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Journal Article
American Journal of Psychiatry, ISSN 0002-953X, 02/2006, Volume 163, Issue 2, pp. 210 - 216
Journal Article
Journal Article
JOURNAL OF NEUROSCIENCE, ISSN 0270-6474, 08/2012, Volume 32, Issue 34, pp. 11820 - 11834
In Alzheimer disease (AD), the perturbation of the endoplasmic reticulum (ER) calcium (Ca2+) homeostasis has been linked to presenilins, the catalytic core in... 
PRESENILIN-1 MUTATIONS | CA2+ LEAK CHANNELS | CORTICAL-NEURONS | CALCIUM-RELEASE | SINGLE-CHANNEL ACTIVITY | RECOGNITION MEMORY | NEUROBLASTOMA SH-SY5Y CELLS | PRECURSOR PROTEIN | N-TERMINUS | NEUROSCIENCES | I-CRAC | Amyloid Precursor Protein Secretases - genetics | Calcium - metabolism | Embryo, Mammalian | Humans | Calcium Channel Blockers - therapeutic use | Memory Disorders - metabolism | Aminophenols - therapeutic use | RNA, Messenger - metabolism | Phosphorylation - genetics | Endoplasmic Reticulum - drug effects | Muscle Relaxants, Central - pharmacology | Amyloid beta-Peptides - metabolism | Exploratory Behavior - drug effects | Caffeine - pharmacology | Purines - therapeutic use | Phosphorylation - drug effects | Disease Models, Animal | Membrane Potentials - drug effects | Mice, Transgenic | Dantrolene - pharmacology | Mutation - genetics | Enzyme Inhibitors - therapeutic use | Amyloid Precursor Protein Secretases - metabolism | Patch-Clamp Techniques | Memory Disorders - etiology | Analysis of Variance | Ryanodine Receptor Calcium Release Channel - genetics | Cytosol - metabolism | Plaque, Amyloid - metabolism | Mice | Inositol 1,4,5-Trisphosphate Receptors - genetics | Membrane Potentials - genetics | Alzheimer Disease - complications | Cytosol - drug effects | Endoplasmic Reticulum - metabolism | Ryanodine Receptor Calcium Release Channel - metabolism | Endoplasmic Reticulum - pathology | Maleimides - therapeutic use | Transfection | Inositol 1,4,5-Trisphosphate Receptors - metabolism | Reaction Time - drug effects | Amyloid beta-Protein Precursor - metabolism | Neurons - physiology | Membrane Proteins - metabolism | Neurons - drug effects | Neuroblastoma - pathology | Brain - cytology | Peptide Fragments - metabolism | Plaque, Amyloid - pathology | Gene Expression Regulation - genetics | Cells, Cultured | Maze Learning - drug effects | Gene Expression Regulation - drug effects | Nerve Tissue Proteins - metabolism | Amyloid beta-Protein Precursor - genetics | Animals | Memory Disorders - drug therapy | Recognition (Psychology) - drug effects | Alzheimer Disease - metabolism | Alzheimer Disease - genetics | Index Medicus
Journal Article
Journal Article
Diabetes, Obesity and Metabolism, ISSN 1462-8902, 08/2014, Volume 16, Issue 8, pp. 761 - 765
We assessed the efficacy and safety of sitagliptin compared with α‐glucosidase inhibitor ( αGI ) in 120 of Japanese patients with type 2 diabetes mellitus (... 
type 2 diabetes | DPP‐IV | inhibitor | sulphonylureas | α‐glucosidase inhibitor | randomized trial | Type 2 diabetes | Randomized trial | α-glucosidase inhibitor | Sulphonylureas | DPP-IV inhibitor | VOGLIBOSE | MONOTHERAPY | HYPERGLYCEMIA | DOUBLE-BLIND TRIAL | alpha-glucosidase inhibitor | ENDOCRINOLOGY & METABOLISM | MELLITUS | Glycated Hemoglobin A - analysis | Triazoles - adverse effects | Glycoside Hydrolase Inhibitors - adverse effects | Dipeptidyl-Peptidase IV Inhibitors - adverse effects | Dipeptidyl-Peptidase IV Inhibitors - therapeutic use | Humans | Middle Aged | Glycoside Hydrolase Inhibitors - therapeutic use | Male | Pyrazines - therapeutic use | Hypoglycemia - prevention & control | 1-Deoxynojirimycin - therapeutic use | Drug Therapy, Combination - adverse effects | Inositol - therapeutic use | Inositol - adverse effects | 1-Deoxynojirimycin - analogs & derivatives | Female | 1-Deoxynojirimycin - adverse effects | Sitagliptin Phosphate | Hypoglycemia - chemically induced | Triazoles - therapeutic use | Hypoglycemic Agents - therapeutic use | Hyperglycemia - prevention & control | Japan | Sulfonylurea Compounds - therapeutic use | Inositol - analogs & derivatives | Diabetes Mellitus, Type 2 - blood | Gastrointestinal Agents - therapeutic use | Pyrazines - adverse effects | Aged | Gastrointestinal Agents - adverse effects | Diabetes Mellitus, Type 2 - drug therapy | alpha-Glucosidases - metabolism | alpha-Glucosidases - chemistry | Index Medicus
Journal Article
Diabetes, Obesity and Metabolism, ISSN 1462-8902, 04/2012, Volume 14, Issue 4, pp. 348 - 357
Aims: To evaluate the efficacy and safety of linagliptin 5 and 10 mg vs. placebo and voglibose in Japanese patients with type 2 diabetes mellitus (T2DM).... 
glucosidase inhibitor | DPP‐4 inhibitor | glycaemic control | incretin therapy | Incretin therapy | α-glucosidase inhibitor | DPP-4 inhibitor | Glycaemic control | CONTROLLED-TRIAL | METFORMIN | DIPEPTIDYL PEPTIDASE-4 INHIBITOR | SULFONYLUREA | EFFICACY | MELLITUS | COMBINATION | a-glucosidase inhibitor | BETA-CELL FUNCTION | PHARMACOKINETICS | ENDOCRINOLOGY & METABOLISM | Dipeptidyl-Peptidase IV Inhibitors - adverse effects | Dipeptidyl-Peptidase IV Inhibitors - therapeutic use | Humans | Middle Aged | Male | Purines - administration & dosage | Diabetes Mellitus, Type 2 - epidemiology | Dose-Response Relationship, Drug | Inositol - therapeutic use | Aged, 80 and over | Adult | Female | Quinazolines - administration & dosage | Linagliptin | Purines - adverse effects | Purines - therapeutic use | Hypoglycemic Agents - therapeutic use | Double-Blind Method | Drug Administration Schedule | Japan | Treatment Outcome | Inositol - analogs & derivatives | Dipeptidyl-Peptidase IV Inhibitors - administration & dosage | Blood Glucose - drug effects | Analysis of Variance | Quinazolines - therapeutic use | Quinazolines - adverse effects | Aged | Diabetes Mellitus, Type 2 - drug therapy | Type 2 diabetes | Medical colleges | Medical research | Safety and security measures | Glycosylated hemoglobin | Medicine, Experimental | Hemoglobin | Hypoglycemic agents | Universities and colleges | Diabetes | Diabetes therapy | Index Medicus
Journal Article
Cardiovascular Diabetology, ISSN 1475-2840, 07/2014, Volume 13, Issue 1, pp. 110 - 110
Background: Alpha glucosidase inhibitor (GI) attenuates postprandial hyperglycemia (PPH) and reduces the risk of cardiovascular events in patients with... 
Dipeptidyl peptidase 4 (DPP-4) inhibitors | Endothelial function | Flow-mediated dilatation | Alpha glucosidase inhibitor | CD34 | PROGENITOR CELLS | DIPEPTIDYL PEPTIDASE-4 INHIBITOR | GLYCEMIC CONTROL | CARDIAC & CARDIOVASCULAR SYSTEMS | MYOCARDIAL-INFARCTION | VASCULAR-DISEASE | FLOW-MEDIATED VASODILATION | GLUCAGON-LIKE PEPTIDE-1 | ENDOCRINOLOGY & METABOLISM | CARDIOVASCULAR-DISEASE | JAPANESE PATIENTS | CORONARY-ARTERY-DISEASE | Prospective Studies | Dipeptidyl-Peptidase IV Inhibitors - therapeutic use | Humans | Middle Aged | Endothelium, Vascular - drug effects | Glycoside Hydrolase Inhibitors - therapeutic use | Male | Pyrazines - therapeutic use | Dipeptidyl-Peptidase IV Inhibitors - pharmacology | Endothelium, Vascular - physiology | Young Adult | Inositol - therapeutic use | Aged, 80 and over | Adult | Female | Sitagliptin Phosphate | Triazoles - therapeutic use | Inositol - pharmacology | Glycoside Hydrolase Inhibitors - pharmacology | Inositol - analogs & derivatives | Triazoles - pharmacology | Diabetes Mellitus, Type 2 - diagnosis | Aged | Diabetes Mellitus, Type 2 - drug therapy | Pyrazines - pharmacology | Urine | Oxidative stress | Peptides | Internal medicine | Colleges & universities | Cardiovascular disease | Dentistry | Medicine | Hyperglycemia | Hospitals | Coronary vessels | Diabetes | Acute coronary syndromes | Drug dosages | Pharmaceutical sciences | Pharmaceuticals | Index Medicus
Journal Article
Journal Article