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Journal Article
BIOCHEMICAL JOURNAL, ISSN 0264-6021, 10/2013, Volume 455, Issue 1, pp. 75 - 85
The resistance of mosquitoes to chemical insecticides is threatening vector control programmes worldwide. Cytochrome P450 monooxygenases (CYPs) are known to... 
DENGUE VECTOR | recombinant system | VECTOR AEDES-AEGYPTI | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | insecticide | IN-VITRO METABOLISM | ANOPHELES-GAMBIAE | resistance | mosquito | YEAST | MALARIA VECTOR | cytochrome P450 monooxygenase | metabolism | P450 | pyrethroid | Inactivation, Metabolic | Insecticides - chemistry | NADPH-Ferrihemoprotein Reductase - genetics | Saccharomyces cerevisiae - genetics | Benzoates - metabolism | Cytochrome P-450 Enzyme System - metabolism | Insecticide Resistance - genetics | NADPH-Ferrihemoprotein Reductase - chemistry | Saccharomyces cerevisiae - drug effects | Isoenzymes - chemistry | Pyrethrins - pharmacology | Insect Vectors - drug effects | Isoenzymes - metabolism | Insecticide Resistance - drug effects | Aedes - enzymology | Pyrethrins - metabolism | Insect Proteins - metabolism | Insect Vectors - enzymology | Insecticides - pharmacology | Benzaldehydes - chemistry | Escherichia coli - enzymology | NADPH-Ferrihemoprotein Reductase - metabolism | Oxidation-Reduction | Isoenzymes - genetics | Anopheles - drug effects | Insect Proteins - genetics | Benzaldehydes - pharmacology | Aedes - drug effects | Pyrethrins - chemistry | Anopheles - enzymology | Benzaldehydes - metabolism | Cytochrome P-450 Enzyme System - chemistry | Animals | Genetic Engineering | Insecticides - metabolism | Escherichia coli - genetics | Insect Proteins - chemistry | Cytochrome P-450 Enzyme System - genetics | Saccharomyces cerevisiae - enzymology | Molecular Docking Simulation | AeCPR, Aedes aegypti CPR | 7-OH, 7-hydroxycoumarin | SRS, substrate recognition site | CPR, NADPH-cytochrome P450-reductase | Rt, retention time | Cyt b5, cytochrome b5 | PBAld, 3-phenoxybenzaldehyde | qPCR, quantitative real-time PCR | PBA, 3-phenoxybenzoic acid | PBAlc, 3-phenoxybenzoic alcohol | TFA, trifluoroacetic acid
Journal Article
Plant, cell and environment, ISSN 0140-7791, 2019, Volume 42, Issue 7, pp. 2309 - 2323
Feeding by insect herbivores such as caterpillars and aphids induces plant resistance mechanisms that are mediated by the phytohormones jasmonic acid (JA) and... 
phloem-sucking herbivores | secondary metabolites | Arabidopsis | retrograde signalling | indole glucosinolates | aphid resistance | phytohormone signalling | phloem‐sucking herbivores | TREHALOSE METABOLISM | ARABIDOPSIS-THALIANA | SIGNALING PATHWAYS | INSECTICIDE RESISTANCE | PLANT SCIENCES | SALICYLIC-ACID | CABBAGE APHID | HERBIVORE | GLUCOSINOLATE BIOSYNTHESIS | JASMONATE | MYZUS-PERSICAE | Erythritol - analogs & derivatives | Salicylic Acid - metabolism | Cytochrome P-450 Enzyme System - metabolism | Glucosinolates - metabolism | Arabidopsis Proteins - metabolism | Erythritol - metabolism | Disease Resistance - genetics | Erythritol - pharmacology | Arabidopsis Proteins - genetics | Sugar Phosphates | Erythritol - genetics | Metabolome | Arabidopsis - metabolism | Secondary Metabolism | Arabidopsis - genetics | Transcription Factors - metabolism | Oxylipins - metabolism | Brassica | Gene Expression Regulation, Plant - drug effects | Metabolic Networks and Pathways - genetics | Animals | Disease Resistance - physiology | Signal Transduction - drug effects | Cyclopentanes - metabolism | Plant Growth Regulators - metabolism | Plant Growth Regulators - pharmacology | Aphids - drug effects | Phosphates | Arabidopsis thaliana | Enzymes | Physiological aspects | Aphididae | Genetic transcription | Plants | Plant hormones | Plant metabolites | Salicylic acid | Transcription | Genes | Plant resistance | Crosstalk | Biosynthesis | Metabolism | Gene expression | Erythritol | Signal transduction | Molecular modelling | Pathways | Acids | Insects | Metabolites | Caterpillars | Metabolic engineering | Metabolic pathways | Herbivores | Jasmonic acid | Original
Journal Article
Environmental Toxicology and Chemistry, ISSN 0730-7268, 07/2017, Volume 36, Issue 7, pp. 1764 - 1774
The aim of the present study was to evaluate the accumulation of cypermethrin and chlorpyrifos when the fish Jenynsia multidentata was exposed to these... 
Tissue distribution | Mixtures | Metabolism | Gas chromatography electron capture detector | High‐performance liquid chromatography electrospray ionization source quadrupole time‐of‐flight analyzer | High-performance liquid chromatography electrospray ionization source quadrupole time-of-flight analyzer | CHANNEL CATFISH | MICROCYSTIN-LR | RAINBOW-TROUT | IN-VITRO METABOLISM | GUPPIES POECILIA-RETICULATA | CYTOCHROME-P450 ISOFORMS | P-GLYCOPROTEIN | ENVIRONMENTAL SCIENCES | PYRETHROID PESTICIDES | TOXICOLOGY | GLUTATHIONE-S-TRANSFERASE | RISK-ASSESSMENT | Cyprinodontiformes - metabolism | Intestines - drug effects | Insecticides - chemistry | Liver - enzymology | Chlorpyrifos - analysis | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Intestines - metabolism | Chromatography, High Pressure Liquid | Chlorpyrifos - metabolism | Gills - drug effects | Spectrometry, Mass, Electrospray Ionization | Liver - drug effects | Biotransformation | Female | Pyrethrins - metabolism | Muscles - metabolism | Insecticides - analysis | Pyrethrins - toxicity | Liver - metabolism | Glutathione Transferase - metabolism | Gills - metabolism | Cytochrome P-450 CYP1A1 - metabolism | Water Pollutants, Chemical - analysis | Water Pollutants, Chemical - metabolism | Animals | Insecticides - metabolism | Water Pollutants, Chemical - toxicity | Pyrethrins - analysis | Muscles - drug effects | Chlorpyrifos - toxicity | Insecticides - toxicity | Insecticides | Enzyme inhibitors | Chlorpyrifos | Cytochrome | Enzymes | Liver | Cytochrome P450 | Pesticides | Organs | Gills | Exposure | Glycoproteins | Accumulation | Agrochemicals | Bioaccumulation | Intestine | Biological magnification | Cypermethrin | Fish | Inhibition | P-Glycoprotein | Index Medicus
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 2007, Volume 221, Issue 1, pp. 1 - 12
Hydrolytic metabolism of pyrethroid insecticides in humans is one of the major catabolic pathways that clear these compounds from the body... 
Pyrethroids | Xenobiotic metabolism | Carboxylesterases | CHOLESTERYL ESTER HYDROLASE | carboxylesterases | IDENTIFICATION | xenobiotic metabolism | PESTICIDES | pyrethroids | DELTAMETHRIN | IN-VITRO | PLASMA | METABOLISM | ENZYMES | PURIFICATION | MAMMALIAN CARBOXYLESTERASES | PHARMACOLOGY & PHARMACY | TOXICOLOGY | Liver - enzymology | Humans | Microsomes, Liver - metabolism | Chlorpyrifos - metabolism | Carboxylic Ester Hydrolases - blood | Valerates - chemistry | Umbelliferones - metabolism | Chlorpyrifos - chemistry | Microsomes, Liver - enzymology | Molecular Structure | Pyrethrins - metabolism | Pancreas - enzymology | Benzyl Alcohols - chemistry | Carboxylesterase - blood | Chlorpyrifos - analogs & derivatives | Electrophoresis, Polyacrylamide Gel | Rats | Umbelliferones - chemistry | Valerates - metabolism | Lipase - metabolism | Carboxylesterase - metabolism | Blotting, Western | Pyrethrins - chemistry | Hydrolysis | Nitrobenzoates - metabolism | Animals | Benzyl Alcohols - metabolism | Thiolester Hydrolases - metabolism | Kinetics | Carboxylic Ester Hydrolases - metabolism | Intestines - enzymology | Physiological aspects | Liver | Adenosine triphosphatase | SMALL INTESTINE | CLEARANCE | LIPASES | SUBSTRATES | HYDROLYSIS | RATS | 60 APPLIED LIFE SCIENCES | ALCOHOLS | IN VITRO | MICROSOMES | LIVER | ACETATES | STEARATES | MAN | INSECTICIDES
Journal Article
Scientific reports, ISSN 2045-2322, 2017, Volume 7, Issue 1, pp. 2386 - 9
Cry1A insecticidal toxins bind sequentially to different larval gut proteins facilitating oligomerization, membrane insertion and pore formation. Cry1Ac... 
MANDUCA-SEXTA | TRICHOPLUSIA-NI | ALKALINE-PHOSPHATASE | CABBAGE-LOOPER | MULTIDISCIPLINARY SCIENCES | PRE-PORE | INSECT RESISTANCE | HELICOVERPA-ARMIGERA LARVAE | PORE FORMATION | FIELD-EVOLVED RESISTANCE | MODIFIED BT TOXINS | Insecticides - chemistry | Hemolysin Proteins - pharmacology | Microvilli - chemistry | Hemolysin Proteins - genetics | Protein Multimerization | Bacterial Proteins - chemistry | Cell-Derived Microparticles - chemistry | Hemolysin Proteins - chemistry | Cell Membrane - chemistry | Larva - drug effects | Endotoxins - chemistry | Biological Control Agents - chemistry | Protein Engineering | Multidrug Resistance-Associated Proteins - genetics | Cell Membrane - metabolism | Cell-Derived Microparticles - metabolism | Larva - chemistry | Biological Control Agents - metabolism | Insect Proteins - metabolism | Cell Membrane - drug effects | Endotoxins - metabolism | Endotoxins - genetics | Insecticide Resistance | Larva - metabolism | Bacterial Proteins - genetics | Multidrug Resistance-Associated Proteins - chemistry | Insect Proteins - genetics | Microvilli - drug effects | Bacterial Proteins - pharmacology | Manduca - drug effects | Animals | Insecticides - metabolism | Microvilli - metabolism | Insect Proteins - chemistry | Protein Isoforms | Protein Binding | Bacterial Proteins - metabolism | Mutation | Multidrug Resistance-Associated Proteins - metabolism | Endotoxins - pharmacology | Hemolysin Proteins - metabolism | Moths - drug effects | Oligomerization | Cry1Ac toxin | Membrane vesicles | Toxins | Cadherin | ABC transporter | Western blotting
Journal Article