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1. Full Text EZH2 is regulated by ERK/AKT and targets integrin alpha2 gene to control Epithelial–Mesenchymal Transition and anoikis in colon cancer cells
by Ferraro, Angelo and Mourtzoukou, Despoina and Kosmidou, Vivian and Avlonitis, Spiros and Kontogeorgos, George and Zografos, George and Pintzas, Alexander
The international journal of biochemistry & cell biology, ISSN 1357-2725, 02/2013, Volume 45, Issue 2, pp. 243 - 254
ITGα2 | Anoikis | Metastasis | EMT | EZH2 | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | RNA, Small Interfering - genetics | Intestinal Mucosa - metabolism | Polycomb Repressive Complex 2 - genetics | Humans | Gene Expression Regulation, Neoplastic | Integrin alpha2 - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Transcription Factor AP-1 - metabolism | Colonic Neoplasms - metabolism | Gene Knockdown Techniques | Epithelial-Mesenchymal Transition | Proto-Oncogene Proteins c-akt - metabolism | Caco-2 Cells | Promoter Regions, Genetic | Cell Survival | HCT116 Cells | Lymphatic Metastasis | Colon - metabolism | Enhancer of Zeste Homolog 2 Protein | Protein Transport | Integrin alpha2 - genetics | Cell Transformation, Neoplastic | Colonic Neoplasms - pathology | Protein Binding | Polycomb Repressive Complex 2 - metabolism | Cell Movement | Care and treatment | Genes | DNA binding proteins | Gene expression | Colon cancer | Messenger RNA | Analysis | Cancer cells | Genetic research | Genetic aspects | Health aspects | Integrins | Cancer | Index Medicus
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2. Full Text Tr1 cells, but not foxp3 + regulatory T cells, suppress NLRP3 inflammasome activation via an IL-10-dependent mechanism
by Yao, Yu and Vent-Schmidt, Jens and McGeough, Matthew D and Wong, May and Hoffman, Hal M and Steiner, Theodore S and Levings, Megan K
The Journal of immunology (1950), ISSN 0022-1767, 07/2015, Volume 195, Issue 2, pp. 488 - 497
Life Sciences & Biomedicine | Immunology | Science & Technology | Forkhead Transcription Factors - immunology | Antigens, CD - immunology | NLR Family, Pyrin Domain-Containing 3 Protein | Coculture Techniques | Adoptive Transfer | Interleukin-1beta - genetics | Antigens, CD - genetics | T-Lymphocytes, Regulatory - immunology | Adenosine Triphosphate - pharmacology | Inflammasomes - drug effects | Bone Marrow Cells - immunology | T-Lymphocytes, Regulatory - cytology | Bone Marrow Cells - drug effects | Cell Differentiation | Transcription Factors - immunology | Carrier Proteins - immunology | Macrophages - immunology | Proto-Oncogene Proteins c-maf - immunology | Signal Transduction | Bone Marrow Cells - cytology | Mice, Inbred C57BL | Proto-Oncogene Proteins c-maf - genetics | Gene Expression Regulation | Receptors, Aryl Hydrocarbon - genetics | Interleukin-1beta - immunology | Mice, Transgenic | Macrophages - cytology | Transcription Factors - genetics | Forkhead Transcription Factors - genetics | Inflammasomes - genetics | Carrier Proteins - genetics | T-Lymphocytes, Regulatory - drug effects | Animals | Integrin alpha2 - genetics | Inflammasomes - immunology | Interleukin-10 - genetics | Integrin alpha2 - immunology | Lipopolysaccharides - pharmacology | Macrophages - drug effects | Mice | Mice, Inbred BALB C | T-Lymphocytes, Regulatory - transplantation | Interleukin-10 - immunology | Receptors, Aryl Hydrocarbon - immunology | Positive Regulatory Domain I-Binding Factor 1 | Index Medicus | Abridged Index Medicus
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3. Full Text Genome‐wide DNA methylation patterns in pancreatic ductal adenocarcinoma reveal epigenetic deregulation of SLIT‐ROBO, ITGA2 and MET signaling
by Nones, Katia and Waddell, Nic and Song, Sarah and Patch, Ann‐Marie and Miller, David and Johns, Amber and Wu, Jianmin and Kassahn, Karin S and Wood, David and Bailey, Peter and Fink, Lynn and Manning, Suzanne and Christ, Angelika N and Nourse, Craig and Kazakoff, Stephen and Taylor, Darrin and Leonard, Conrad and Chang, David K and Jones, Marc D and Thomas, Michelle and Watson, Clare and Pinese, Mark and Cowley, Mark and Rooman, Ilse and Pajic, Marina and Butturini, Giovanni and Malpaga, Anna and Corbo, Vincenzo and Crippa, Stefano and Falconi, Massimo and Zamboni, Giuseppe and Castelli, Paola and Lawlor, Rita T and Gill, Anthony J and Scarpa, Aldo and Pearson, John V and Biankin, Andrew V and Grimmond, Sean M and APGI
International journal of cancer, ISSN 0020-7136, 09/2014, Volume 135, Issue 5, pp. 1110 - 1118
SLIT‐ROBO pathway | stellate cell activation | pancreatic cancer | axon‐guidance | methylation | SLIT-ROBO pathway | axon-guidance | Life Sciences & Biomedicine | Oncology | Science & Technology | Gastroenterology. Liver. Pancreas. Abdomen | Biological and medical sciences | Multiple tumors. Solid tumors. Tumors in childhood (general aspects) | Medical sciences | Liver. Biliary tract. Portal circulation. Exocrine pancreas | Tumors | Epigenesis, Genetic | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Male | Gene Expression Profiling | Pancreatic Ducts - pathology | Integrins - metabolism | Promoter Regions, Genetic - genetics | Carcinoma, Pancreatic Ductal - genetics | RNA, Messenger - biosynthesis | DNA Methylation | Wnt Proteins - genetics | Base Sequence | Aged, 80 and over | Adult | Female | Pancreatic Stellate Cells - pathology | Cell Adhesion - genetics | Membrane Proteins - genetics | Intercellular Signaling Peptides and Proteins - genetics | Pancreatic Neoplasms - genetics | Signal Transduction - genetics | Nerve Tissue Proteins - genetics | Sequence Analysis, DNA | Proto-Oncogene Proteins c-met - genetics | Transforming Growth Factor beta - genetics | Integrin alpha2 - genetics | Aged | Receptors, Immunologic - genetics | Epigenetic inheritance | RNA | Genomics | Genomes | Gene expression | Promoters (Genetics) | Analysis | Pancreatic cancer | DNA | Genetic research | Bone morphogenetic proteins | Genetic aspects | Methylation | Integrins | Cancer | DNA methylation | Epigenetics | Deoxyribonucleic acid--DNA | Index Medicus
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4. Full Text Dicer1-mediated miRNA processing shapes the mRNA profile and function of murine platelets
by Rowley, Jesse W and Chappaz, Stéphane and Corduan, Aurélie and Chong, Mark M. W and Campbell, Robert and Khoury, Amanda and Manne, Bhanu Kanth and Wurtzel, Jeremy G. T and Michael, James V and Goldfinger, Lawrence E and Mumaw, Michele M and Nieman, Marvin T and Kile, Benjamin T and Provost, Patrick and Weyrich, Andrew S
Blood, ISSN 0006-4971, 04/2016, Volume 127, Issue 14, pp. 1743 - 1751
Life Sciences & Biomedicine | Hematology | Science & Technology | Pulmonary Embolism - genetics | Argonaute Proteins - metabolism | Argonaute Proteins - genetics | Ribonuclease III - genetics | Ribonuclease III - metabolism | Humans | RNA, Messenger - genetics | MicroRNAs - metabolism | RNA Processing, Post-Transcriptional - physiology | RNA, Messenger - metabolism | Integrin beta3 - biosynthesis | Mice, Knockout | DEAD-box RNA Helicases - genetics | Animals | Integrin alpha2 - genetics | Blood Platelets - metabolism | Integrin beta3 - genetics | Mice | MicroRNAs - genetics | Pulmonary Embolism - chemically induced | DEAD-box RNA Helicases - metabolism | Integrin alpha2 - biosynthesis | Pulmonary Embolism - metabolism | Index Medicus | Abridged Index Medicus | Plenary Paper
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5. Full Text Autocrine semaphorin3A stimulates alpha2 beta1 integrin expression/function in breast tumor cells
by Pan, Hongjie and Wanami, Luke S and Dissanayake, Thusitha R and Bachelder, Robin E
Breast cancer research and treatment, ISSN 0167-6806, 11/2009, Volume 118, Issue 1, pp. 197 - 205
Neuropilin-1 | Integrin | Breast tumor | Migration | Semaphorin3A | Life Sciences & Biomedicine | Oncology | Science & Technology | Adenocarcinoma - pathology | Humans | Neoplasm Proteins - physiology | Gene Expression Regulation, Neoplastic | Breast Neoplasms - metabolism | Neuropilin-1 - physiology | Neoplasm Metastasis | Adenocarcinoma - metabolism | Cell Line, Tumor - pathology | Female | Neoplasm Proteins - genetics | Cell Line, Tumor - metabolism | Integrin alpha2beta1 - biosynthesis | Integrin alpha2beta1 - immunology | Neoplasm Invasiveness | Neoplasm Proteins - biosynthesis | Autocrine Communication - physiology | Integrin alpha2beta1 - physiology | Semaphorin-3A - pharmacology | Antibodies, Neutralizing - pharmacology | Collagen Type I | Cytoskeleton - ultrastructure | Recombinant Proteins - pharmacology | Cell Adhesion | Breast Neoplasms - pathology | Semaphorin-3A - physiology | Integrin alpha2beta1 - antagonists & inhibitors | Integrin alpha2beta1 - genetics | Cell Movement | Index Medicus
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6. Full Text The extreme C-terminal region of kindlin-2 is critical to its regulation of integrin activation
by Hirbawi, Jamila and Bialkowska, Katarzyna and Bledzka, Kamila M and Liu, Jianmin and Fukuda, Koichi and Qin, Jun and Plow, Edward F
The Journal of biological chemistry, ISSN 0021-9258, 08/2017, Volume 292, Issue 34, pp. 14258 - 14269
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Leukemia, Erythroblastic, Acute - metabolism | Cricetulus | Talin - chemistry | Humans | Integrin beta3 - chemistry | Protein Multimerization | Integrin alpha2 - metabolism | Integrin alpha2 - chemistry | Neoplasm Proteins - metabolism | Recombinant Fusion Proteins - metabolism | Talin - genetics | Gene Deletion | Integrin beta3 - genetics | Membrane Proteins - metabolism | Protein Interaction Domains and Motifs | Neoplasm Proteins - genetics | Peptide Fragments - genetics | CHO Cells | Recombinant Proteins - metabolism | Peptide Fragments - metabolism | Membrane Proteins - genetics | Recombinant Proteins - chemistry | Neoplasm Proteins - chemistry | Macrophages - cytology | Recombinant Fusion Proteins - chemistry | Talin - metabolism | Integrin beta3 - metabolism | Macrophages - metabolism | Peptide Fragments - chemistry | Animals | Integrin alpha2 - genetics | Membrane Proteins - chemistry | Neoplasm Proteins - agonists | Leukemia, Erythroblastic, Acute - pathology | Cell Line, Tumor | Luminescent Proteins - genetics | RAW 264.7 Cells | Mice | Mutation | Amino Acid Substitution | Luminescent Proteins - metabolism | Index Medicus | membrane | talin | cell adhesion | protein chemistry | kindlin | integrin | Cell Biology
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7. Full Text Matrix stiffness regulation of integrin‐mediated mechanotransduction during osteogenic differentiation of human mesenchymal stem cells
by Shih, Yu‐Ru V and Tseng, Kuo‐Fung and Lai, Hsiu‐Yu and Lin, Chi‐Hung and Lee, Oscar K
Journal of bone and mineral research, ISSN 0884-0431, 04/2011, Volume 26, Issue 4, pp. 730 - 738
mesenchymal stem cell | matrix stiffness | integrin | mechanotransduction | osteogenic differentiation | Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Vertebrates: osteoarticular system, musculoskeletal system | Skeleton and joints | RNA, Small Interfering - genetics | Osteogenesis - physiology | Gene Expression - drug effects | Gene Expression - genetics | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Collagen Type I - chemistry | Osteocalcin - genetics | Acrylic Resins - chemical synthesis | Integrin alpha2 - metabolism | Mechanotransduction, Cellular - physiology | rho-Associated Kinases - antagonists & inhibitors | Elasticity - physiology | Mesenchymal Stromal Cells - cytology | Collagen Type I - genetics | rho-Associated Kinases - metabolism | Extracellular Matrix - physiology | Myosin-Light-Chain Phosphatase - metabolism | Osteoblasts - cytology | Phosphorylation - drug effects | Cell Differentiation - physiology | Focal Adhesion Kinase 1 - metabolism | Mesenchymal Stromal Cells - drug effects | Calcification, Physiologic - drug effects | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Osteoblasts - drug effects | Calcification, Physiologic - physiology | Mesenchymal Stromal Cells - metabolism | Acrylic Resins - chemistry | beta Catenin - metabolism | Biomechanical Phenomena | Integrin alpha2 - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Cell Differentiation - drug effects | Protein Kinase Inhibitors - pharmacology | Osteoblasts - metabolism | Focal Adhesion Kinase 1 - antagonists & inhibitors | Core Binding Factor Alpha 1 Subunit - genetics | Mitogen-Activated Protein Kinase 1 - metabolism | Index Medicus
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8. Full Text Aging of blood can be tracked by DNA methylation changes at just three CpG sites
by Weidner, Carola I and Lin, Qiong and Koch, Carmen M and Eisele, Lewin and Beier, Fabian and Ziegler, Patrick and Bauerschlag, Dirk O and Jöckel, Karl-Heinz and Erbel, Raimund and Mühleisen, Thomas W and Zenke, Martin and Brümmendorf, Tim H and Wagner, Wolfgang
Genome biology, ISSN 1474-760X, 02/2014, Volume 15, Issue 2, pp. R24 - R24
Genetics & Heredity | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Blood Cells | Cellular Senescence - genetics | Aging - genetics | Integrin alpha2 - genetics | Amidohydrolases - genetics | Epigenesis, Genetic | Humans | CpG Islands - genetics | DNA Methylation - genetics | Cyclic Nucleotide Phosphodiesterases, Type 4 - genetics | Genome, Human | Induced Pluripotent Stem Cells | Index Medicus | Research
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9. Full Text Platelet-targeted gene therapy with human factor VIII establishes haemostasis in dogs with haemophilia A
by Du, Lily M and Nurden, Paquita and Nurden, Alan T and Nichols, Timothy C and Bellinger, Dwight A and Jensen, Eric S and Haberichter, Sandra L and Merricks, Elizabeth and Raymer, Robin A and Fang, Juan and Koukouritaki, Sevasti B and Jacobi, Paula M and Hawkins, Troy B and Cornetta, Kenneth and Shi, Qizhen and Wilcox, David A
Nature communications, ISSN 2041-1723, 2013, Volume 4, Issue 1, pp. 2773 - 2773
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Humans | Factor VIII - genetics | Gene Expression Regulation - physiology | Dog Diseases - genetics | Integrin alpha2 - metabolism | Blood Platelets - physiology | Hemophilia A - therapy | Hemophilia A - veterinary | Genetic Therapy - veterinary | Animals | Integrin alpha2 - genetics | Hemostasis | Dog Diseases - therapy | Dogs | Genetic Therapy - methods | Index Medicus
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10.