X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (6873) 6873
Book Chapter (8) 8
Conference Proceeding (5) 5
Publication (5) 5
Dissertation (4) 4
Magazine Article (4) 4
Book / eBook (2) 2
Book Review (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
animals (5145) 5145
insulin-secreting cells - drug effects (4191) 4191
insulin-secreting cells - metabolism (4184) 4184
humans (3630) 3630
insulin - metabolism (2748) 2748
mice (2665) 2665
male (2544) 2544
endocrinology & metabolism (2396) 2396
rats (2147) 2147
insulin secretion (2124) 2124
insulin (1941) 1941
diabetes (1871) 1871
glucose (1861) 1861
female (1528) 1528
insulin-secreting cells - cytology (1290) 1290
cell line (1179) 1179
insulin-secreting cells - pathology (1162) 1162
apoptosis (1154) 1154
insulin-secreting cells - physiology (1075) 1075
pancreatic beta cells (1020) 1020
pancreas (994) 994
glucose - pharmacology (968) 968
insulin resistance (944) 944
blood glucose - metabolism (942) 942
type 2 diabetes (892) 892
biochemistry & molecular biology (881) 881
cell biology (875) 875
cells, cultured (872) 872
expression (864) 864
apoptosis - drug effects (834) 834
diabetes mellitus (821) 821
glucose - metabolism (799) 799
diabetes mellitus, type 2 - drug therapy (785) 785
insulin-secretion (784) 784
secretion (773) 773
diabetes mellitus, type 2 - metabolism (733) 733
mice, inbred c57bl (701) 701
hypoglycemic agents - pharmacology (696) 696
oxidative stress (690) 690
middle aged (673) 673
adult (662) 662
insulin - blood (662) 662
pharmacology & pharmacy (617) 617
dextrose (614) 614
hypoglycemic agents - therapeutic use (590) 590
beta cells (568) 568
islets of langerhans - metabolism (568) 568
abridged index medicus (554) 554
internal medicine (547) 547
metabolism (545) 545
activation (544) 544
physiology (541) 541
glucose tolerance test (533) 533
rats, wistar (531) 531
pancreatic beta-cells (530) 530
glucagon-like peptide-1 (518) 518
islets (515) 515
cell line, tumor (510) 510
islets of langerhans - drug effects (505) 505
cell survival - drug effects (497) 497
rodents (486) 486
signal transduction (484) 484
signal transduction - drug effects (482) 482
gene expression (481) 481
hyperglycemia (471) 471
analysis (467) 467
research (467) 467
medicine & public health (461) 461
type 1 diabetes (447) 447
proteins (445) 445
calcium - metabolism (438) 438
research article (429) 429
dose-response relationship, drug (427) 427
insulin-secreting cells (426) 426
medicine (426) 426
medicine, research & experimental (423) 423
multidisciplinary sciences (423) 423
endocrine system (421) 421
glucose metabolism (421) 421
physiological aspects (419) 419
blood glucose - drug effects (416) 416
obesity (413) 413
beta-cells (412) 412
cell proliferation - drug effects (411) 411
beta-cell function (405) 405
gene-expression (394) 394
insulin-resistance (390) 390
in-vitro (388) 388
homeostasis (382) 382
rats, sprague-dawley (376) 376
mice, knockout (374) 374
diabetes-mellitus (368) 368
diabetes mellitus, type 2 - physiopathology (358) 358
pancreatic-islets (352) 352
phosphorylation (351) 351
time factors (351) 351
diabetes mellitus, type 2 - blood (348) 348
diabetes mellitus, experimental - drug therapy (341) 341
diabetes mellitus, experimental - metabolism (340) 340
metabolic diseases (337) 337
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (6831) 6831
Chinese (55) 55
Japanese (55) 55
German (13) 13
Hungarian (5) 5
Russian (5) 5
Italian (4) 4
Polish (3) 3
Czech (2) 2
French (2) 2
Korean (2) 2
Swedish (2) 2
Ukrainian (2) 2
Danish (1) 1
Portuguese (1) 1
Spanish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal Article
Biomaterials, ISSN 0142-9612, 2011, Volume 32, Issue 36, pp. 9685 - 9695
Abstract Hydrogels provide three-dimensional frameworks with tissue-like elasticity and high permeability for culturing therapeutically relevant cells or tissues... 
Advanced Basic Science | Dentistry | Degradation | Hydrogel | Photopolymerization | Type 1 diabetes | CHYMOTRYPSIN | MATERIALS SCIENCE, BIOMATERIALS | ISLETS | ENGINEERING, BIOMEDICAL | PROTEIN-KINASE | NETWORK STRUCTURE | TRANSPLANTATION | IN-VITRO | HMSC VIABILITY | POLY(ETHYLENE GLYCOL) HYDROGELS | PANCREATIC BETA-CELLS | Cells, Immobilized - radiation effects | Chymotrypsin - metabolism | Cell Count | Cross-Linking Reagents - pharmacology | Biophysical Phenomena - drug effects | Elastic Modulus - drug effects | Polyethylene Glycols - chemistry | Hydrogels - chemical synthesis | Spheroids, Cellular - radiation effects | Spheroids, Cellular - cytology | Cells, Immobilized - drug effects | Polymerization - drug effects | Light | Sulfhydryl Compounds - chemistry | Insulin-Secreting Cells - cytology | Spheroids, Cellular - drug effects | Cell Survival - drug effects | Polymerization - radiation effects | Click Chemistry - methods | Sulfhydryl Compounds - chemical synthesis | Cell Survival - radiation effects | Cells, Immobilized - cytology | Biophysical Phenomena - radiation effects | Elastic Modulus - radiation effects | Animals | Insulin-Secreting Cells - drug effects | Cell Proliferation - drug effects | Mice | Hydrogels - pharmacology | Hydrogels - chemistry | Cell Proliferation - radiation effects | Insulin-Secreting Cells - radiation effects | Enzymes | Ethylene glycol | Pancreatic beta cells | Biological products | Polymerization | Permeability | Glucose | Dextrose | Beta cells | photopolymerization | type 1 diabetes | degradation
Journal Article
Diabetes, ISSN 0012-1797, 11/2011, Volume 60, Issue 11, pp. 2872 - 2882
OBJECTIVE-To evaluate whether healthy or diabetic adult mice can tolerate an extreme loss of pancreatic a-cells and how this sudden massive depletion affects beta-cell function and blood glucose homeostasis... 
INSULIN | HYPERGLUCAGONEMIA | ENDOCRINE PANCREAS | GLUCOSE-HOMEOSTASIS | ENDOCRINOLOGY & METABOLISM | RECEPTOR GENE | SECRETION | DIFFERENTIATION | HYPERPLASIA | ISLET CELLS | EXPRESSION | Insulin-Secreting Cells - secretion | Apoptosis - drug effects | Cell Count | Glucagon - genetics | Male | Diphtheria Toxin - toxicity | Insulin - blood | Glucagon - blood | Diabetes Mellitus, Experimental - blood | Hypoglycemia - prevention & control | Intercellular Signaling Peptides and Proteins - metabolism | Glucagon-Secreting Cells - drug effects | Insulin-Secreting Cells - metabolism | Hyperglycemia - chemically induced | Glucagon-Secreting Cells - metabolism | Diabetes Mellitus, Experimental - chemically induced | Diabetes Mellitus, Experimental - metabolism | Glucagon-Secreting Cells - secretion | Hyperglycemia - prevention & control | Promoter Regions, Genetic | Signal Transduction | Glucagon-Secreting Cells - pathology | Intercellular Signaling Peptides and Proteins - genetics | Pancreas - drug effects | Pancreas - pathology | Receptors, Glucagon - metabolism | Mice, Transgenic | Pancreas - metabolism | Heparin-binding EGF-like Growth Factor | Insulin - metabolism | Animals | Insulin-Secreting Cells - drug effects | Tamoxifen - pharmacology | Diabetes Mellitus, Experimental - pathology | Glucagon - metabolism | Mice | Streptozocin - toxicity | Insulin-Secreting Cells - pathology | Selective Estrogen Receptor Modulators - pharmacology | Islet Studies
Journal Article
CELL DEATH & DISEASE, ISSN 2041-4889, 01/2018, Volume 9, Issue 2, pp. 96 - 15
Journal Article
Journal of Cell Science, ISSN 0021-9533, 10/2006, Volume 119, Issue 20, pp. 4199 - 4206
.... In this paper we studied its localization in human pancreatic islet cells, and its effect on cellular zinc content and insulin secretion... 
Zinc transport | Langerhans islets | Insulin | Zinc | Beta cell | Insulin secretion | beta cell | ACTIVATION | insulin | GLUCAGON-RELEASE | zinc transport | DEATH | insulin secretion | IDENTIFICATION | CELL BIOLOGY | DIABETES-MELLITUS | SUPPLEMENTATION | PANCREATIC BETA-CELLS | MICE | MEMBRANE-PROTEINS | zinc | FLUORESCENT-PROBE | Islets of Langerhans - drug effects | Gene Expression - drug effects | Zinc Transporter 8 | Gene Expression - genetics | Zinc - metabolism | Humans | Secretory Vesicles - metabolism | Cation Transport Proteins - physiology | Male | Green Fluorescent Proteins - genetics | Recombinant Fusion Proteins - metabolism | Dose-Response Relationship, Drug | Insulin-Secreting Cells - metabolism | Cation Transport Proteins - metabolism | Islets of Langerhans - metabolism | Islets of Langerhans - cytology | Cation Transport Proteins - genetics | Biological Transport - drug effects | Cell Membrane - metabolism | Insulin-Secreting Cells - cytology | Insulin Secretion | Cell Membrane - drug effects | Cell Line | Cell Survival - drug effects | Green Fluorescent Proteins - metabolism | Glucose - pharmacology | Microscopy, Confocal | Insulin - metabolism | Animals | Insulin-Secreting Cells - drug effects | Models, Biological | Secretory Vesicles - drug effects | Recombinant Fusion Proteins - genetics | Glucagon - metabolism | Mice | HeLa Cells | Zinc - pharmacology | Microscopy, Fluorescence | Green Fluorescent Proteins | Cell Membrane | Glucagon | Glucose | Recombinant Fusion Proteins | Life Sciences | Biological Transport | Insulin-Secreting Cells | Gene Expression | Cell Survival | Secretory Vesicles | Cation Transport Proteins | Islets of Langerhans | Hela Cells | Cancer
Journal Article
American Journal of Physiology - Endocrinology and Metabolism, ISSN 0193-1849, 08/2016, Volume 311, Issue 2, pp. E380 - E395
Type 1 diabetes (T1D) originates from autoimmune beta-cell destruction. IMT504 is an immunomodulatory oligonucleotide that increases mesenchymal stem cell cloning capacity and reverts toxic diabetes in rats... 
Insulitis | β-cells | Islet gene expression | Serum cytokines | OLIGODEOXYNUCLEOTIDES | ACTIVATION | PHYSIOLOGY | serum cytokines | islet gene expression | REG FAMILY GENES | PROLIFERATION | MESENCHYMAL STEM-CELLS | IL-6 | insulitis | ENDOCRINOLOGY & METABOLISM | beta-cells | STREPTOZOTOCIN | EXPRESSION | ONSET | Islets of Langerhans - drug effects | Apoptosis - drug effects | Chemokine CXCL1 - drug effects | Diabetes Mellitus, Experimental - genetics | Diabetes Mellitus, Type 1 - metabolism | Male | Chemokine CXCL1 - genetics | RNA, Messenger - metabolism | Nestin - drug effects | Insulin - genetics | Interleukin-6 - metabolism | Disease Models, Animal | Somatostatin - genetics | Lithostathine - drug effects | Blood Glucose - drug effects | Insulin - metabolism | Protein Precursors - drug effects | Tumor Necrosis Factor-alpha - drug effects | Mice | Mice, Inbred BALB C | Proglucagon - genetics | Blood Glucose - metabolism | Oligodeoxyribonucleotides - pharmacology | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Tumor Necrosis Factor-alpha - metabolism | Platelet Endothelial Cell Adhesion Molecule-1 - genetics | Indoleamine-Pyrrole 2,3,-Dioxygenase - drug effects | Stem Cells - metabolism | Insulin-Secreting Cells - metabolism | Proglucagon - drug effects | Somatostatin - drug effects | Islets of Langerhans - metabolism | Nestin - genetics | Diabetes Mellitus, Experimental - metabolism | RNA, Messenger - drug effects | Glucose Tolerance Test | Protein Precursors - genetics | Cytokines - metabolism | Islets of Langerhans - pathology | Lithostathine - genetics | Diabetes Mellitus, Type 1 - genetics | Transcriptome - drug effects | Pancreatitis-Associated Proteins | Proteins - genetics | Animals | Cytokines - drug effects | Insulin-Secreting Cells - drug effects | Platelet Endothelial Cell Adhesion Molecule-1 - drug effects | Proteins - drug effects | Stem Cells - drug effects | Cell Proliferation - drug effects | Physiological aspects | Models | Diabetes | Oligonucleotides | Index Medicus
Journal Article
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2011, Volume 108, Issue 28, pp. 11692 - 11697
.... We report here that GABA exerts antidiabetic effects by acting on both the islet β-cells and immune system... 
Depolarization | Antiinflammatories | Cytokines | Diabetes complications | Islet cells | Mice | Diabetes | Type 2 diabetes mellitus | Insulin | Type 1 diabetes mellitus | Inflammation | Regulatory T-cell | AMINOBUTYRIC-ACID GABA | insulin | RAT | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | RECEPTOR | RELEASE | inflammation | AUTOIMMUNITY | regulatory T-cell | MICE | EXPRESSION | T-CELLS | ONSET | Apoptosis - drug effects | Male | Phosphatidylinositol 3-Kinases - metabolism | T-Lymphocytes, Regulatory - immunology | gamma-Aminobutyric Acid - physiology | Inflammation Mediators - metabolism | Female | Diabetes Mellitus, Type 1 - immunology | Proto-Oncogene Proteins c-akt - metabolism | Immunosuppressive Agents - pharmacology | Insulin-Secreting Cells - physiology | Membrane Potentials - drug effects | Hyperglycemia - prevention & control | Diabetes Mellitus, Type 1 - physiopathology | Diabetes Mellitus, Type 1 - pathology | gamma-Aminobutyric Acid - pharmacology | Mice, Transgenic | Insulin-Secreting Cells - immunology | Diabetes Mellitus, Type 1 - drug therapy | Regeneration - drug effects | T-Lymphocytes, Regulatory - drug effects | Animals | Insulin-Secreting Cells - drug effects | Signal Transduction - drug effects | Calcium Signaling - drug effects | Mice, Inbred NOD | Cell Proliferation - drug effects | Insulin-Secreting Cells - pathology | Cytokines - biosynthesis | GABA | Physiological aspects | Pancreatic beta cells | Research | Type 1 diabetes | Biological Sciences
Journal Article
Cell stem cell, ISSN 1934-5909, 2016, Volume 18, Issue 6, pp. 755 - 768
Journal Article
Molecular Endocrinology, ISSN 1944-9917, 2009, Volume 23, Issue 6, pp. 893 - 900
Journal Article
Journal Article