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1. Full Text Auxin Regulation of Cytokinin Biosynthesis in Arabidopsis thaliana: A Factor of Potential Importance for Auxin-Cytokinin-Regulated Development
by Anders Nordström and Petr Tarkowski and Danuse Tarkowska and Rikke Norbaek and Crister Åstot and Karel Dolezal and Göran Sandberg and Jake MacMillan
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2004, Volume 101, Issue 21, pp. 8039 - 8044
One of the most long-lived models in plant science is the belief that the long-distance transport and ratio of two plant hormones, auxin and cytokinin, at the... 
Deuterium | Cytokinins | Leaves | Physical Sciences | Plant growth regulators | Plant roots | Auxins | Biosynthesis | Plants | Hormones | Insulin antibodies | WILD-TYPE | TRANSGENIC TOBACCO | RESISTANT MUTANTS | METABOLISM | MULTIDISCIPLINARY SCIENCES | GROWTH | IPT GENE | ABSCISIC-ACID | IDENTIFICATION | MASS-SPECTROMETRY | ISOPENTENYL TRANSFERASE | Isopentenyladenosine - biosynthesis | Arabidopsis - drug effects | Plant Roots - metabolism | Indoleacetic Acids - metabolism | Adenosine Monophosphate - metabolism | Arabidopsis - growth & development | Cytokinins - biosynthesis | Mutation - genetics | Arabidopsis - metabolism | Plant Roots - drug effects | Arabidopsis - genetics | Plant Components, Aerial - metabolism | Isopentenyladenosine - analogs & derivatives | Time Factors | Indoleacetic Acids - pharmacology | Adenosine Monophosphate - analogs & derivatives | Isopentenyladenosine - metabolism | Adenosine Monophosphate - biosynthesis | Cytokinins - metabolism | Plant Components, Aerial - drug effects | Research | Models | Botany | Index Medicus | Biological Sciences | Naturvetenskap | Natural Sciences
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2. Full Text Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice
by Holland, William L and Bikman, Benjamin T and Wang, Li-Ping and Yuguang, Guan and Sargent, Katherine M and Bulchand, Sarada and Knotts, Trina A and Shui, Guanghou and Clegg, Deborah J and Wenk, Markus R and Pagliassotti, Michael J and Scherer, Philipp E and Summers, Scott A
Journal of Clinical Investigation, ISSN 0021-9738, 05/2011, Volume 121, Issue 5, pp. 1858 - 1870
Obesity is associated with an enhanced inflammatory response that exacerbates insulin resistance and contributes to diabetes, atherosclerosis, and... 
3T3-L1 ADIPOCYTES | MEDICINE, RESEARCH & EXPERIMENTAL | SKELETAL-MUSCLE | SPHINGOLIPID BIOSYNTHESIS | IMMUNE-RESPONSE | TOLL-LIKE RECEPTOR-4 | INHIBITOR MYRIOCIN | ACCUMULATION | DIET-INDUCED OBESITY | NF-KAPPA-B | ADIPOSE-TISSUE | Sphingolipids - chemistry | Soybeans | Ceramides - metabolism | Cytokines - metabolism | Hyperlipidemias - metabolism | Mice, Inbred C57BL | Insulin Resistance | Rats | Toll-Like Receptor 4 - genetics | Male | Toll-Like Receptor 4 - chemistry | I-kappa B Proteins - metabolism | Rats, Sprague-Dawley | Obesity - metabolism | Inflammation - metabolism | Lipids - chemistry | Animals | Glucose - metabolism | Mice | Mice, Inbred BALB C | Diabetes Mellitus, Experimental - metabolism | Fatty Acids - metabolism | Toll-like receptors | Physiological aspects | Ceramides | Insulin resistance | Lipids | Research | Risk factors | Index Medicus | Abridged Index Medicus
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3. Recombinant DNA products
: insulin, interferon and growth hormone
by Bollon, Arthur P., 1942
1984, ISBN 9780849355424, 191
Somatotropin | Biological products | Interferons | DNA, Recombinant | Genetic engineering | Biosynthesis | Recombinant DNA | Insulin
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4. Full Text DGAT enzymes and triacylglycerol biosynthesis
by Yen, Chi-Liang Eric and Stone, Scot J and Koliwad, Suneil and Harris, Charles and Farese Jr, Robert V
Journal of Lipid Research, ISSN 0022-2275, 2008, Volume 49, Issue 11, pp. 2283 - 2301
Triacylglycerols (triglycerides) (TGs) are the major storage molecules of metabolic energy and FAs in most living organisms. Excessive accumulation of TGs,... 
Obesity | Adipose | Fatty acyl-CoA | Intestine | Acyl-CoA:diacylglycerol acyltransferase | Diacylglycerol | Triglycerides | Lipoprotein | Mammary gland | Triacylglycerols | intestine | lipoprotein | ATP-DEPENDENT INACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DIACYLGLYCEROL ACYLTRANSFERASE ACTIVITY | COA-CHOLESTEROL ACYLTRANSFERASE | adipose | triglycerides | ENDOPLASMIC-RETICULUM STRESS | RAT-LIVER MICROSOMES | WHITE ADIPOSE-TISSUE | acyl-CoA : diacylglycerol acyltransferase | ACYL-COENZYME-A | INSULIN-RESISTANCE | IMPROVES HEPATIC STEATOSIS | triacylglycerols | ACID TRANSPORT PROTEIN-4 | fatty acyl-CoA | mammary gland | diacylglycerol | obesity | Thematic Review | acyl-CoA: diacylglycerol acyltransferase
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5. Full Text MAFA controls genes implicated in insulin biosynthesis and secretion
by Wang, H and Brun, T and Kataoka, K and Sharma, A J and Wollheim, C B
Diabetologia, ISSN 0012-186X, 2/2007, Volume 50, Issue 2, pp. 348 - 358
Effects of the transcription factor v-maf musculoaponeurotic fibrosarcoma oncogene homologue A (MAFA) on the regulation of beta cell gene expression and... 
Beta cells | Human | Islet insulin secretion | Medicine & Public Health | Human Physiology | Metabolic Diseases | Internal Medicine | MAFA | Metabolism | LACTATE-DEHYDROGENASE | KEY REGULATOR | DIFFERENTIATION FACTOR NKX6.1 | PDX-1 | islet insulin secretion | GLUCOSE | ENDOCRINOLOGY & METABOLISM | PANCREATIC BETA-CELLS | metabolism | MICE | human | TRANSCRIPTION FACTOR | EXPRESSION | beta cells | GLUCAGON | Insulin-Secreting Cells - physiology | Humans | Insulinoma | Gene Expression Regulation | Lectins, C-Type - physiology | Rats | Lectins, C-Type - genetics | Insulin - biosynthesis | Membrane Glycoproteins - genetics | Mice, Knockout | Insulin - metabolism | Insulin-Secreting Cells - metabolism | Membrane Glycoproteins - physiology | Animals | Cell Line, Tumor | Transcription, Genetic | Mice | Lectins, C-Type - deficiency | Insulin - genetics | Pancreatic Neoplasms | Insulin Secretion | Membrane Glycoproteins - deficiency | Genetic research | Insulin | Diabetes therapy | Cellular proteins | Glucagon | Sarcoma | RNA | Developmental biology | Isoenzymes | Genes | Genetic transcription | Glucose | Cells | Dextrose | Universities and colleges | Diabetes | Index Medicus | beta-cells | MafA | insulin secretion | human islets
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6. Full Text Human adipose tissue-derived mesenchymal stem cells differentiate into insulin, somatostatin, and glucagon expressing cells
by Timper, Katharina and Seboek, Dalma and Eberhardt, Michael and Linscheid, Philippe and Christ-Crain, Mirjam and Keller, Ulrich and Müller, Beat and Zulewski, Henryk
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 2006, Volume 341, Issue 4, pp. 1135 - 1140
Mesenchymal stem cells (MSC) from mouse bone marrow were shown to adopt a pancreatic endocrine phenotype in vitro and to reverse diabetes in an animal model.... 
Human | Nestin | Adipose tissue | Glucagon | Isl-1 | Differentiation | Insulin | Mesenchymal stem cells | ABCG2 | PROGENITOR CELLS | VITRO | differentiation | TRANSPORTER | insulin | RAT | BIOCHEMISTRY & MOLECULAR BIOLOGY | nestin | ENDOCRINE | adipose tissue | BIOPHYSICS | HUMAN BONE-MARROW | mesenchymal stem cells | IN-VIVO | glucagon | PANCREATIC BETA-CELLS | STROMAL CELLS | human | BRAIN | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Glucagon - biosynthesis | Homeodomain Proteins - biosynthesis | Neoplasm Proteins - biosynthesis | Humans | Cells, Cultured | Adipose Tissue - cytology | Intermediate Filament Proteins - biosynthesis | Mesenchymal Stromal Cells - metabolism | Proto-Oncogene Proteins c-kit - biosynthesis | Insulin - biosynthesis | Somatostatin - biosynthesis | ATP-Binding Cassette Transporters - biosynthesis | Mesenchymal Stromal Cells - cytology | Stem Cell Factor - biosynthesis | Nerve Tissue Proteins - biosynthesis | Thy-1 Antigens - biosynthesis | LIM-Homeodomain Proteins | Cell Differentiation | Transcription Factors | Stem cell research | Analysis | Stem cells | Somatostatin | Diabetes | Hormones | Intermediate filament proteins | Index Medicus | TRANSCRIPTION FACTORS | PANCREAS | PHENOTYPE | BONE MARROW | CELL PROLIFERATION | 60 APPLIED LIFE SCIENCES | INSULIN | POLYMERASE CHAIN REACTION | IN VITRO | SOMATOSTATIN | MICE | STEM CELLS | ADIPOSE TISSUE | GLUCAGON
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7. Full Text PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11- HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a chinese population
by Hu, Cheng and Zhang, Rong and Wang, Congrong and Wang, Jie and Ma, Xiaojing and Lu, Jingyi and Qin, Wen and Hou, Xuhong and Wang, Chen and Bao, Yuqian and Xiang, Kunsan and Jia, Weiping
PLoS ONE, ISSN 1932-6203, 10/2009, Volume 4, Issue 10, pp. e7643 - e7643
Background: Recent advance in genetic studies added the confirmed susceptible loci for type 2 diabetes to eighteen. In this study, we attempt to analyze the... 
BIOLOGY | Homeodomain Proteins - biosynthesis | Cation Transport Proteins - biosynthesis | Zinc Transporter 8 | Humans | Middle Aged | Gene Expression Regulation | Insulysin - biosynthesis | Kinesin - biosynthesis | Male | Transcription Factors - biosynthesis | Diabetes Mellitus, Type 2 - metabolism | Cyclin-Dependent Kinase Inhibitor p15 - biosynthesis | PPAR gamma - biosynthesis | Potassium Channels, Inwardly Rectifying - biosynthesis | RNA-Binding Proteins - biosynthesis | Diabetes Mellitus, Type 2 - ethnology | tRNA Methyltransferases | China | Cyclin-Dependent Kinase Inhibitor p16 - biosynthesis | Female | Aged | Polymorphism, Single Nucleotide | Cyclin-Dependent Kinase 5 - biosynthesis | Type 2 diabetes | Glucose metabolism | Physiological aspects | Genetic aspects | Single nucleotide polymorphisms | Glucose | Chromosomes | Dextrose | Plasma | Genes | Risk | Genomes | Thyroid gland | Single-nucleotide polymorphism | Body mass index | Prediction models | Population | Age | Obesity | Middle age | Diabetes mellitus | Health risks | Regression analysis | Metabolism | Insulin | Empirical analysis | Loci | Studies | Glucose tolerance | Alleles | Insulin resistance | Diagnostic systems | Diabetes | Peroxisome proliferator-activated receptors | Endocrinology | Tumors | Index Medicus
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8. Full Text Arabidopsis Asa1 Is Important for Jasmonate-Mediated Regulation of Auxin Biosynthesis and Transport during Lateral Root Formation
by Jiaqiang Sun and Yingxiu Xu and Songqing Ye and Hongling Jiang and Qian Chen and Fang Liu and Wenkun Zhou and Rong Chen and Xugang Li and Olaf Tietz and Xiaoyan Wu and Jerry D. Cohen and Klaus Palme and Chuanyou Li
The Plant Cell, ISSN 1040-4651, 5/2009, Volume 21, Issue 5, pp. 1495 - 1511
Plant roots show an impressive degree of plasticity in adapting their branching patterns to ever-changing growth conditions. An important mechanism underlying... 
Meristems | Plant growth regulators | Plant roots | Auxins | Biosynthesis | Gene expression regulation | Plants | Seedlings | Plant cells | Insulin antibodies | INITIATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PLANT SCIENCES | CELL BIOLOGY | ETHYLENE | GENE | PIN | HIGHER-PLANTS | THALIANA | PATHWAY | GROWTH | TRYPTOPHAN BIOSYNTHESIS | FOUNDER CELLS | Arabidopsis - physiology | Arabidopsis Proteins - genetics | Arabidopsis Proteins - physiology | Arabidopsis - drug effects | Plant Roots - metabolism | Indoleacetic Acids - metabolism | Acetates - metabolism | Arabidopsis Proteins - pharmacology | Plant Roots - genetics | Cyclopentanes - pharmacology | Anthranilate Synthase - pharmacology | Arabidopsis - metabolism | Plant Roots - drug effects | Arabidopsis Proteins - metabolism | Oxylipins - metabolism | Anthranilate Synthase - genetics | Oxylipins - pharmacology | Cyclopentanes - metabolism | Acetates - pharmacology | Biological Transport - drug effects | Mutation | Anthranilate Synthase - metabolism | Ethylenes - pharmacology | Plant Roots - growth & development | Physiological aspects | Genetic aspects | Auxin | Chemical properties | Jasmonates | Arabidopsis | Index Medicus | s
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9. Full Text Metformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent Biosynthesis
by Griss, Takla and Vincent, Emma E and Egnatchik, Robert and Chen, Jocelyn and Ma, Eric H and Faubert, Brandon and Viollet, Benoit and DeBerardinis, Ralph J and Jones, Russell G
PLoS Biology, ISSN 1544-9173, 12/2015, Volume 13, Issue 12, pp. e1002309 - e1002309
Metformin is a biguanide widely prescribed to treat Type II diabetes that has gained interest as an antineoplastic agent. Recent work suggests that metformin... 
DIABETES-MELLITUS | LKB1-AMPK PATHWAY | ATP CITRATE LYASE | RESPIRATORY-CHAIN | ACTIVATED PROTEIN-KINASE | REDUCTIVE GLUTAMINE-METABOLISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOLOGY | COMPLEX 1 | ALPHA-KETOGLUTARATE | AMPK | TUMOR-GROWTH | Neoplasms - metabolism | AMP-Activated Protein Kinases - metabolism | Humans | Drug Resistance, Neoplasm | Phosphoproteins - metabolism | Antineoplastic Agents - pharmacology | Protein-Serine-Threonine Kinases - metabolism | Eukaryotic Initiation Factors - genetics | Eukaryotic Initiation Factors - metabolism | Metformin - pharmacology | Cells, Cultured | Citric Acid Cycle - drug effects | Protein-Serine-Threonine Kinases - genetics | Electron Transport Chain Complex Proteins - genetics | Mitochondria - metabolism | Mitochondria - drug effects | Mitochondria - pathology | Phosphoproteins - genetics | Hypoglycemic Agents - pharmacology | Mice, Knockout | Neoplasms - drug therapy | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Embryo, Mammalian - cytology | Electron Transport Chain Complex Proteins - metabolism | Lipid Metabolism - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Mutation | Neoplasms - pathology | AMP-Activated Protein Kinases - genetics | Index Medicus | Life Sciences | Cellular Biology | Cancer | Cell growth | Insulin-like growth factors | Kinases | Cancer therapies
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10. Full Text Soluble Carbohydrates Regulate Auxin Biosynthesis via PIF Proteins in Arabidopsis
by Ilkka Sairanen and Ondřej Novák and Aleš Pěnčík and Yoshihisa Ikeda and Brian Jones and Göran Sandberg and Karin Ljung and Umeå Plant Science Centre (UPSC) and Umeå universitet and Teknisk-naturvetenskapliga fakulteten
The Plant Cell, ISSN 1040-4651, 12/2012, Volume 24, Issue 12, pp. 4907 - 4916
Plants are necessarily highly competitive and have finely tuned mechanisms to adjust growth and development in accordance with opportunities and limitations in... 
Liquids | Plant growth regulators | RESEARCH ARTICLES | Genes | Auxins | Biosynthesis | Gene expression regulation | Plants | Sugars | Insulin antibodies | Seedlings | TRYPTOPHAN | BIOCHEMISTRY & MOLECULAR BIOLOGY | HYPOCOTYL ELONGATION | ROOT-GROWTH | LIGHT | THALIANA SEEDLINGS | PLANT DEVELOPMENT | BHLH TRANSCRIPTION FACTORS | SUGAR | PLANT SCIENCES | CELL BIOLOGY | SUCROSE | SHADE AVOIDANCE | Arabidopsis - genetics | Arabidopsis Proteins - metabolism | Arabidopsis Proteins - genetics | Arabidopsis - drug effects | Basic Helix-Loop-Helix Transcription Factors - genetics | Basic Helix-Loop-Helix Transcription Factors - metabolism | Indoleacetic Acids - metabolism | Glucose - pharmacology | Arabidopsis - metabolism | Arabidopsis thaliana | Plant proteins | Carbohydrates | Auxin | Phytochemistry | Physiological aspects | Research | Health aspects | Index Medicus | Biological Sciences | Naturvetenskap | Natural Sciences | Biologiska vetenskaper
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11. Full Text Adiponectin promotes adipocyte differentiation, insulin sensitivity, and lipid accumulation
by Fu, Yuchang and Luo, Nanlan and Klein, Richard L and Timothy Garvey, W
Journal of Lipid Research, ISSN 0022-2275, 2005, Volume 46, Issue 7, pp. 1369 - 1379
Adiponectin is secreted from adipocytes, and low circulating levels have been epidemiologically associated with obesity, insulin resistance, type 2 diabetes,... 
Adipocytokine | Glucose | Lipid metabolism | Obesity/diabetes | Gene expression | adipocytokine | BINDING-PROTEIN-ALPHA | 3T3-L1 ADIPOCYTES | glucose | PIMA INDIAN POPULATION | DIFFERENT MECHANISMS | BIOCHEMISTRY & MOLECULAR BIOLOGY | lipid metabolism | FATTY-ACID OXIDATION | ADIPOSE CONVERSION | ENERGY HOMEOSTASIS | obesity/diabetes | GENE-EXPRESSION | PPAR-GAMMA | HORMONE ADIPONECTIN | gene expression | Fatty Acid-Binding Proteins | Adipocytes - cytology | Intercellular Signaling Peptides and Proteins - biosynthesis | Adipocytes - drug effects | Adiponectin | Intercellular Signaling Peptides and Proteins - physiology | Muscle Proteins - biosynthesis | CCAAT-Enhancer-Binding Protein-alpha - biosynthesis | Insulin Resistance - physiology | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | CCAAT-Enhancer-Binding Proteins - biosynthesis | Trans-Activators - biosynthesis | Insulin - pharmacology | Glucose Transporter Type 4 | Carrier Proteins - biosynthesis | Lipid Metabolism | Transcription Factors - biosynthesis | 3T3-L1 Cells | PPAR gamma - biosynthesis | Monosaccharide Transport Proteins - biosynthesis | Animals | Cell Differentiation - drug effects | Mice | Sterol Regulatory Element Binding Protein 1 | DNA-Binding Proteins - biosynthesis | Index Medicus
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12. Full Text Transcriptomic and genomic analysis of human hepatocellular carcinomas and hepatoblastomas
by Luo, Jian‐Hua and Ren, Baoguo and Keryanov, Sergei and Tseng, George C and Rao, Uma N. M and Monga, Satdarshan P and Strom, Steven and Demetris, Anthony J and Nalesnik, Michael and Yu, Yan P and Ranganathan, Sarangarajan and Michalopoulos, George K
Hepatology, ISSN 0270-9139, 10/2006, Volume 44, Issue 4, pp. 1012 - 1024
This study analyzed gene expression patterns and global genomic alterations in hepatocellular carcinomas (HCC), hepatoblastomas (HPBL), tissue adjacent to HCC... 
OVEREXPRESSION | GLYPICAN-3 | CARCINOGENESIS | PEG10 | GROWTH | GENE-EXPRESSION | HAKATA ANTIGEN | IMPRINTED GENE | TUMOR | GASTROENTEROLOGY & HEPATOLOGY | ENDOGENOUS INHIBITOR | Fibronectins - biosynthesis | Hepatoblastoma - genetics | Humans | Gene Expression Regulation, Neoplastic | Gene Expression Profiling | Lectins - biosynthesis | Transforming Growth Factor beta - biosynthesis | Glypicans | Sialoglycoproteins - biosynthesis | Carcinoma, Hepatocellular - genetics | Hepatoblastoma - metabolism | Fibrosis - genetics | Transforming Growth Factor beta1 | Insulin-Like Growth Factor II | Liver Neoplasms - genetics | Carrier Proteins - biosynthesis | Intercellular Signaling Peptides and Proteins | Osteopontin | Glycoproteins - biosynthesis | Membrane Proteins - biosynthesis | Proteins - metabolism | Repressor Proteins - biosynthesis | Liver Neoplasms - metabolism | Adaptor Proteins, Signal Transducing - biosynthesis | Genome | Carcinoma, Hepatocellular - metabolism | Cluster Analysis | Heparan Sulfate Proteoglycans - biosynthesis | Index Medicus | SAM, Significance Analysis for Microarrays | NL, normal liver | DE, differentially expressed | HCC: hepatocellular carcinoma | FDR, false discovery rate | PAM, Prediction Analysis for Microarrays | HPBL: hepatoblastoma of childhood | AT, tissue adjacent to tumor
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13. Full Text The Arabidopsis YUCCA1 Flavin Monooxygenase Functions in the Indole-3-Pyruvic Acid Branch of Auxin Biosynthesis
by Anna N. Stepanova and Jeonga Yun and Linda M. Robles and Ondrej Novak and Wenrong He and Hongwei Guo and Karin Ljung and Jose M. Alonso and Sveriges lantbruksuniversitet
The Plant Cell, ISSN 1040-4