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Diabetes (New York, N.Y.), ISSN 0012-1797, 11/2011, Volume 60, Issue 11, pp. 2872 - 2882
OBJECTIVE-To evaluate whether healthy or diabetic adult mice can tolerate an extreme loss of pancreatic a-cells and how this sudden massive depletion affects beta-cell function and blood glucose homeostasis... 
INSULIN | HYPERGLUCAGONEMIA | ENDOCRINE PANCREAS | GLUCOSE-HOMEOSTASIS | ENDOCRINOLOGY & METABOLISM | RECEPTOR GENE | SECRETION | DIFFERENTIATION | HYPERPLASIA | ISLET CELLS | EXPRESSION | Insulin-Secreting Cells - secretion | Apoptosis - drug effects | Cell Count | Glucagon - genetics | Male | Diphtheria Toxin - toxicity | Insulin - blood | Glucagon - blood | Diabetes Mellitus, Experimental - blood | Hypoglycemia - prevention & control | Intercellular Signaling Peptides and Proteins - metabolism | Glucagon-Secreting Cells - drug effects | Insulin-Secreting Cells - metabolism | Hyperglycemia - chemically induced | Glucagon-Secreting Cells - metabolism | Diabetes Mellitus, Experimental - chemically induced | Diabetes Mellitus, Experimental - metabolism | Glucagon-Secreting Cells - secretion | Hyperglycemia - prevention & control | Promoter Regions, Genetic | Signal Transduction | Glucagon-Secreting Cells - pathology | Intercellular Signaling Peptides and Proteins - genetics | Pancreas - drug effects | Pancreas - pathology | Receptors, Glucagon - metabolism | Mice, Transgenic | Pancreas - metabolism | Heparin-binding EGF-like Growth Factor | Insulin - metabolism | Animals | Insulin-Secreting Cells - drug effects | Tamoxifen - pharmacology | Diabetes Mellitus, Experimental - pathology | Glucagon - metabolism | Mice | Streptozocin - toxicity | Insulin-Secreting Cells - pathology | Selective Estrogen Receptor Modulators - pharmacology | Islet Studies
Journal Article
PLoS genetics, ISSN 1553-7404, 2013, Volume 9, Issue 1, p. e1003274
Journal Article
Journal of cell science, ISSN 0021-9533, 10/2006, Volume 119, Issue 20, pp. 4199 - 4206
Insulin-secreting pancreatic beta cells are exceptionally rich in zinc. In these cells, zinc is required for zinc-insulin crystallization within secretory vesicles... 
Zinc transport | Langerhans islets | Insulin | Zinc | Beta cell | Insulin secretion | beta cell | ACTIVATION | insulin | GLUCAGON-RELEASE | zinc transport | DEATH | insulin secretion | IDENTIFICATION | CELL BIOLOGY | DIABETES-MELLITUS | SUPPLEMENTATION | PANCREATIC BETA-CELLS | MICE | MEMBRANE-PROTEINS | zinc | FLUORESCENT-PROBE | Islets of Langerhans - drug effects | Gene Expression - drug effects | Zinc Transporter 8 | Gene Expression - genetics | Zinc - metabolism | Humans | Secretory Vesicles - metabolism | Cation Transport Proteins - physiology | Male | Green Fluorescent Proteins - genetics | Recombinant Fusion Proteins - metabolism | Dose-Response Relationship, Drug | Insulin-Secreting Cells - metabolism | Cation Transport Proteins - metabolism | Islets of Langerhans - metabolism | Islets of Langerhans - cytology | Cation Transport Proteins - genetics | Biological Transport - drug effects | Cell Membrane - metabolism | Insulin-Secreting Cells - cytology | Insulin Secretion | Cell Membrane - drug effects | Cell Line | Cell Survival - drug effects | Green Fluorescent Proteins - metabolism | Glucose - pharmacology | Microscopy, Confocal | Insulin - metabolism | Animals | Insulin-Secreting Cells - drug effects | Models, Biological | Secretory Vesicles - drug effects | Recombinant Fusion Proteins - genetics | Glucagon - metabolism | Mice | HeLa Cells | Zinc - pharmacology | Microscopy, Fluorescence | Green Fluorescent Proteins | Cell Membrane | Glucagon | Glucose | Recombinant Fusion Proteins | Life Sciences | Biological Transport | Insulin-Secreting Cells | Gene Expression | Cell Survival | Secretory Vesicles | Cation Transport Proteins | Islets of Langerhans | Hela Cells | Cancer
Journal Article
Nature (London), ISSN 1476-4687, 2010, Volume 464, Issue 7292, pp. 1149 - 1154
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 4/2011, Volume 108, Issue 16, pp. 6380 - 6385
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 12/2015, Volume 10, Issue 12, p. e0144597
The transcription factor Pax6 is an important regulator of development and cell differentiation in various organs... 
IDENTITY | ALPHA-CELLS | MOUSE PANCREAS | MULTIDISCIPLINARY SCIENCES | BETA-CELLS | INSULIN-SECRETION | 7B2 | MICE | ENZYMATIC-ACTIVITY | DIFFERENTIATION | EXPRESSION | Paired Box Transcription Factors - genetics | Homeodomain Proteins - metabolism | Somatostatin-Secreting Cells - cytology | Male | Cell Lineage - drug effects | Pancreatic Polypeptide-Secreting Cells - metabolism | Pancreatic Polypeptide-Secreting Cells - cytology | Glucagon-Secreting Cells - drug effects | Insulin-Secreting Cells - metabolism | Gene Expression Regulation, Developmental | Glucagon-Secreting Cells - metabolism | Somatostatin-Secreting Cells - drug effects | Female | Integrases - metabolism | Cell Differentiation | Insulin-Secreting Cells - cytology | Eye Proteins - genetics | Insulin - genetics | Cell Lineage - genetics | Genes, Reporter | Repressor Proteins - metabolism | Glucagon-Secreting Cells - cytology | Signal Transduction | Bacterial Proteins - genetics | Ghrelin - genetics | Repressor Proteins - genetics | PAX6 Transcription Factor | Pancreatic Polypeptide-Secreting Cells - drug effects | Homeodomain Proteins - genetics | Mice, Knockout | Ghrelin - metabolism | Insulin - metabolism | Animals | Eye Proteins - metabolism | Insulin-Secreting Cells - drug effects | Tamoxifen - pharmacology | Bacterial Proteins - metabolism | Luminescent Proteins - genetics | Mice | Integrases - genetics | Somatostatin-Secreting Cells - metabolism | Paired Box Transcription Factors - metabolism | Crosses, Genetic | Luminescent Proteins - metabolism | Care and treatment | Research | Glucagon | Pancreas | Ghrelin | Risk factors | Spinal cord | Cerebral cortex | Transcription factors | Deactivation | Maturation | Developmental biology | Genes | Organs | Glucose | Kinases | Cell differentiation | Inactivation | Insulin | Proteins | Pax6 protein | Rodents | Diabetes | Alzheimers disease | Life Sciences | Development Biology
Journal Article
Cell stem cell, ISSN 1934-5909, 2016, Volume 18, Issue 6, pp. 755 - 768
Journal Article
Diabetologia, ISSN 1432-0428, 2017, Volume 60, Issue 8, pp. 1454 - 1466
Pancreatic beta-like cells generated from human induced pluripotent stem cells (hiPSCs) or human embryonic stem cells... 
BMP4 | Medicine & Public Health | Human Physiology | Metabolic Diseases | Beta-like cells | Sodium cromoglicate | Internal Medicine | Insulin–neurogenin 3 | Small molecule | Human iPSC | PROGENITOR CELLS | ANTIALLERGIC DRUGS | HUMAN IPS CELLS | BETA-CELLS | MAST-CELLS | Insulin-neurogenin 3 | PLURIPOTENT STEM-CELLS | ISLET TRANSPLANTATION | IN-VITRO | DISODIUM-CROMOGLYCATE | ENDOCRINOLOGY & METABOLISM | INSULIN-PRODUCING CELLS | Embryonic Stem Cells - metabolism | Induced Pluripotent Stem Cells - drug effects | Homeodomain Proteins - metabolism | Humans | Pancreas - cytology | Male | Pancreas - metabolism | Bone Morphogenetic Protein 4 - metabolism | Insulin-Secreting Cells - metabolism | Animals | Cromolyn Sodium - pharmacology | Embryonic Stem Cells - drug effects | Insulin-Secreting Cells - drug effects | Cell Differentiation - drug effects | Trans-Activators - metabolism | Insulin-Secreting Cells - cytology | Mice | Induced Pluripotent Stem Cells - cytology | Induced Pluripotent Stem Cells - metabolism | Embryonic stem cells | Bone morphogenetic proteins | Analysis | Explants | Cell culture | Bone morphogenetic protein 4 | Embryo cells | Stem cell transplantation | Gene expression | Ribonucleic acid--RNA | Insulin | Neurogenin 3 | Neurogenin | Homeobox | Sodium | Rodents | Stem cells | Pancreas | Growth factors | Pluripotency | Inhibitory postsynaptic potentials
Journal Article
Journal Article