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PLoS genetics, ISSN 1553-7390, 2011, Volume 7, Issue 7, pp. e1002114 - e1002114
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 01/2014, Volume 124, Issue 1, pp. 222 - 236
Acute myelogenous leukemia (AML) subtypes that result from oncogenic activation of homeobox (HOX) transcription factors are associated with poor prognosis. The... 
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Phosphorothioate Oligonucleotides - genetics | Homeodomain Proteins - metabolism | Humans | Leukemia, Myeloid, Acute - metabolism | Regulatory Sequences, Nucleic Acid | Transcriptome | Induction Chemotherapy | MicroRNAs - metabolism | Neoplasm Proteins - metabolism | DNA-Binding Proteins - metabolism | Cell Transformation, Neoplastic - genetics | Base Sequence | Pre-B-Cell Leukemia Transcription Factor 1 | Binding Sites | Leukemia, Myeloid, Acute - therapy | Neoplastic Stem Cells - physiology | Doxorubicin - administration & dosage | Proto-Oncogene Proteins - metabolism | Leukemia, Myeloid, Acute - pathology | Mice, Inbred C57BL | Combined Modality Therapy | Gene Expression Regulation, Leukemic | Mice, SCID | Cell Transformation, Neoplastic - metabolism | Cytarabine - administration & dosage | Transcription Factors - metabolism | Xenograft Model Antitumor Assays | Animals | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Protein Binding | Mice, Inbred NOD | Mice | MicroRNAs - genetics | Myeloid Ecotropic Viral Integration Site 1 Protein | MicroRNA | Genetic transcription | Research | Flow cytometry | Insects | Leukemia | Cloning | MicroRNAs | Cell cycle | Software | Signatures | Gene expression | Deoxyribonucleic acid--DNA | Children & youth | Index Medicus | Abridged Index Medicus
Journal Article
PLoS biology, ISSN 1545-7885, 10/2015, Volume 13, Issue 10, pp. e1002274 - 28
Organ growth is controlled by patterning signals that operate locally (e.g., Wingless/Ints [Wnts], Bone Morphogenetic Proteins... 
Biochemistry & Molecular Biology | Biology | Life Sciences & Biomedicine - Other Topics | Life Sciences & Biomedicine | Science & Technology | Drosophila melanogaster - physiology | TOR Serine-Threonine Kinases - metabolism | MicroRNAs - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Drosophila Proteins - metabolism | Trans-Activators - chemistry | Drosophila melanogaster - genetics | Recombinant Fusion Proteins - metabolism | TOR Serine-Threonine Kinases - antagonists & inhibitors | Cell Nucleus - metabolism | TOR Serine-Threonine Kinases - genetics | Wings, Animal - growth & development | RNA Interference | Gene Expression Regulation, Developmental | Gene Deletion | Trans-Activators - genetics | Luminescent Proteins - chemistry | Larva - genetics | Protein Interaction Domains and Motifs | Active Transport, Cell Nucleus | Nuclear Proteins - genetics | Drosophila Proteins - antagonists & inhibitors | Peptide Fragments - genetics | Protein-Serine-Threonine Kinases - metabolism | Peptide Fragments - metabolism | Signal Transduction | Animals, Genetically Modified | Drosophila melanogaster - cytology | Nuclear Proteins - metabolism | Wings, Animal - enzymology | Drosophila Proteins - chemistry | Recombinant Fusion Proteins - chemistry | Nuclear Proteins - chemistry | Larva - cytology | Wings, Animal - metabolism | Peptide Fragments - chemistry | Animals | Animal Nutritional Physiological Phenomena | Caloric Restriction - adverse effects | Nuclear Proteins - antagonists & inhibitors | Luminescent Proteins - genetics | Trans-Activators - metabolism | Drosophila Proteins - genetics | Larva - physiology | Mutation | Trans-Activators - antagonists & inhibitors | Luminescent Proteins - metabolism | Bone morphogenetic proteins | Genetic aspects | Research | Drosophila | Index Medicus | Proteins | Insects | Cloning | Kinases | Metabolism | Gene expression | Insulin | Apoptosis
Journal Article
Nature (London), ISSN 1476-4687, 06/2012, Volume 486, Issue 7401, pp. 80 - 84
..., as well as members of the EGFR and RAF class of proteins (5-7). However, results of this approach have been mixed (8-10). Difficulties include rapidly emerging... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Niacinamide - analogs & derivatives | Proto-Oncogene Proteins c-ret - metabolism | Humans | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Male | Phenylurea Compounds | Extracellular Signal-Regulated MAP Kinases - metabolism | Protein Kinase Inhibitors - adverse effects | Drosophila Proteins - metabolism | Molecular Targeted Therapy | Drosophila melanogaster - genetics | Heterocyclic Compounds, 4 or More Rings - pharmacology | Multiple Endocrine Neoplasia Type 2b - genetics | Multiple Endocrine Neoplasia Type 2b - enzymology | Benzenesulfonates - pharmacology | Multiple Endocrine Neoplasia Type 2b - drug therapy | Protein Kinase Inhibitors - chemistry | Polypharmacy | Heterocyclic Compounds, 4 or More Rings - therapeutic use | Drug-Related Side Effects and Adverse Reactions | src-Family Kinases - metabolism | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Drug Evaluation, Preclinical | Drosophila Proteins - antagonists & inhibitors | Disease Models, Animal | src-Family Kinases - antagonists & inhibitors | Heterocyclic Compounds, 4 or More Rings - chemistry | Heterocyclic Compounds, 4 or More Rings - adverse effects | Survival Rate | Drosophila melanogaster - drug effects | Xenograft Model Antitumor Assays | Animals | Signal Transduction - drug effects | Protein Kinase Inhibitors - therapeutic use | Sorafenib | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Cell Transformation, Neoplastic - drug effects | Drosophila Proteins - genetics | Cell Transformation, Neoplastic - pathology | Proto-Oncogene Proteins c-ret - genetics | Chemotherapy | Physiological aspects | Genetic aspects | Cellular signal transduction | Research | Carcinogenesis | Risk factors | Cancer | Proteins | Nuclear magnetic resonance--NMR | Insects | Toxicity | Mutation | Kinases | Drug dosages | Cell adhesion & migration | Index Medicus
Journal Article
PLoS pathogens, ISSN 1553-7374, 09/2019, Volume 15, Issue 9, pp. e1008065 - e1008065
Most known thioredoxin-type proteins (Trx) participate in redox pathways, using two highly conserved cysteine residues to catalyze thiol-disulfide exchange reactions... 
Parasitology | Life Sciences & Biomedicine | Microbiology | Science & Technology | Virology | Recombinant Proteins - metabolism | Molecular Chaperones - metabolism | Oxidation-Reduction | Trypanosoma brucei brucei - metabolism | Protozoan Proteins - antagonists & inhibitors | Humans | Mitochondrial Proteins - antagonists & inhibitors | Molecular Chaperones - genetics | Genes, Protozoan | Mitochondrial Proteins - genetics | Recombinant Proteins - genetics | Trypanosoma brucei brucei - genetics | Protozoan Proteins - genetics | Molecular Chaperones - antagonists & inhibitors | Gene Knockdown Techniques | Animals | Protozoan Proteins - metabolism | Thioredoxins - genetics | Mitochondrial Proteins - metabolism | Trypanosoma brucei brucei - pathogenicity | Thioredoxins - metabolism | Thioredoxins - antagonists & inhibitors | Mutation | Physiological aspects | Molecular chaperones | Trypanosoma brucei | Bacterial proteins | Analysis | Cysteine | Thiols | Thioredoxin | Recombinant proteins | Cystine | Cell proliferation | Cell culture | Reductases | Residues | Temperature | Serine | Iron | Genomes | Parasites | Proteins | Mitochondria | Ribonucleotide reductase | E coli | Parasitic diseases | Infectivity | Oxidation | Heat stress | Sulfur | Disulfide reductase | Protozoa | Developmental biology | RNA-mediated interference | Chemical reactions | Ribonucleic acid--RNA | Metabolism | Depletion | Insects | Heat exchange | Lysis | Heat tolerance | Immunofluorescence | Index Medicus | RNA | Ribonucleic acid
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 09/2013, Volume 110, Issue 37, pp. E3526 - E3534
Journal Article