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PLoS ONE, ISSN 1932-6203, 04/2009, Volume 4, Issue 4, pp. e5254 - e5254
textabstractBackground: This Phase 1/2a study evaluated the safety, immunogenicity, and efficacy of an experimental malaria vaccine comprised of the... 
parasite antibody | pruritus | myalgia | papule | drug combination | major clinical study | drug dose comparison | apical membrane antigen I | malaria falciparum | Plasmodium | Plasmodium falciparum | fatigue | double blind procedure | phase 1 clinical trial | drug fever | female | protozoal protein | immunology | clinical trial | apical membrane antigen 1 | lipid A | drug safety | malaria vaccine | article | immunogenicity | nausea | antibody response | adolescent | animal | injection site erythema | metabolism | adult | male | drug derivative | injection site swelling | gamma interferon | injection site pain | arthralgia | antibody detection | enzyme linked immunosorbent assay | immunological adjuvant | chloroquine | drug eruption | genetics | controlled clinical trial | ASO2A adjuvant | sporozoite | human | skin inflammation | parasite antigen | phase 2 clinical trial | drug megadose | parasitemia | low drug dose | middle aged | liposome | randomized controlled trial | controlled study | allele | saponin | drug efficacy | membrane protein | drug induced headache | malaise | NATURAL IMMUNE-RESPONSES | FALCIPARUM CIRCUMSPOROZOITE PROTEIN | IMMUNIZATION | SAFETY | FORMULATIONS | PLASMODIUM-FALCIPARUM | MULTIDISCIPLINARY SCIENCES | MONKEYS | NAIVE ADULTS | PRECLINICAL EVALUATION | IMMUNOGENICITY TRIAL | Malaria, Falciparum - prevention & control | Adjuvants, Immunologic - administration & dosage | Adjuvants, Immunologic - pharmacology | Antigens, Protozoan - immunology | Saponins - administration & dosage | Humans | Lipid A - analogs & derivatives | Middle Aged | Plasmodium falciparum - immunology | Protozoan Proteins - genetics | Malaria Vaccines - adverse effects | Antigens, Protozoan - administration & dosage | Malaria Vaccines - immunology | Adult | Plasmodium falciparum - metabolism | Antigens, Protozoan - genetics | Protozoan Proteins - administration & dosage | Lipid A - administration & dosage | Double-Blind Method | Enzyme-Linked Immunosorbent Assay | Membrane Proteins - genetics | Membrane Proteins - immunology | Membrane Proteins - administration & dosage | Animals | Malaria Vaccines - administration & dosage | Adolescent | Alleles | Lipid A - pharmacology | Drug Combinations | Protozoan Proteins - immunology | Saponins - pharmacology | Antigens | Medical research | Malaria | Analysis | Medical societies | Vaccination | Malaria vaccine | Medicine, Experimental | Interferon | Vaccines | Biological response modifiers | Health care | Growth rate | Peptides | Goats | Homology | Parasites | Appropriate technology | Aquatic insects | Proteins | Confidence intervals | Biological effects | Pain | Lymphocytes | Mathematical models | Safety | Parasitemia | Recombinant | Formulations | Vector-borne diseases | Enzymes | Evaluation | Immune response | Effectiveness | Statistical analysis | Membrane proteins | Studies | Polymerase chain reaction | Mosquitoes | Population (statistical) | Immunogenicity | γ-Interferon | Light microscopy | Adults | Erythema
Journal Article
Vaccine, ISSN 0264-410X, 2012, Volume 31, Issue 3, pp. 524 - 532
Highlights ► This Phase 1 trial evaluated the safety and immunogenicity of an RSV (F) nanoparticle vaccine. ► The vaccine was well-tolerated and no related... 
Allergy and Immunology | Respiratory syncytial virus (RSV) | Palivizumab | Fusion protein (F protein) | Competitive ELISA | SF9 insect cell | Microneutralization | Aluminum phosphate | Anti-F IgG | Nanoparticle vaccine | UNITED-STATES | MEDICINE, RESEARCH & EXPERIMENTAL | NEUTRALIZING ANTIBODIES | IMMUNE GLOBULIN | COTTON RATS | INFLUENZA | RISK | IMMUNOLOGY | F-GLYCOPROTEIN | INFANTS | INFECTION | YOUNG-CHILDREN | Recombinant Fusion Proteins - immunology | Single-Blind Method | Biotechnology | Respiratory Syncytial Virus Vaccines - immunology | Adjuvants, Immunologic - administration & dosage | Aluminum Compounds - adverse effects | Phosphates - administration & dosage | Recombinant Fusion Proteins - adverse effects | Humans | Middle Aged | Male | Nanoparticles - adverse effects | Vaccines, Synthetic - immunology | Antibodies, Viral - blood | Adjuvants, Immunologic - adverse effects | Young Adult | Respiratory Syncytial Virus Vaccines - adverse effects | Sf9 Cells | Technology, Pharmaceutical | Vaccines, Virosome - immunology | Vaccines, Synthetic - adverse effects | Placebos - adverse effects | Adult | Female | Placebos - administration & dosage | Recombinant Fusion Proteins - administration & dosage | Vaccines, Virosome - administration & dosage | Vaccines, Synthetic - genetics | Vaccines, Virosome - genetics | Animals | Aluminum Compounds - administration & dosage | Phosphates - adverse effects | Vaccines, Virosome - adverse effects | Respiratory Syncytial Virus Vaccines - administration & dosage | Adolescent | Recombinant Fusion Proteins - genetics | Nanoparticles - administration & dosage | Vaccines, Synthetic - administration & dosage | Respiratory Syncytial Virus Vaccines - genetics | Antibodies, Neutralizing - blood | Virus diseases | Phosphates | Vaccines | Immunoglobulin G | Enzyme-linked immunosorbent assay | Proteins | Nanoparticles | Infections | Index Medicus
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2013, Volume 110, Issue 37, pp. 14995 - 15000
Huntington disease (HD) is a progressive neurodegenerative disorder caused by dominant polyglutamine (polyQ) expansion within the N terminus of huntingtin... 
Aggregation | Proteins | Eclosion | Phenotypes | Neurodegenerative diseases | Drosophila | Huntington disease | Medical genetics | Copper | Survival rates | PRION PROTEIN | IN-VITRO | MODIFIERS | METALS | MODELS | DROSOPHILA-MELANOGASTER | ALZHEIMERS-DISEASE | BASAL GANGLIA | MULTIDISCIPLINARY SCIENCES | MUTANT HUNTINGTIN | NEURODEGENERATIVE DISEASES | Cation Transport Proteins - antagonists & inhibitors | Copper-transporting ATPases | Humans | Peptides - genetics | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | Brain - metabolism | Drosophila melanogaster - metabolism | Peptides - metabolism | RNA Interference | Cation Transport Proteins - metabolism | Copper - metabolism | Cation Transport Proteins - genetics | Female | Drosophila Proteins - antagonists & inhibitors | Disease Models, Animal | Genes, Insect | Recombinant Proteins - metabolism | Gene Expression | Animals, Genetically Modified | Recombinant Proteins - genetics | Huntington Disease - metabolism | Nerve Tissue Proteins - genetics | Trinucleotide Repeat Expansion | Huntington Disease - etiology | Nerve Tissue Proteins - metabolism | Huntingtin Protein | Animals | Copper - administration & dosage | Huntington Disease - genetics | Protein Binding | Drosophila Proteins - genetics | Amino Acid Substitution | Huntington's chorea | Physiological aspects | Genetic aspects | Research | Gene expression | Health aspects | Binding sites (Biochemistry) | Glutamine | Index Medicus | Biological Sciences
Journal Article
Nature, ISSN 0028-0836, 09/2015, Volume 525, Issue 7567, pp. 124 - 128
Mitochondria are involved in a variety of cellular functions, including ATP production, amino acid and lipid biogenesis and breakdown, signalling and... 
APOPTOSIS | MUTANTS | ACID | MITOFUSIN 2 | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | DYNAMICS | DYSFUNCTION | STRESS | DROSOPHILA | PARKINSONS-DISEASE | Humans | JNK Mitogen-Activated Protein Kinases - metabolism | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | Antigens, CD - metabolism | Stearic Acids - metabolism | Drosophila melanogaster - metabolism | Ubiquitination - drug effects | Acetyltransferases - deficiency | Mitochondria - genetics | Larva - drug effects | Larva - genetics | Membrane Proteins - metabolism | Stearic Acids - administration & dosage | Larva - metabolism | Drosophila melanogaster - cytology | Ubiquitin-Protein Ligases - metabolism | Mitochondria - metabolism | Mitochondria - drug effects | Mitochondria - pathology | Receptors, Transferrin - metabolism | Drosophila melanogaster - drug effects | Animals | Mitochondrial Dynamics - drug effects | Diet | Signal Transduction - drug effects | Drosophila Proteins - deficiency | Ubiquitin-Protein Ligases - deficiency | Drosophila Proteins - genetics | HeLa Cells | Ubiquitin-Protein Ligases - genetics | Stearic Acids - pharmacology | Tumor Suppressor Proteins | Mitochondria | Cell receptors | Genetic aspects | Stearic acid | Genetic regulation | Health aspects | Proteins | Insects | Acids | Morphology | Parkinsons disease | Pink | Parkinsons | Drosophila | mitochondria | metabolism | mitofusin | Parkin
Journal Article
Vaccine, ISSN 0264-410X, 2017, Volume 35, Issue 18, pp. 2358 - 2364
Highlights • A novel vaccine platform greatly enhances antibody responses to a malaria antigen. • Protection against transgenic sporozoite challenge in a mouse... 
Allergy and Immunology | Chemokine | Sporozoite | Vaccine | Malaria | Immunity | Macrophage inflammatory protein 3 alpha | MEDICINE, RESEARCH & EXPERIMENTAL | CHEMOKINES | IMMUNOLOGY | ADJUVANT | FALCIPARUM CIRCUMSPOROZOITE PROTEIN | RESPONSES | DNA VACCINES | ANTITUMOR IMMUNITY | MONOCLONAL-ANTIBODIES | PLASMODIUM-YOELII SPOROZOITES | EXPRESSION | ANTIGEN | Recombinant Fusion Proteins - immunology | Plasmodium berghei - immunology | Chemokine CCL20 - metabolism | Adjuvants, Immunologic - administration & dosage | Poly I-C - administration & dosage | Dendritic Cells - immunology | Humans | Plasmodium falciparum - immunology | Vaccines, Synthetic - immunology | Protozoan Proteins - genetics | Recombinant Fusion Proteins - metabolism | Adjuvants, Immunologic - metabolism | Malaria Vaccines - immunology | Adjuvants, Immunologic - genetics | Chemokine CCL20 - genetics | Female | Plasmodium berghei - isolation & purification | Disease Models, Animal | Mice, Inbred C57BL | Parasite Load | Vaccines, Synthetic - genetics | Malaria - prevention & control | Animals | Malaria Vaccines - administration & dosage | Recombinant Fusion Proteins - genetics | Liver - parasitology | Vaccines, Synthetic - administration & dosage | Protozoan Proteins - immunology | Malaria Vaccines - genetics | Genetic engineering | Vaccines | Analysis | Antigens | Medical research | Dendritic cells | Liver | Vaccination | Malaria vaccine | Macrophages | Plasmodium falciparum | Medicine, Experimental | Flow cytometry | Intravenous administration | Clinical trials | Aquatic insects | Proteins | Circumsporozoite protein | Deoxyribonucleic acid--DNA | Vector-borne diseases | Immunoglobulins | Cytokines | Inflammation | Poly (I:C) | CCR6 protein | Studies | Ligands | Laboratory animals | Macrophage inflammatory protein | Chemokines
Journal Article
Scientific Reports, ISSN 2045-2322, 01/2016, Volume 6, Issue 1, p. 18848
Transmission-blocking vaccines (TBV) target the sexual-stages of the malaria parasite in the mosquito midgut and are widely considered to be an essential tool... 
PROTECTS MICE | OLIGOMERIZATION DOMAIN | STAGE | MULTIDISCIPLINARY SCIENCES | POXVIRUS | CANDIDATE | ANTIBODY-RESPONSES | PROTEINS | ADENOVIRUS | ADJUVANT | ANTIGEN | Immunogenicity, Vaccine | Recombinant Fusion Proteins - immunology | Malaria, Falciparum - prevention & control | Adjuvants, Immunologic - administration & dosage | Antigens, Protozoan - immunology | Germinal Center - immunology | Humans | Vaccination | Germinal Center - drug effects | Plasmodium falciparum - drug effects | Plasmodium falciparum - immunology | Protozoan Proteins - genetics | Life Cycle Stages - immunology | Pichia - metabolism | Insect Vectors - drug effects | Adjuvants, Immunologic - chemistry | Malaria Vaccines - immunology | Adenoviridae - genetics | Adjuvants, Immunologic - genetics | Antigens, Protozoan - genetics | Protozoan Proteins - administration & dosage | Adenoviridae - immunology | Recombinant Fusion Proteins - administration & dosage | Life Cycle Stages - drug effects | Gene Expression | Genetic Vectors - chemistry | Genetic Vectors - immunology | Plasmids - immunology | Culicidae - drug effects | Antibodies, Protozoan - biosynthesis | Malaria, Falciparum - parasitology | Animals | Malaria Vaccines - administration & dosage | Insect Vectors - parasitology | Malaria, Falciparum - immunology | Pichia - genetics | Plasmids - chemistry | Recombinant Fusion Proteins - genetics | Vaccines, Synthetic | Culicidae - parasitology | Mice | Mice, Inbred BALB C | Plasmodium falciparum - growth & development | Protozoan Proteins - immunology | Malaria Vaccines - genetics | Proteins | Nanoparticles | Antigens | Disease transmission | Malaria | Immunogenicity | Midgut | Antibodies | Vectors | Vaccines | Vectors (Biology) | Antibody response
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 2012, Volume 7, Issue 4, p. e34624
Bacillus thuringiensis (Bt) crystal (Cry) proteins are effective against a select number of insect pests, but improvements are needed to increase efficacy and... 
TRIBOLIUM-CASTANEUM | CRY1AB TOXIN | CRYSTAL PROTEINS | SEQUENCE | MIDGUT | BIOLOGY | RESISTANCE | CHORISTONEURA-FUMIFERANA | RECEPTOR | DELTA-ENDOTOXIN | IDENTIFICATION | Administration, Oral | Larva - metabolism | DNA, Complementary - genetics | Molecular Sequence Data | Tenebrio - metabolism | Gene Expression Profiling | Transcriptome - drug effects | Sequence Analysis, DNA | Bacterial Proteins - administration & dosage | Hemolysin Proteins - administration & dosage | Tenebrio - genetics | Animals | Bacterial Proteins - toxicity | Biosynthetic Pathways - drug effects | Time Factors | Larva - drug effects | Microarray Analysis | Base Sequence | Endotoxins - administration & dosage | Hemolysin Proteins - toxicity | Tenebrio - drug effects | Endotoxins - toxicity | Energy Metabolism - drug effects | RNA sequencing | RNA | Genes | Genomics | Gene expression | Fatty acids | Glucose metabolism | DNA microarrays | Analysis | Physiological aspects | Binding proteins | Health aspects | Protein binding | Tricarboxylic acid cycle | Allergens | Larvae | Plant pathology | Control methods | Cytology | Mesothelioma | Genomes | Kinases | Phosphatase | Immunity | Proteins | Signal transduction | Mitochondria | Synthesis | Role models | Life sciences | Binding | Medical research | Protein biosynthesis | Chitin | Exposure | Pests | Metabolism | Apolipoproteins | Ribonucleic acid--RNA | Membrane proteins | Studies | Signaling | Insects | Glycolysis | Toxins | Intoxication | Electron transport | Protein structure | Apoptosis | Ribonucleic acid
Journal Article
Vaccine, ISSN 0264-410X, 2011, Volume 30, Issue 2, pp. 273 - 279
Journal Article
Neuron, ISSN 0896-6273, 10/2012, Volume 76, Issue 2, pp. 383 - 395
Long-term memory and synaptic plasticity are thought to require the synthesis of new proteins at activated synapses. The CPEB family of RNA binding proteins,... 
CYTOPLASMIC POLYADENYLATION ELEMENT | CAMKII MESSENGER-RNA | LOCAL PROTEIN-SYNTHESIS | SYNAPSES | NEURONAL ISOFORM | CONDITIONED COURTSHIP | LONG-TERM FACILITATION | APLYSIA CPEB | SYNAPTIC PLASTICITY | NEUROSCIENCES | TRANSLATIONAL CONTROL | Courtship | Drosophila Proteins - classification | Immunoprecipitation | mRNA Cleavage and Polyadenylation Factors - metabolism | Gene Expression Regulation, Developmental - genetics | Male | Green Fluorescent Proteins - genetics | Chromatography, High Pressure Liquid | Drosophila Proteins - metabolism | RNA, Messenger - metabolism | Microscopy, Immunoelectron | RNA - genetics | mRNA Cleavage and Polyadenylation Factors - classification | Brain - metabolism | Protein Isoforms - metabolism | Mass Spectrometry | Brain - ultrastructure | Mushroom Bodies - cytology | mRNA Cleavage and Polyadenylation Factors - genetics | Mushroom Bodies - metabolism | RNA - metabolism | Cell Line | Green Fluorescent Proteins - metabolism | RNA-Binding Proteins - physiology | Animals, Genetically Modified | Drosophila | Genotype | Transcription Factors - genetics | Mutation - genetics | Transcription Factors - classification | Transcription Factors - metabolism | Learning - physiology | Animals | Larva | Biogenic Amines - administration & dosage | Embryo, Nonmammalian | Mitogen-Activated Protein Kinases - genetics | Drosophila Proteins - genetics | Memory - physiology | Protein Isoforms - genetics | Protein Structure, Tertiary - physiology | Messenger RNA | Binding proteins | Neurons | Genes | Protein binding | Proteins | Behavior | Insects | Protein synthesis | Long term memory | RNA-binding protein | Translation | Gene targeting | Plasticity (synaptic) | Synapses
Journal Article