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Diabetes/Metabolism Research and Reviews, ISSN 1520-7552, 02/2014, Volume 30, Issue 2, pp. 104 - 119
Summary Insulin remains the most effective and consistent means of controlling blood glucose levels in diabetes. Since 1946, neutral protamine Hagedorn (NPH)... 
basal insulin | type 1 diabetes | type 2 diabetes | basal insulin analogues | long‐acting insulin | Basal insulin analogues | Type 2 diabetes | Long-acting insulin | Basal insulin | Type 1 diabetes | GLARGINE U300 FORMULATION | TIME-ACTION PROFILE | long-acting insulin | PRE/SELF-MIXED INSULIN | TREAT-TO-TARGET | IMPROVES GLYCEMIC CONTROL | ENDOCRINOLOGY & METABOLISM | HUMAN NPH INSULIN | STEADY-STATE CONDITIONS | SUPERIOR FPG CONTROL | QUALITY-OF-LIFE | Hypoglycemic Agents - therapeutic use | Recombinant Proteins - therapeutic use | Drugs, Investigational - adverse effects | Insulin, Regular, Human - genetics | Humans | Drugs, Investigational - therapeutic use | Recombinant Proteins - chemistry | Insulin, Long-Acting - chemistry | Clinical Trials as Topic | Hypoglycemic Agents - chemistry | Recombinant Proteins - adverse effects | Insulin, Regular, Human - analogs & derivatives | Insulin, Regular, Human - therapeutic use | Diabetes Mellitus, Type 1 - drug therapy | Insulin, Long-Acting - genetics | Drugs, Investigational - chemistry | Insulin, Long-Acting - adverse effects | Animals | Insulin, Long-Acting - therapeutic use | Diabetes Mellitus, Type 2 - drug therapy | Insulin, Regular, Human - chemistry | Hypoglycemic Agents - adverse effects | Chemistry, Pharmaceutical - trends | Glucose metabolism | Blood sugar | Insulin | Polyols | Diabetes therapy
Journal Article
Diabetologia: clinical and experimental diabetes and metabolism, ISSN 0012-186X, 01/2012, Volume 55, Issue 1, pp. 51 - 62
textabstractAims/hypothesis Several publications suggest an association between certain types of insulin and cancer, but with conflicting results. We... 
Insulin glargine | Medicine & Public Health | Human Physiology | Metabolic Diseases | Insulin analogues | Internal Medicine | Breast cancer | Insulin | Cancer | MORTALITY | METAANALYSIS | DIABETES-MELLITUS | BREAST-CANCER | THERAPY | RESEARCH NETWORK | COLORECTAL-CANCER | ENDOCRINOLOGY & METABOLISM | MALIGNANCIES | COHORT | EXPOSURE | Follow-Up Studies | Humans | Middle Aged | Netherlands - epidemiology | Patient Admission | Male | Risk | Incidence | Dose-Response Relationship, Drug | Neoplasms - complications | Neoplasms - chemically induced | Hypoglycemic Agents - administration & dosage | Community Pharmacy Services | Female | Insulin - analogs & derivatives | Medical Record Linkage | Diabetes Mellitus, Type 2 - complications | Breast Neoplasms - epidemiology | Hypoglycemic Agents - therapeutic use | Proportional Hazards Models | Insulin, Regular, Human - adverse effects | Insulin - administration & dosage | Insulin, Regular, Human - therapeutic use | Insulin, Regular, Human - administration & dosage | Breast Neoplasms - complications | Insulin, Long-Acting - adverse effects | Insulin, Long-Acting - administration & dosage | Insulin Glargine | Insulin, Long-Acting - therapeutic use | Breast Neoplasms - chemically induced | Diabetes Mellitus, Type 2 - drug therapy | Electronic Health Records | Hypoglycemic Agents - adverse effects | Insulin - adverse effects | Insulin - therapeutic use | Neoplasms - epidemiology | Cohort Studies | Heterocyclic compounds | Oncology, Experimental | Research | Risk factors | Public health | Medical informatics
Journal Article
Diabetes, Obesity and Metabolism, ISSN 1462-8902, 07/2018, Volume 20, Issue 7, pp. 1563 - 1577
Aims To conduct a review in order to assess the safety of intranasal human insulin in clinical studies as well as the temporal stability of nasal insulin... 
insulin resistance | obesity therapy | database research | HUMAN BRAIN | ALZHEIMERS-DISEASE | RANDOMIZED CONTROLLED-TRIAL | MILD COGNITIVE IMPAIRMENT | NASAL INSULIN | ENDOCRINOLOGY & METABOLISM | DOUBLE-BLIND | CENTRAL-NERVOUS-SYSTEM | PILOT-CLINICAL-TRIAL | CEREBRAL-BLOOD-FLOW | ADMINISTERED INSULIN | Recombinant Proteins - therapeutic use | Humans | Recombinant Proteins - adverse effects | Hypoglycemia - prevention & control | Hypoglycemic Agents - administration & dosage | Drug Compounding | Protein Stability | Hypoglycemia - chemically induced | Hypoglycemic Agents - therapeutic use | Hyperglycemia - prevention & control | Drug Stability | Insulin, Regular, Human - adverse effects | Recombinant Proteins - chemistry | Hypoglycemic Agents - chemistry | Administration, Intranasal | Insulin, Regular, Human - therapeutic use | Recombinant Proteins - administration & dosage | Diabetes Mellitus, Type 1 - drug therapy | Insulin, Regular, Human - administration & dosage | Diabetes Mellitus, Type 2 - blood | Diabetes Mellitus, Type 1 - blood | Aerosols | Diabetes Mellitus, Type 2 - drug therapy | Insulin, Regular, Human - chemistry | Hypoglycemic Agents - adverse effects | Medical research | Safety and security measures | Online searching | Medicine, Experimental | Insulin resistance | Internet/Web search services | Database searching | Insulin | Side effects | Safety | Hypoglycemia | Irritation
Journal Article
Diabetes, Obesity and Metabolism, ISSN 1462-8902, 02/2016, Volume 18, Issue 2, pp. 159 - 168
Aims To compare the immunogenicity profiles and the potential effects on clinical outcomes of LY2963016 insulin glargine (LY IGlar) and Lantus® insulin... 
insulin antibody | biosimilar insulin | insulin glargine | LY2963016 insulin glargine | Insulin glargine | Insulin antibody | Biosimilar insulin | CONTROLLED-TRIAL | RESPONSES | EFFICACY | SAFETY | ENDOCRINOLOGY & METABOLISM | NAIVE | Immunogenetic Phenomena - drug effects | Recombinant Proteins - therapeutic use | Insulin, Regular, Human - genetics | Humans | Diabetes Mellitus, Type 1 - complications | Insulin Antibodies - analysis | Recombinant Proteins - adverse effects | Incidence | Hypoglycemia - prevention & control | Diabetes Mellitus, Type 2 - immunology | Diabetes Mellitus, Type 1 - immunology | Drug Hypersensitivity - complications | Hypoglycemia - chemically induced | Diabetes Mellitus, Type 2 - complications | Drug Hypersensitivity - etiology | Hypoglycemic Agents - therapeutic use | Hyperglycemia - prevention & control | Biosimilar Pharmaceuticals - therapeutic use | Insulin Glargine - adverse effects | Double-Blind Method | Insulin Glargine - therapeutic use | Asymptomatic Diseases - epidemiology | Insulin, Regular, Human - adverse effects | Insulin, Regular, Human - analogs & derivatives | Insulin, Regular, Human - therapeutic use | Biosimilar Pharmaceuticals - adverse effects | Diabetes Mellitus, Type 1 - drug therapy | Cross Reactions | Insulin Glargine - analogs & derivatives | Diabetes Mellitus, Type 2 - blood | Drug Hypersensitivity - epidemiology | Drug Hypersensitivity - immunology | Diabetes Mellitus, Type 1 - blood | Diabetes Mellitus, Type 2 - drug therapy | Hypoglycemic Agents - adverse effects | Type 2 diabetes | Care and treatment | Comparative analysis | Insulin | Original
Journal Article
Diabetes, ISSN 0012-1797, 02/2018, Volume 67, Issue 2, pp. 299 - 308
Insulin has a narrow therapeutic index, reflected in a small margin between a dose that achieves good glycemic control and one that causes hypoglycemia. Once... 
SYSTEM | LECTIN | MANNOSE RECEPTOR | ENDOCRINOLOGY & METABOLISM | HYPOGLYCEMIA | PATCHES | DELIVERY | Mannose-Binding Lectins - metabolism | Recombinant Proteins - therapeutic use | Cricetulus | Humans | Diabetes Mellitus, Type 1 - metabolism | Half-Life | Male | Metabolic Clearance Rate | Recombinant Proteins - pharmacokinetics | Recombinant Proteins - adverse effects | Lectins, C-Type - genetics | Dose-Response Relationship, Drug | Hypoglycemia - prevention & control | Lectins, C-Type - metabolism | Mannose-Binding Lectins - agonists | Hypoglycemic Agents - administration & dosage | Lectins, C-Type - agonists | Receptor, Insulin - genetics | Swine | Drug Design | Swine, Miniature | Drug Evaluation, Preclinical | Hypoglycemia - chemically induced | CHO Cells | Binding, Competitive | Hypoglycemic Agents - therapeutic use | Recombinant Proteins - metabolism | Hyperglycemia - prevention & control | Hypoglycemic Agents - pharmacokinetics | Receptors, Cell Surface - agonists | Insulin, Regular, Human - adverse effects | Receptors, Cell Surface - metabolism | Insulin, Regular, Human - analogs & derivatives | Insulin, Regular, Human - therapeutic use | Insulin, Regular, Human - pharmacokinetics | Diabetes Mellitus, Type 1 - drug therapy | Animals | Mannose-Binding Lectins - genetics | Diabetes Mellitus, Type 1 - blood | Dogs | Animals, Inbred Strains | Ligands | Receptor, Insulin - metabolism | Receptor, Insulin - agonists | Hypoglycemic Agents - adverse effects | Receptors, Cell Surface - genetics | Control | Hypoglycemia | Blood sugar | Insulin | Health aspects | Risk factors
Journal Article
Diabetes, Obesity and Metabolism, ISSN 1462-8902, 05/2017, Volume 19, Issue 5, pp. 615 - 621
Aims Hypoglycaemia is the major limiting factor in achieving optimal glycaemic control in people with type 1 diabetes (T1DM), especially intensively treated... 
hypoglycaemia | naltrexone | counter‐regulatory hormonal response | counter-regulatory hormonal response | PHARMACOKINETICS | INSULIN-INDUCED HYPOGLYCEMIA | COUNTERREGULATION | DELTA | NALOXONE | ENDOCRINOLOGY & METABOLISM | AWARENESS | AUTONOMIC FAILURE | Glycated Hemoglobin A - analysis | Naltrexone - therapeutic use | Hypoglycemia - epidemiology | Nausea - chemically induced | Humans | Epinephrine - secretion | Male | Risk | Hypoglycemia - prevention & control | Hypoglycemic Agents - blood | Adult | Female | Hypoglycemia - chemically induced | Sensory System Agents - therapeutic use | Hypoglycemic Agents - therapeutic use | Sensory System Agents - adverse effects | Hypoglycemic Agents - pharmacokinetics | Blood Glucose - analysis | Double-Blind Method | Insulin, Regular, Human - adverse effects | Insulin, Regular, Human - therapeutic use | Connecticut - epidemiology | Insulin, Regular, Human - pharmacokinetics | Diabetes Mellitus, Type 1 - drug therapy | Cross-Over Studies | Delayed-Action Preparations - adverse effects | Diabetes Mellitus, Type 1 - blood | Epinephrine - blood | Delayed-Action Preparations - therapeutic use | Glucose Clamp Technique | Drug Monitoring | Naltrexone - adverse effects | Hypoglycemic Agents - adverse effects | Insulin, Regular, Human - blood | Glucose | Diabetes | Narcotics | Hypoglycemia
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