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International Journal of Cancer, ISSN 0020-7136, 03/2014, Volume 134, Issue 6, pp. 1436 - 1444
Journal Article
Clinical Epigenetics, ISSN 1868-7075, 01/2016, Volume 8, Issue 1, p. 11
Background: Insulin-like growth factors 1 and 2 (IGF1 and IGF2) and their binding proteins (IGFBPs) are expressed in the placenta and known to regulate fetal... 
DNA methylation | Placental expression | Small fetus | Large fetus | Insulin growth factor | HUMAN PLACENTA | FACTOR-II | 5-METHYLCYTOSINE | GENE-EXPRESSION PATTERNS | FETUS | IMPRINTED GENES | HORMONE | MESSENGER-RNA | ONCOLOGY | GENETICS & HEREDITY | BINDING-PROTEIN 3 | IGF-II | Insulin-Like Growth Factor Binding Protein 3 - genetics | Insulin-Like Growth Factor Binding Proteins - physiology | Insulin-Like Growth Factor II - physiology | Humans | Fetal Growth Retardation - genetics | Insulin-Like Growth Factor I - genetics | Promoter Regions, Genetic - genetics | Case-Control Studies | DNA Methylation | Insulin-Like Growth Factor II - genetics | Fetal Growth Retardation - etiology | Adult | Female | Insulin-Like Growth Factor Binding Protein 4 - physiology | Insulin-Like Growth Factor Binding Protein 2 - physiology | Infant, Newborn | Insulin-Like Growth Factor Binding Protein 3 - physiology | Insulin-Like Growth Factor Binding Proteins - genetics | Insulin-Like Growth Factor Binding Protein 1 - physiology | Insulin-Like Growth Factor Binding Protein 4 - genetics | Insulin-Like Growth Factor Binding Protein 2 - genetics | Placenta - metabolism | Pregnancy | Insulin-Like Growth Factor I - physiology | Infant, Small for Gestational Age | Insulin-Like Growth Factor Binding Protein 1 - genetics | Infants (Newborn) | Epigenetic inheritance | RNA | Growth | Genes | Gene expression | Purines | Pyrimidines | Fetus | Binding proteins | Methylation | Protein binding
Journal Article
JOURNAL OF CLINICAL INVESTIGATION, ISSN 0021-9738, 07/2008, Volume 118, Issue 7, pp. 2609 - 2619
Although some cancers are initially sensitive to EGFR tyrosine kinase inhibitors (TKIs), resistance invariably develops. We investigated mechanisms of acquired... 
BREAST-CANCER | GENE-MUTATIONS | MEDICINE, RESEARCH & EXPERIMENTAL | LUNG-CANCER | GROWTH-FACTOR-RECEPTOR | T790M MUTATIONS | IN-VIVO | TUMOR-CELLS | ANTITUMOR-ACTIVITY | GEFITINIB SENSITIVITY | ERLOTINIB | Insulin-Like Growth Factor Binding Protein 3 - genetics | Receptor, IGF Type 1 - metabolism | Insulin-Like Growth Factor I - pharmacology | Receptor, ErbB-3 - metabolism | Receptor, IGF Type 1 - antagonists & inhibitors | Gene Expression - drug effects | Carcinoma, Squamous Cell - pathology | Humans | Drug Resistance, Neoplasm | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Insulin-Like Growth Factor Binding Protein 3 - metabolism | Insulin Receptor Substrate Proteins | Insulin-Like Growth Factor Binding Protein 4 - metabolism | Female | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Cell Survival - drug effects | Insulin-Like Growth Factor Binding Proteins - genetics | Insulin-Like Growth Factor Binding Protein 4 - genetics | Insulin-Like Growth Factor II - metabolism | Insulin-Like Growth Factor Binding Proteins - metabolism | Xenograft Model Antitumor Assays | Animals | Carcinoma, Squamous Cell - drug therapy | Mice, Nude | Protein Kinase Inhibitors - therapeutic use | Quinazolines - therapeutic use | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Mice | Protein Kinase Inhibitors - pharmacology | Adaptor Proteins, Signal Transducing - metabolism | Quinazolines - pharmacology | Insulin-Like Growth Factor I - metabolism | Tyrosine | Phenols | Binding proteins | Analysis | Cancer cells
Journal Article
Cellular and Molecular Life Sciences, ISSN 1420-682X, 2019, Volume 76, Issue 10, pp. 2015 - 2030
Women with triple-negative breast cancer (TNBC) are generally treated by chemotherapy but their responsiveness may be blunted by DNA double-strand break (DSB)... 
IGF binding protein | P54NRB | PSF | lncRNA | TNBC | PARP inhibitors | SURVIVAL | CELLS | APOPTOSIS | ACTIVATION | FACTOR-BINDING PROTEIN-3 | ACTIN | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | EGFR | CELL BIOLOGY | PROMOTES | Insulin-Like Growth Factor Binding Protein 3 - genetics | RNA-Binding Proteins - genetics | Protein Binding - genetics | Humans | Insulin-Like Growth Factor Binding Protein 3 - metabolism | PTB-Associated Splicing Factor - genetics | RNA Interference | Octamer Transcription Factors - genetics | Protein Binding - drug effects | Triple Negative Breast Neoplasms - pathology | Female | Gene Expression Regulation, Neoplastic - drug effects | Octamer Transcription Factors - metabolism | DNA End-Joining Repair - drug effects | PTB-Associated Splicing Factor - metabolism | Nuclear Matrix-Associated Proteins - metabolism | RNA, Long Noncoding - genetics | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | Poly(ADP-ribose) Polymerases - metabolism | Poly(ADP-ribose) Polymerases - genetics | Triple Negative Breast Neoplasms - genetics | Nuclear Matrix-Associated Proteins - genetics | Triple Negative Breast Neoplasms - metabolism | Cell Line, Tumor | Benzimidazoles - pharmacology | RNA, Long Noncoding - metabolism | RNA-Binding Proteins - metabolism | DNA damage | Antisense RNA | Breast cancer | Proteins | Chemotherapy | Analysis | DNA | Genetic research | Genetic aspects | Protein kinases | Protein binding | Nuclear facilities | Cancer | Protein kinase C | Complex formation | Yeast | Chemoresistance | Proline | Homology | Kinases | DNA repair | Insulin-like growth factor-binding protein 3 | Inhibition | Gefitinib | Repair | Dimerization | Deoxyribonucleic acid--DNA | Splicing | Epidermal growth factor receptors | Etoposide | Poly(ADP-ribose) polymerase | siRNA | Double-strand break repair | RNA-binding protein | DNA-dependent protein kinase | Ribonucleic acids | Cell lines | Non-homologous end joining | Splicing factors | Glutamine
Journal Article
by Niu, X and Zhang, T and Liao, L and Zhou, L and Lindner, D.J and Zhou, M and Rini, B and Yan, Q and Yang, H
Oncogene, ISSN 0950-9232, 02/2012, Volume 31, Issue 6, pp. 776 - 786
In clear-cell renal cell carcinoma (ccRCC), inactivation of the tumor suppressor von Hippel-Lindau (VHL) occurs in the majority of the tumors and is causal for... 
hypoxia-inducible factor | JARID1C/KDM5C/SMCX | von Hippel-Lindau | gene expression | trimethyl H3K4 | METHYLATION | ACTIVATION | PROLYL HYDROXYLATION | STABILIZATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | HYPOXIA-INDUCIBLE-FACTOR | CANCER | RENAL-CELL CARCINOMA | CELL BIOLOGY | INACTIVATION | INHIBITION | ONCOLOGY | GENETICS & HEREDITY | HIF-ALPHA | Insulin-Like Growth Factor Binding Protein 3 - genetics | Kidney Neoplasms - genetics | Oxidoreductases, N-Demethylating - genetics | Cell Proliferation | Humans | Collagen Type VI - metabolism | Gene Expression Regulation, Neoplastic | Carcinoma, Renal Cell - genetics | Transplantation, Heterologous | Kidney Neoplasms - metabolism | Collagen Type VI - genetics | Basic Helix-Loop-Helix Transcription Factors - metabolism | Insulin-Like Growth Factor Binding Protein 3 - metabolism | RNA Interference | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | HEK293 Cells | Lysine - metabolism | Von Hippel-Lindau Tumor Suppressor Protein - genetics | Oxidoreductases, N-Demethylating - metabolism | Von Hippel-Lindau Tumor Suppressor Protein - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Carcinoma, Renal Cell - pathology | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Tumor Burden | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Carcinoma, Renal Cell - metabolism | Animals | Histone Demethylases | Mice, Nude | Cell Line, Tumor | Kidney Neoplasms - pathology | Mice | Histones - metabolism | Mutation | Methylation | Histones | Physiological aspects | Tumor suppressor genes | Genetic aspects | Research | Carcinoma, Renal cell | Gene expression | Proteins | Kidney diseases | Cellular biology | Cancer | Hypoxia-inducible factors | Enzymes | RNA | Promoters | renal cell carcinoma | Lysine | Xenografts | Insulin-like growth factor-binding protein 3 | genomics | Tumorigenesis | VHL protein | Differentiation | Neoplasia | Histone H3 | Oncogenes | KDM5C | JARID1C | hypoxia inducible factor | SMCX
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2016, Volume 11, Issue 4, p. e0154256
Insulin-like growth factor (IGF) signalling plays a key role in homing, progression, and treatment resistance in multiple myeloma (MM). In the extracellular... 
BREAST-CANCER | INSULIN | MURINE MODEL | IGFBP-2 | MULTIDISCIPLINARY SCIENCES | RECEPTOR | FACTOR-I | BORTEZOMIB | EXPRESSION | FIBROBLASTS | INHIBITS TUMOR-GROWTH | Insulin-Like Growth Factor Binding Protein 3 - genetics | Prognosis | Monoclonal Gammopathy of Undetermined Significance - genetics | Humans | Middle Aged | Monoclonal Gammopathy of Undetermined Significance - diagnosis | Gene Expression Regulation, Neoplastic | Male | Insulin-Like Growth Factor I - genetics | Case-Control Studies | Insulin-Like Growth Factor II - genetics | Insulin-Like Growth Factor Binding Protein 3 - metabolism | Monoclonal Gammopathy of Undetermined Significance - blood | Bone Marrow - metabolism | Female | Multiple Myeloma - blood | Enzyme-Linked Immunosorbent Assay | Multiple Myeloma - diagnosis | Signal Transduction | Insulin-Like Growth Factor Binding Protein 2 - metabolism | Insulin-Like Growth Factor II - metabolism | Insulin-Like Growth Factor Binding Protein 2 - genetics | Insulin-Like Growth Factor Binding Protein 1 - metabolism | Multiple Myeloma - pathology | Monoclonal Gammopathy of Undetermined Significance - pathology | Bone Marrow - pathology | Protein Binding | Aged | Insulin-Like Growth Factor I - metabolism | Multiple Myeloma - genetics | Insulin-Like Growth Factor Binding Protein 1 - genetics | Bone marrow | Cellular signal transduction | Research | Binding proteins | Insulin-like growth factor 1 | Multiple myeloma | Homing behavior | Insulin-like growth factor I | Insulin-like growth factor-binding protein 2 | Insulin-like growth factor-binding protein 1 | Gammopathy | Insulin-like growth factors | Homing | Proteins | Immunology | Compartments | Fibroblasts | Insulin-like growth factor-binding protein 3 | Insulin-like growth factor II | Physical growth | Enzyme-linked immunosorbent assay | Hematology | Monoclonal gammopathy | Breast cancer | Bioavailability | Metabolism | Gene expression | Insulin | Patients | Signaling | Medical prognosis | Protein expression | Internet | Bone | Receptor mechanisms | Endocrinology
Journal Article
Oncogene, ISSN 0950-9232, 03/2013, Volume 32, Issue 10, pp. 1274 - 1283
Although many cancers initially respond to cisplatin (CDDP)-based chemotherapy, resistance frequently develops. Insulin-like growth factor-binding protein-3... 
IGFBP-3 | NSCLC | cisplatin resistance | hypermethylation | IGFIR | OXIDATIVE STRESS | GEFITINIB | BIOCHEMISTRY & MOLECULAR BIOLOGY | DRUG-RESISTANCE | CHEMOTHERAPY | CELL BIOLOGY | GROWTH-FACTOR RECEPTOR | INDUCED DNA HYPERMETHYLATION | GENE | ONCOLOGY | MUTATION | GENETICS & HEREDITY | TUMOR-GROWTH | EXPRESSION | Insulin-Like Growth Factor Binding Protein 3 - genetics | Lung Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - genetics | Receptor, IGF Type 1 - metabolism | Phosphorylation | Humans | Lung Neoplasms - metabolism | Drug Resistance, Neoplasm | Lung Neoplasms - pathology | Insulin-Like Growth Factor Binding Protein 3 - deficiency | Proto-Oncogene Proteins c-akt - genetics | DNA Methylation | Receptor, Epidermal Growth Factor - metabolism | Transfection | Insulin-Like Growth Factor Binding Protein 3 - metabolism | Antineoplastic Agents - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Promoter Regions, Genetic | Signal Transduction | Carcinoma, Non-Small-Cell Lung - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Cisplatin - pharmacology | Receptor, IGF Type 1 - genetics | Insulin-Like Growth Factor Binding Protein 3 - biosynthesis | Cell Line, Tumor | Carcinoma, Non-Small-Cell Lung - drug therapy | Physiological aspects | Dosage and administration | Research | Growth factor receptors | Lung cancer, Non-small cell | Drug therapy | Drug resistance | Binding proteins | Health aspects | Cisplatin | Proteins | Signal transduction | Oncology | Epidermal growth factor | Lung cancer | Translation | Epidermal growth factor receptors | Tumor cells | biomarkers | Non-small cell lung carcinoma | AKT protein | Tumor cell lines | 1-Phosphatidylinositol 3-kinase | Chemotherapy | Derepression | Insulin-like growth factor I receptors | DNA methylation | Insulin-like growth factor-binding protein 3
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2014, Volume 289, Issue 36, pp. 25079 - 25087
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2015, Volume 10, Issue 3, pp. e0119225 - e0119225
Journal Article