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American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 09/2011, Volume 301, Issue 3, pp. C559 - C565
Deliu E, Tica AA, Motoc D, Brailoiu GC, Brailoiu E. Intracellular angiotensin II activates rat myometrium. Am J Physiol Cell Physiol 301: C559-C565, 2011.... 
Calcium imaging | Microinjection | Cytosolic calcium concentration | Endoplasmic reticulum | CYCLIC ADP-RIBOSE | PHYSIOLOGY | ANG-II | LIVER LYSOSOMES | RECEPTOR | microinjection | METABOLIC-CLEARANCE | BLOOD-PRESSURE | UTERINE | CELL BIOLOGY | SIGNAL-TRANSDUCTION | RENAL ENDOSOMES | SMOOTH-MUSCLE-CELLS | calcium imaging | cytosolic calcium concentration | endoplasmic reticulum | Myometrium - drug effects | Type C Phospholipases - metabolism | Brefeldin A - pharmacology | Angiotensin II Type 1 Receptor Blockers - pharmacology | Autophagy - drug effects | Endosomes - metabolism | Angiotensin II Type 2 Receptor Blockers - pharmacology | Macrocyclic Compounds - pharmacology | Saralasin - pharmacology | Endoplasmic Reticulum - drug effects | Estrenes - pharmacology | Myometrium - metabolism | Inositol 1,4,5-Trisphosphate Receptors - antagonists & inhibitors | Ryanodine - pharmacology | Angiotensin II - pharmacology | Pyridines - administration & dosage | Endocytosis - drug effects | Enzyme Inhibitors - pharmacology | Losartan - pharmacology | Saralasin - administration & dosage | Rats | Imidazoles - pharmacology | Piperazines - pharmacology | Rats, Sprague-Dawley | Receptor, Angiotensin, Type 2 - metabolism | Signal Transduction - drug effects | Calcium Signaling - drug effects | Models, Biological | Receptor, Angiotensin, Type 1 - metabolism | Oxazoles - pharmacology | Losartan - administration & dosage | Angiotensin II - administration & dosage | Calcium Signaling - physiology | Endoplasmic Reticulum - metabolism | Imidazoles - administration & dosage | Type C Phospholipases - antagonists & inhibitors | Lysosomes - metabolism | Inositol 1,4,5-Trisphosphate Receptors - metabolism | Pyrrolidinones - pharmacology | Macrolides - pharmacology | NADP - analogs & derivatives | Female | NADP - metabolism | Heparin - pharmacology | Angiotensin II - metabolism | Arsenicals - pharmacology | Cells, Cultured | Sirolimus - pharmacology | Myometrium - cytology | Animals | Egtazic Acid - pharmacology | Uterus - cytology | Signal Transduction - physiology | Pyridines - pharmacology | Carbolines - pharmacology | Myometrium | Cell receptors | Calcium channels | Genetic aspects | Properties | Angiotensin | Receptors and Signal Transduction
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 03/2006, Volume 26, Issue 11, pp. 2862 - 2870
Neuronal activity evokes localized changes in blood flow. Although this response, termed neurovascular coupling, is widely used to monitor human brain function... 
Arachidonic acid metabolites | Retina | Calcium | Glia | ATP | Blood flow | arachidonic acid metabolites | NEURONAL-ACTIVITY | 20-HETE | calcium | RAT | ASTROCYTE-MEDIATED CONTROL | CALCIUM WAVES | ARACHIDONIC-ACID | glia | NEUROSCIENCES | HEMODYNAMIC-RESPONSE | retina | NITRIC-OXIDE | blood flow | MULLER CELLS | BRAIN | Arterioles - physiology | Cytochrome P-450 Enzyme Inhibitors | Rats, Long-Evans | Arterioles - enzymology | Nitric Oxide Synthase - physiology | Male | Vasodilation - radiation effects | Retinal Vessels - enzymology | Retinal Vessels - physiology | Hydroxyeicosatetraenoic Acids - biosynthesis | Vasoconstriction - radiation effects | Photolysis | Cyclic N-Oxides - pharmacology | Inositol 1,4,5-Trisphosphate - analogs & derivatives | Eye Proteins - antagonists & inhibitors | Purinergic Antagonists | Signal Transduction - radiation effects | Cytochrome P-450 Enzyme System - physiology | Hydrazines - pharmacology | Rats | Imidazoles - pharmacology | Retinal Vessels - drug effects | Arterioles - drug effects | Vasoconstriction - drug effects | Cytochrome P-450 CYP4A - physiology | Signal Transduction - drug effects | Miconazole - pharmacology | Eye Proteins - physiology | Retinal Vessels - radiation effects | Vasodilation - drug effects | Arterioles - radiation effects | Nitric Oxide - pharmacology | Caproates - pharmacology | Vasomotor System - drug effects | Nitric Oxide Synthase - antagonists & inhibitors | Inositol 1,4,5-Trisphosphate - pharmacology | Adenosine Triphosphate - pharmacology | Vasoconstriction - physiology | 8,11,14-Eicosatrienoic Acid - analogs & derivatives | Proadifen - pharmacology | Nitric Oxide Donors - pharmacology | Vasodilation - physiology | 8,11,14-Eicosatrienoic Acid - pharmacology | NG-Nitroarginine Methyl Ester - pharmacology | Calcium Signaling - radiation effects | Cytochrome P-450 CYP4A - antagonists & inhibitors | Neuroglia - physiology | Nitric Oxide - physiology | Vasomotor System - radiation effects | Animals | Vasomotor System - physiology | Amidines - pharmacology | In Vitro Techniques
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 04/2011, Volume 31, Issue 14, pp. 5205 - 5212
Alcohol addiction (alcoholism) is one of the most prevalent substance abuse disorders worldwide. Addiction is thought to arise, in part, from a maladaptive... 
CHRONIC INTERMITTENT ETHANOL | CORTICOTROPIN-RELEASING-FACTOR | INOSITOL 1,4,5-TRISPHOSPHATE | C57BL/6J MICE | PROTEIN-KINASE | GABAERGIC SYNAPSES | CA2+ CHANNELS | MIDBRAIN DOPAMINE NEURONS | LONG-TERM POTENTIATION | HIPPOCAMPAL-NEURONS | NEUROSCIENCES | Peptide Hormones - pharmacology | Electric Stimulation | Receptors, N-Methyl-D-Aspartate - metabolism | Conditioning, Operant - physiology | Neuronal Plasticity - drug effects | Inositol 1,4,5-Trisphosphate - pharmacology | Male | Ventral Tegmental Area - cytology | Central Nervous System Depressants - pharmacology | Dose-Response Relationship, Drug | Quinoxalines - pharmacology | Drug Interactions | Conditioning, Operant - drug effects | Long-Term Potentiation - drug effects | Long-Term Potentiation - physiology | Neurons - drug effects | Ventral Tegmental Area - drug effects | Dopamine Uptake Inhibitors - pharmacology | Drug Administration Schedule | Amphibian Proteins - pharmacology | Colforsin - pharmacology | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Biophysics | Corticotropin-Releasing Hormone - pharmacology | Cocaine - pharmacology | Methoxyhydroxyphenylglycol - analogs & derivatives | Methoxyhydroxyphenylglycol - pharmacology | Ethanol - pharmacology | Animals | Analysis of Variance | Dopamine Antagonists - pharmacology | Mice | In Vitro Techniques | Salicylamides - pharmacology
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2005, Volume 102, Issue 52, pp. 19144 - 19149
Journal Article
Nature Neuroscience, ISSN 1097-6256, 10/2011, Volume 14, Issue 10, pp. 1276 - 1284
Astrocytes communicate with synapses by means of intracellular calcium ([Ca2+](i)) elevations, but local calcium dynamics in astrocytic processes have never... 
DENDRITIC SPINES | RAT DENTATE GYRUS | NEURONAL-ACTIVITY | HIPPOCAMPAL ASTROCYTES | IN-VIVO | GLUTAMATE EXOCYTOSIS | BERGMANN GLIAL-CELLS | POSTSYNAPTIC CURRENTS | LONG-TERM POTENTIATION | GRANULE CELLS | NEUROSCIENCES | Synaptic Transmission - physiology | Calcium - metabolism | Calcium Signaling - physiology | Sucrose - pharmacology | Cell Communication - physiology | Synapses - metabolism | Egtazic Acid - analogs & derivatives | Synaptic Transmission - drug effects | Tetrodotoxin - pharmacology | Electric Stimulation - methods | Action Potentials - drug effects | Heparin - pharmacology | Animals, Newborn | Purinergic P2Y Receptor Antagonists - pharmacology | Astrocytes - drug effects | Synapses - drug effects | Gene Expression Regulation - genetics | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Sodium Channel Blockers - pharmacology | Biophysics | Chelating Agents - pharmacology | Hippocampus - cytology | Inositol 1,4,5-Trisphosphate Receptors - deficiency | Adenosine Diphosphate - pharmacology | Mice, Knockout | Action Potentials - physiology | Astrocytes - ultrastructure | Gene Expression Regulation - drug effects | Astrocytes - physiology | Patch-Clamp Techniques | Animals | Egtazic Acid - pharmacology | Calcium Signaling - drug effects | Models, Biological | Cell Communication - drug effects | Thapsigargin - pharmacology | Mice | In Vitro Techniques | Adenosine Diphosphate - analogs & derivatives
Journal Article
Journal of Inorganic Biochemistry, ISSN 0162-0134, 12/2015, Volume 153, pp. 49 - 59
Heart tissue becomes zinc-depleted and the capacity to mobilize labile zinc is diminished, indicating zinc dyshomeostasis during ischemia/reperfusion (I/R).... 
Hypoxia | Reoxygenation | Proteolysis | Caspase-3 | Zinc | Apoptosis | ACTIVATION | RAT | MITOCHONDRIAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | REPERFUSION INJURY | CARDIOMYOPATHY | CARDIAC-CELLS | DEATH | INTRACELLULAR ZINC | CHEMISTRY, INORGANIC & NUCLEAR | ACUTE MYOCARDIAL-INFARCTION | Receptor, Epidermal Growth Factor - genetics | Caspase Inhibitors - pharmacology | Phosphorylation | Receptor, ErbB-2 - genetics | Protein Multimerization | Caspase 3 - metabolism | Receptor, ErbB-2 - metabolism | RNA, Messenger - metabolism | Cell Hypoxia | Receptor, Epidermal Growth Factor - metabolism | Zinc Compounds - pharmacology | Amino Acid Chloromethyl Ketones - pharmacology | Receptor, ErbB-2 - antagonists & inhibitors | Proteasome Inhibitors - pharmacology | Benzothiazoles - pharmacology | Chlorides - pharmacology | Down-Regulation | RNA, Messenger - genetics | Rats | Tyrphostins - pharmacology | Cardiotonic Agents - pharmacology | Leupeptins - pharmacology | Myocytes, Cardiac - pathology | Animals | Myocytes, Cardiac - drug effects | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Thiones - pharmacology | Quinazolines - pharmacology | Organometallic Compounds - pharmacology | Proteins | Membrane lipids | Inositol | RNA | Antifungal agents | Permeability | Antibacterial agents | Phosphotransferases | Tyrosine | Cell death
Journal Article
European Neuropsychopharmacology, ISSN 0924-977X, 2015, Volume 25, Issue 4, pp. 505 - 511
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2013, Volume 288, Issue 36, pp. 26052 - 26066
Journal Article
The Journal of Physiology, ISSN 0022-3751, 05/2009, Volume 587, Issue 10, pp. 2275 - 2298
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 09/2017, Volume 139, pp. 3 - 14
Marine sponges have consistently been the richest source of new marine natural products with unprecedented chemical scaffolds and potent biological activities... 
Porifera | Marine natural products | Drug discovery | ANDROGEN RECEPTOR | INOSITOL 5-PHOSPHATASE | MAST-CELLS | PAPUA-NEW-GUINEA | STRUCTURE ELUCIDATION | MARINE SPONGE | SHIP1 ACTIVATOR AQX-1125 | IN-VIVO | PHARMACOLOGY & PHARMACY | CYSTITIS/BLADDER PAIN SYNDROME | RESISTANT PROSTATE-CANCER | Indans - adverse effects | Anti-Asthmatic Agents - therapeutic use | Humans | Drugs, Investigational - therapeutic use | Antineoplastic Agents - therapeutic use | Prodrugs - chemistry | Nonsteroidal Anti-Androgens - chemistry | Oligopeptides - therapeutic use | Nonsteroidal Anti-Androgens - therapeutic use | Sterols - adverse effects | Glycerol - analogs & derivatives | Porifera - chemistry | Benzhydryl Compounds - therapeutic use | Oligopeptides - chemistry | Anti-Asthmatic Agents - chemistry | Glycerol - therapeutic use | Indans - chemistry | Anti-Asthmatic Agents - pharmacology | Pyrrolidinones - adverse effects | Antimitotic Agents - adverse effects | Pyrrolidinones - therapeutic use | Antimitotic Agents - therapeutic use | Biological Products - isolation & purification | Biological Products - chemistry | Pyrrolidinones - isolation & purification | Cyclohexanols - therapeutic use | Oligopeptides - pharmacology | Anti-Asthmatic Agents - adverse effects | Cyclohexanols - adverse effects | Drugs, Investigational - adverse effects | Drugs, Investigational - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Oligopeptides - adverse effects | Indans - therapeutic use | Benzhydryl Compounds - chemistry | Drugs, Investigational - chemistry | Sterols - therapeutic use | Benzhydryl Compounds - adverse effects | Antineoplastic Agents - adverse effects | Cyclohexanols - chemistry | Nonsteroidal Anti-Androgens - adverse effects | Drug Design | Antineoplastic Agents - pharmacology | Glycerol - pharmacology | Aquatic Organisms - chemistry | Nonsteroidal Anti-Androgens - pharmacology | Sterols - pharmacology | Sterols - chemistry | Antineoplastic Agents - chemistry | Drug Discovery | Pyrrolidinones - chemistry | Prodrugs - adverse effects | Animals | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Antimitotic Agents - pharmacology | Benzhydryl Compounds - pharmacology | Prodrugs - therapeutic use | Prodrugs - pharmacology | Antimitotic Agents - chemistry | Chemical oceanography | Index Medicus
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 01/2011, Volume 31, Issue 3, pp. 1114 - 1127
Reactive oxygen species (ROS) such as superoxide are emerging as important signaling molecules in physiological plasticity but also in peripheral and spinal... 
DORSAL-HORN NEURONS | GENE-RELATED PEPTIDE | PERSISTENT PAIN | PROTEIN-KINASE | ULTRASONIC VOCALIZATIONS | METABOTROPIC GLUTAMATE RECEPTORS | LONG-TERM POTENTIATION | SIGNAL-REGULATED KINASE | SYNAPTIC PLASTICITY | HIPPOCAMPAL-NEURONS | NEUROSCIENCES | Glycine - analogs & derivatives | Amygdala - drug effects | Pain Perception - physiology | Reactive Oxygen Species - metabolism | Receptors, Metabotropic Glutamate - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Spin Labels | Pain - metabolism | Macrocyclic Compounds - pharmacology | Pain Perception - drug effects | Cyclic N-Oxides - pharmacology | Neurons - physiology | Superoxides - metabolism | Receptor, Metabotropic Glutamate 5 | Vocalization, Animal - drug effects | Neurons - drug effects | Cyclic AMP-Dependent Protein Kinases - metabolism | NG-Nitroarginine Methyl Ester - pharmacology | Enzyme Inhibitors - pharmacology | Vocalization, Animal - physiology | Pain Measurement - drug effects | Mitochondria - metabolism | Antioxidants - pharmacology | Mitochondria - drug effects | Patch-Clamp Techniques | Animals | Analysis of Variance | Glycine - pharmacology | Pain - physiopathology | Benzoates - pharmacology | Signal Transduction - physiology | Oxazoles - pharmacology | Pyridines - pharmacology | Thiazoles - pharmacology | Receptors, Metabotropic Glutamate - agonists | Amygdala - physiology | Excitatory Amino Acid Antagonists | Inositol 1,4,5-Trisphosphate - metabolism
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 10/2008, Volume 28, Issue 10, pp. 1774 - 1781
OBJECTIVE—The purpose of this study was to test the hypothesis that H2O2 contributes to the EDHF phenomenon by mobilizing endothelial Ca stores. METHODS AND... 
Thimerosal | Hydrogen peroxide | SERCA pump | EDHF | PANCREATIC ACINAR-CELLS | hydrogen peroxide | CYTOCHROME-P450 EPOXYGENASES | DEPENDENT HYPERPOLARIZATION | ACTIVATED POTASSIUM CHANNELS | RABBIT AORTA | MESENTERIC-ARTERY | SMOOTH-MUSCLE | GAP-JUNCTIONS | NITRIC-OXIDE | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | K+ CHANNELS | thimerosal | Myography | Amitrole - pharmacology | Gap Junctions - metabolism | Oxidants - pharmacology | Calcium - metabolism | Catalase - antagonists & inhibitors | Endoplasmic Reticulum - metabolism | Homeostasis | Cytoplasm - metabolism | Endothelium, Vascular - drug effects | Male | Apamin - pharmacology | Endothelium, Vascular - enzymology | Thimerosal - pharmacology | Dose-Response Relationship, Drug | Glutathione - pharmacology | Inositol 1,4,5-Trisphosphate Receptors - metabolism | Potassium Channels, Calcium-Activated - metabolism | Indoles - pharmacology | Sarcoplasmic Reticulum Calcium-Transporting ATPases - antagonists & inhibitors | Iliac Artery - metabolism | Biological Factors - metabolism | Potassium Channel Blockers - pharmacology | Pyrazoles - pharmacology | Rabbits | Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism | Vasodilator Agents - pharmacology | Glutathione - analogs & derivatives | Enzyme Inhibitors - pharmacology | Hydrogen Peroxide - metabolism | Peptides - pharmacology | Catalase - metabolism | Animals | Calcium Signaling - drug effects | Endothelium, Vascular - metabolism | Vasodilation - drug effects | In Vitro Techniques | Microscopy, Fluorescence | Index Medicus
Journal Article
Nature Neuroscience, ISSN 1097-6256, 05/2010, Volume 13, Issue 5, pp. 622 - 629
Stress and anxiety disorders are risk factors for depression and these behaviors are modulated by corticotrophin-releasing factor receptor 1 (CRFR1) and... 
INTERNALIZATION | CORTICOTROPIN-RELEASING-FACTOR | PDZ PROTEINS | CORTICAL PYRAMIDAL NEURONS | DESENSITIZATION | SEROTONIN RECEPTORS | TRAFFICKING | CENTRAL-NERVOUS-SYSTEM | ENDOCYTOSIS | NEUROSCIENCES | RAB GTPASES | Embryo, Mammalian | Amphetamines - pharmacology | Humans | Receptors, Corticotropin-Releasing Hormone - genetics | Male | Anxiety - drug therapy | Receptors, Serotonin, 5-HT2 - metabolism | Serotonin - pharmacology | Dose-Response Relationship, Drug | Fluorobenzenes - pharmacology | Serotonin 5-HT2 Receptor Antagonists | Transfection | Piperidines - pharmacology | Reaction Time - drug effects | Behavior, Animal - drug effects | Inositol Phosphates - metabolism | Anxiety - metabolism | Cyclic AMP - metabolism | Ionophores - pharmacology | Disease Models, Animal | Hormones - pharmacology | Maze Learning - physiology | Neurons | Cells, Cultured | Anxiety - physiopathology | Monensin - pharmacology | Rats | Behavior, Animal - physiology | Maze Learning - drug effects | Mutation - genetics | Prefrontal Cortex - cytology | Corticotropin-Releasing Hormone - pharmacology | Receptors, Corticotropin-Releasing Hormone - physiology | Animals | Receptors, Serotonin, 5-HT2 - genetics | Serotonin Agents - pharmacology | Signal Transduction - drug effects | Signal Transduction - physiology | Biotinylation - methods | Mice | Serotonin 5-HT2 Receptor Agonists | Endocytosis | Physiological aspects | Cellular signal transduction | Anxiety | Genetic aspects | Research | Genetic regulation
Journal Article