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1. Full Text Gene expression profiling combined with functional analysis identify integrin beta1 (ITGB1) as a potential prognosis biomarker in triple negative breast cancer
by Klahan, Sukhontip and Huang, Wan-Chen and Chang, Che-Mai and Wong, Henry Sung-Ching and Huang, Chi-Cheng and Wu, Mei-Shin and Lin, Yu-Chiao and Lu, Hsing-Fang and Hou, Ming-Feng and Chang, Wei-Chiao
Pharmacological research, ISSN 1043-6618, 02/2016, Volume 104, pp. 31 - 37
ITGB1 | Store-operated calcium channel | Triple negative breast cancer | Cell migration | RNA, Small Interfering - genetics | Cell Proliferation | Prognosis | Calcium - metabolism | Humans | Asian Continental Ancestry Group - genetics | Gene Expression Regulation, Neoplastic | Gene Silencing | Gene Expression Profiling | RNA, Messenger - metabolism | Integrin beta1 - metabolism | Triple Negative Breast Neoplasms - genetics | Cell Cycle | Taiwan | Cell Line, Tumor | Female | Biomarkers, Tumor - genetics | Integrin beta1 - genetics | Cell Movement | Medical colleges | Pharmacogenetics | Natural language interfaces | Drugstores | Breast cancer | Gene expression | Language processing | Analysis | Pharmacy | Genetic research | Computational linguistics | Integrins | Index Medicus
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2. Full Text Integrin beta1 over‐expression associates with resistance to tyrosine kinase inhibitor gefitinib in non‐small cell lung cancer
by Ju, Lixia and Zhou, Caicun and Li, Wei and Yan, Linghua
Journal of cellular biochemistry, ISSN 0730-2312, 12/2010, Volume 111, Issue 6, pp. 1565 - 1574
integrin β1 | gefitinib | resistance | non‐small cell lung cancer | non-small cell lung cancer | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Cell Cycle - genetics | Cell Adhesion - genetics | Apoptosis - drug effects | Humans | Carcinoma, Non-Small-Cell Lung - metabolism | Apoptosis - genetics | Antineoplastic Agents - therapeutic use | Cell Adhesion - drug effects | Reverse Transcriptase Polymerase Chain Reaction | Sequence Analysis, DNA | Cell Movement - genetics | Integrin beta1 - metabolism | Cell Movement - drug effects | Drug Resistance, Neoplasm - genetics | Protein Kinase Inhibitors - therapeutic use | Quinazolines - therapeutic use | Cell Line, Tumor | Cell Proliferation - drug effects | Carcinoma, Non-Small-Cell Lung - drug therapy | Cell Cycle - drug effects | Integrin beta1 - genetics | Index Medicus
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3. Full Text Beta1 integrin inhibits apoptosis induced by cyclic stretch in annulus fibrosus cells via ERK1/2 MAPK pathway
by Zhang, Kai and Zhang, Kai and Ding, Wei and Ding, Wei and Sun, Wei and Sun, Wei and Sun, Xiao-jiang and Sun, Xiao-jiang and Xie, You-zhuan and Xie, You-zhuan and Zhao, Chang-qing and Zhao, Chang-qing and Zhao, Jie and Zhao, Jie
Apoptosis (London), ISSN 1360-8185, 1/2016, Volume 21, Issue 1, pp. 13 - 24
Biochemistry, general | Biomedicine | β1 integrin | Cyclic stretch | Intervertebral disc degeneration | Cancer Research | Oncology | Cell Biology | Virology | Apoptosis | ERK | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Phosphorylation | Humans | Caspase 3 - metabolism | Stress, Mechanical | Apoptosis - genetics | Male | Intervertebral Disc Degeneration - metabolism | Intervertebral Disc Degeneration - pathology | Transfection | Mitogen-Activated Protein Kinase 1 - genetics | Caspase 3 - genetics | Lentivirus - genetics | Intervertebral Disc - pathology | Mechanotransduction, Cellular - genetics | Chondrocytes - metabolism | Disease Models, Animal | Intervertebral Disc Degeneration - genetics | Chondrocytes - pathology | Lumbar Vertebrae - metabolism | Genetic Vectors - chemistry | Mitogen-Activated Protein Kinase 3 - genetics | Gene Expression Regulation | Genetic Vectors - metabolism | Rats | Intervertebral Disc - metabolism | Rats, Sprague-Dawley | Integrin beta1 - metabolism | Osteoblasts - pathology | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Lumbar Vertebrae - pathology | Integrin beta1 - genetics | Osteoblasts - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Backache | Analysis | Integrins | Index Medicus
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4. Full Text Beta1 integrin blockade overcomes doxorubicin resistance in human T-cell acute lymphoblastic leukemia
by Berrazouane, Sofiane and Boisvert, Marc and Salti, Suzanne and Mourad, Walid and Al-Daccak, Reem and Barabé, Frédéric and Aoudjit, Fawzi
Cell death & disease, ISSN 2041-4889, 05/2019, Volume 10, Issue 5, pp. 357 - 357
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - pathology | RNA, Small Interfering - genetics | Antibiotics, Antineoplastic - pharmacology | Apoptosis - drug effects | Humans | Collagen Type I - chemistry | Extracellular Matrix - metabolism | Collagen - chemistry | Focal Adhesion Kinase 2 - antagonists & inhibitors | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - mortality | Proteoglycans - chemistry | Extracellular Matrix - chemistry | Focal Adhesion Kinase 2 - genetics | Focal Adhesion Kinase 2 - metabolism | T-Lymphocytes - metabolism | T-Lymphocytes - drug effects | T-Lymphocytes - pathology | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Collagen Type I - metabolism | Signal Transduction | Jurkat Cells | Proteoglycans - metabolism | Antibodies, Neutralizing - pharmacology | Gene Expression Regulation, Leukemic | Cell Adhesion - drug effects | Integrin beta1 - metabolism | Xenograft Model Antitumor Assays | Collagen - metabolism | Drug Resistance, Neoplasm - genetics | Animals | Mice, Nude | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Survival Analysis | Cell Line, Tumor | Laminin - chemistry | Laminin - metabolism | Primary Cell Culture | Integrin beta1 - genetics | Doxorubicin - pharmacology | Drug Combinations | RNA, Small Interfering - metabolism | Tyrosine | Collagen (type I) | Acute lymphatic leukemia | Therapeutic applications | Proline-rich tyrosine kinase 2 | Leukemia | Chemoresistance | Proline | Lymphocytes T | siRNA | Lymphatic leukemia | Doxorubicin | Cell adhesion & migration | Cell adhesion | Xenografts | Bone marrow | Extracellular matrix | Protein-tyrosine kinase | Integrins | Index Medicus
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5. Full Text Integrin expression profiling identifies integrin alpha5 and beta1 as prognostic factors in early stage non-small cell lung cancer
by Dingemans, Anne-Marie C and van den Boogaart, Vivian and Vosse, Bettine A and van Suylen, Robert-Jan and Griffioen, Arjan W and Thijssen, Victor L
Molecular cancer, ISSN 1476-4598, 06/2010, Volume 9, Issue 1, pp. 152 - 152
Biochemistry & Molecular Biology | Oncology | Life Sciences & Biomedicine | Science & Technology | Integrin alphaV - biosynthesis | Prognosis | Lung Neoplasms - mortality | Humans | Lung Neoplasms - metabolism | Middle Aged | Male | Gene Expression Profiling | Aged, 80 and over | Adult | Female | Retrospective Studies | Integrin alphaV - genetics | Lung Neoplasms - genetics | Gene Expression | Biomarkers, Tumor - analysis | Carcinoma, Non-Small-Cell Lung - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Kaplan-Meier Estimate | Reverse Transcriptase Polymerase Chain Reaction | Carcinoma, Non-Small-Cell Lung - mortality | Integrin beta1 - biosynthesis | Disease-Free Survival | Aged | Integrin beta1 - genetics | Polymerase chain reaction | Usage | Physiological aspects | Genetic aspects | Research | Lung cancer, Non-small cell | Integrins | Index Medicus
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6. Full Text Major host factors involved in epithelial cell invasion of Campylobacter jejuni: role of fibronectin, integrin beta1, FAK, Tiam-1, and DOCK180 in activating Rho GTPase Rac1
by Boehm, Manja and Krause-Gruszczynska, Malgorzata and Rohde, Manfred and Tegtmeyer, Nicole and Takahashi, Seiichiro and Oyarzabal, Omar A and Backert, Steffen
Frontiers in cellular and infection microbiology, ISSN 2235-2988, 2011, Volume 1, pp. 17 - 17
Rho family GTPases | signaling | virulence | cellular invasion | molecular pathogenesis | Campylobacter jejuni - ultrastructure | Focal Adhesion Kinase 1 - genetics | RNA, Small Interfering - genetics | Guanine Nucleotide Exchange Factors - physiology | Campylobacter jejuni - pathogenicity | Humans | Neuropeptides - physiology | Integrin beta1 - physiology | rac GTP-Binding Proteins - antagonists & inhibitors | Fibronectins - deficiency | Virulence - genetics | rac GTP-Binding Proteins - genetics | Base Sequence | Focal Adhesion Kinase 1 - deficiency | rac GTP-Binding Proteins - physiology | T-Lymphoma Invasion and Metastasis-inducing Protein 1 | Bacterial Outer Membrane Proteins - genetics | Campylobacter jejuni - genetics | Carrier Proteins - physiology | Cell Line | Genes, Bacterial | Microscopy, Electron, Scanning | Signal Transduction | Epithelial Cells - ultrastructure | Focal Adhesion Kinase 1 - physiology | Mice, Knockout | Carrier Proteins - genetics | Animals | Host-Pathogen Interactions - genetics | rac1 GTP-Binding Protein - physiology | Models, Biological | Epithelial Cells - microbiology | rac1 GTP-Binding Protein - antagonists & inhibitors | Fibronectins - physiology | Virulence - physiology | Fibronectins - genetics | Mice | Bacterial Outer Membrane Proteins - physiology | Enzyme Activation | Mutation | Integrin beta1 - genetics | Campylobacter Infections - etiology | Host-Pathogen Interactions - physiology | rac1 GTP-Binding Protein - genetics | Index Medicus | Virulence | signalling
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7. Full Text Latent TGF-β structure and activation
by Shi, Minlong and Zhu, Jianghai and Wang, Rui and Chen, Xing and Mi, Lizhi and Walz, Thomas and Springer, Timothy A
Nature (London), ISSN 0028-0836, 06/2011, Volume 474, Issue 7351, pp. 343 - 351
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Structure in molecular biology | Molecular biophysics | Crystalline structure | Latent TGF-beta Binding Proteins - chemistry | Multigene Family | Receptors, Transforming Growth Factor beta - chemistry | Humans | Transforming Growth Factor beta1 - metabolism | Integrins - chemistry | Camurati-Engelmann Syndrome - genetics | Molecular Sequence Data | Activins - metabolism | Crystallography, X-Ray | Antigens, Neoplasm - chemistry | Integrins - metabolism | Transforming Growth Factor beta1 - chemistry | Swine | HEK293 Cells | Antigens, Neoplasm - metabolism | Oligopeptides - chemistry | Transforming Growth Factor beta1 - biosynthesis | Latent TGF-beta Binding Proteins - metabolism | Protein Structure, Tertiary | Amino Acid Sequence | Cell Line | Models, Molecular | Transforming Growth Factor beta1 - genetics | Oligopeptides - metabolism | Mutation - genetics | Amino Acid Motifs | Animals | Receptors, Transforming Growth Factor beta - metabolism | Index Medicus
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8. Full Text Compact spheroid formation by ovarian cancer cells is associated with contractile behavior and an invasive phenotype
by Sodek, Katharine L and Ringuette, Maurice J and Brown, Theodore J
International journal of cancer, ISSN 0020-7136, 05/2009, Volume 124, Issue 9, pp. 2060 - 2070
contraction | 3D culture | invasion | myofibroblast | spheroid | Spheroid | Myofibroblast | Contraction | Invasion | Life Sciences & Biomedicine | Oncology | Science & Technology | Gynecology. Andrology. Obstetrics | Biological and medical sciences | Medical sciences | Tumors | Female genital diseases | Cell Proliferation | Humans | Transforming Growth Factor beta1 - metabolism | Ovarian Neoplasms - pathology | Spheroids, Cellular - pathology | Extracellular Matrix - metabolism | Transglutaminases - genetics | GTP-Binding Proteins - genetics | Female | Ovarian Neoplasms - metabolism | Tumor Cells, Cultured | Fibroblasts - metabolism | Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase - genetics | Neoplasm Invasiveness | Spheroids, Cellular - metabolism | Transforming Growth Factor beta1 - genetics | Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase - metabolism | Cell Adhesion | Fibronectins - metabolism | Integrin beta1 - metabolism | Receptors, Urokinase Plasminogen Activator - metabolism | Collagen - metabolism | Phenotype | Transglutaminases - metabolism | Connective Tissue Growth Factor - genetics | Fibroblasts - cytology | Receptors, Urokinase Plasminogen Activator - genetics | Integrin beta1 - genetics | Extracellular Matrix - pathology | Connective Tissue Growth Factor - metabolism | Cell Movement | GTP-Binding Proteins - metabolism | Index Medicus
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9. Full Text Human 'brite/beige' adipocytes develop from capillary networks, and their implantation improves metabolic homeostasis in mice
by Min, So Yun and Kady, Jamie and Nam, Minwoo and Rojas-Rodriguez, Raziel and Berkenwald, Aaron and Kim, Jong Hun and Noh, Hye-Lim and Kim, Jason K and Cooper, Marcus P and Fitzgibbons, Timothy and Brehm, Michael A and Corvera, Silvia
Nature medicine, ISSN 1078-8956, 03/2016, Volume 22, Issue 3, pp. 312 - 318
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Enkephalins - metabolism | Humans | Middle Aged | Ion Channels - genetics | Male | RNA, Messenger - metabolism | Enkephalins - genetics | Mitochondrial Proteins - metabolism | Diet, High-Fat | Iodide Peroxidase - metabolism | Adipocytes, Brown - transplantation | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Oxygen Consumption | Apoptosis Regulatory Proteins - metabolism | Protein Precursors - metabolism | Mice | Iodide Peroxidase - genetics | Blood Glucose - metabolism | Integrin beta1 - genetics | Adipocytes, White - metabolism | Glucose Intolerance - metabolism | Proprotein Convertase 1 - genetics | Adipocytes, Brown - metabolism | Homeostasis | Mitochondrial Proteins - genetics | DNA-Binding Proteins - metabolism | Polymerase Chain Reaction | Apoptosis Regulatory Proteins - genetics | Adult | Female | Capillaries | Glucose Tolerance Test | Protein Precursors - genetics | Proprotein Convertase 1 - metabolism | Cell Transplantation | Adipocytes, White - transplantation | DNA-Binding Proteins - genetics | Obesity - metabolism | Integrin beta1 - metabolism | Interleukin-33 - genetics | Animals | Ion Channels - metabolism | Receptor, Platelet-Derived Growth Factor alpha - genetics | Adipocytes - metabolism | Fluorescent Antibody Technique | Interleukin-33 - metabolism | Adipocytes - transplantation | Aged | Glucose Clamp Technique | Uncoupling Protein 1 | Neovascularization, Physiologic | Adipose tissues | Physiological aspects | Genetic aspects | Research | Index Medicus | cytokine | human adipocyte | glucose | progenitors | adipokine | capillary | adrenergic | thermogenic adipose tissue | implant
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10. Full Text Gain of glycosylation in integrin α3 causes lung disease and nephrotic syndrome
by Nicolaou, Nayia and Margadant, Coert and Kevelam, Sietske H and Lilien, Marc R and Oosterveld, Michiel J. S and Kreft, Maaike and van Eerde, Albertien M and Pfundt, Rolph and Terhal, Paulien A and van der Zwaag, Bert and Nikkels, Peter G. J and Sachs, Norman and Goldschmeding, Roel and Knoers, Nine V. A. M and Renkema, Kirsten Y and Sonnenberg, Arnoud
The Journal of clinical investigation, ISSN 0021-9738, 2012, Volume 122, Issue 12, pp. 4375 - 4387
Lung Diseases, Interstitial - metabolism | Humans | Protein Multimerization | Protein Processing, Post-Translational - genetics | Nephrotic Syndrome - metabolism | Endoplasmic Reticulum - metabolism | Infant | Nephrotic Syndrome - genetics | Integrin alpha3 - metabolism | Lung Diseases, Interstitial - diagnosis | Glomerular Mesangium - metabolism | Proteolysis | Base Sequence | Fatal Outcome | Female | Nephrotic Syndrome - diagnosis | Gene Expression | Integrin alpha3 - genetics | Podocytes - metabolism | Tetraspanin 24 - metabolism | Genetic Association Studies | Cells, Cultured | Models, Molecular | Nephrotic Syndrome - pathology | Glycosylation | Sequence Analysis, DNA | Integrin beta1 - metabolism | Point Mutation | Glomerular Mesangium - pathology | Lung Diseases, Interstitial - genetics | Pedigree | Proteasome Endopeptidase Complex - metabolism | Integrin beta1 - genetics | Index Medicus | Abridged Index Medicus
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11. Full Text Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1
by Young-Pearse, Tracy L and Chen, Allen C and Chang, Rui and Marquez, Cesar and Selkoe, Dennis J
Neural development, ISSN 1749-8104, 2008, Volume 3, Issue 1, pp. 15 - 15
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Developmental Biology | Science & Technology | Cricetulus | Neurites - physiology | Humans | Green Fluorescent Proteins - genetics | Cerebral Cortex - cytology | Amyloid beta-Protein Precursor - secretion | Neurons - ultrastructure | Transfection | Amyloid beta-Protein Precursor - metabolism | Neurons - physiology | Female | CHO Cells | Cricetinae | Mice, Inbred C57BL | Cells, Cultured | Rats | Hippocampus - cytology | Nerve Tissue Proteins - genetics | Rats, Sprague-Dawley | Mice, Knockout | Integrin beta1 - metabolism | Nerve Tissue Proteins - metabolism |