiation effects | Animals | Vasomotor System - physiology | Amidines - pharmacology | In Vitro Techniques
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
3. Full Text Previous ethanol experience enhances synaptic plasticity of NMDA receptors in the ventral tegmental area
by Bernier, Brian E and Whitaker, Leslie R and Morikawa, Hitoshi
Journal of Neuroscience, ISSN 0270-6474, 04/2011, Volume 31, Issue 14, pp. 5205 - 5212
Alcohol addiction (alcoholism) is one of the most prevalent substance abuse disorders worldwide. Addiction is thought to arise, in part, from a maladaptive... 
CHRONIC INTERMITTENT ETHANOL | CORTICOTROPIN-RELEASING-FACTOR | INOSITOL 1,4,5-TRISPHOSPHATE | C57BL/6J MICE | PROTEIN-KINASE | GABAERGIC SYNAPSES | CA2+ CHANNELS | MIDBRAIN DOPAMINE NEURONS | LONG-TERM POTENTIATION | HIPPOCAMPAL-NEURONS | NEUROSCIENCES | Peptide Hormones - pharmacology | Electric Stimulation | Receptors, N-Methyl-D-Aspartate - metabolism | Conditioning, Operant - physiology | Neuronal Plasticity - drug effects | Inositol 1,4,5-Trisphosphate - pharmacology | Male | Ventral Tegmental Area - cytology | Central Nervous System Depressants - pharmacology | Dose-Response Relationship, Drug | Quinoxalines - pharmacology | Drug Interactions | Conditioning, Operant - drug effects | Long-Term Potentiation - drug effects | Long-Term Potentiation - physiology | Neurons - drug effects | Ventral Tegmental Area - drug effects | Dopamine Uptake Inhibitors - pharmacology | Drug Administration Schedule | Amphibian Proteins - pharmacology | Colforsin - pharmacology | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Biophysics | Corticotropin-Releasing Hormone - pharmacology | Cocaine - pharmacology | Methoxyhydroxyphenylglycol - analogs & derivatives | Methoxyhydroxyphenylglycol - pharmacology | Ethanol - pharmacology | Animals | Analysis of Variance | Dopamine Antagonists - pharmacology | Mice | In Vitro Techniques | Salicylamides - pharmacology
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
4. Full Text The cannabinoid agonist WIN55,212-2 increases intracellular calcium via CB1 receptor coupling to Gq/11 G proteins
by Jane E. Lauckner and Bertil Hille and Ken Mackie
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2005, Volume 102, Issue 52, pp. 19144 - 19149
Central nervous system responses to cannabis are primarily mediated by CB 1 receptors, which couple preferentially to G i/o G proteins. Here, we used calcium... 
Aminoalkylindole | Inositol phosphate | Neurons | Phospholipase C | Analgesics - pharmacology | Calcium - metabolism | Humans | Endoplasmic Reticulum - metabolism | Type C Phospholipases - metabolism | Cytoplasm - metabolism | Benzoxazines | Arachidonic Acids - chemistry | Calcium - chemistry | GTP-Binding Protein alpha Subunits, Gq-G11 - chemistry | Piperidines - pharmacology | Time Factors | Dronabinol - analogs & derivatives | Fluorescent Dyes - pharmacology | Receptor, Cannabinoid, CB1 - chemistry | Neurons - metabolism | Cyclohexanols - pharmacology | Dronabinol - pharmacology | Immunosuppressive Agents - pharmacology | Endocannabinoids | Ryanodine - pharmacology | Pertussis Toxin - pharmacology | Pyrazoles - pharmacology | Cell Line | Glycerides - chemistry | Cannabinoids - chemistry | Morpholines - pharmacology | Rats | Excitatory Amino Acid Antagonists - pharmacology | GTP-Binding Protein alpha Subunits, Gq-G11 - physiology | Fura-2 - analogs & derivatives | Naphthalenes - pharmacology | Hippocampus - metabolism | Receptor, Cannabinoid, CB1 - metabolism | Animals | Fura-2 - pharmacology | Protein Binding | Protein Conformation | DNA, Complementary - metabolism | phospholipase C | Biological Sciences | aminoalkylindole | neurons | inositol phosphate
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
5. Full Text Local Ca2+ detection and modulation of synaptic release by astrocytes
by Di Castro, Maria Amalia and Chuquet, Julien and Liaudet, Nicolas and Bhaukaurally, Khaleel and Santello, Mirko and Bouvier, David and Tiret, Pascale and Volterra, Andrea
Nature Neuroscience, ISSN 1097-6256, 10/2011, Volume 14, Issue 10, pp. 1276 - 1284
Astrocytes communicate with synapses by means of intracellular calcium ([Ca2+](i)) elevations, but local calcium dynamics in astrocytic processes have never... 
DENDRITIC SPINES | RAT DENTATE GYRUS | NEURONAL-ACTIVITY | HIPPOCAMPAL ASTROCYTES | IN-VIVO | GLUTAMATE EXOCYTOSIS | BERGMANN GLIAL-CELLS | POSTSYNAPTIC CURRENTS | LONG-TERM POTENTIATION | GRANULE CELLS | NEUROSCIENCES | Synaptic Transmission - physiology | Calcium - metabolism | Calcium Signaling - physiology | Sucrose - pharmacology | Cell Communication - physiology | Synapses - metabolism | Egtazic Acid - analogs & derivatives | Synaptic Transmission - drug effects | Tetrodotoxin - pharmacology | Electric Stimulation - methods | Action Potentials - drug effects | Heparin - pharmacology | Animals, Newborn | Purinergic P2Y Receptor Antagonists - pharmacology | Astrocytes - drug effects | Synapses - drug effects | Gene Expression Regulation - genetics | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Sodium Channel Blockers - pharmacology | Biophysics | Chelating Agents - pharmacology | Hippocampus - cytology | Inositol 1,4,5-Trisphosphate Receptors - deficiency | Adenosine Diphosphate - pharmacology | Mice, Knockout | Action Potentials - physiology | Astrocytes - ultrastructure | Gene Expression Regulation - drug effects | Astrocytes - physiology | Patch-Clamp Techniques | Animals | Egtazic Acid - pharmacology | Calcium Signaling - drug effects | Models, Biological | Cell Communication - drug effects | Thapsigargin - pharmacology | Mice | In Vitro Techniques | Adenosine Diphosphate - analogs & derivatives
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
6. Full Text Zinc pyrithione inhibits caspase-3 activity, promotes ErbB1-ErbB2 heterodimerization and suppresses ErbB2 downregulation in cardiomyocytes subjected to ischemia/reperfusion
by Bodiga, Vijaya Lakshmi and Bodiga, Sreedhar and Thokala, Sandhya and Vemuri, Praveen Kumar
Journal of Inorganic Biochemistry, ISSN 0162-0134, 12/2015, Volume 153, pp. 49 - 59
Heart tissue becomes zinc-depleted and the capacity to mobilize labile zinc is diminished, indicating zinc dyshomeostasis during ischemia/reperfusion (I/R).... 
Hypoxia | Reoxygenation | Proteolysis | Caspase-3 | Zinc | Apoptosis | ACTIVATION | RAT | MITOCHONDRIAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | REPERFUSION INJURY | CARDIOMYOPATHY | CARDIAC-CELLS | DEATH | INTRACELLULAR ZINC | CHEMISTRY, INORGANIC & NUCLEAR | ACUTE MYOCARDIAL-INFARCTION | Receptor, Epidermal Growth Factor - genetics | Caspase Inhibitors - pharmacology | Phosphorylation | Receptor, ErbB-2 - genetics | Protein Multimerization | Caspase 3 - metabolism | Receptor, ErbB-2 - metabolism | RNA, Messenger - metabolism | Cell Hypoxia | Receptor, Epidermal Growth Factor - metabolism | Zinc Compounds - pharmacology | Amino Acid Chloromethyl Ketones - pharmacology | Receptor, ErbB-2 - antagonists & inhibitors | Proteasome Inhibitors - pharmacology | Benzothiazoles - pharmacology | Chlorides - pharmacology | Down-Regulation | RNA, Messenger - genetics | Rats | Tyrphostins - pharmacology | Cardiotonic Agents - pharmacology | Leupeptins - pharmacology | Myocytes, Cardiac - pathology | Animals | Myocytes, Cardiac - drug effects | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Thiones - pharmacology | Quinazolines - pharmacology | Organometallic Compounds - pharmacology | Proteins | Membrane lipids | Inositol | RNA | Antifungal agents | Permeability | Antibacterial agents | Phosphotransferases | Tyrosine | Cell death
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
7. Full Text Potentiation of neurite outgrowth by brexpiprazole, a novel serotonin–dopamine activity modulator: A role for serotonin 5-HT1A and 5-HT2A receptors
by Ishima, Tamaki and Futamura, Takashi and Ohgi, Yuta and Yoshimi, Noriko and Kikuchi, Tetsuro and Hashimoto, Kenji
European Neuropsychopharmacology, ISSN 0924-977X, 2015, Volume 25, Issue 4, pp. 505 - 511
Abstract Brexpiprazole, a novel atypical antipsychotic drug, is currently being tested in clinical trials for treatment of psychiatric disorders, such as... 
Internal Medicine | Psychiatry | Brexpiprazole | IP3 receptors | 5-HT2A receptor | Ca2+signaling | Neurite outgrowth | 5-HT1A receptor | receptor | signaling | receptors | IP | 5-HT | Ca | Ca2+ signaling | PSYCHIATRY | INDUCED COGNITIVE DEFICITS | SCHIZOPHRENIA | TRISPHOSPHATE | CHAPERONE | NEUROSCIENCES | CLINICAL NEUROLOGY | NERVE GROWTH-FACTOR | INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR | ANTIPSYCHOTIC-DRUGS | SIGMA-1 RECEPTORS | PHARMACOLOGY & PHARMACY | PC12 CELLS | Boron Compounds - pharmacology | Rats | Thiophenes - pharmacology | Quinolones - pharmacology | Nerve Growth Factor | PC12 Cells | Piperazines - pharmacology | Macrocyclic Compounds - pharmacology | Dose-Response Relationship, Drug | Drug Synergism | Fluorobenzenes - pharmacology | Animals | Serotonin Agents - pharmacology | Piperidines - pharmacology | Inositol 1,4,5-Trisphosphate Receptors - metabolism | Aripiprazole - therapeutic use | Inositol 1,4,5-Trisphosphate Receptors - antagonists & inhibitors | HSP90 Heat-Shock Proteins - metabolism | Oxazoles - pharmacology | Pyridines - pharmacology | Receptor, Serotonin, 5-HT2A - metabolism | Neurites - drug effects | Receptor, Serotonin, 5-HT1A - metabolism
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
8. Full Text β-Glucosidase 2 (GBA2) activity and imino sugar pharmacology
by Ridley, Christina M and Thur, Karen E and Shanahan, Jessica and Thillaiappan, Nagendra Babu and Shen, Ann and Uhl, Karly and Walden, Charlotte M and Rahim, Ahad A and Waddington, Simon N and Platt, Frances M and Van Der Spoel, Aarnoud C
Journal of Biological Chemistry, ISSN 0021-9258, 09/2013, Volume 288, Issue 36, pp. 26052 - 26066
beta-Glucosidase 2 (GBA2) is an enzyme that cleaves the membrane lipid glucosylceramide into glucose and ceramide. The GBA2 gene is mutated in genetic... 
DISEASE TYPE-C | SITE-SPECIFIC CHAPERONES | IN-VITRO | CONDURITOL-B-EPOXIDE | BIOCHEMISTRY & MOLECULAR BIOLOGY | GLYCOSPHINGOLIPID SYNTHESIS | GLUCOCEREBROSIDASE DEFICIENCY | NONLYSOSOMAL GLUCOSYLCERAMIDASE | SUBSTRATE REDUCTION THERAPY | N-BUTYLDEOXYNOJIRIMYCIN | GAUCHER-DISEASE | Inositol - pharmacology | 1-Deoxynojirimycin - pharmacokinetics | Humans | Enzyme Inhibitors - pharmacology | Cercopithecus aethiops | Inositol - analogs & derivatives | Spastic Paraplegia, Hereditary - drug therapy | Inositol - pharmacokinetics | 1-Deoxynojirimycin - pharmacology | beta-Glucosidase - antagonists & inhibitors | Animals | Enzyme Inhibitors - pharmacokinetics | Cell Line, Tumor | beta-Glucosidase - metabolism | 1-Deoxynojirimycin - analogs & derivatives | Mice | Cerebellar Ataxia - drug therapy | Cerebellar Ataxia - enzymology | Spastic Paraplegia, Hereditary - enzymology | COS Cells | Hydrogen-Ion Concentration | Enzyme Inhibitors | Glycolipids | Glycoside Hydrolases | Sphingolipid | Conduritol B Epoxide | Lipids | Membrane Lipids | Glucosylceramide | Nonlysosomal Glucosylceramidase | Miglustat | Mechanism-based Enzyme Inhibitor
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
9. Full Text TRPC channels function independently of STIM1 and Orai1
by Wayne I. DeHaven and Bertina F. Jones and John G. Petranka and Jeremy T. Smyth and Takuro Tomita and Gary S. Bird and James W. Putney, Jr
The Journal of Physiology, ISSN 0022-3751, 05/2009, Volume 587, Issue 10, pp. 2275 - 2298
Recent studies have defined roles for STIM1 and Orai1 as calcium sensor and calcium channel, respectively, for Ca 2+ -release activated Ca 2+ (CRAC) channels,... 
CATION CHANNELS | OPERATED CA2+ ENTRY | PHYSIOLOGY | CALCIUM-ENTRY | HEK293 CELLS | SMOOTH-MUSCLE-CELLS | TRANSIENT-RECEPTOR | STORE DEPLETION | PLASMA-MEMBRANE | NEUROSCIENCES | CRAC CHANNEL | INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR | RNA, Small Interfering - genetics | Cell Adhesion Molecules - genetics | Gadolinium - pharmacology | Membrane Microdomains - metabolism | Humans | Neoplasm Proteins - physiology | Inositol 1,4,5-Trisphosphate - pharmacology | beta-Cyclodextrins - pharmacology | Calcium Channels - physiology | Transfection | Diglycerides - pharmacology | Membrane Proteins - physiology | Cell Membrane - metabolism | Myocytes, Smooth Muscle - drug effects | Cell Membrane - drug effects | Stromal Interaction Molecule 1 | Cell Line | TRPC6 Cation Channel | Electrophysiological Phenomena - physiology | Myocytes, Smooth Muscle - physiology | Stromal Interaction Molecule 2 | Barium - pharmacology | Chelating Agents - pharmacology | Arginine Vasopressin - pharmacology | ORAI1 Protein | Carbachol - pharmacology | Calcium Signaling - drug effects | Membrane Microdomains - drug effects | Thapsigargin - pharmacology | TRPC Cation Channels - physiology | Electrophysiological Phenomena - drug effects | RNA | Calcium channels | Molecular & Cellular
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
10. Full Text Sponging off nature for new drug leads
by Andersen, Raymond J
Biochemical Pharmacology, ISSN 0006-2952, 09/2017, Volume 139, pp. 3 - 14
Marine sponges have consistently been the richest source of new marine natural products with unprecedented chemical scaffolds and potent biological activities... 
Porifera | Marine natural products | Drug discovery | ANDROGEN RECEPTOR | INOSITOL 5-PHOSPHATASE | MAST-CELLS | PAPUA-NEW-GUINEA | STRUCTURE ELUCIDATION | MARINE SPONGE | SHIP1 ACTIVATOR AQX-1125 | IN-VIVO | PHARMACOLOGY & PHARMACY | CYSTITIS/BLADDER PAIN SYNDROME | RESISTANT PROSTATE-CANCER | Indans - adverse effects | Anti-Asthmatic Agents - therapeutic use | Humans | Drugs, Investigational - therapeutic use | Antineoplastic Agents - therapeutic use | Prodrugs - chemistry | Nonsteroidal Anti-Androgens - chemistry | Oligopeptides - therapeutic use | Nonsteroidal Anti-Androgens - therapeutic use | Sterols - adverse effects | Glycerol - analogs & derivatives | Porifera - chemistry | Benzhydryl Compounds - therapeutic use | Oligopeptides - chemistry | Anti-Asthmatic Agents - chemistry | Glycerol - therapeutic use | Indans - chemistry | Anti-Asthmatic Agents - pharmacology | Pyrrolidinones - adverse effects | Antimitotic Agents - adverse effects | Pyrrolidinones - therapeutic use | Antimitotic Agents - therapeutic use | Biological Products - isolation & purification | Biological Products - chemistry | Pyrrolidinones - isolation & purification | Cyclohexanols - therapeutic use | Oligopeptides - pharmacology | Anti-Asthmatic Agents - adverse effects | Cyclohexanols - adverse effects | Drugs, Investigational - adverse effects | Drugs, Investigational - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Oligopeptides - adverse effects | Indans - therapeutic use | Benzhydryl Compounds - chemistry | Drugs, Investigational - chemistry | Sterols - therapeutic use | Benzhydryl Compounds - adverse effects | Antineoplastic Agents - adverse effects | Cyclohexanols - chemistry | Nonsteroidal Anti-Androgens - adverse effects | Drug Design | Antineoplastic Agents - pharmacology | Glycerol - pharmacology | Aquatic Organisms - chemistry | Nonsteroidal Anti-Androgens - pharmacology | Sterols - pharmacology | Sterols - chemistry | Antineoplastic Agents - chemistry | Drug Discovery | Pyrrolidinones - chemistry | Prodrugs - adverse effects | Animals | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Antimitotic Agents - pharmacology | Benzhydryl Compounds - pharmacology | Prodrugs - therapeutic use | Prodrugs - pharmacology | Antimitotic Agents - chemistry | Chemical oceanography | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
11. Full Text Mitochondrial reactive oxygen species are activated by mGluR5 through IP3 and activate ERK and PKA to increase excitability of amygdala neurons and pain behavior
by Li, Zhen and Ji, Guangchen and Neugebauer, Volker
Journal of Neuroscience, ISSN 0270-6474, 01/2011, Volume 31, Issue 3, pp. 1114 - 1127
Reactive oxygen species (ROS) such as superoxide are emerging as important signaling molecules in physiological plasticity but also in peripheral and spinal... 
DORSAL-HORN NEURONS | GENE-RELATED PEPTIDE | PERSISTENT PAIN | PROTEIN-KINASE | ULTRASONIC VOCALIZATIONS | METABOTROPIC GLUTAMATE RECEPTORS | LONG-TERM POTENTIATION | SIGNAL-REGULATED KINASE | SYNAPTIC PLASTICITY | HIPPOCAMPAL-NEURONS | NEUROSCIENCES | Glycine - analogs & derivatives | Amygdala - drug effects | Pain Perception - physiology | Reactive Oxygen Species - metabolism | Receptors, Metabotropic Glutamate - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Spin Labels | Pain - metabolism | Macrocyclic Compounds - pharmacology | Pain Perception - drug effects | Cyclic N-Oxides - pharmacology | Neurons - physiology | Superoxides - metabolism | Receptor, Metabotropic Glutamate 5 | Vocalization, Animal - drug effects | Neurons - drug effects | Cyclic AMP-Dependent Protein Kinases - metabolism | NG-Nitroarginine Methyl Ester - pharmacology | Enzyme Inhibitors - pharmacology | Vocalization, Animal - physiology | Pain Measurement - drug effects | Mitochondria - metabolism | Antioxidants - pharmacology | Mitochondria - drug effects | Patch-Clamp Techniques | Animals | Analysis of Variance | Glycine - pharmacology | Pain - physiopathology | Benzoates - pharmacology | Signal Transduction - physiology | Oxazoles - pharmacology | Pyridines - pharmacology | Thiazoles - pharmacology | Receptors, Metabotropic Glutamate - agonists | Amygdala - physiology | Excitatory Amino Acid Antagonists | Inositol 1,4,5-Trisphosphate - metabolism
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
12. Full Text Hydrogen Peroxide Potentiates the EDHF Phenomenon by Promoting Endothelial Ca2+ Mobilization
by Edwards, David H and Li, Yiwen and Griffith, Tudor M
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 10/2008, Volume 28, Issue 10, pp. 1774 - 1781
OBJECTIVE—The purpose of this study was to test the hypothesis that H2O2 contributes to the EDHF phenomenon by mobilizing endothelial Ca stores. METHODS AND... 
Thimerosal | Hydrogen peroxide | SERCA pump | EDHF | PANCREATIC ACINAR-CELLS | hydrogen peroxide | CYTOCHROME-P450 EPOXYGENASES | DEPENDENT HYPERPOLARIZATION | ACTIVATED POTASSIUM CHANNELS | RABBIT AORTA | MESENTERIC-ARTERY | SMOOTH-MUSCLE | GAP-JUNCTIONS | NITRIC-OXIDE | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | K+ CHANNELS | thimerosal | Myography | Amitrole - pharmacology | Gap Junctions - metabolism | Oxidants - pharmacology | Calcium - metabolism | Catalase - antagonists & inhibitors | Endoplasmic Reticulum - metabolism | Homeostasis | Cytoplasm - metabolism | Endothelium, Vascular - drug effects | Male | Apamin - pharmacology | Endothelium, Vascular - enzymology | Thimerosal - pharmacology | Dose-Response Relationship, Drug | Glutathione - pharmacology | Inositol 1,4,5-Trisphosphate Receptors - metabolism | Potassium Channels, Calcium-Activated - metabolism | Indoles - pharmacology | Sarcoplasmic Reticulum Calcium-Transporting ATPases - antagonists & inhibitors | Iliac Artery - metabolism | Biological Factors - metabolism | Potassium Channel Blockers - pharmacology | Pyrazoles - pharmacology | Rabbits | Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism | Vasodilator Agents - pharmacology | Glutathione - analogs & derivatives | Enzyme Inhibitors - pharmacology | Hydrogen Peroxide - metabolism | Peptides - pharmacology | Catalase - metabolism | Animals | Calcium Signaling - drug effects | Endothelium, Vascular - metabolism | Vasodilation - drug effects | In Vitro Techniques | Microscopy, Fluorescence | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
13. Full Text CRF receptor 1 regulates anxiety behavior via sensitization of 5-HT2 receptor signaling
by Magalhaes, Ana C and Holmes, Kevin D and Dale, Lianne B and Comps-Agrar, Laetitia and Lee, Dennis and Yadav, Prem N and Drysdale, Linsay and Poulter, Michael O and Roth, Bryan L and Pin, Jean-Philippe and Anisman, Hymie and Ferguson, Stephen S.G
Nature Neuroscience, ISSN 1097-6256, 05/2010, Volume 13, Issue 5, pp. 622 - 629
Stress and anxiety disorders are risk factors for depression and these behaviors are modulated by corticotrophin-releasing factor receptor 1 (CRFR1) and... 
INTERNALIZATION | CORTICOTROPIN-RELEASING-FACTOR | PDZ PROTEINS | CORTICAL PYRAMIDAL NEURONS | DESENSITIZATION | SEROTONIN RECEPTORS | TRAFFICKING | CENTRAL-NERVOUS-SYSTEM | ENDOCYTOSIS | NEUROSCIENCES | RAB GTPASES | Embryo, Mammalian | Amphetamines - pharmacology | Humans | Receptors, Corticotropin-Releasing Hormone - genetics | Male | Anxiety - drug therapy | Receptors, Serotonin, 5-HT2 - metabolism | Serotonin - pharmacology | Dose-Response Relationship, Drug | Fluorobenzenes - pharmacology | Serotonin 5-HT2 Receptor Antagonists | Transfection | Piperidines - pharmacology | Reaction Time - drug effects | Behavior, Animal - drug effects | Inositol Phosphates - metabolism | Anxiety - metabolism | Cyclic AMP - metabolism | Ionophores - pharmacology | Disease Models, Animal | Hormones - pharmacology | Maze Learning - physiology | Neurons | Cells, Cultured | Anxiety - physiopathology | Monensin - pharmacology | Rats | Behavior, Animal - physiology | Maze Learning - drug effects | Mutation - genetics | Prefrontal Cortex - cytology | Corticotropin-Releasing Hormone - pharmacology | Receptors, Corticotropin-Releasing Hormone - physiology | Animals | Receptors, Serotonin, 5-HT2 - genetics | Serotonin Agents - pharmacology | Signal Transduction - drug effects | Signal Transduction - physiology | Biotinylation - methods | Mice | Serotonin 5-HT2 Receptor Agonists | Endocytosis | Physiological aspects | Cellular signal transduction | Anxiety | Genetic aspects | Research | Genetic regulation
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights