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integrins - metabolism (193) 193
integrins (163) 163
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binding (36) 36
gene expression regulation, neoplastic (36) 36
integrins - biosynthesis (36) 36
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integrin alpha6beta1 - genetics (35) 35
medicine (35) 35
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by Hoshino, Ayuko and Costa-Silva, Bruno and Shen, Tang-Long and Rodrigues, Goncalo and Hashimoto, Ayako and Tesic Mark, Milica and Molina, Henrik and Kohsaka, Shinji and Di Giannatale, Angela and Ceder, Sophia and Singh, Swarnima and Williams, Caitlin and Soplop, Nadine and Uryu, Kunihiro and Pharmer, Lindsay and King, Tari and Bojmar, Linda and Davies, Alexander E and Ararso, Yonathan and Zhang, Tuo and Zhang, Haiying and Hernandez, Jonathan and Weiss, Joshua M and Dumont-Cole, Vanessa D and Kramer, Kimberly and Wexler, Leonard H and Narendran, Aru and Schwartz, Gary K and Healey, John H and Sandstrom, Per and Jørgen Labori, Knut and Kure, Elin H and Grandgenett, Paul M and Hollingsworth, Michael A and De Sousa, Maria and Kaur, Sukhwinder and Jain, Maneesh and Mallya, Kavita and Batra, Surinder K and Jarnagin, William R and Brady, Mary S and Fodstad, Oystein and Muller, Volkmar and Pantel, Klaus and Minn, Andy J and Bissell, Mina J and Garcia, Benjamin A and Kang, Yibin and Rajasekhar, Vinagolu K and Ghajar, Cyrus M and Matei, Irina and Peinado, Hector and Bromberg, Jacqueline and Lyden, David and Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States) and Weill Cornell Medicine, New York, NY (United States) and Memorial Sloan Kettering Cancer Center, New York, NY (United States) and Medicinska fakulteten and Region Östergötland and Kirurgiska kliniken US and Linköpings universitet and Institutionen för klinisk och experimentell medicin and Avdelningen för kliniska vetenskaper and Centrum för kirurgi, ortopedi och cancervård
Nature, ISSN 0028-0836, 11/2015, Volume 527, Issue 7578, pp. 329 - 335
Ever since Stephen Paget's 1889 hypothesis, metastatic organotropism has remained one of cancer's greatest mysteries. Here we demonstrate that exosomes from... 
CELLS | BONE METASTASES | VESICLES | BREAST-CANCER METASTASIS | MULTIDISCIPLINARY SCIENCES | IN-VIVO | GROWTH | NICHE | MICROVESICLES | PROTEINS | PROTEOMICS | Exosomes - metabolism | Tropism | Phosphorylation | Epithelial Cells - metabolism | Receptors, Vitronectin - antagonists & inhibitors | Humans | Lung - cytology | Integrin beta4 - metabolism | Integrins - metabolism | Brain - metabolism | Integrin alpha6beta1 - metabolism | S100 Proteins - genetics | Neoplasm Metastasis - prevention & control | Female | Kupffer Cells - metabolism | Lung - metabolism | Receptors, Vitronectin - metabolism | Epithelial Cells - cytology | Integrin alpha6beta4 - metabolism | Fibroblasts - metabolism | Biomarkers - metabolism | Brain - cytology | Kupffer Cells - cytology | Endothelial Cells - metabolism | Liver - metabolism | Mice, Inbred C57BL | Integrin alpha6beta4 - antagonists & inhibitors | Organ Specificity | Animals | Endothelial Cells - cytology | Neoplasm Metastasis - pathology | Cell Line, Tumor | Integrin beta Chains - metabolism | Fibroblasts - cytology | Liver - cytology | Mice | Genes, src | Integrins - antagonists & inhibitors | Complications and side effects | Development and progression | Cell organelles | Metastasis | Health aspects | Integrins | Tumors | Studies | Microscopy | Liver | Melanoma | Fibroblasts | Breast cancer | Chemokines | Index Medicus | mechanisms of disease | cancer microenvironment | BASIC BIOLOGICAL SCIENCES | metastasis | 60 APPLIED LIFE SCIENCES | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap
Journal Article
Oncotarget, ISSN 1949-2553, 2015, Volume 6, Issue 13, pp. 11434 - 11446
Chondrosarcoma is a malignant tumor that produces cartilage matrix. The most lethal aspect is its metastatic property. We demonstrated that amphiregulin (AR)... 
Chondrosarcoma | Integrin | Amphiregulin | Cell migration | Index Medicus
Journal Article
Nature cell biology, ISSN 1465-7392, 10/2014, Volume 16, Issue 10, pp. 8 - 941
The mechanism by which angiogenic endothelial cells break the physical barrier of the vascular basement membrane and consequently sprout to form new vessels in... 
F-ACTIN | INVADOPODIA | TIP CELLS | INTEGRIN | BLOOD-VESSELS | EXTRACELLULAR-MATRIX | MICE | GROWTH-FACTOR | TRANSFORMED FIBROBLASTS | BASEMENT-MEMBRANE | CELL BIOLOGY | Neoplasms - metabolism | Cell Membrane Structures - physiology | Tetradecanoylphorbol Acetate - pharmacology | Humans | Lung Neoplasms - metabolism | Male | Melanoma, Experimental - metabolism | Green Fluorescent Proteins - genetics | Vascular Endothelial Growth Factor A - metabolism | Lung Neoplasms - physiopathology | Integrin alpha6beta1 - metabolism | Melanoma, Experimental - physiopathology | Cell Membrane Structures - metabolism | RNA Interference | HEK293 Cells | Integrin alpha6beta1 - genetics | Neovascularization, Pathologic - physiopathology | Neoplasms - physiopathology | Vascular Endothelial Growth Factor A - pharmacology | Endothelial Cells - physiology | Lung Neoplasms - blood supply | Green Fluorescent Proteins - metabolism | Cell Membrane Structures - drug effects | Melanoma, Experimental - blood supply | Endothelial Cells - metabolism | Mice, Inbred C57BL | Cells, Cultured | Neoplasms - blood supply | Matrix Metalloproteinase 14 - metabolism | Basement Membrane - metabolism | Mice, Knockout | Microscopy, Confocal | Animals | Cell Line, Tumor | Neovascularization, Pathologic - metabolism | HeLa Cells | Laminin - metabolism | Microscopy, Fluorescence | Endothelial Cells - drug effects | Blood vessels | Physiological aspects | Cell research | Neovascularization | Research | Index Medicus
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 06/2017, Volume 487, Issue 3, pp. 525 - 531
Laminins are major cell-adhesive proteins of basement membranes that interact with integrins in a divalent cation-dependent manner. Laminin-511 consists of α5,... 
Extracellular matrix | Laminin | Integrin | Cell adhesion | Basement membrane | Integrin alpha6beta1 - metabolism | Laminin - genetics | Integrin alpha6beta1 - chemistry | Ions - chemistry | Metals - metabolism | Metals - chemistry | Humans | Laminin - chemistry | Laminin - metabolism | Ions - metabolism | Binding Sites | Index Medicus
Journal Article
STEM CELLS, ISSN 1066-5099, 02/2013, Volume 31, Issue 2, pp. 317 - 326
The promising clinical effects of mesenchymal stromal/stem cells (MSCs) rely especially on paracrine and nonimmunogenic mechanisms. Delivery routes are... 
Systemic infusion | Cell adherence | Biodistribution | Cell surface | Lung | Mesenchymal stromal/stem cell | PROGENITOR CELLS | STEM-CELLS | MYOCARDIAL-INFARCTION | TISSUE-REPAIR | CELL & TISSUE ENGINEERING | CELL BIOLOGY | ONCOLOGY | HUMAN BONE-MARROW | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENE-EXPRESSION | MICE | UMBILICAL-CORD BLOOD | IN-VIVO DISTRIBUTION | HEMATOLOGY | HEMATOPOIETIC STEM | Proto-Oncogene Proteins c-met - metabolism | Integrin alpha4beta1 - metabolism | Humans | Half-Life | Transplantation, Heterologous | Lung - cytology | Integrin alpha6beta1 - metabolism | Mesenchymal Stromal Cells - cytology | Integrin alpha4 - genetics | Integrin alpha6beta1 - genetics | Isotope Labeling | Female | Cell Differentiation | Lung - metabolism | Technetium Compounds | Biomarkers - metabolism | Gene Expression | Bone Marrow Cells - cytology | Mesenchymal Stromal Cells - metabolism | Integrin alpha4beta1 - genetics | Integrin alpha6 - genetics | Fetal Blood - cytology | Fetal Blood - metabolism | Cell Adhesion | Cord Blood Stem Cell Transplantation | Proto-Oncogene Proteins c-met - genetics | Integrin alpha6 - metabolism | Animals | Integrin alpha4 - metabolism | Mice, Nude | Mice | Infusions, Intravenous | Bone Marrow Cells - metabolism | Lung - immunology | Mesenchymal Stem Cell Transplantation | Fibronectins | Analysis | Stem cells | Product development | Information management | Universities and colleges | Blood banks | Integrins | Bone marrow | Medical research | Index Medicus
Journal Article
Journal Article