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1. Full Text IGF binding proteins in cancer: Mechanistic and clinical insights
by Baxter, Robert C
Nature Reviews Cancer, ISSN 1474-175X, 2014, Volume 14, Issue 5, pp. 329 - 341
The six members of the family of insulin-like growth factor (IGF) binding proteins (IGFBPs) were originally characterized as passive reservoirs of circulating... 
HUMAN BREAST-CARCINOMA | HISTONE DEACETYLASE INHIBITOR | HUMAN-SKIN FIBROBLASTS | ONCOLOGY | FACTOR (IGF)-BINDING PROTEIN-3 | MESSENGER-RNA EXPRESSION | SQUAMOUS-CELL CARCINOMA | RETINOID-X-RECEPTOR | HUMAN OSTEOSARCOMA CELLS | EPITHELIAL OVARIAN-CANCER | GROWTH-FACTOR-I | Biomarkers - metabolism | Neoplasms - metabolism | Protein Structure, Tertiary | Cell Proliferation | Prognosis | Cell Survival | Humans | Biological Availability | Insulin-Like Growth Factor Binding Protein 2 - metabolism | Insulin-Like Growth Factor Binding Proteins - metabolism | Insulin-Like Growth Factor Binding Protein 1 - metabolism | Animals | Cell Nucleus - metabolism | Insulin-Like Growth Factor Binding Protein 3 - metabolism | Ligands | Transcription, Genetic | DNA Damage | Transforming Growth Factor beta - metabolism | Somatomedins - metabolism | Apoptosis | Oncology, Experimental | Physiological aspects | Insulin-like growth factors | Genetic aspects | Research | Binding proteins | Cancer
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2. Full Text Peripheral regulation of the growth hormone-insulin-like growth factor system in fish and other vertebrates
by Reindl, Katie M and Sheridan, Mark A
Comparative Biochemistry and Physiology, Part A, ISSN 1095-6433, 11/2012, Volume 163, Issue 3-4, pp. 231 - 245
The growth hormone (GH)-insulin-like growth factor (IGF) system plays a major role in coordinating the growth of vertebrates including fish. Considerable... 
Fish | Growth hormone binding protein | Insulin-like growth factor-1 receptor | Insulin-like growth factor binding protein | Growth hormone receptor | CIRCULATING IGF-I | PHYSIOLOGY | RAINBOW-TROUT | MESSENGER-RNA EXPRESSION | FACTOR-I GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TISSUE-SPECIFIC EXPRESSION | AQUACULTURE RELATED STRESSORS | FACTOR-BINDING-PROTEIN | GH-BINDING | ZOOLOGY | RECOMBINANT BOVINE SOMATOTROPIN | TILAPIA OREOCHROMIS-MOSSAMBICUS | Insulin-Like Growth Factor Binding Proteins - genetics | Receptors, Somatotropin - metabolism | Carrier Proteins - secretion | Growth Hormone - metabolism | Humans | Gene Expression Regulation | Fish Proteins - metabolism | Fish Proteins - secretion | Receptors, Somatotropin - genetics | Insulin-Like Growth Factor Binding Proteins - metabolism | Carrier Proteins - genetics | Fish Proteins - genetics | Somatomedins - secretion | Vertebrates | Animals | Carrier Proteins - metabolism | Receptors, Somatomedin - metabolism | Somatomedins - genetics | Receptors, Somatomedin - genetics | Insulin-Like Growth Factor Binding Proteins - secretion | Somatomedins - metabolism | Somatotropin | Inositol | Proteases | Animal behavior | Thyroxine | Physiological aspects | Hormones, Sex | Plant lipids | Binding proteins | Adenylic acid | Mitogens | Protein binding
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3. Full Text Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins
by Guix, M and Faber, AC and Wang, SE and Olivares, MG and Song, Y and Qu, S and Rinehart, C and Seidel, B and Yee, D and Arteaga, CL and Engelman, JA
JOURNAL OF CLINICAL INVESTIGATION, ISSN 0021-9738, 07/2008, Volume 118, Issue 7, pp. 2609 - 2619
Although some cancers are initially sensitive to EGFR tyrosine kinase inhibitors (TKIs), resistance invariably develops. We investigated mechanisms of acquired... 
BREAST-CANCER | GENE-MUTATIONS | MEDICINE, RESEARCH & EXPERIMENTAL | LUNG-CANCER | GROWTH-FACTOR-RECEPTOR | T790M MUTATIONS | IN-VIVO | TUMOR-CELLS | ANTITUMOR-ACTIVITY | GEFITINIB SENSITIVITY | ERLOTINIB | Insulin-Like Growth Factor Binding Protein 3 - genetics | Receptor, IGF Type 1 - metabolism | Insulin-Like Growth Factor I - pharmacology | Receptor, ErbB-3 - metabolism | Receptor, IGF Type 1 - antagonists & inhibitors | Gene Expression - drug effects | Carcinoma, Squamous Cell - pathology | Humans | Drug Resistance, Neoplasm | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Insulin-Like Growth Factor Binding Protein 3 - metabolism | Insulin Receptor Substrate Proteins | Insulin-Like Growth Factor Binding Protein 4 - metabolism | Female | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Cell Survival - drug effects | Insulin-Like Growth Factor Binding Proteins - genetics | Insulin-Like Growth Factor Binding Protein 4 - genetics | Insulin-Like Growth Factor II - metabolism | Insulin-Like Growth Factor Binding Proteins - metabolism | Xenograft Model Antitumor Assays | Animals | Carcinoma, Squamous Cell - drug therapy | Mice, Nude | Protein Kinase Inhibitors - therapeutic use | Quinazolines - therapeutic use | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Mice | Protein Kinase Inhibitors - pharmacology | Adaptor Proteins, Signal Transducing - metabolism | Quinazolines - pharmacology | Insulin-Like Growth Factor I - metabolism | Tyrosine | Phenols | Binding proteins | Analysis | Cancer cells
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4. Full Text Insulin-like growth factors (IGFs), IGF receptors, and IGF-binding proteins: Roles in skeletal muscle growth and differentiation
by Duan, Cunming and Ren, Hongxia and Gao, Shan
General and Comparative Endocrinology, ISSN 0016-6480, 2010, Volume 167, Issue 3, pp. 344 - 351
Abstract The insulin-like growth factor (IGF) signaling pathway consists of multiple IGF ligands, IGF receptors, and IGF-binding proteins (IGFBPs). Studies in... 
Endocrinology & Metabolism | IGFBP | HIF-1 | Myoblast | mTOR | IGF | Hypoxia | Proliferation | Akt | MAPK | MTOR | MYOBLAST DIFFERENTIATION | SIGNALING PATHWAYS | FACTOR-I RECEPTORS | CELL-SURVIVAL | POSTNATAL-GROWTH | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | FACTOR SYSTEM | EMBRYONIC GROWTH | DEVELOPMENTAL EXPRESSION | TRANSGENIC MICE | Receptors, Somatomedin - physiology | Insulin-Like Growth Factor Binding Proteins - genetics | Insulin-Like Growth Factor Binding Proteins - physiology | Muscle, Skeletal - growth & development | Muscle, Skeletal - metabolism | Signal Transduction - genetics | Muscle, Skeletal - physiology | Insulin-Like Growth Factor Binding Proteins - metabolism | Somatomedins - physiology | Cell Differentiation - genetics | Animals | Models, Biological | Receptors, Somatomedin - metabolism | Somatomedins - genetics | Receptors, Somatomedin - genetics | Signal Transduction - physiology | Somatomedins - metabolism | Proteins | Cell research
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5. Full Text Insulin-like growth factor-binding proteins and bone metabolism
by Cheryl A. Conover
American Journal of Physiology - Endocrinology And Metabolism, ISSN 0193-1849, 01/2008, Volume 294, Issue 1, pp. 10 - 14
Insulin-like growth factor-binding proteins (IGFBPs) are important regulators of bone metabolism. However, their precise roles are not fully understood, since... 
Insulin-like growth factors | PHYSIOLOGY | HUMAN OSTEOBLASTS | FACTOR-I | insulin-like growth factors | FORMATION PARAMETERS | CELL-CULTURES | PROTEOLYTIC ACTIVITY | MINERAL DENSITY | IGF SYSTEM | ENDOCRINOLOGY & METABOLISM | RECOMBINANT HUMAN | PROTEASE | TRANSGENIC MICE | Insulin-Like Growth Factor Binding Proteins - metabolism | Insulin-Like Growth Factor Binding Proteins - physiology | Animals | Bone and Bones - metabolism | Humans
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6. Full Text The 12th-14th type III repeats of fibronectin function as a highly promiscuous growth factor-binding domain
by Martino, Mikaël M and Hubbell, Jeffrey A
FASEB Journal, ISSN 0892-6638, 12/2010, Volume 24, Issue 12, pp. 4711 - 4721
It has recently been shown that some growth factors (GFs) have strong interactions with nonproteoglycan extracellular matrix proteins. Relevant here, the... 
Heparin-binding domain | Tissue engineering | Extracellular matrix | tissue engineering | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | VITRONECTIN | CONTROLLED-RELEASE | FIBRIN GELS | CELL BIOLOGY | heparin-binding domain | CELL-MIGRATION | BIOLOGICAL-ACTIVITY | ENDOTHELIAL-CELLS | BIOLOGY | HEPARAN-SULFATE | EXTRACELLULAR-MATRIX | DIFFERENTIATION | extracellular matrix | Fibronectins - pharmacology | Enzyme-Linked Immunosorbent Assay | Humans | Cells, Cultured | Extracellular Matrix - metabolism | Vascular Endothelial Growth Factor A - metabolism | Fibronectins - metabolism | Insulin-Like Growth Factor Binding Proteins - metabolism | Cell Movement - drug effects | Intercellular Signaling Peptides and Proteins - metabolism | Platelet-Derived Growth Factor - metabolism | Fibronectins - chemistry | Protein Binding - drug effects | Cell Proliferation - drug effects | Fibronectins - genetics | Phosphorylation - drug effects | Transforming Growth Factor beta - metabolism | Heparin - pharmacology | Tissue Engineering
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7. Full Text Muscle Mitohormesis Promotes Longevity via Systemic Repression of Insulin Signaling
by Owusu-Ansah, Edward and Song, Wei and Perrimon, Norbert
Cell, ISSN 0092-8674, 10/2013, Volume 155, Issue 3, pp. 699 - 712
Mitochondrial dysfunction is usually associated with aging. To systematically characterize the compensatory stress signaling cascades triggered in response to... 
LIFE-SPAN | OXIDATIVE STRESS | HOMEOSTASIS | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOCHONDRIAL-FUNCTION | GROWTH | DETERMINANT | HOMOLOG | AUTOPHAGY | MODULATION | CELL BIOLOGY | Drosophila melanogaster - physiology | Reactive Oxygen Species - metabolism | Signal Transduction | Larva - metabolism | Drosophila melanogaster - cytology | Male | Mitochondria - metabolism | Longevity | Drosophila Proteins - metabolism | Unfolded Protein Response | Insulin-Like Growth Factor Binding Proteins - metabolism | Insulin - metabolism | Animals | Aging | Drosophila melanogaster - growth & development | Female | Muscles - metabolism | Muscles - cytology | Genetic transcription | Binding proteins | Insulin | Analysis | Genes | Protein binding
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8. Full Text Glucagon Decreases IGF-1 Bioactivity in Humans, Independently of Insulin, by Modulating Its Binding Proteins
by Sarem, Zeinab and Bumke-Vogt, Christiane and Mahmoud, Ayman M and Assefa, Biruhalem and Weickert, Martin O and Adamidou, Aikatarini and Bähr, Volker and Frystyk, Jan and Möhlig, Matthias and Spranger, Joachim and Lieske, Stefanie and Birkenfeld, Andreas L and Pfeiffer, Andreas F H and Arafat, Ayman M
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 09/2017, Volume 102, Issue 9, pp. 3480 - 3490
CONTEXT:Depending on its lipolytic activity, glucagon plays a promising role in obesity treatment. Glucagon-induced growth hormone (GH) release can promote its... 
FOXO | STIMULATION | GROWTH-HORMONE | GHRELIN | ENDOCRINOLOGY & METABOLISM | SECRETION | SUPPRESSION | EXPRESSION | AXIS | Humans | Insulin-Like Growth Factor Binding Proteins - drug effects | Diabetes Mellitus, Type 1 - metabolism | Glucagon - administration & dosage | Male | Insulin-Like Growth Factor I - drug effects | Forkhead Box Protein O1 - drug effects | Dose-Response Relationship, Drug | Statistics, Nonparametric | Adult | Female | Forkhead Box Protein O1 - metabolism | Double-Blind Method | Drug Administration Schedule | Enzyme-Linked Immunosorbent Assay | Growth Hormone - drug effects | Growth Hormone - metabolism | Obesity - physiopathology | Injections, Intramuscular | Blotting, Western | Diabetes Mellitus, Type 1 - drug therapy | Obesity - metabolism | Insulin-Like Growth Factor Binding Proteins - metabolism | Diabetes Mellitus, Type 1 - diagnosis | Insulin-Like Growth Factor I - metabolism | TOR protein | Phosphorylation | Glucagon | Insulin-like growth factor I | Insulin-like growth factor-binding protein 2 | Insulin-like growth factor-binding protein 1 | AKT protein | Insulin-like growth factors | Kinases | Proteins | Biomedical materials | Reduction | FOXO1 protein | Osteosarcoma | Forkhead protein | Insulin-like growth factor-binding protein 3 | Biocompatibility | Lipid metabolism | Protein transport | Translocation | Obesity | Secretion | Diabetes mellitus | Rapamycin | Osteosarcoma cells | Gene expression | Metabolism | Insulin | Biological activity | Nuclear transport | Hepatocytes | Growth hormone
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9. Full Text Insulin-like growth factor binding protein 7 and tissue inhibitor of metalloproteinases-2: Differential expression and secretion in human kidney tubule cells
by Emlet, David R and Pastor-Soler, Nuria and Marciszyn, Allison and Wen, Xiaoyan and Gomez, Hernando and Humphries, William H and Morrisroe, Seth and Volpe, Jacob K and Kellum, John A
American Journal of Physiology - Renal Physiology, ISSN 0363-6127, 02/2017, Volume 312, Issue 2, pp. F284 - F296
We have characterized the expression and secretion of the acute kidney injury (AKI) biomarkers insulin-like growth factor binding protein 7 (IGFBP7) and tissue... 
Biomarkers | TIMP-2 | IGFBP7 | Acute kidney injury | PHYSIOLOGY | RAT-KIDNEY | biomarkers | IN-SITU HYBRIDIZATION | GELATINASE-ASSOCIATED LIPOCALIN | CYCLE ARREST BIOMARKERS | RENAL PROXIMAL TUBULE | MATRIX METALLOPROTEINASES | MOLECULE-1 KIM-1 | GAMMA-GLUTAMYL-TRANSPEPTIDASE | EPITHELIAL-CELLS | UROLOGY & NEPHROLOGY | acute kidney injury | and TIMP-2 | TAMM-HORSFALL GLYCOPROTEIN | Insulin-Like Growth Factor Binding Proteins - metabolism | Tissue Inhibitor of Metalloproteinase-2 - metabolism | Lipocalin-2 - metabolism | Humans | Kidney Tubules, Proximal - metabolism | Hepatitis A Virus Cellular Receptor 1 - metabolism | Acute Kidney Injury - metabolism | Organ Specificity | Reperfusion Injury - metabolism | Kidney Tubules, Distal - metabolism | Physiological aspects | Insulin-like growth factors | Kidneys | Metalloproteins
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10. Full Text Circulating insulin‐like growth factor peptides and prostate cancer risk: A systematic review and meta‐analysis
by Rowlands, Mari‐Anne and Gunnell, David and Harris, Ross and Vatten, Lars J and Holly, Jeff M.P and Martin, Richard M
International Journal of Cancer, ISSN 0020-7136, 05/2009, Volume 124, Issue 10, pp. 2416 - 2429
Insulin‐like growth factors (IGF‐I, IGF‐II) and their binding proteins (IGFBP‐1–6) play a key role in cell proliferation, differentiation and apoptosis,... 
prostate cancer | insulin‐like growth factor binding protein | meta‐analysis | insulin‐like growth factor | Insulin-like growth factor binding protein | Insulin-like growth factor | Prostate cancer | Meta-analysis | STORED SERUM | FACTOR AXIS | meta-analysis | FACTOR-I | HYPERPLASIA | IGFBP-3 | ONCOLOGY | FACTOR (IGF)-I | SERUM-LEVELS | ELEVATED LEVELS | IGF-BINDING PROTEIN-3 | insulin-like growth factor | insulin-like growth factor binding protein | ANTIGEN | Insulin-Like Growth Factor Binding Proteins - metabolism | Peptides - blood | Somatomedins - chemistry | Humans | Insulin-Like Growth Factor Binding Proteins - chemistry | Risk Factors | Prostatic Neoplasms - blood | Male | Somatomedins - metabolism | Index Medicus
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