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Nature cell biology, ISSN 1476-4679, 2010, Volume 12, Issue 3, pp. 299 - 305
For most types of cancers, the cell at the origin of tumour initiation is still unknown. Here, we used mouse genetics to identify cells at the origin of basal... 
POPULATION | STEM-CELLS | SONIC HEDGEHOG | EPIDERMIS | HAIR FOLLICLE BULGE | KERATINOCYTES | CANCER | EXPRESSION | HUMAN HOMOLOG | MOUSE SKIN | CELL BIOLOGY | Epithelial Cells - metabolism | Cadherins - metabolism | Receptors, G-Protein-Coupled - metabolism | Skin - metabolism | Cell Count | Ear, External - pathology | Integrin beta4 - metabolism | Tail - pathology | Hair Follicle - pathology | Hedgehog Proteins - genetics | Neoplastic Stem Cells - metabolism | Kruppel-Like Transcription Factors - metabolism | Smoothened Receptor | Neoplastic Stem Cells - pathology | Cell Differentiation | Patched Receptors | Skin - pathology | Keratin-10 - metabolism | Epidermis - metabolism | Epidermis - pathology | RNA, Untranslated | Bacterial Proteins - genetics | Receptors, Cell Surface - metabolism | Epithelial Cells - pathology | Genes, Reporter - genetics | Mice, Transgenic | Carcinoma, Basal Cell - pathology | Mice, Inbred Strains | Clone Cells - metabolism | Keratin-14 - genetics | Carcinoma, Basal Cell - metabolism | Keratin-15 - metabolism | Keratin-19 - genetics | Proteins - genetics | Cell Lineage | Animals | Clone Cells - pathology | Proteins - metabolism | Models, Biological | Hair Follicle - metabolism | Bacterial Proteins - metabolism | Luminescent Proteins - genetics | Mice | Receptors, G-Protein-Coupled - genetics | Integrases - genetics | Keratin-15 - genetics | Luminescent Proteins - metabolism | Basal cell carcinoma | Stem cells | Genetic aspects | Cellular signal transduction | Research | Health aspects | Risk factors
Journal Article
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 2014, Volume 146, Issue 7, pp. 1784 - 1794.e6
Background & Aims Premalignant lesions and early stage tumors contain immunosuppressive microenvironments that create barriers for cancer vaccines. Kras G12D/+... 
Gastroenterology and Hepatology | Tumor Microenvironment | Pancreatic Cancer | Listeria Vaccine | Immunity | MONOCYTOGENES | DUCTAL ADENOCARCINOMA | ONCOGENIC KRAS | CANCER | TUMORS | ADOPTIVE TRANSFER | IMMUNOTHERAPY | MOUSE MODEL | TC17 CELLS | SUPPRESSOR-CELLS | GASTROENTEROLOGY & HEPATOLOGY | Pancreatic Neoplasms - metabolism | Proto-Oncogene Proteins p21(ras) - genetics | Homeodomain Proteins - metabolism | Humans | Carcinoma, Pancreatic Ductal - metabolism | Interferon-gamma - metabolism | Mice, 129 Strain | Carcinoma, Pancreatic Ductal - genetics | T-Lymphocytes, Regulatory - immunology | Cancer Vaccines - therapeutic use | Carcinoma in Situ - genetics | Time Factors | Forkhead Transcription Factors - metabolism | Listeria monocytogenes - metabolism | Disease Models, Animal | Carcinoma in Situ - pathology | Antibodies, Monoclonal - pharmacology | Pancreatic Neoplasms - pathology | Mice, Transgenic | Disease Progression | Interleukin-17 - metabolism | Cyclophosphamide - pharmacology | Pancreatic Neoplasms - immunology | Mice | Mutation | Carcinoma in Situ - metabolism | T-Lymphocytes, Regulatory - metabolism | Carcinoma in Situ - drug therapy | Carcinoma in Situ - immunology | Listeria monocytogenes - immunology | Tumor Suppressor Protein p53 - genetics | Pancreatic Neoplasms - drug therapy | Inflammation Mediators - metabolism | Trans-Activators - genetics | Integrases - metabolism | Carcinoma, Pancreatic Ductal - immunology | Proto-Oncogene Proteins p21(ras) - metabolism | Mice, Inbred C57BL | Receptors, Chemokine - metabolism | Tumor Suppressor Protein p53 - metabolism | Pancreatic Neoplasms - genetics | Carcinoma, Pancreatic Ductal - pathology | Homeodomain Proteins - genetics | Cancer Vaccines - immunology | Carcinoma, Pancreatic Ductal - drug therapy | Animals | Listeria monocytogenes - genetics | Trans-Activators - metabolism | CD11b Antigen - metabolism | Integrases - genetics | Medical colleges | Vaccines | Listeria | Developmental biology | Pancreatic cancer | Contamination
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2014, Volume 111, Issue 36, pp. 13193 - 13198
Journal Article
Nature communications, ISSN 2041-1723, 2019, Volume 10, Issue 1, pp. 1444 - 1444
Journal Article
Journal Article
Kidney international, ISSN 0085-2538, 2013, Volume 83, Issue 6, pp. 1065 - 1075
Collapsing focal segmental glomerulosclerosis (cFSGS) is a progressive kidney disease characterized by glomerular collapse with epithelial hyperplasia. Here we... 
parietal epithelial cell | focal segmental glomerulosclerosis | podocyte loss | Notch signaling | Focal segmental glomerulosclerosis | Parietal epithelial cell | Podocyte loss | KINASE | MOUSE | NOTCH | SCLEROSIS | RATS | MESENCHYMAL TRANSITION | NEPHRON | PATHWAY | DISEASE | UROLOGY & NEPHROLOGY | TGF-BETA/SMAD | Cell Proliferation | RNA, Untranslated - metabolism | Homeodomain Proteins - metabolism | Humans | Hyperplasia | Transforming Growth Factor beta1 - metabolism | Proteinuria - pathology | RNA, Untranslated - genetics | Dibenzazepines - pharmacology | Basic Helix-Loop-Helix Transcription Factors - metabolism | Time Factors | Serrate-Jagged Proteins | Disease Models, Animal | Jagged-1 Protein | Biomarkers - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Membrane Proteins - genetics | Enzyme Inhibitors - pharmacology | Epithelial Cells - pathology | Mice, Transgenic | Kidney Glomerulus - pathology | Podocytes - pathology | Proteinuria - genetics | Amyloid Precursor Protein Secretases - metabolism | Interleukin-2 Receptor alpha Subunit - metabolism | Claudin-1 - genetics | Mice | Receptor, Notch1 - antagonists & inhibitors | Calcium-Binding Proteins - genetics | Cell Movement | Transcription Factor HES-1 | Epithelial Cells - metabolism | Epithelial Cells - drug effects | Glomerulosclerosis, Focal Segmental - genetics | Intercellular Signaling Peptides and Proteins - metabolism | Interleukin-2 Receptor alpha Subunit - genetics | Claudin-1 - metabolism | Kidney Glomerulus - metabolism | Integrases - metabolism | Membrane Proteins - metabolism | Calcium-Binding Proteins - metabolism | Cell Line | Podocytes - metabolism | Kidney Glomerulus - drug effects | Intercellular Signaling Peptides and Proteins - genetics | Proteinuria - metabolism | Antibodies, Monoclonal | Receptor, Notch1 - metabolism | Homeodomain Proteins - genetics | Glomerulosclerosis, Focal Segmental - metabolism | Animals | Exotoxins | Podocytes - drug effects | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Integrases - genetics | Glomerulosclerosis, Focal Segmental - pathology | Apoptosis
Journal Article
Journal Article
Journal Article
Journal Article
Nature communications, ISSN 2041-1723, 07/2016, Volume 7, Issue 1, p. 12205
Journal Article