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Circulation Research, ISSN 0009-7330, 09/2005, Volume 97, Issue 7, pp. 663 - 673
Journal Article
Journal Article
Blood, ISSN 0006-4971, 2009, Volume 113, Issue 19, pp. 4614 - 4626
A plethora of myeloma growth factors (MGFs) has been identified, but their relative importance and cooperation have not been determined. We investigated 5 MGFs... 
INTERLEUKIN-6 IL-6 | INSULIN | ONCOSTATIN-M | EGF | SURVIVAL FACTOR | BONE-MARROW | PROLIFERATION | FACTOR-I | MONOCLONAL-ANTIBODIES | HEMATOLOGY | HUMAN MULTIPLE-MYELOMA | Receptor, IGF Type 1 - metabolism | Translocation, Genetic | Insulin-Like Growth Factor I - pharmacology | Cell Proliferation | Leukocyte Common Antigens - metabolism | Prognosis | Oligonucleotide Array Sequence Analysis | Humans | Culture Media, Serum-Free | Immunoblotting | Tumor Necrosis Factor Ligand Superfamily Member 13 - pharmacology | Chromosomes, Human, Pair 4 - genetics | Hepatocyte Growth Factor - pharmacology | RNA, Messenger - metabolism | Immunoenzyme Techniques | Multiple Myeloma - drug therapy | Flow Cytometry | Cell Survival - drug effects | Enzyme-Linked Immunosorbent Assay | Receptors, Interleukin-6 - genetics | RNA, Messenger - genetics | In Situ Hybridization, Fluorescence | Recombinant Proteins - pharmacology | Multiple Myeloma - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Receptor, IGF Type 1 - genetics | Blotting, Western | Cell Division - drug effects | Heparin-binding EGF-like Growth Factor | Multiple Myeloma - pathology | Interleukin-6 - pharmacology | Intercellular Signaling Peptides and Proteins - pharmacology | Cell Line, Tumor | Chromosomes, Human, Pair 14 - genetics | Receptors, Interleukin-6 - metabolism | growth factor | IGF-1 | myeloma | HGF | IL-6 | APRIL
Journal Article
Journal Article
Oncogene, ISSN 0950-9232, 01/2006, Volume 25, Issue 2, pp. 176 - 185
The induction of senescence-like growth arrest has emerged as a putative contributor to the anticancer effects of chemotherapeutic agents. Clinical trials are... 
Sirt1 | MAPK | Ras | Akt/PKB | Sirtinol | Cellular senescence | TRANSCRIPTION FACTORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN DEACETYLASES | TUMOR-CELLS | sirtinol | DEPSIPEPTIDE FR901228 | CELL BIOLOGY | cellular senescence | TERMINAL PROLIFERATION ARREST | HUMAN-FIBROBLASTS | ONCOLOGY | IN-VIVO | GENETICS & HEREDITY | HISTONE DEACETYLASE INHIBITORS | PC12 CELLS | Lung Neoplasms - drug therapy | Receptor, IGF Type 1 - metabolism | Insulin-Like Growth Factor I - pharmacology | Humans | Lung Neoplasms - metabolism | Cellular Senescence - drug effects | Lung Neoplasms - pathology | Phosphatidylinositol 3-Kinases - metabolism | Breast Neoplasms - metabolism | Genes, ras - physiology | Receptor, Epidermal Growth Factor - metabolism | Plasminogen Activator Inhibitor 1 - metabolism | Sirtuin 1 | beta-Galactosidase - metabolism | Benzamides - pharmacology | p38 Mitogen-Activated Protein Kinases - metabolism | Phosphorylation - drug effects | Tumor Cells, Cultured | Proto-Oncogene Proteins c-akt - metabolism | Naphthols - pharmacology | Enzyme Activation - drug effects | Breast Neoplasms - drug therapy | Tyrosine - metabolism | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Breast Neoplasms - pathology | Histone Deacetylase Inhibitors | Epidermal Growth Factor - pharmacology | Sirtuins - antagonists & inhibitors | Mitogen-Activated Protein Kinase 1 - metabolism
Journal Article
Arthroscopy: The Journal of Arthroscopic and Related Surgery, ISSN 0749-8063, 2011, Volume 27, Issue 11, pp. 1459 - 1471
Purpose The purpose of this study was to determine whether a one-time physiologic dose of insulin when compared with the growth factors insulin-like growth... 
Orthopedics | PROGENITOR CELLS | SURGERY | SPORT SCIENCES | BIOMECHANICAL EVALUATION | MODEL | BINDING-PROTEINS | SPINAL-FUSION | SUTURE ANCHORS | DOUBLE-ROW FIXATION | STROMAL CELLS | ORTHOPEDICS | CULTURES | GROWTH-FACTOR-I | Intracellular Signaling Peptides and Proteins - pharmacology | Insulin-Like Growth Factor I - pharmacology | Humans | Middle Aged | Collagen Type III - metabolism | Male | Rotator Cuff - surgery | Tenascin - metabolism | Dose-Response Relationship, Drug | Intracellular Signaling Peptides and Proteins - administration & dosage | Mesenchymal Stromal Cells - cytology | Rotator Cuff Injuries | Tendons - cytology | Arthroscopy | Basic Helix-Loop-Helix Transcription Factors - metabolism | Fibroblast Growth Factors - administration & dosage | Insulin-Like Growth Factor I - administration & dosage | Polymerase Chain Reaction | Aged, 80 and over | Bone Marrow Cells - drug effects | Female | Insulin - pharmacology | Mesenchymal Stromal Cells - drug effects | Collagen Type I - metabolism | Bone Marrow Cells - cytology | Mesenchymal Stromal Cells - metabolism | Insulin - administration & dosage | Fibroblast Growth Factors - pharmacology | Growth Differentiation Factor 5 - pharmacology | Cell Differentiation - drug effects | Growth Differentiation Factor 5 - administration & dosage | Aged | Bone Marrow Cells - metabolism | Decorin - metabolism | Orthopedic surgery | Insulin | Stem cells | Diabetes therapy
Journal Article
Scientific Reports, ISSN 2045-2322, 02/2017, Volume 7, Issue 1, p. 43006
Journal Article
JOURNAL OF CLINICAL INVESTIGATION, ISSN 0021-9738, 07/2008, Volume 118, Issue 7, pp. 2609 - 2619
Although some cancers are initially sensitive to EGFR tyrosine kinase inhibitors (TKIs), resistance invariably develops. We investigated mechanisms of acquired... 
BREAST-CANCER | GENE-MUTATIONS | MEDICINE, RESEARCH & EXPERIMENTAL | LUNG-CANCER | GROWTH-FACTOR-RECEPTOR | T790M MUTATIONS | IN-VIVO | TUMOR-CELLS | ANTITUMOR-ACTIVITY | GEFITINIB SENSITIVITY | ERLOTINIB | Insulin-Like Growth Factor Binding Protein 3 - genetics | Receptor, IGF Type 1 - metabolism | Insulin-Like Growth Factor I - pharmacology | Receptor, ErbB-3 - metabolism | Receptor, IGF Type 1 - antagonists & inhibitors | Gene Expression - drug effects | Carcinoma, Squamous Cell - pathology | Humans | Drug Resistance, Neoplasm | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Insulin-Like Growth Factor Binding Protein 3 - metabolism | Insulin Receptor Substrate Proteins | Insulin-Like Growth Factor Binding Protein 4 - metabolism | Female | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Cell Survival - drug effects | Insulin-Like Growth Factor Binding Proteins - genetics | Insulin-Like Growth Factor Binding Protein 4 - genetics | Insulin-Like Growth Factor II - metabolism | Insulin-Like Growth Factor Binding Proteins - metabolism | Xenograft Model Antitumor Assays | Animals | Carcinoma, Squamous Cell - drug therapy | Mice, Nude | Protein Kinase Inhibitors - therapeutic use | Quinazolines - therapeutic use | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Mice | Protein Kinase Inhibitors - pharmacology | Adaptor Proteins, Signal Transducing - metabolism | Quinazolines - pharmacology | Insulin-Like Growth Factor I - metabolism | Tyrosine | Phenols | Binding proteins | Analysis | Cancer cells
Journal Article