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Science, ISSN 0036-8075, 7/2004, Volume 305, Issue 5683, pp. 528 - 532
We describe the efficacy of L-870812, an inhibitor of HIV-1 and SIV integrase, in rhesus macaques infected with the simian-human immunodeficiency virus (SHIV)... 
Antiretrovirals | Animals | Viremia | Antivirals | Viruses | Reports | Infections | Cellular immunity | Integrase inhibitors | Viral load | HIV 1 | CELLS | HIV | MULTIDISCIPLINARY SCIENCES | ACTIVE ANTIRETROVIRAL THERAPY | TRANSCRIPTION | IMMUNODEFICIENCY-VIRUS TYPE-1 | RESISTANCE | Anti-HIV Agents - pharmacology | HIV Integrase Inhibitors - pharmacology | Integrase Inhibitors - blood | Drug Resistance, Viral | Integrase Inhibitors - pharmacology | Macaca mulatta | HIV Integrase - metabolism | HIV Integrase Inhibitors - administration & dosage | Leukocytes, Mononuclear - virology | Viral Load | Anti-HIV Agents - administration & dosage | CD4-Positive T-Lymphocytes - immunology | Acquired Immunodeficiency Syndrome - immunology | Simian Acquired Immunodeficiency Syndrome - virology | Simian Immunodeficiency Virus - genetics | HIV-1 - physiology | Anti-HIV Agents - therapeutic use | Integrases - metabolism | Anti-HIV Agents - blood | Integrase Inhibitors - therapeutic use | Acquired Immunodeficiency Syndrome - virology | Naphthyridines - blood | Virus Replication - drug effects | HIV-1 - drug effects | Cells, Cultured | CD4 Lymphocyte Count | Viremia - drug therapy | HIV-1 - genetics | Acquired Immunodeficiency Syndrome - drug therapy | Simian Immunodeficiency Virus - enzymology | Simian Immunodeficiency Virus - physiology | HIV Integrase - genetics | Integrase Inhibitors - administration & dosage | Simian Acquired Immunodeficiency Syndrome - drug therapy | Simian Acquired Immunodeficiency Syndrome - immunology | Naphthyridines - therapeutic use | HIV Integrase Inhibitors - therapeutic use | HIV Integrase Inhibitors - blood | HIV-1 - enzymology | Mutation | CD8-Positive T-Lymphocytes - immunology | Immunity, Cellular | Integrases - genetics | Naphthyridines - administration & dosage | Simian Immunodeficiency Virus - drug effects | Naphthyridines - pharmacology | Physiological aspects | Research | HIV (Viruses) | Drug therapy | Chemotherapy | Immunology | Monkeys & apes | Human immunodeficiency virus--HIV | Immune system | Index Medicus
Journal Article
PLoS Pathogens, ISSN 1553-7366, 07/2009, Volume 5, Issue 7, pp. e1000515 - e1000515
Journal Article
2011, 1. Aufl., Wiley series in drug discovery and development, ISBN 9781118015377, xiii, 506 p., [16] p. of plates
This book comprehensively covers the mechanisms of action and inhibitor design for HIV-1 integrase. It serves as a resource for scientists facing challenging... 
Antiviral agents | HIV Integrase | Enzymes | Inhibitors | Drug Design | pharmacology | HIV (Viruses) | HIV Integrase Inhibitors | Science | Chemistry | Industrial & Technical
Book
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2012, Volume 287, Issue 25, pp. 21189 - 21203
Journal Article
Journal Article