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Clinical Epigenetics, ISSN 1868-7075, 01/2016, Volume 8, Issue 1, p. 11
Background: Insulin-like growth factors 1 and 2 (IGF1 and IGF2) and their binding proteins (IGFBPs) are expressed in the placenta and known to regulate fetal... 
DNA methylation | Placental expression | Small fetus | Large fetus | Insulin growth factor | HUMAN PLACENTA | FACTOR-II | 5-METHYLCYTOSINE | GENE-EXPRESSION PATTERNS | FETUS | IMPRINTED GENES | HORMONE | MESSENGER-RNA | ONCOLOGY | GENETICS & HEREDITY | BINDING-PROTEIN 3 | IGF-II | Insulin-Like Growth Factor Binding Protein 3 - genetics | Insulin-Like Growth Factor Binding Proteins - physiology | Insulin-Like Growth Factor II - physiology | Humans | Fetal Growth Retardation - genetics | Insulin-Like Growth Factor I - genetics | Promoter Regions, Genetic - genetics | Case-Control Studies | DNA Methylation | Insulin-Like Growth Factor II - genetics | Fetal Growth Retardation - etiology | Adult | Female | Insulin-Like Growth Factor Binding Protein 4 - physiology | Insulin-Like Growth Factor Binding Protein 2 - physiology | Infant, Newborn | Insulin-Like Growth Factor Binding Protein 3 - physiology | Insulin-Like Growth Factor Binding Proteins - genetics | Insulin-Like Growth Factor Binding Protein 1 - physiology | Insulin-Like Growth Factor Binding Protein 4 - genetics | Insulin-Like Growth Factor Binding Protein 2 - genetics | Placenta - metabolism | Pregnancy | Insulin-Like Growth Factor I - physiology | Infant, Small for Gestational Age | Insulin-Like Growth Factor Binding Protein 1 - genetics | Infants (Newborn) | Epigenetic inheritance | RNA | Growth | Genes | Gene expression | Purines | Pyrimidines | Fetus | Binding proteins | Methylation | Protein binding
Journal Article
Diabetic Medicine, ISSN 0742-3071, 04/2016, Volume 33, Issue 4, pp. 471 - 477
Aims To assess resource utilization associated with severe hypoglycaemia across three insulin regimens in a large phase 3a clinical programme involving people... 
GLYCEMIC CONTROL | 26-WEEK | GLARGINE | NAIVE PATIENTS | ENDOCRINOLOGY & METABOLISM | OPEN-LABEL | TO-TARGET TRIAL | BEGIN | BASAL-BOLUS TREATMENT | TYPE-2 | DEGLUDEC/INSULIN ASPART | Hypoglycemia - therapy | Hypoglycemic Agents - economics | Dipeptidyl-Peptidase IV Inhibitors - therapeutic use | Humans | Middle Aged | Insulin Detemir - therapeutic use | Insulin Detemir - economics | Clinical Trials, Phase III as Topic | Hypoglycemic Agents - administration & dosage | Hypoglycemic Agents - therapeutic use | Sitagliptin Phosphate - administration & dosage | Costs and Cost Analysis | Administration, Oral | Drug Therapy, Combination - economics | Dipeptidyl-Peptidase IV Inhibitors - administration & dosage | Insulin Aspart - economics | Insulin, Long-Acting - adverse effects | Insulin, Long-Acting - administration & dosage | Diabetes Mellitus, Type 1 - economics | Diabetes Mellitus, Type 1 - blood | Insulin, Long-Acting - therapeutic use | Hypoglycemic Agents - adverse effects | Insulin Aspart - adverse effects | Cohort Studies | Insulin Aspart - therapeutic use | Dipeptidyl-Peptidase IV Inhibitors - adverse effects | Diabetes Mellitus, Type 2 - economics | Insulin, Long-Acting - economics | Dipeptidyl-Peptidase IV Inhibitors - economics | Insulin Glargine - administration & dosage | Drug Therapy, Combination - adverse effects | Insulin Aspart - administration & dosage | Insulin Detemir - administration & dosage | Insulin Detemir - adverse effects | Hypoglycemia - physiopathology | Adult | Hypoglycemia - economics | Hypoglycemia - chemically induced | Severity of Illness Index | Insulin Glargine - adverse effects | Drug Administration Schedule | Insulin Glargine - economics | Insulin Glargine - therapeutic use | Sitagliptin Phosphate - economics | Diabetes Mellitus, Type 1 - drug therapy | Diabetes Mellitus, Type 2 - blood | Health Care Costs | Sitagliptin Phosphate - therapeutic use | Diabetes Mellitus, Type 2 - drug therapy | Drug Combinations | Sitagliptin Phosphate - adverse effects | Type 2 diabetes | Adults | Type 1 diabetes | Insulin | Analysis | Emergency medical care | Diabetes | Hypoglycemia | Complications | Research
Journal Article
Journal Article
Drugs, ISSN 0012-6667, 7/2012, Volume 72, Issue 11, pp. 1495 - 1520
Biphasic insulin aspart 30 (BIAsp 30) includes 30% soluble rapid-acting insulin aspart (IAsp) along with an intermediate-acting 70% protaminated IAsp that... 
Pharmacotherapy | Internal Medicine | Medicine & Public Health | Pharmacology/Toxicology | Glimepiride | Hypoglycaemia | Pioglitazone | Insulin-aspartinsulin-protamine-aspart | Sitagliptin | Blood-glucose | Exenatide | Insulin-glulisine | Insulin-neutral-protamine-lisproinsulin- lispro | Sulfonylureas | Rosiglitazone | Diabetes-mellitus | Metformin | Glibenclamide | Insulin-detemir | Insulin-glargine | Thiazolidinediones | MULTIPLE DAILY INJECTIONS | COST-EFFECTIVENESS | IMPROVES GLYCEMIC CONTROL | BASAL INSULIN | MONOMERIC INSULINS | HUMAN PREMIX INSULIN | TYPE-2 DIABETES PATIENTS | TWICE-DAILY INJECTIONS | PHARMACOLOGY & PHARMACY | OPEN-LABEL | TOXICOLOGY | SUBGROUP ANALYSIS | Hypoglycemic Agents - therapeutic use | Insulin Aspart - therapeutic use | Hypoglycemic Agents - pharmacokinetics | Biphasic Insulins - adverse effects | Humans | Insulin Aspart - pharmacokinetics | Insulin, Isophane - pharmacokinetics | Biphasic Insulins - pharmacokinetics | Hypoglycemic Agents - pharmacology | Biphasic Insulins - pharmacology | Insulin, Isophane - therapeutic use | Animals | Biphasic Insulins - therapeutic use | Insulin, Isophane - adverse effects | Insulin Aspart - pharmacology | Insulin, Isophane - pharmacology | Hypoglycemic Agents - adverse effects | Insulin Aspart - adverse effects | Pharmaceutical research | Insulin aspart | Clinical trials | Product development | Research | Pharmaceutical industry | Testing | Review
Journal Article
Journal Article
Journal Article
Diabetes/Metabolism Research and Reviews, ISSN 1520-7552, 01/2016, Volume 32, Issue 1, pp. 21 - 39
Summary The level of glycaemic control necessary to achieve optimal short‐term and long‐term outcomes in subjects with type 1 diabetes mellitus (T1DM)... 
continuous subcutaneous insulin infusion | diabetes mellitus | rapid‐acting insulin analogue | pharmacoeconomics | pregnancy | paediatric | Pregnancy | Rapid-acting insulin analogue | Pharmacoeconomics | Paediatric | Diabetes mellitus | Continuous subcutaneous insulin infusion | MULTIPLE DAILY INJECTIONS | GLYCEMIC CONTROL | ARTIFICIAL PANCREAS | SEVERE HYPOGLYCEMIA | AUGMENTED PUMP THERAPY | RANDOMIZED CONTROLLED-TRIAL | METABOLIC-CONTROL | CLOSED-LOOP CONTROL | rapid-acting insulin analogue | ENDOCRINOLOGY & METABOLISM | QUALITY-OF-LIFE | BLOOD-GLUCOSE CONTROL | Insulin, Short-Acting - adverse effects | Insulin, Short-Acting - economics | Hypoglycemic Agents - economics | Insulin, Short-Acting - administration & dosage | Humans | Insulins - economics | Hypoglycemia - prevention & control | Hypoglycemic Agents - administration & dosage | Computer Security | Insulin Infusion Systems - economics | Hypoglycemia - chemically induced | Precision Medicine | Hypoglycemic Agents - therapeutic use | Hyperglycemia - prevention & control | Blood Glucose - analysis | Insulins - administration & dosage | Europe | Insulin Infusion Systems - adverse effects | Evidence-Based Medicine | Insulin Infusion Systems - trends | Diabetes Mellitus, Type 1 - drug therapy | Infusions, Subcutaneous | Monitoring, Ambulatory | Health Care Costs | Diabetes Mellitus, Type 1 - economics | Diabetes Mellitus, Type 1 - blood | Quality of Life | Insulins - therapeutic use | Hypoglycemic Agents - adverse effects | Insulins - adverse effects | Insulin, Short-Acting - therapeutic use | Insulin | Diabetes | Hyperglycemia | Patient satisfaction | Quality of life | Life Sciences | Human health and pathology | Endocrinology and metabolism | Review
Journal Article
Lancet, The, ISSN 0140-6736, 2012, Volume 379, Issue 9825, pp. 1489 - 1497
Journal Article