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1. Full Text Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells
by Xian, Lingling and Wu, Xiangwei and Pang, Lijuan and Lou, Michael and Rosen, Clifford J and Qiu, Tao and Crane, Janet and Frassica, Frank and Zhang, Liming and Rodriguez, Juan Pablo and Jia, Xiaofeng and Yakar, Shoshana and Xuan, Shouhong and Efstratiadis, Argiris and Wan, Mei and Cao, Xu
Nature Medicine, ISSN 1078-8956, 07/2012, Volume 18, Issue 7, pp. 1095 - 1101
Insulin-like growth factor 1 (IGF-1), the most abundant growth factor in the bone matrix, maintains bone mass in adulthood. We now report that IGF-1 released... 
MEDICINE, RESEARCH & EXPERIMENTAL | LIFE-SPAN | PHYSIOLOGY | RESORPTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | OSTEOPOROSIS | CELL BIOLOGY | INSULIN-RECEPTOR | OSTEOBLAST PROGENITORS | RELEVANCE | FRACTURES | POSTMENOPAUSAL WOMEN | GROWTH-FACTOR-I | Bone Matrix - metabolism | Immunohistochemistry | Mesenchymal Stromal Cells - enzymology | Bone and Bones - pathology | Receptor, IGF Type 1 - metabolism | Insulin-Like Growth Factor I - pharmacology | Femur - pathology | TOR Serine-Threonine Kinases - metabolism | Cell Count | Humans | Aging - drug effects | Insulin-Like Growth Factor Binding Protein 3 - pharmacology | Phosphatidylinositol 3-Kinases - metabolism | Femur - diagnostic imaging | Insulin Receptor Substrate Proteins - metabolism | X-Ray Microtomography | Bone and Bones - drug effects | Insulin-Like Growth Factor Binding Protein 3 - metabolism | Bone Matrix - drug effects | Bone and Bones - metabolism | Insulin-Like Growth Factor I - administration & dosage | Bone Resorption - metabolism | Insulin-Like Growth Factor Binding Protein 3 - administration & dosage | Receptor, IGF Type 1 - deficiency | Proto-Oncogene Proteins c-akt - metabolism | Femur - growth & development | Mesenchymal Stromal Cells - drug effects | Bone Resorption - blood | Osteoblasts - enzymology | Osteoblasts - drug effects | Osteogenesis - drug effects | Rats | Enzyme Activation - drug effects | Mice, Knockout | Bone Resorption - diagnostic imaging | Osteoblasts - pathology | Organ Size - drug effects | Animals | Cell Differentiation - drug effects | Bone Resorption - pathology | Mice | Mesenchymal Stromal Cells - pathology | Insulin-Like Growth Factor I - metabolism | Aging - metabolism | Physiological aspects | Research | Insulin-like growth factor 1 | Protein kinases | Stem cells | Bone marrow | Insulin-like growth factors
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2. Full Text MicroRNA-7 targets IGF1R (insulin-like growth factor 1 receptor) in tongue squamous cell carcinoma cells
by Jiang, Lu and Liu, Xiqiang and Chen, Zujian and Jin, Yi and Heidbreder, Caroline E and Kolokythas, Antonia and Wang, Anxun and Dai, Yang and Zhou, Xiaofeng
Biochemical Journal, ISSN 0264-6021, 2010, Volume 432, Issue 1, pp. 199 - 205
miR-7 (microRNA-7) has been characterized as a tumour suppressor in several human cancers. It targets a number of proto-oncogenes that contribute to cell... 
Akt (protein kinase B) | Tongue squamous cell carcinoma (TSCC) | microRNA-7 (miR-7) | Tumour suppressor | Insulin-like growth factor 1 receptor (IGF1R) | Proliferation | proliferation | tumour suppressor | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | DISMUTASE 2 SOD2 | INVASION | insulin-like growth factor 1 receptor (IGF1R) | PATHWAY | tongue squamous cell carcinoma (TSCC) | GENE-EXPRESSION | CANCER STATISTICS | Receptor, IGF Type 1 - metabolism | Insulin-Like Growth Factor I - pharmacology | Luciferases - metabolism | Apoptosis - drug effects | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Gene Expression Regulation, Neoplastic | 3' Untranslated Regions - genetics | RNA, Messenger - metabolism | Luciferases - genetics | Transfection | Base Sequence | Proto-Oncogene Proteins c-akt - metabolism | Tongue Neoplasms - metabolism | Tongue Neoplasms - genetics | Down-Regulation | RNA, Messenger - genetics | Binding Sites - genetics | Enzyme Activation - drug effects | Reverse Transcriptase Polymerase Chain Reaction | Receptor, IGF Type 1 - genetics | Tongue Neoplasms - pathology | Blotting, Western | Cell Line, Tumor | Cell Proliferation - drug effects | MicroRNAs - genetics | Cell Cycle - drug effects
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3. Full Text MicroRNA-497 targets insulin-like growth factor 1 receptor and has a tumour suppressive role in human colorectal cancer
by Guo, S.T and Jiang, C.C and Wang, G.P and Li, Y.P and Wang, C.Y and Guo, X.Y and Yang, R.H and Feng, Y and Wang, F.H and Tseng, H.-Y and Thorne, R.F and Jin, L and Zhang, X.D
Oncogene, ISSN 0950-9232, 04/2013, Volume 32, Issue 15, pp. 1910 - 1920
Past studies have shown that amplified insulin-like growth factor 1 (IGF1)/IGF1 receptor (IGF1-R) signalling has an important role in colorectal cancer (CRC)... 
colorectal cancer | Akt | IGF1-R | copy number variations | miR-497 | APOPTOSIS | CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | IGF-1 | EXPRESSION PROFILES | IGF1R | CELL BIOLOGY | INHIBITION | ONCOLOGY | GENES | GENETICS & HEREDITY | FACTOR-I-RECEPTOR | MUTATIONS | Receptor, IGF Type 1 - metabolism | Cell Proliferation | Colorectal Neoplasms - genetics | Down-Regulation | Humans | Gene Expression Regulation, Neoplastic | Cell Survival - genetics | Apoptosis - genetics | MicroRNAs - metabolism | Signal Transduction - genetics | Cisplatin - pharmacology | Disease Progression | DNA Copy Number Variations | Drug Resistance, Neoplasm - genetics | Cell Line, Tumor | Fluorouracil - pharmacology | MicroRNAs - genetics | 3' Untranslated Regions | Neoplasm Invasiveness - genetics | Proto-Oncogene Proteins c-akt - metabolism | Phosphatidylinositol 3-Kinase - metabolism | Colorectal Neoplasms - metabolism | Insulin-Like Growth Factor I - metabolism | Care and treatment | MicroRNA | Colorectal cancer | Development and progression | Genetic aspects | Cellular signal transduction | Research | Health aspects | Insulin-like growth factor 1 | Risk factors | Insulin-like growth factors | Ribonucleic acid--RNA | Neurons | Tumors | Original
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4. Full Text Elevated insulin‐like growth factor‐1 in Cushing’s disease
by English, Katherine and Chikani, Viral and Dimeski, Goce and Inder, Warrick J
Clinical Endocrinology, ISSN 0300-0664, 07/2019, Volume 91, Issue 1, pp. 141 - 147
ObjectiveTo determine if patients with untreated Cushing's disease have higher serum insulin‐like growth factor‐1 (IGF‐1) compared to matched controls, and if... 
cortisol | glucocorticoids | pituitary diseases | insulin‐like growth factor 1 | Cushing's disease | Nervous system diseases | Pituitary hormones | Diabetes mellitus | Insulin-like growth factors | Adenoma | Insulin | Body mass index | Adrenocorticotropic hormone | Pituitary | Horses | Remission | Growth hormone | Growth factors
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5. Full Text Insulin-Like Growth Factor 1 Alleviates High-Fat Diet–Induced Myocardial Contractile Dysfunction: Role of Insulin Signaling and Mitochondrial Function
by Zhang, Yingmei and Yuan, Ming and Bradley, Katherine M and Dong, Feng and Anversa, Piero and Ren, Jun
Hypertension, ISSN 0194-911X, 03/2012, Volume 59, Issue 3, pp. 680 - 693
Obesity is often associated with reduced plasma insulin-like growth factor 1 (IGF-1) levels, oxidative stress, mitochondrial damage, and cardiac dysfunction.... 
mitochondrial function | IGF-1 | insulin signaling | heart | high fat | oxidative stress | NADPH OXIDASE | HEART-FAILURE | FACTOR-I | VENTRICULAR MYOCYTES | CARDIAC OVEREXPRESSION | PPAR-GAMMA | PERIPHERAL VASCULAR DISEASE | TNF-ALPHA | TRANSCRIPTION FACTOR | INDUCED OBESITY | Insulin-Like Growth Factor I - pharmacology | Immunoprecipitation | Mitochondria, Heart - metabolism | Oxidative Stress | Mitochondria, Heart - pathology | Cardiomegaly - drug therapy | Cells, Cultured | Cardiomegaly - physiopathology | Diet, Atherogenic - adverse effects | Myocardial Contraction - drug effects | Male | Mice, Transgenic | Blotting, Western | Myocytes, Cardiac - pathology | Animals | Myocytes, Cardiac - drug effects | Signal Transduction - drug effects | Myocytes, Cardiac - metabolism | Mice | Apoptosis | Cardiomegaly - metabolism | Disease Models, Animal
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6. Full Text Insulin-like growth factor 1 modulates bioengineered tooth morphogenesis
by Oyanagi, Toshihito and Takeshita, Nobuo and Hara, Mamiko and Ikeda, Etsuko and Chida, Toko and Seki, Daisuke and Yoshida, Michiko and Seiryu, Masahiro and Takano, Ikuko and Kimura, Seiji and Oshima, Masamitsu and Tsuji, Takashi and Takano-Yamamoto, Teruko
Scientific Reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 368 - 15
Regenerative therapy to replace missing teeth is a critical area of research. Functional bioengineered teeth have been produced by the organ germ method using... 
IGF-I | STEM-CELLS | HORMONE | PROTEIN | MULTIDISCIPLINARY SCIENCES | DISTINCT | FACTOR-I | BONE | EXPRESSION | ORGAN | ENAMEL KNOT | Morphogenesis | Cell proliferation | Fibroblast growth factor | Germ cells | Dental enamel | Mesenchyme | Insulin-like growth factor I | Enamel | Teeth | Insulin-like growth factors | Insulin | Fibroblast growth factor 4
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7. Full Text A novel cardiomyocyte-enriched MicroRNA, miR-378, targets insulin-like growth factor 1 receptor: Implications in postnatal cardiac remodeling and cell survival
by Knezevic, Ivana and Patel, Aalok and Sundaresan, Nagalingam R and Gupta, Mahesh P and Solaro, R. John and Nagalingam, Raghu S and Gupta, Madhu
Journal of Biological Chemistry, ISSN 0021-9258, 04/2012, Volume 287, Issue 16, pp. 12913 - 12926
Postnatal cardiac remodeling is characterized by a marked decrease in the insulin-like growth factor 1 (IGF1) and IGF1 receptor (IGF1R) expression. The... 
MYOCYTE APOPTOSIS | OVEREXPRESSION | HYPERTROPHY | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACUTE MYOCARDIAL-INFARCTION | FAILING HUMAN HEART | DILATED CARDIOMYOPATHY | EXPRESSION | FAILURE | TRANSGENIC MICE | Receptor, IGF Type 1 - metabolism | Heart - physiology | Molecular Sequence Data | MicroRNAs - metabolism | Hypoxia - metabolism | Base Sequence | Up-Regulation - physiology | Ventricular Remodeling - genetics | Proto-Oncogene Proteins c-akt - metabolism | Cell Survival - physiology | Gene Expression Regulation, Developmental - physiology | Stress, Physiological - physiology | Myocytes, Cardiac - cytology | Heart - growth & development | Cells, Cultured | Rats | Rats, Sprague-Dawley | Hypoxia - genetics | Animals | Myocytes, Cardiac - physiology | Hypoxia - physiopathology | Signal Transduction - physiology | Mice | MicroRNAs - genetics | Apoptosis - physiology | Gene Regulation | Aging | Cardiac Muscle | MicroRNA | Insulin-like Growth Factor (IGF) | Apoptosis
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8. Full Text Insulinlike Growth Factor 1 Gene Variation in Vertebrates
by Rotwein, Peter
Endocrinology, ISSN 0013-7227, 06/2018, Volume 159, Issue 6, pp. 2288 - 2305
IGF1-a small, single-chain, secreted peptide in mammals-is essential for normal somatic growth and is involved in a variety of other physiological and... 
MESSENGER-RNAS | BODY-WEIGHT | IGF-I | FACTOR-I GENE | BINDING-PROTEIN-DELTA | PROMOTER ELEMENTS | POSTNATAL-GROWTH | ENDOCRINOLOGY & METABOLISM | FUNCTIONAL-ANALYSIS | CARCASS TRAITS | WHOLE-GENOME DUPLICATION | Genetic Variation | Promoter Regions, Genetic | Animals | Vertebrates - classification | Vertebrates - genetics | Exons | Introns | Humans | Insulin-Like Growth Factor I - genetics | Sequence Analysis, DNA | Evolution, Molecular | Reptiles | Insulin-like growth factor I | Igf1 gene | Genes | Gene regulation | Biological evolution | Birds | Homology | Regulatory sequences | Mammals | Kinases | Gene expression | Proteins | Vertebrates | Enhancers | Protein kinase | Janus kinase 2 | Growth hormone | Growth factors
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9. Full Text Insulin-like growth factor 1 receptor and response to anti-IGF1R antibody therapy in osteosarcoma
by Cao, Yu and Roth, Michael and Piperdi, Sajida and Montoya, Kristofer and Sowers, Rebecca and Rao, Pulivarthi and Geller, David and Houghton, Peter and Kolb, E. Anders and Gill, Jonathan and Gorlick, Richard
PLoS ONE, ISSN 1932-6203, 08/2014, Volume 9, Issue 8, p. e106249
Background: Survival outcomes for patients with osteosarcoma (OS) have remained stagnant over the past three decades. Insulin-like growth factor 1 receptor... 
BREAST-CANCER | FIGITUMUMAB | PREDICTORS | MULTIDISCIPLINARY SCIENCES | IMATINIB | IGF-BINDING PROTEIN-3 | PHASE-II | RISK | MONOCLONAL-ANTIBODY | FACTOR-I RECEPTOR | CHEMOTHERAPY | Osteosarcoma - drug therapy | Receptor, IGF Type 1 - antagonists & inhibitors | Neoplasm Proteins - biosynthesis | Humans | Male | Neoplasm Proteins - antagonists & inhibitors | Receptor, IGF Type 1 - biosynthesis | Mice, SCID | Xenograft Model Antitumor Assays | RNA, Messenger - biosynthesis | Animals | Antibodies, Neoplasm - pharmacology | RNA, Neoplasm - biosynthesis | Cell Line, Tumor | Female | Antineoplastic Agents - pharmacology | Mice | Gene Expression Regulation, Neoplastic - drug effects | Osteosarcoma - metabolism | Osteosarcoma - pathology | Cell proliferation | Therapy | Pediatrics | Biotechnology | Flow cytometry | Copy number | Exons | Leukemia | Xenotransplantation | Colorectal cancer | Antibodies | Clinical trials | Oncology | Insulin-like growth factors | Metastasis | Kinases | Bone surgery | Cancer therapies | Cell surface | Osteosarcoma | Immunotherapy | Xenografts | Biocompatibility | Bioindicators | Medical research | Hematology | Breast cancer | Gene expression | Insulin | Patients | Medicine | Cytometry | Bone cancer | Hospitals | Medical prognosis | Cell lines | Biomarkers | Mutation | Tumors | Apoptosis
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10. Full Text Insulin-like growth factor 1 (IGF-1) stabilizes nascent blood vessels
by Jacobo, Sarah Melissa P and Kazlauskas, Andrius
Journal of Biological Chemistry, ISSN 0021-9258, 03/2015, Volume 290, Issue 10, pp. 6349 - 6360
Here we report that VEGF-A and IGF-1 differ in their ability to stabilize newly formed blood vessels and endothelial cell tubes. Although VEGF-A failed to... 
RETINAL NEOVASCULARIZATION | DIABETIC-RETINOPATHY | REGRESSION | MIGRATION | ACTIVATION | LYSOPHOSPHATIDIC ACID | ANGIOGENESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOTHELIAL-CELLS | FACTOR-I RECEPTOR | VASCULAR MORPHOGENESIS | Lysophospholipids - administration & dosage | Blood Vessels - growth & development | Retinal Vessels - metabolism | Blood Vessels - metabolism | Insulin-Like Growth Factor I - genetics | Vascular Endothelial Growth Factor A - metabolism | Endothelium, Vascular - growth & development | Vascular Endothelial Growth Factor A - genetics | Cell Movement - genetics | Animals | MAP Kinase Signaling System - drug effects | Endothelium, Vascular - metabolism | Retinal Vessels - growth & development | Mice | Insulin-Like Growth Factor I - metabolism | Neovascularization, Physiologic | Cell Migration | Angiogenesis | Signal Transduction | Vascular Biology | VEGF | LPA | Insulin-like Growth Factor (IGF)
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11. Full Text Serum Insulin-Like Growth Factor 1 and the Risk of Ischemic Stroke: The Framingham Study
by Saber, Hamidreza and Himali, Jayandra J and Beiser, Alexa S and Shoamanesh, Ashkan and Pikula, Aleksandra and Roubenoff, Ronenn and Romero, Jose R and Kase, Carlos S and Vasan, Ramachandran S and Seshadri, Sudha
Stroke, ISSN 0039-2499, 07/2017, Volume 48, Issue 7, pp. 1760 - 1765
BACKGROUND AND PURPOSE—Low insulin-like growth factor 1 (IGF-1) has been associated with increased risk of atherosclerosis and atrial fibrillation in... 
INTIMA-MEDIA THICKNESS | IGF-I | NITRIC-OXIDE SYNTHASE | IGF-1 | MECHANISMS | FACTOR-I | CLINICAL NEUROLOGY | ATRIAL-FIBRILLATION | atrial fibrillation | GLUCOSE | ENDOTHELIAL-CELLS | BINDING PROTEIN-1 | PERIPHERAL VASCULAR DISEASE | risk | insulin resistance | ASSOCIATION | ischemic stroke | Prospective Studies | Follow-Up Studies | Humans | Risk Factors | Stroke - diagnosis | Male | Biomarkers - blood | Massachusetts - epidemiology | Stroke - blood | Insulin Resistance - physiology | Aged, 80 and over | Female | Stroke - epidemiology | Aged | Insulin-Like Growth Factor I - metabolism | Cohort Studies | Risk | Ischemic Stroke | Insulin-resistance
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12. Full Text IP1867B suppresses the insulin-like growth factor 1 receptor (IGF1R) ablating epidermal growth factor receptor inhibitor resistance in adult high grade gliomas
by Mihajluk, K and Simms, C and Reay, M and Madureira, P.A and Howarth, A and Murray, P and Nasser, S and Duckworth, C.A and Pritchard, D.M and Pilkington, G.J and Hill, R
Cancer Letters, ISSN 0304-3835, 08/2019, Volume 458, pp. 29 - 38
High grade gliomas (HGGs) are aggressive primary brain tumours with local invasive growth and poor clinical prognosis. Clinical outcome is compounded by... 
Drug repurposing | Adult high grade glioma | IGFR1 | EGFR | SURVIVAL | GLIOBLASTOMA-MULTIFORME | ASPIRIN | TUMORS | ADJUVANT TEMOZOLOMIDE | THERAPY | ONCOLOGY | CONCOMITANT | CENTRAL-NERVOUS-SYSTEM | RADIOTHERAPY | Aspirin | Epidermal growth factor | Gliomas | Analysis | Brain tumors | Therapeutics | Physiological aspects | Research institutes | Homeopathy | Materia medica and therapeutics | Brain | Cell culture | Transcription | Insulin-like growth factor I | Brain cancer | Kinases | Cancer therapies | Interleukin 6 | Proteins | Reduction | Blood-brain barrier | DNA methylation | Lesions | Growth factors | Drug dosages | Deoxyribonucleic acid--DNA | Medical research | NF-κB protein | Data analysis | Epidermal growth factor receptors | Stat3 protein | Radiation therapy | Insulin | Resistance factors | Ablation | Patients | Sensitivity | Brain research | Inhibitors | Biopsy | Ligands | Tumors
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13. Full Text Insulin-Like Growth Factor 1 Receptor Is a Potential Therapeutic Target for Gastrointestinal Stromal Tumors
by Chi Tarn and Lori Rink and Erin Merkel and Douglas Flieder and Harsh Pathak and Daphne Koumbi and Joseph R. Testa and Burton Eisenberg and Margaret von Mehren and Andrew K. Godwin
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2008, Volume 105, Issue 24, pp. 8387 - 8392
A subset of gastrointestinal stromal tumors (GISTs) lack gain-of-function mutations in c-KIT and PDGFRα. These so-called wild-type (WT) GISTs tend to be less... 
Pediatrics | Receptors | Gastrointestinal stromal tumors | Somatomedins | Exons | Cell lines | Genetic mutation | Summarization | Tumors | Cancer | Imatinib mesylase | Adult wild-type GIST | Pediatric GIST | NYP-AEW541 | Tyrosine kinase inhibitors | CARCINOMA CELLS | MULTIDISCIPLINARY SCIENCES | adult wild-type GIST | C-KIT | FACTOR-I | ANTITUMOR-ACTIVITY | pediatric GIST | tyrosine kinase inhibitors | BREAST-CANCER | GROWTH-FACTOR RECEPTOR | imatinib mesylase | COPY NUMBER CHANGES | TYROSINE KINASE INHIBITOR | EXPRESSION | IMATINIB MESYLATE | Gastrointestinal Stromal Tumors - enzymology | RNA, Small Interfering - genetics | Receptor, IGF Type 1 - metabolism | Receptor, IGF Type 1 - antagonists & inhibitors | Humans | Gene Expression Regulation, Neoplastic | Antineoplastic Agents - therapeutic use | Mitogen-Activated Protein Kinase Kinases - metabolism | DNA Mutational Analysis | Proto-Oncogene Proteins c-kit - genetics | Antineoplastic Agents - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Pyrroles - therapeutic use | Gastrointestinal Stromal Tumors - genetics | Signal Transduction | Gene Silencing | Piperazines - therapeutic use | Pyrimidines - pharmacology | Imatinib Mesylate | Piperazines - pharmacology | Receptor, IGF Type 1 - genetics | Pyrroles - pharmacology | Gene Amplification | Gastrointestinal Stromal Tumors - drug therapy | Pyrimidines - therapeutic use | Receptor, Platelet-Derived Growth Factor alpha - genetics | Cell Line, Tumor | Cell Proliferation - drug effects | Benzamides | Mutation | Apoptosis | Immunohistochemistry | Prevention | Usage | Care and treatment | Gastrointestinal tumors | Genetic aspects | Research | Insulin-like growth factor 1 | Health aspects | Methods | Risk factors | Biological Sciences
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