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1. Full Text Modification and validation of the triglyceride-to-HDL cholesterol ratio as a surrogate of insulin sensitivity in white juveniles and adults without diabetes mellitus: The single point insulin sensitivity estimator (SPISE)
by Paulmichl, Katharina and Hatunic, Mensud and Højlund, Kurt and Jotic, Aleksandra and Krebs, Michael and Mitrakou, Asimina and Porcellati, Francesca and Tura, Andrea and Bergsten, Peter and Forslund, Anders and Manell, Hannes and Widhalm, Kurt and Weghuber, Daniel and Anderwald, Christian-Heinz and RISC Investigators and Beta-JUDO Investigators and the Beta-JUDO Investigators and on behalf of the RISC Investigators and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Institutionen för kvinnors och barns hälsa and Pediatrik and Uppsala universitet and Institutionen för medicinsk cellbiologi
Clinical Chemistry, ISSN 0009-9147, 09/2016, Volume 62, Issue 9, pp. 1211 - 1219
BACKGROUND: The triglyceride-to-HDL cholesterol (TG/HDL-C) ratio was introduced as a tool to estimate insulin resistance; because circulating lipid... 
INTIMA-MEDIA THICKNESS | CHECK INDEX | CARDIOVASCULAR-DISEASE RISK | OBESE CHILDREN | GLUCOSE-TOLERANCE TEST | NUCLEAR-MAGNETIC-RESONANCE | CAROTID-ARTERY | RESISTANCE ATHEROSCLEROSIS | MEDICAL LABORATORY TECHNOLOGY | HIGH-DENSITY-LIPOPROTEIN | BETA-CELL FUNCTION | Diabetes Mellitus - blood | Glucose Tolerance Test | Humans | Middle Aged | Male | Insulin - blood | Obesity - blood | Adolescent | Triglycerides - blood | Cholesterol, HDL - blood | Adult | Female | Cohort Studies | Triglycerides | Glucose | Obesity in adolescence | Fatty acids | Insulin | Dextrose | Blood | Analysis and chemistry | Blood cholesterol | Analysis | Insulin resistance | Adults | Cardiovascular diseases | Studies | Obesity | Teenagers | Rodents | Index Medicus | Clinical Medicine | Medical and Health Sciences | Endokrinologi och diabetes | Klinisk medicin | Medicin och hälsovetenskap | Endocrinology and Diabetes
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2. Full Text Physical activity and insulin sensitivity the RISC study
by Balkau, Beverley and Mhamdi, Leila and Oppert, Jean-Michel and Nolan, John and Golay, Alain and Porcellati, Francesca and Laakso, Markku and Ferrannini, Ele and EGIR-RISC Study Grp and EGIR-RISC Study Group and on behalf of the EGIR-RISC Study Group
Diabetes, ISSN 0012-1797, 10/2008, Volume 57, Issue 10, pp. 2613 - 2618
OBJECTIVE-Physical activity is a modifiable risk factor for type 2 diabetes, partly through its action on insulin sensitivity. We report the relation between... 
OBESITY | WALKING | METABOLIC RISK | GLUCOSE | ENDOCRINOLOGY & METABOLISM | CARDIOVASCULAR-DISEASE | RESISTANCE | MUSCLE | INTENSITY | ACCELEROMETER | EXERCISE | Body Mass Index | Motor Activity - physiology | Life Style | Cross-Sectional Studies | Insulin Resistance - physiology | Humans | Middle Aged | Adult | Female | Male | Glucose Clamp Technique | Blood Glucose - metabolism | Physiological aspects | Insulin resistance | Development and progression | Exercise | Research | Index Medicus | Abridged Index Medicus | Metabolism
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3. Full Text Surrogate measures of insulin sensitivity vs the hyperinsulinaemic–euglycaemic clamp: a meta-analysis
by Otten, Julia and Ahrén, Bo and Olsson, Tommy and Medicinska fakulteten and Institutionen för folkhälsa och klinisk medicin and Umeå universitet and Medicin
Diabetologia, ISSN 0012-186X, 9/2014, Volume 57, Issue 9, pp. 1781 - 1788
We aimed to identify which surrogate index of insulin sensitivity has the strongest correlation with the reference measurement, the... 
Medicine & Public Health | Human Physiology | Insulin sensitivity | Metabolic Diseases | Internal Medicine | Glucose | Surrogate markers | Insulin | Hyperinsulinaemic–euglycaemic clamp | Meta-analysis | Hyperinsulinaemic-euglycaemic clamp | DEPENDENT DIABETES-MELLITUS | SIMPLE INDEXES | HOMEOSTASIS MODEL ASSESSMENT | PUBLICATION BIAS | GLUCOSE-TOLERANCE TEST | ENDOCRINOLOGY & METABOLISM | RESISTANCE | ORAL GLUCOSE | SECRETION | POSTMENOPAUSAL WOMEN | OBESE | Glucose Clamp Technique | Blood Glucose - analysis | Insulin Resistance - physiology | Humans | Measurement | Glucose metabolism | Analysis | Glucose tolerance tests | Dextrose | Index Medicus | Clinical Medicine | Medical and Health Sciences | Endokrinologi och diabetes | Medicin och hälsovetenskap | Klinisk medicin | Endocrinology and Diabetes
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4. Full Text The dynamic insulin sensitivity and secretion test—a novel measure of insulin sensitivity
by McAuley, Kirsten A and Berkeley, Juliet E and Docherty, Paul D and Lotz, Thomas F and Te Morenga, Lisa A and Shaw, Geoff M and Williams, Sheila M and Chase, J. Geoffrey and Mann, Jim I
Metabolism, ISSN 0026-0495, 2011, Volume 60, Issue 12, pp. 1748 - 1756
Abstract The objective was to validate the methodology for the dynamic insulin sensitivity and secretion test (DISST) and to demonstrate its potential in... 
Endocrinology & Metabolism | MINIMAL MODEL | GLUCOSE | ENDOCRINOLOGY & METABOLISM | RESISTANCE | 2-COMPARTMENT | HUMANS | MUSCLE | BETA-CELL FUNCTION | INDEXES | Diabetes Mellitus - blood | Humans | Middle Aged | Insulin Resistance | Male | Insulin - blood | Glucose - administration & dosage | Insulin - metabolism | Adult | Female | Aged | Diabetes Mellitus - diagnosis | Glucose Clamp Technique | Blood Glucose - metabolism | Insulin Secretion | Measurement | Medical testing products | Analysis | Glucose | Glucose tolerance tests | Insulin | Dextrose | Index Medicus
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5. Full Text Effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile and inflammation markers in metabolic syndrome – a randomized study (SYSDIET)
by Uusitupa, M and Hermansen, K and Savolainen, M. J and Schwab, U and Kolehmainen, M and Brader, L and Mortensen, L. S and Cloetens, L and Johansson‐Persson, A and Önning, G and Landin‐Olsson, M and Herzig, K.‐H and Hukkanen, J and Rosqvist, F and Iggman, D and Paananen, J and Pulkki, K. J and Siloaho, M and Dragsted, L and Barri, T and Overvad, K and Bach Knudsen, K. E and Hedemann, M. S and Arner, P and Dahlman, I and Borge, G. I. A and Baardseth, P and Ulven, S. M and Gunnarsdottir, I and Jónsdóttir, S and Thorsdottir, I and Orešič, M and Poutanen, K. S and Risérus, U and Åkesson, B and Örebro universitet and Institutionen för medicinska vetenskaper
Journal of Internal Medicine, ISSN 0954-6820, 07/2013, Volume 274, Issue 1, pp. 52 - 66
Background Different healthy food patterns may modify cardiometabolic risk. We investigated the effects of an isocaloric healthy Nordic diet on insulin... 
metabolic syndrome | cardiovascular risk | intervention | inflammation | ordic diet | Intervention | Nordic diet | Inflammation | Metabolic syndrome | Cardiovascular risk | CONTROLLED-TRIAL | ENDOTHELIAL DYSFUNCTION | INTERLEUKIN-1 RECEPTOR ANTAGONIST | MEDITERRANEAN DIET | APOLIPOPROTEIN-B | BLOOD-PRESSURE | MEDICINE, GENERAL & INTERNAL | DENSITY-LIPOPROTEIN CHOLESTEROL | PLASMA-CONCENTRATIONS | CARDIOVASCULAR-DISEASE | HDL-CHOLESTEROL | Blood Pressure | Humans | Middle Aged | Male | Metabolic Syndrome - metabolism | Apolipoproteins B - blood | Iceland | Inflammation - blood | Apolipoproteins A - blood | Interleukin 1 Receptor Antagonist Protein - blood | Metabolic Syndrome - blood | Sweden | Lipids - blood | Metabolic Syndrome - physiopathology | Cholesterol, LDL - blood | Diet - methods | Glucose Tolerance Test | Insulin Resistance | Fatty Acids - analysis | Treatment Outcome | Biomarkers - blood | Energy Intake | Finland | Cholesterol, HDL - blood | Denmark | Blood Glucose - metabolism | Medical research | Blood cholesterol | Analysis | Low density lipoproteins | Medicine, Experimental | Lipids | Insulin | Index Medicus | Original | Hälsovetenskaper | Näringslära | Medical and Health Sciences | Medicin och hälsovetenskap | Nutrition and Dietetics | Health Sciences
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6. Full Text High-dose resveratrol supplementation in obese men an investigator- initiated, randomized, placebo-controlled clinical trial of substrate metabolism, insulin sensitivity, and body composition
by Poulsen, Morten M and Vestergaard, Poul F and Clasen, Berthil F and Radko, Yulia and Christensen, Lars P and Stødkilde-Jørgensen, Hans and Møller, Niels and Jessen, Niels and Pedersen, Steen B and Jørgensen, Jens Otto L
Diabetes, ISSN 0012-1797, 04/2013, Volume 62, Issue 4, pp. 1186 - 1195
Obesity, diabetes, hypertension, and hyperlipidemia constitute risk factors for morbidity and premature mortality. Based on animal and in vitro studies,... 
LIFE-SPAN | HUMAN ADIPOSE-TISSUE | GROWTH-HORMONE | FATTY LIVER-DISEASE | IN-VIVO | CALORIC RESTRICTION | ENDOCRINOLOGY & METABOLISM | HUMANS | HEALTHY-VOLUNTEERS | CANCER CHEMOPREVENTIVE AGENT | SIRT1 EXPRESSION | Stilbenes - administration & dosage | Double-Blind Method | Obesity - drug therapy | Stilbenes - therapeutic use | Humans | Middle Aged | Gene Expression Regulation | Male | Dose-Response Relationship, Drug | Young Adult | Antioxidants - therapeutic use | Pilot Projects | Body Composition - drug effects | Insulin Resistance - physiology | Adolescent | Antioxidants - administration & dosage | Adult | Aged | Dietary Supplements | Energy Metabolism - drug effects | Glucose metabolism | Obesity | Complications and side effects | Care and treatment | Resveratrol | Physiological aspects | Genetic aspects | Dosage and administration | Research | Index Medicus | Abridged Index Medicus | Original Research
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7. Full Text Effects of dietary fat modification on insulin sensitivity and on other risk factors of the metabolic syndrome-LIPGENE: a European randomized dietary intervention study
by Tierney, A.C and McMonagle, J and Shaw, D.I and Gulseth, H.L and Helal, O and Saris, W.H and Paniagua, J.A and Golabek Leszczynska, I and Defoort, C and Williams, C.M and Karsltrom, B and Vessby, B and Dembinska Kiec, A and Lopez Miranda, J and Blaak, E.E and von, C.A and Gibney, M.J and Lovegrove, J.A and Roche, H.M and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Uppsala universitet and Institutionen för folkhälso- och vårdvetenskap and Klinisk nutrition och metabolism
International Journal of Obesity, ISSN 0307-0565, 01/2011, Volume 35, Issue 6, pp. 800 - 809
Background: Excessive energy intake and obesity lead to the metabolic syndrome (MetS). Dietary saturated fatty acids (SFAs) may be particularly detrimental on... 
insulin sensitivity | LC n-3 PUFA | MetS | LIPGENE | dietary fat | SFA | LIFE-STYLE INTERVENTION | ACIDS | IMPAIRED GLUCOSE-TOLERANCE | SUPPLEMENTATION | LIPOPROTEIN METABOLISM | WOMEN | NUTRITION & DIETETICS | MEN | ENDOCRINOLOGY & METABOLISM | CARDIOVASCULAR-DISEASE | SATURATED-FAT | TYPE-2 DIABETES-MELLITUS | Fatty Acids - adverse effects | Obesity - diet therapy | Dietary Fats - metabolism | Diet, Fat-Restricted - methods | Europe | Humans | Middle Aged | Risk Factors | Male | Feeding Behavior - physiology | Obesity - metabolism | Energy Intake - physiology | Insulin Resistance - physiology | Dietary Fats - administration & dosage | Fatty Acids - administration & dosage | Female | Metabolic Syndrome - prevention & control | Glycerol - blood | Fatty Acids, Unsaturated - administration & dosage | Usage | Physiological aspects | Dietary fat | Research | Metabolic syndrome X | Glucose tolerance tests | Enzyme-linked immunosorbent assay | Risk factors | Index Medicus | Näringslära | Medical and Health Sciences | Medicin och hälsovetenskap | MEDICIN | Hälsovetenskaper | MEDICINE | Nutrition and Dietetics | Health Sciences
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8. Full Text Limitations in the use of indices using glucose and insulin levels to predict insulin sensitivity: Impact of race and gender and superiority of the indices derived from oral glucose tolerance test in African Americans
by Pisprasert, Veeradej and Ingram, Katherine H and Lopez-Davila, Maria F and Munoz, A. Julian and Garvey, W. Timothy
Diabetes Care, ISSN 0149-5992, 04/2013, Volume 36, Issue 4, pp. 845 - 853
OBJECTIVE-To examine the utility of commonly used insulin sensitivity indices in nondiabetic European Americans (EAs) and African Americans (AAs). RESEARCH... 
CHECK INDEX | CLEARANCE | HOMEOSTASIS MODEL ASSESSMENT | NON-HISPANIC WHITES | CLAMP TECHNIQUE | IN-VIVO | ENDOCRINOLOGY & METABOLISM | RESISTANCE | BLACK | SECRETION | BETA-CELL FUNCTION | Immunoassay | Glucose Tolerance Test | Humans | Middle Aged | African Americans | European Continental Ancestry Group | Male | Insulin - blood | Absorptiometry, Photon | Insulin Resistance - physiology | Adult | Female | Glucose Clamp Technique | Blood Glucose - metabolism | Drugs | Physiological aspects | Dosage and administration | Research | Health aspects | Insulin | European Americans | Studies | Hyperglycemia | Diet | Insulin resistance | Diabetes | Glucose | Index Medicus | Original Research
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9. Full Text Insulin sensitivity and carotid intima-media thickness: relationship between insulin sensitivity and cardiovascular risk study
by Kozakova, M and Natali, A and Dekker, J.M and Beck-Nielsen, H and Laakso, M and Nilsson, P and Balkau, B and Ferrannini, E and RISC Investigators and Internmedicin - epidemiologi and EpiHealth: Epidemiology for Health and Internal Medicine - Epidemiology and Lund University and Lunds universitet
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 2013, Volume 33, Issue 6, pp. 1409 - 1417
Objective-Despite a wealth of experimental data in animal models, the independent association of insulin resistance with early carotid atherosclerosis in man... 
Adipokine | Glucose | Fatty acids | Atherosclerosis | Carotid intima-media thickness | atherosclerosis | LEPTIN | glucose | FASTING PLASMA-GLUCOSE | METABOLIC SYNDROME | fatty acids | adipokine | media thickness | carotid intima | ENDOTHELIAL FUNCTION | ADIPONECTIN | FREE FATTY-ACIDS | RESISTANCE | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | GENDER-DIFFERENCES | PROGRESSION | Age Distribution | Prognosis | Humans | Middle Aged | Carotid Artery Diseases - physiopathology | Male | Incidence | Carotid Artery Diseases - diagnostic imaging | Sensitivity and Specificity | Cardiovascular Diseases - epidemiology | Adult | Female | Retrospective Studies | Fatty Acids - metabolism | Cardiovascular Diseases - diagnosis | Glucose Tolerance Test | Blood Glucose - analysis | Cardiovascular Diseases - metabolism | Risk Assessment | Carotid Intima-Media Thickness | Insulin Resistance | Carotid Artery Diseases - epidemiology | Adipokines - metabolism | Cholesterol, LDL - metabolism | Sex Distribution | Glucose Clamp Technique | Cohort Studies | Index Medicus | Medical and Health Sciences | Medicin och hälsovetenskap | Klinisk medicin | Kardiologi | Clinical Medicine | Cardiac and Cardiovascular Systems | acids | fatty
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10. Full Text Dual peroxisome proliferator- activated receptor α/δ agonist gft505 improves hepatic and peripheral insulin sensitivity in abdominally obese subjects
by Cariou, Bertrand and Hanf, Remy and Lambert-Porcheron, Stephanie and Zair, Yassine and Sauvinet, Valerie and Noel, Benoit and Flet, Laurent and Vidal, Hubert and Staels, Bart and Laville, Martine
Diabetes Care, ISSN 0149-5992, 10/2013, Volume 36, Issue 10, pp. 2923 - 2930
OBJECTIVEThe development of new insulin sensitizers is an unmet need for the treatment of type 2 diabetes. We investigated the effect of GFT505, a dual... 
SKELETAL-MUSCLE | LIPID-METABOLISM | DELTA AGONIST | GLUCOSE-METABOLISM | ENDOCRINOLOGY & METABOLISM | NONALCOHOLIC STEATOHEPATITIS | PPAR-GAMMA AGONISTS | ROSIGLITAZONE | ACID OXIDATION | TYPE-2 DIABETES-MELLITUS | LIVER FAT | Liver - enzymology | Obesity - drug therapy | Humans | Middle Aged | Propionates - therapeutic use | Male | Muscle, Skeletal - metabolism | Lipoproteins - blood | Obesity - blood | Obesity - metabolism | Cross-Over Studies | Liver - drug effects | Insulin Resistance - physiology | Propionates - adverse effects | Muscle, Skeletal - drug effects | PPAR delta - agonists | Chalcones - therapeutic use | Adult | Female | PPAR alpha - agonists | Chalcones - adverse effects | Index Medicus | Original Research
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11. Full Text Very Low-Calorie Diet Mimics the Early Beneficial Effect of Roux-en-Y Gastric Bypass on Insulin Sensitivity and beta-Cell Function in Type 2 Diabetic Patients
by Jackness, C and Karmally, W and Febres, G and Conwell, IM and Ahmed, L and Bessler, M and McMahon, DJ and Korner, J
DIABETES, ISSN 0012-1797, 09/2013, Volume 62, Issue 9, pp. 3027 - 3032
Marked improvement in glycemic control occurs in patients with type 2 diabetes mellitus shortly after Roux-en-Y gastric bypass surgery (RYGB) and before there... 
CLEARANCE | MINIMAL MODEL | OBESE-PATIENTS | ENDOCRINOLOGY & METABOLISM | WEIGHT-LOSS | BARIATRIC SURGERY | MELLITUS | RESTRICTION | GLUCOSE-TOLERANCE | HYPOCALORIC DIET | REMISSION | Insulin-Secreting Cells - physiology | Gastric Bypass | Caloric Restriction | Humans | Middle Aged | Diabetes Mellitus, Type 2 - diet therapy | Male | Young Adult | Insulin Resistance - physiology | Adolescent | Adult | Female | Aged | Diabetes Mellitus, Type 2 - surgery | Index Medicus | Abridged Index Medicus | Original Research
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